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  1. although being central for the biology and druggability of hormone-receptor positive, HER2 negative metastatic breast cancer (MBC), ESR1 and PIK3CA mutations are simplistically dichotomized as mutated or wild ...

    Authors: Lorenzo Gerratana, Andrew A. Davis, Marko Velimirovic, Katherine Clifton, Whitney L. Hensing, Ami N. Shah, Charles S. Dai, Carolina Reduzzi, Paolo D’Amico, Firas Wehbe, Arielle Medford, Seth A. Wander, William J. Gradishar, Amir Behdad, Fabio Puglisi, Cynthia X. Ma…
    Citation: Breast Cancer Research 2023 25:112
    Content type: Research Published on:

  2. Latin American and Hispanic women are less likely to develop breast cancer (BC) than women of European descent. Observational studies have found an inverse relationship between the individual proportion of Nat...

    Authors: Linda Zollner, Diana Torres, Ignacio Briceno, Michael Gilbert, Gabriela Torres-Mejía, Joe Dennis, Manjeet K. Bolla, Qin Wang, Ute Hamann and Justo Lorenzo Bermejo
    Citation: Breast Cancer Research 2023 25:111
    Content type: Research Published on:

  3. Gene expression (GEX) signatures in breast cancer provide prognostic information, but little is known about their predictive value for tamoxifen treatment. We examined the tamoxifen-predictive value and progno...

    Authors: Christine Lundgren, Julia Tutzauer, Sarah E. Church, Olle Stål, Maria Ekholm, Carina Forsare, Bo Nordenskjöld, Mårten Fernö, Pär-Ola Bendahl and Lisa Rydén
    Citation: Breast Cancer Research 2023 25:110
    Content type: Research Published on:

  4. Triple-negative breast cancer (TNBC) is a subtype of breast cancer with higher aggressiveness and poorer outcomes. Recently, long non-coding RNAs (lncRNAs) have become the crucial gene regulators in the progre...

    Authors: Dan Luo, Yiran Liang, Yajie Wang, Fangzhou Ye, Yuhan Jin, Yaming Li, Dianwen Han, Zekun Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, Liyu Jiang and Qifeng Yang
    Citation: Breast Cancer Research 2023 25:109
    Content type: Research Published on:

  7. Breast cancer liver metastases (BCLM) is a common cause of breast cancer-related death. The prognostic and predictive value of receptor expression and St Gallen classification is challenged by receptor status ...

    Authors: Marcus Sundén, Sofia Norgren, Robert Lundqvist, Anne Andersson, Malin Sund and Oskar Hemmingsson
    Citation: Breast Cancer Research 2023 25:105
    Content type: Research Published on:

  8. Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity contributes to breast cancer remains unclear. The inflammatory adip...

    Authors: Rhianna Rachael Romany Blyth, Charles N. Birts and Stephen A. Beers
    Citation: Breast Cancer Research 2023 25:104
    Content type: Review Published on:

  9. The phase III MONALEESA-3 trial included first- (1L) and second-line (2L) patients and demonstrated a significant overall survival (OS) benefit for ribociclib + fulvestrant in patients with hormone receptor–po...

    Authors: P. Neven, P. A. Fasching, S. Chia, G. Jerusalem, M. De Laurentiis, S.-A. Im, K. Petrakova, G. V. Bianchi, M. Martín, A. Nusch, G. S. Sonke, L. De la Cruz-Merino, J. T. Beck, J. P. Zarate, Y. Wang, A. Chakravartty…
    Citation: Breast Cancer Research 2023 25:103
    Content type: Research Published on:

  10. Intratumor heterogeneity is a well-established hallmark of cancer that impedes cancer research, diagnosis, and treatment. Previously, we phenotypically sorted human breast cancer cells based on migratory poten...

    Authors: Lauren A. Hapach, Wenjun Wang, Samantha C. Schwager, Devika Pokhriyal, Emily D. Fabiano and Cynthia A. Reinhart-King
    Citation: Breast Cancer Research 2023 25:102
    Content type: Research Published on:

  12. The interface zone, area around invasive carcinoma, can be thought of as the actual tissue of the tumor microenvironment with precedent alterations for tumor invasion. However, the heterogeneity and characteri...

    Authors: Wei Yang, Meiyu Xu, Shuoqi Xu, Qingxian Guan, Shuaiming Geng, Juanhong Wang, Wei Wei, Hongwei Xu, Ying Liu, Yong Meng and Ming-Qing Gao
    Citation: Breast Cancer Research 2023 25:100
    Content type: Research Published on:

  13. Obesity increases breast cancer risk and breast cancer-specific mortality, particularly for people with estrogen receptor (ER)-positive tumors. Body mass index (BMI) is used to define obesity, but it may not b...

    Authors: Marisol Castillo-Castrejon, Barbara Mensah Sankofi, Stevi Johnson Murguia, Abasi-ama Udeme, Hoaning Howard Cen, Yi Han Xia, Nisha S. Thomas, William L. Berry, Kenneth L. Jones, Vincent R. Richard, Rene P. Zahedi, Christoph H. Borchers, James D. Johnson and Elizabeth A. Wellberg
    Citation: Breast Cancer Research 2023 25:99
    Content type: Research Published on:

  15. Emerging data indicate that variations in quantitative epithelial and stromal tissue composition and their relative abundance in benign breast biopsies independently impact risk of future invasive breast cance...

    Authors: Mustapha Abubakar, Alyssa Klein, Shaoqi Fan, Scott Lawrence, Karun Mutreja, Jill E. Henry, Ruth M. Pfeiffer, Maire A. Duggan and Gretchen L. Gierach
    Citation: Breast Cancer Research 2023 25:97
    Content type: Research Published on:

  16. Targeted estrogen receptor degradation has been approved to effectively treat ER + breast cancers. Due to the poor bioavailability of fulvestrant, the first generation of SERD, many efforts were made to develo...

    Authors: Feng Zhou, Guimei Yang, Liting Xue, Yajing Liu, Yao Guo, Ji Zhu, Linlin Yuan, Peng Gu, Feng Tang, Jinwen Shan and Renhong Tang
    Citation: Breast Cancer Research 2023 25:96
    Content type: Research Published on:

  17. Laboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC), may be important in breast cancer etiology and explain associations betw...

    Authors: Mindy C. DeRouen, Juan Yang, Yuqing Li, Adrian A. Franke, Anne N. Tome, Kami K. White, Brenda Y. Hernandez, Yurii Shvetsov, Veronica Setiawan, Anna H. Wu, Lynne R. Wilkens, Loïc Le Marchand, Lenora W. M. Loo and Iona Cheng
    Citation: Breast Cancer Research 2023 25:95
    Content type: Research Published on:

  18. Authors: M. G. Muoio, M. Pellegrino, V. Rapicavoli, M. Talia, G. Scavo, V. Sergi, V. Vella, S. Pettinato, M. G. Galasso, R. Lappano, D. Scordamaglia, F. Cirillo, A. Pulvirenti, D. C. Rigiracciolo, M. Maggiolini, A. Belfiore…
    Citation: Breast Cancer Research 2023 25:94
    Content type: Publisher Correction Published on:

    The original article was published in Breast Cancer Research 2023 25:84

  19. Genome-wide studies of gene–environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~...

    Authors: Pooja Middha, Xiaoliang Wang, Sabine Behrens, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Thaïs Baert, Laura E. Beane Freeman…
    Citation: Breast Cancer Research 2023 25:93
    Content type: Research Published on:

  20. Breast density is strongly associated with breast cancer risk. Fully automated quantitative density assessment methods have recently been developed that could facilitate large-scale studies, although data on a...

    Authors: Laurel A. Habel, Stacey E. Alexeeff, Ninah Achacoso, Vignesh A. Arasu, Aimilia Gastounioti, Lawrence Gerstley, Robert J. Klein, Rhea Y. Liang, Jafi A. Lipson, Walter Mankowski, Laurie R. Margolies, Joseph H. Rothstein, Daniel L. Rubin, Li Shen, Adriana Sistig, Xiaoyu Song…
    Citation: Breast Cancer Research 2023 25:92
    Content type: Research Published on:

  21. A hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher cap...

    Authors: Nuria G. Martínez-Illescas, Silvia Leal, Patricia González, Osvaldo Graña-Castro, Juan José Muñoz-Oliveira, Alfonso Cortés-Peña, María Gómez-Gil, Zaira Vega, Verónica Neva, Andrea Romero, Miguel Quintela-Fandino, Eva Ciruelos, Consuelo Sanz, Sofía Aragón, Leisy Sotolongo, Sara Jiménez…
    Citation: Breast Cancer Research 2023 25:91
    Content type: Research Published on:

  22. The communication between tumor cells and tumor microenvironment plays a critical role in cancer development. Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment and tak...

    Authors: Huijuan Dai, Wenting Xu, Lulu Wang, Xiao Li, Xiaonan Sheng, Lei Zhu, Ye Li, Xinrui Dong, Weihang Zhou, Chenyu Han, Yan Mao and Linli Yao
    Citation: Breast Cancer Research 2023 25:90
    Content type: Research Published on:

  23. Cardiovascular disease (CVD) is the leading cause of death worldwide. The aim of this study was to examine if CVD affects the mortality of women after a breast cancer diagnosis and population controls differen...

    Authors: Annika Möhl, Sabine Behrens, Fabian Flaßkamp, Nadia Obi, Annika Kreienbrinck, Bernd Holleczek, Kathleen Gali, Jenny Chang-Claude and Heiko Becher
    Citation: Breast Cancer Research 2023 25:89
    Content type: Research Published on:

  24. Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with limited therapeutic options readily available. Immunotherapy such as immune checkpoint inhibition has been investigated in...

    Authors: Chanjuan Zheng, Xi Xu, Muyao Wu, Lian Xue, Jianyu Zhu, Hongzhuo Xia, Siyu Ding, Shujun Fu, Xinyu Wang, Yian Wang, Guangchun He, Xia Liu and Xiyun Deng
    Citation: Breast Cancer Research 2023 25:88
    Content type: Review Published on:

  25. Deep learning analysis of radiological images has the potential to improve diagnostic accuracy of breast cancer, ultimately leading to better patient outcomes. This paper systematically reviewed the current li...

    Authors: Richard Adam, Kevin Dell’Aquila, Laura Hodges, Takouhie Maldjian and Tim Q. Duong
    Citation: Breast Cancer Research 2023 25:87
    Content type: Review Published on:

  26. Carcinoma-associated fibroblasts (CAFs) play a critical role in cancer progression and immune cell modulation. In this study, it was aimed to evaluate the roles of CAFs-derived IL-6 in doxorubicin (Dox) resist...

    Authors: Nisa Chuangchot, Pranisa Jamjuntra, Supaporn Yangngam, Piriya Luangwattananun, Suyanee Thongchot, Mutita Junking, Peti Thuwajit, Pa-Thai Yenchitsomanus and Chanitra Thuwajit
    Citation: Breast Cancer Research 2023 25:86
    Content type: Research Published on:

  27. Chemoresistance involves metastasis and aggressiveness of breast cancer (BC). Chemotherapy-elicited exosomes have been reported to be associated with drug resistance and pro-metastatic capacity of BC cells. No...

    Authors: Wenjie Xia, Wuzhen Chen, Chao Ni, Xuli Meng, Jun Wu, Qiong Yang, Hongchao Tang, Hongjun Yuan and Shan Fang
    Citation: Breast Cancer Research 2023 25:85
    Content type: Research Published on:

  28. The receptor for advanced glycation end products (RAGE) is implicated in diabetes and obesity complications, as well as in breast cancer (BC). Herein, we evaluated whether RAGE contributes to the oncogenic act...

    Authors: M. G. Muoio, M. Pellegrino, V. Rapicavoli, M. Talia, G. Scavo, V. Sergi, V. Vella, S. Pettinato, M. G. Galasso, R. Lappano, D. Scordamaglia, F. Cirillo, A. Pulvirenti, D. C. Rigiracciolo, M. Maggiolini, A. Belfiore…
    Citation: Breast Cancer Research 2023 25:84
    Content type: Research Published on:

    The Publisher Correction to this article has been published in Breast Cancer Research 2023 25:94

  30. Microbial dysbiosis has emerged as an important element in the development and progression of various cancers, including breast cancer. However, the microbial composition of the breast from healthy individuals...

    Authors: Rana German, Natascia Marino, Chris Hemmerich, Ram Podicheti, Douglas B. Rusch, Leah T. Stiemsma, Hongyu Gao, Xiaoling Xuei, Pam Rockey and Anna Maria Storniolo
    Citation: Breast Cancer Research 2023 25:82
    Content type: Research Published on:

  31. Patients with HER2-positive metastatic breast cancer (MBC) are at high risk of developing central nervous system (CNS) metastases. A potent and selective HER2 inhibitor with good blood–brain barrier (BBB) pene...

    Authors: Jian Zhang, Nicholas P. McAndrew, Xiaojia Wang, Yiqun Du, Brian DiCarlo, Mei Wang, Kan Chen, Wenlei Yu and Xichun Hu
    Citation: Breast Cancer Research 2023 25:81
    Content type: Research Published on:

  32. Some breast carcinomas detected at screening, especially ductal carcinoma in situ, may have limited potential for progression to symptomatic disease. To determine non-progression is a challenge, but if all scr...

    Authors: Torunn Heggland, Lars Johan Vatten, Signe Opdahl and Harald Weedon-Fekjær
    Citation: Breast Cancer Research 2023 25:80
    Content type: Research Published on:

  33. There are few prospective studies on the correlations between MRI features and whole RNA-sequencing data in breast cancer according to molecular subtypes. The purpose of our study was to explore the associatio...

    Authors: Ah Young Park, Mi-Ryung Han, Bo Kyoung Seo, Hye-Yeon Ju, Gil Soo Son, Hye Yoon Lee, Young Woo Chang, Jungyoon Choi, Kyu Ran Cho, Sung Eun Song, Ok Hee Woo and Hyun Soo Park
    Citation: Breast Cancer Research 2023 25:79
    Content type: Research Published on:

  34. New drugs for locally advanced or metastatic breast cancer have led to clinical benefits, aside with increasing costs to healthcare systems. The current financing model for health technology assessment (HTA) p...

    Authors: Filipa Alves da Costa, Fábio Cardoso Borges, Adriana Ramos, Alexandra Mayer, Claudia Brito, Catarina Ramos, Catarina Bernardo, Mariane Cossito, Cláudia Furtado, Arlindo R. Ferreira, Diogo Martins-Branco, Ana da Costa Miranda and António Lourenço
    Citation: Breast Cancer Research 2023 25:78
    Content type: Research Published on:

  35. The immunohistochemical test (IHC) of HER2 and HR can provide prognostic information and treatment guidance for invasive breast cancer patients. We aimed to develop noninvasive image signatures ISHER2 and ISHR of...

    Authors: Xinzhi Teng, Jiang Zhang, Xinyu Zhang, Xinyu Fan, Ta Zhou, Yu-hua Huang, Lu Wang, Elaine Yuen Phin Lee, Ruijie Yang and Jing Cai
    Citation: Breast Cancer Research 2023 25:77
    Content type: Research Published on:

  36. FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and cancer growth and progression. It is expres...

    Authors: Benita S. Katzenellenbogen, Valeria Sanabria Guillen and John A. Katzenellenbogen
    Citation: Breast Cancer Research 2023 25:76
    Content type: Review Published on:

  37. DNA damage and DNA damage repair (DDR) are important therapeutic targets for triple-negative breast cancer (TNBC), a subtype with limited chemotherapy efficiency and poor outcome. However, the role of microRNA...

    Authors: Yue Zhang, Lianqiu Lv, Renjing Zheng, Rong Xie, Yuanhang Yu, Han Liao, Jianying Chen and Bo Zhang
    Citation: Breast Cancer Research 2023 25:75
    Content type: Research Published on:

  38. RHAMM is a multifunctional protein that is upregulated in breast tumors, and the presence of strongly RHAMM+ve cancer cell subsets associates with elevated risk of peripheral metastasis. Experimentally, RHAMM imp...

    Authors: Cornelia Tolg, Maja Milojevic, Freda W. Qi, Hailie A. Pavanel, M. Elizabeth O. Locke, Jenny Ma, Mathew Price, Andrew C. Nelson, James B. McCarthy, Kathleen A. Hill and Eva A. Turley
    Citation: Breast Cancer Research 2023 25:74
    Content type: Research Published on:

  40. Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA...

    Authors: Karin Kast, Esther M. John, John L. Hopper, Nadine Andrieu, Catherine Noguès, Emmanuelle Mouret-Fourme, Christine Lasset, Jean-Pierre Fricker, Pascaline Berthet, Véronique Mari, Lucie Salle, Marjanka K. Schmidt, Margreet G. E. M. Ausems, Encarnacion B. Gomez Garcia, Irma van de Beek, Marijke R. Wevers…
    Citation: Breast Cancer Research 2023 25:72
    Content type: Research Published on:

  41. The introduction of pertuzumab has greatly improved pathological complete response (pCR) rates in HER2-positive breast cancer, yet effects on long-term survival have been limited and it is uncertain which pati...

    Authors: M. C. Liefaard, A. van der Voort, M. S. van Ramshorst, J. Sanders, S. Vonk, H. M. Horlings, S. Siesling, L. de Munck, A. E. van Leeuwen, M. Kleijn, L. Mittempergher, M. M. Kuilman, A. M. Glas, J. Wesseling, E. H. Lips and G. S. Sonke
    Citation: Breast Cancer Research 2023 25:71
    Content type: Research Published on:

  42. Authors: Armin Aryannejad, Sahar Saeedi Moghaddam, Baharnaz Mashinchi, Mohammadreza Tabary, Negar Rezaei, Sarvenaz Shahin, Nazila Rezaei, Mohsen Naghavi, Bagher Larijani and Farshad Farzadfar
    Citation: Breast Cancer Research 2023 25:70
    Content type: Correction Published on:

    The original article was published in Breast Cancer Research 2023 25:47

  43. Familial breast cancer is in most cases unexplained due to the lack of identifiable pathogenic variants in the BRCA1 and BRCA2 genes. The somatic mutational landscape and in particular the extent of BRCA-like tum...

    Authors: Lars v. B. Andersen, Martin J. Larsen, Helen Davies, Andrea Degasperi, Henriette Roed Nielsen, Louise A. Jensen, Lone Kroeldrup, Anne-Marie Gerdes, Anne-Vibeke Lænkholm, Torben A. Kruse, Serena Nik-Zainal and Mads Thomassen
    Citation: Breast Cancer Research 2023 25:69
    Content type: Research Published on:

  44. Most patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these cancers is generally immunosuppressive and cont...

    Authors: Kathleen A. O’Leary, Amber M. Bates, Won Jong Jin, Brian M. Burkel, Raghava N. Sriramaneni, Sarah E. Emma, Erin J. Nystuen, Elizabeth G. Sumiec, Suzanne M. Ponik, Zachary S. Morris and Linda A. Schuler
    Citation: Breast Cancer Research 2023 25:68
    Content type: Research Published on:

  45. Xentuzumab is a humanised monoclonal antibody that binds to IGF-1 and IGF-2, neutralising their proliferative activity and restoring inhibition of AKT by everolimus. This study evaluated the addition of xentuz...

    Authors: Peter Schmid, Javier Cortes, Ana Joaquim, Noelia Martínez Jañez, Serafín Morales, Tamara Díaz-Redondo, Sibel Blau, Patrick Neven, Julie Lemieux, José Ángel García-Sáenz, Lowell Hart, Tsvetan Biyukov, Navid Baktash, Dan Massey, Howard A. Burris III and Hope S. Rugo
    Citation: Breast Cancer Research 2023 25:67
    Content type: Research Published on:

  46. Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with littl...

    Authors: Kristin L. Young, Andrew F. Olshan, Kathryn Lunetta, Mariaelisa Graff, Lindsay A. Williams, Song Yao, Gary R. Zirpoli, Melissa Troester and Julie R. Palmer
    Citation: Breast Cancer Research 2023 25:66
    Content type: Research Published on:

  47. Changes in microcirculation of axillary lymph nodes (ALNs) may indicate metastasis. Reliable noninvasive imaging technique to quantify such variations is lacking. We aim to develop and investigate a contrast-f...

    Authors: Giulia Ferroni, Soroosh Sabeti, Tasneem Abdus-Shakur, Lorenzo Scalise, Jodi M. Carter, Robert T. Fazzio, Nicholas B. Larson, Mostafa Fatemi and Azra Alizad
    Citation: Breast Cancer Research 2023 25:65
    Content type: Research Published on:

  48. Researchers have suggested that longitudinal trajectories of mammographic breast density (MD) can be used to understand changes in breast cancer (BC) risk over a woman’s lifetime. Some have suggested, based on...

    Authors: Maya Illipse, Kamila Czene, Per Hall and Keith Humphreys
    Citation: Breast Cancer Research 2023 25:64
    Content type: Research Published on:

  49. Breast cancer presents as one of the top health threats to women around the world. Myeloid cells are the most abundant cells and the major immune coordinator in breast cancer tumor microenvironment (TME), targ...

    Authors: Chenxuan Yang, Jiaxiang Liu, Shuangtao Zhao, Qingyao Shang, Fei Ren, Kexin Feng, Ruixuan Zhang, Xiyu Kang, Xin Wang and Xiang Wang
    Citation: Breast Cancer Research 2023 25:63
    Content type: Research Published on:

  50. Although trastuzumab and other HER2-targeted therapies have significantly improved survival in patients with HER2 overexpressed or amplified (HER2+) breast cancer, a significant proportion of patients do not r...

    Authors: Shuying Liu, Shelly M. Xie, Wenbin Liu, Mihai Gagea, Ariella B. Hanker, Nguyen Nguyen, Akshara Singareeka Raghavendra, Gloria Yang-Kolodji, Fuliang Chu, Sattva S. Neelapu, Adriano Marchese, Samir Hanash, Johann Zimmermann, Carlos L. Arteaga and Debasish Tripathy
    Citation: Breast Cancer Research 2023 25:62
    Content type: Research Published on:
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Breast Cancer Research

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