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  1. Research article

    Assessment of the prognostic role of a 94-single nucleotide polymorphisms risk score in early breast cancer in the SIGNAL/PHARE prospective cohort: no correlation with clinico-pathological characteristics and outcomes

    Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effec...

    Elsa Curtit, Xavier Pivot, Julie Henriques, Sophie Paget-Bailly, Pierre Fumoleau, Maria Rios, Hervé Bonnefoi, Thomas Bachelot, Patrick Soulié, Christelle Jouannaud, Hugues Bourgeois, Thierry Petit, Isabelle Tennevet, David Assouline, Marie-Christine Mathieu, Jean-Philippe Jacquin…

    Breast Cancer Research 2017 19:98

    Published on: 22 August 2017

  2. Research article

    Combining quantitative and qualitative breast density measures to assess breast cancer risk

    Accurately identifying women with dense breasts (Breast Imaging Reporting and Data System [BI-RADS] heterogeneously or extremely dense) who are at high breast cancer risk will facilitate discussions of supplem...

    Karla Kerlikowske, Lin Ma, Christopher G. Scott, Amir P. Mahmoudzadeh, Matthew R. Jensen, Brian L. Sprague, Louise M. Henderson, V. Shane Pankratz, Steven R. Cummings, Diana L. Miglioretti, Celine M. Vachon and John A. Shepherd

    Breast Cancer Research 2017 19:97

    Published on: 22 August 2017

  3. Meeting report

    The ninth ENBDC Weggis meeting: growth and in-depth characterisation of normal and neoplastic breast cells

    Mammary gland biologists gathered for the ninth annual workshop of the European Network for Breast Development and Cancer (ENBDC) at Weggis on the shores of Lake Lucerne in March 2017. The main themes were oes...

    Katrin E. Wiese, Romain J. Amante, Maria dM. Vivanco, Mohamed Bentires-Alj and Richard D. Iggo

    Breast Cancer Research 2017 19:96

    Published on: 22 August 2017

  4. Research article

    White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)

    Several studies have suggested that global DNA methylation in circulating white blood cells (WBC) is associated with breast cancer risk.

    Susan R. Sturgeon, J. Richard Pilsner, Kathleen F. Arcaro, Kaoru Ikuma, Haotian Wu, Soon-Mi Kim, Nayha Chopra-Tandon, Adam R. Karpf, Regina G. Ziegler, Catherine Schairer, Raji Balasubramanian and David A. Reckhow

    Breast Cancer Research 2017 19:94

    Published on: 18 August 2017

  5. Research article

    Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

    We previously performed a case–control genome-wide association study in women treated with selective estrogen receptor modulators (SERMs) for breast cancer prevention and identified single nucleotide polymorph...

    Sisi Qin, James N. Ingle, Mohan Liu, Jia Yu, D. Lawrence Wickerham, Michiaki Kubo, Richard M. Weinshilboum and Liewei Wang

    Breast Cancer Research 2017 19:95

    Published on: 18 August 2017

  6. Research article

    Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer

    Selinexor (KPT-330) is an oral agent that has been shown to inhibit the nuclear exporter XPO1. Given the pressing need for novel therapies for triple-negative breast cancer (TNBC), we sought to determine the a...

    Natalia Paez Arango, Erkan Yuca, Ming Zhao, Kurt W. Evans, Stephen Scott, Charissa Kim, Ana Maria Gonzalez-Angulo, Filip Janku, Naoto T. Ueno, Debu Tripathy, Argun Akcakanat, Aung Naing and Funda Meric-Bernstam

    Breast Cancer Research 2017 19:93

    Published on: 15 August 2017

  7. Research article

    Concurrent antitumor and bone-protective effects of everolimus in osteotropic breast cancer

    The mammalian target of rapamycin inhibitor everolimus is approved as an antitumor agent in advanced estrogen receptor-positive breast cancer. Surrogate bone marker data from clinical trials suggest effects on...

    Andrew J. Browne, Marie L. Kubasch, Andy Göbel, Peyman Hadji, David Chen, Martina Rauner, Friedrich Stölzel, Lorenz C. Hofbauer and Tilman D. Rachner

    Breast Cancer Research 2017 19:92

    Published on: 9 August 2017

  8. Research article

    Effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes and PD-L1 expression in breast cancer and its clinical significance

    The effects of neoadjuvant chemotherapy on immune markers remain largely unknown. The specific aim of this study was to assess stromal tumor-infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1...

    Vasiliki Pelekanou, Daniel E. Carvajal-Hausdorf, Mehmet Altan, Brad Wasserman, Cristobal Carvajal-Hausdorf, Hallie Wimberly, Jason Brown, Donald Lannin, Lajos Pusztai and David L. Rimm

    Breast Cancer Research 2017 19:91

    Published on: 7 August 2017

  9. Research article

    Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade

    New molecular targets are needed for women with triple-negative breast cancer (TNBC). This pre-clinical study investigated the combination of the EGFR inhibitor gefitinib with the sphingosine kinase (SphK) inh...

    Janet L. Martin, Sohel M. Julovi, Mike Z. Lin, Hasanthi C. de Silva, Frances M. Boyle and Robert C. Baxter

    Breast Cancer Research 2017 19:90

    Published on: 4 August 2017

  10. Research article

    A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer

    Targeted therapies in HER2-positive metastatic breast cancer significantly improve outcomes but efficacy is limited by therapeutic resistance. HER2 is an acutely sensitive Heat Shock Protein 90 (HSP90) client ...

    Komal Jhaveri, Rui Wang, Eleonora Teplinsky, Sarat Chandarlapaty, David Solit, Karen Cadoo, James Speyer, Gabriella D’Andrea, Sylvia Adams, Sujata Patil, Sofia Haque, Tara O’Neill, Kent Friedman, Francisco J. Esteva, Clifford Hudis and Shanu Modi

    Breast Cancer Research 2017 19:89

    Published on: 2 August 2017

  11. Research article

    AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

    Absence of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) correlates with poor long-term survival in patients with triple negative breast cancer (TNBC). These incomplete treatment respon...

    Sheheryar Kabraji, Xavier Solé, Ying Huang, Clyde Bango, Michaela Bowden, Aditya Bardia, Dennis Sgroi, Massimo Loda and Sridhar Ramaswamy

    Breast Cancer Research 2017 19:88

    Published on: 1 August 2017

  12. Research article

    Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies

    The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations...

    Sinead Toomey, Alexander J. Eustace, Joanna Fay, Katherine M. Sheehan, Aoife Carr, Malgorzata Milewska, Stephen F. Madden, Ausra Teiserskiene, Elaine W. Kay, Norma O’Donovan, William Gallagher, Liam Grogan, Oscar Breathnach, Janice Walshe, Catherine Kelly, Brian Moulton…

    Breast Cancer Research 2017 19:87

    Published on: 27 July 2017

  13. Research article

    Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

    Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased proliferation. Proliferation may be restored in secondary metastases by mesenchymal-to-epith...

    H. J. Hugo, N. P. A. D. Gunasinghe, B. G. Hollier, T. Tanaka, T. Blick, A. Toh, P. Hill, C. Gilles, M. Waltham and E. W. Thompson

    Breast Cancer Research 2017 19:86

    Published on: 27 July 2017

  14. Research article

    Body size in early life and risk of breast cancer

    Body size in early life is inversely associated with adult breast cancer (BC) risk, but it is unclear whether the associations differ by tumor characteristics.

    Md. Shajedur Rahman Shawon, Mikael Eriksson and Jingmei Li

    Breast Cancer Research 2017 19:84

    Published on: 21 July 2017

  15. Research article

    Hormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population

    Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer (CBC) risk. However, information on influential covaria...

    Anne S. Reiner, Charles F. Lynch, Julia S. Sisti, Esther M. John, Jennifer D. Brooks, Leslie Bernstein, Julia A. Knight, Li Hsu, Patrick Concannon, Lene Mellemkjær, Marc Tischkowitz, Robert W. Haile, Ronglai Shen, Kathleen E. Malone, Meghan Woods, Xiaolin Liang…

    Breast Cancer Research 2017 19:83

    Published on: 19 July 2017

  16. Research article

    Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort

    Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones.

    Renée T. Fortner, Eglé Tolockiene, Helena Schock, Husam Oda, Hans-Åke Lakso, Göran Hallmans, Rudolf Kaaks, Paolo Toniolo, Anne Zeleniuch-Jacquotte, Kjell Grankvist and Eva Lundin

    Breast Cancer Research 2017 19:82

    Published on: 18 July 2017

  17. Research article

    Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age

    The underlying biological mechanisms through which epidemiologically defined breast cancer risk factors contribute to disease risk remain poorly understood. Identification of the molecular changes associated w...

    Kevin C. Johnson, E. Andres Houseman, Jessica E. King and Brock C. Christensen

    Breast Cancer Research 2017 19:81

    Published on: 10 July 2017

  18. Research article

    Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice

    Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time ...

    Nguyen M. Nguyen, Fabia de Oliveira Andrade, Lu Jin, Xiyuan Zhang, Madisa Macon, M. Idalia Cruz, Carlos Benitez, Bryan Wehrenberg, Chao Yin, Xiao Wang, Jianhua Xuan, Sonia de Assis and Leena Hilakivi-Clarke

    Breast Cancer Research 2017 19:77

    Published on: 3 July 2017

  19. Research article

    Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

    Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been o...

    Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson and Christoforos Thomas

    Breast Cancer Research 2017 19:79

    Published on: 3 July 2017

  20. Research article

    The footprint of the ageing stroma in older patients with breast cancer

    Tumours are not only composed of malignant cells but also consist of a stromal micro-environment, which has been shown to influence cancer cell behaviour. Because the ageing process induces accumulation of sen...

    Barbara Brouwers, Debora Fumagalli, Sylvain Brohee, Sigrid Hatse, Olivier Govaere, Giuseppe Floris, Kathleen Van den Eynde, Yacine Bareche, Patrick Schöffski, Ann Smeets, Patrick Neven, Diether Lambrechts, Christos Sotiriou and Hans Wildiers

    Breast Cancer Research 2017 19:78

    Published on: 3 July 2017

  21. Research article

    Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours

    Natural killer (NK) cells play a critical role in cancer immunosurveillance. Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of activated NK cells from a small volume of...

    Mira M. Shenouda, Amy Gillgrass, Tina Nham, Richard Hogg, Amanda J. Lee, Marianne V. Chew, Mahsa Shafaei, Craig Aarts, Dean A. Lee, John Hassell, Anita Bane, Sukhbinder Dhesy-Thind and Ali A. Ashkar

    Breast Cancer Research 2017 19:76

    Published on: 1 July 2017

  22. Research article

    Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis

    The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor ...

    Meghan Morrison Joly, Michelle M. Williams, Donna J. Hicks, Bayley Jones, Violeta Sanchez, Christian D. Young, Dos D. Sarbassov, William J. Muller, Dana Brantley-Sieders and Rebecca S. Cook

    Breast Cancer Research 2017 19:74

    Published on: 30 June 2017

  23. Research article

    Neoadjuvant radiotherapy of early-stage breast cancer and long-term disease-free survival

    Compared with surgery alone, postoperative adjuvant radiotherapy (RT) improves relapse-free survival of patients with early-stage breast cancer. We evaluated the long-term overall and disease-free survival rat...

    Jan Poleszczuk, Kimberly Luddy, Lu Chen, Jae K. Lee, Louis B. Harrison, Brian J. Czerniecki, Hatem Soliman and Heiko Enderling

    Breast Cancer Research 2017 19:75

    Published on: 30 June 2017

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