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  1. Content type: Research article

    Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major cha...

    Authors: Aparna Shinde, Tomasz Wilmanski, Hao Chen, Dorothy Teegarden and Michael K. Wendt

    Citation: Breast Cancer Research 2018 20:76

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  2. Content type: Research article

    Estrogen promotes breast cancer development and progression mainly through estrogen receptor (ER). However, blockage of estrogen production or action prevents development of and suppresses progression of ER-ne...

    Authors: Chuying Wang, Feng Bai, Li-han Zhang, Alexandria Scott, Enxiao Li and Xin-Hai Pei

    Citation: Breast Cancer Research 2018 20:74

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  3. Content type: Research article

    In primary breast cancer metastases frequently arise from a state of dormancy that may persist for extended periods of time. We investigated the efficacy of plasma micro-RNA (miR)-21, miR-23b, miR-190, miR-200...

    Authors: Chara Papadaki, Michalis Stratigos, Georgios Markakis, Maria Spiliotaki, Georgios Mastrostamatis, Christoforos Nikolaou, Dimitrios Mavroudis and Sofia Agelaki

    Citation: Breast Cancer Research 2018 20:72

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  4. Content type: Research article

    The ETS transcription factor ETV4 is involved in the main steps of organogenesis and is also a significant mediator of tumorigenesis and metastasis, such as in breast cancer. Indeed, ETV4 is overexpressed in b...

    Authors: Mandy Dumortier, Franck Ladam, Isabelle Damour, Sophie Vacher, Ivan Bièche, Nathalie Marchand, Yvan de Launoit, David Tulasne and Anne Chotteau-Lelièvre

    Citation: Breast Cancer Research 2018 20:73

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  5. Content type: Research article

    Vitamin D has anticarcinogenic and immune-related properties and may protect against some diseases, including breast cancer. Vitamin D affects gene transcription and may influence DNA methylation.

    Authors: Katie M. O’Brien, Dale P. Sandler, Zongli Xu, H. Karimi Kinyamu, Jack A. Taylor and Clarice R. Weinberg

    Citation: Breast Cancer Research 2018 20:70

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  6. Content type: Research article

    Elevated PD-L1 expression on tumor cells, a context associated with an adaptive immune response, has been linked to the total burden of copy number variants (CNVs) in aneuploid tumors, to microsatellite instab...

    Authors: Michael T. Barrett, Elizabeth Lenkiewicz, Smriti Malasi, Anamika Basu, Jennifer Holmes Yearley, Lakshmanan Annamalai, Ann E. McCullough, Heidi E. Kosiorek, Pooja Narang, Melissa A. Wilson Sayres, Meixuan Chen, Karen S. Anderson and Barbara A. Pockaj

    Citation: Breast Cancer Research 2018 20:71

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  7. Content type: Short report

    The 2013 update of the American Society of Clinical Oncology-College of American Pathologists (ASCO-CAP) human epidermal growth factor receptor 2 (HER2) testing guidelines recommend using an alternative chromo...

    Authors: Neelam V. Desai, Vanda Torous, Joel Parker, James T. Auman, Gary B. Rosson, Cassandra Cruz, Charles M. Perou, Stuart J. Schnitt and Nadine Tung

    Citation: Breast Cancer Research 2018 20:75

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  8. Content type: Research article

    In over 20% of breast conserving operations, postoperative pathological assessment of the excised tissue reveals positive margins, requiring additional surgery. Current techniques for intra-operative assessmen...

    Authors: Dustin W. Shipp, Emad A. Rakha, Alexey A. Koloydenko, R. Douglas Macmillan, Ian O. Ellis and Ioan Notingher

    Citation: Breast Cancer Research 2018 20:69

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  9. Content type: Correction

    After the publication of this work [1], an error was noticed in Fig. 2b, Fig. 3a and Fig. 5b. The Skp1 loading control was accidentally duplicated. We apologize for this error, which did not affect any of the ...

    Authors: Ma’anit Shapira, Eli Kakiashvili, Tzur Rosenberg and Dan D. Hershko

    Citation: Breast Cancer Research 2018 20:68

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    The original article was published in Breast Cancer Research 2006 8:R46

  10. Content type: Research article

    Syndecan-1 (Sdc1), a cell surface heparan sulfate proteoglycan normally expressed primarily by epithelia and plasma cells, is aberrantly induced in stromal fibroblasts of breast carcinomas. Stromal fibroblast-...

    Authors: Colleen Chute, Xinhai Yang, Kristy Meyer, Ning Yang, Keelin O’Neil, Ildiko Kasza, Kevin Eliceiri, Caroline Alexander and Andreas Friedl

    Citation: Breast Cancer Research 2018 20:66

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  11. Content type: Research article

    Circulating tumor cells (CTCs) are the major players in the metastatic process. A potential mechanism of cell migration and invasion is the formation of microtentacles in tumor cells. These structures are supp...

    Authors: G. Kallergi, D. Aggouraki, N. Zacharopoulou, C. Stournaras, V. Georgoulias and S. S. Martin

    Citation: Breast Cancer Research 2018 20:67

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  12. Content type: Research article

    Adjuvant radiotherapy is the standard of care after breast-conserving surgery for primary breast cancer, despite a majority of patients being over- or under-treated. In contrast to adjuvant endocrine therapy a...

    Authors: Martin Sjöström, Johan Staaf, Patrik Edén, Fredrik Wärnberg, Jonas Bergh, Per Malmström, Mårten Fernö, Emma Niméus and Irma Fredriksson

    Citation: Breast Cancer Research 2018 20:64

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  13. Content type: Research article

    The microenvironment and stress factors like glucocorticoids have a strong influence on breast cancer progression but their role in the first stages of breast cancer and, particularly, in myoepithelial cell re...

    Authors: Arantzazu Zubeldia-Plazaola, Leire Recalde-Percaz, Núria Moragas, Mireia Alcaraz, Xieng Chen, Mario Mancino, Patricia Fernández-Nogueira, Miquel Prats de Puig, Flavia Guzman, Aleix Noguera-Castells, Anna López-Plana, Estel Enreig, Neus Carbó, Vanessa Almendro, Pedro Gascón, Paloma Bragado…

    Citation: Breast Cancer Research 2018 20:65

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  14. Content type: Correction

    After the publication of this work [1] an error in Fig. 1c was brought to our attention: the Western blots for PRDX6 and β-actin were similar to those shown in lanes 5-6 of Fig. 4g. To verify these findings, w...

    Authors: Xin-Zhong Chang, Da-Qiang Li, Yi-Feng Hou, Jiong Wu, Jin-Song Lu, Gen-Hong Di, Wei Jin, Zhou-Luo Ou, Zhen-Zhou Shen and Zhi-Ming Shao

    Citation: Breast Cancer Research 2018 20:63

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    The original article was published in Breast Cancer Research 2007 9:R76

  15. Content type: Research article

    Tumor-infiltrating lymphocytes (TILs) evaluated in primary breast cancer (BC) convey prognostic information. Limited data in the metastatic setting are available.

    Authors: Maria Vittoria Dieci, Vassilena Tsvetkova, Enrico Orvieto, Federico Piacentini, Guido Ficarra, Gaia Griguolo, Federica Miglietta, Tommaso Giarratano, Claudia Omarini, Serena Bonaguro, Rocco Cappellesso, Camillo Aliberti, Grazia Vernaci, Carlo Alberto Giorgi, Giovanni Faggioni, Giulia Tasca…

    Citation: Breast Cancer Research 2018 20:62

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  16. Content type: Correction

    After the publication of this work [1] errors were noticed in the total protein loading controls for Figs. 1C, 2B, 3B and 4B.

    Authors: Kheng Tian Lim, Niamh Cosgrave, Arnold David Hill and Leonie S. Young

    Citation: Breast Cancer Research 2018 20:61

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    The original article was published in Breast Cancer Research 2006 8:R33

  17. Content type: Research article

    As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophag...

    Authors: Sara Donzelli, Elisa Milano, Magdalena Pruszko, Andrea Sacconi, Silvia Masciarelli, Ilaria Iosue, Elisa Melucci, Enzo Gallo, Irene Terrenato, Marcella Mottolese, Maciej Zylicz, Alicja Zylicz, Francesco Fazi, Giovanni Blandino and Giulia Fontemaggi

    Citation: Breast Cancer Research 2018 20:59

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  18. Content type: Research article

    Endocrine resistance in estrogen receptor-positive (ER+) breast cancer is a major clinical problem and is associated with accelerated cancer cell growth, increased motility and acquisition of mesenchymal chara...

    Authors: Carla L. Alves, Daniel Elias, Maria B. Lyng, Martin Bak and Henrik J. Ditzel

    Citation: Breast Cancer Research 2018 20:60

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  19. Content type: Research article

    Numerous studies have analyzed associations between apparent diffusion coefficient (ADC) and histopathological features such as Ki-67 proliferation index in breast cancer (BC), with mixed results. The purpose ...

    Authors: Alexey Surov, Paola Clauser, Yun-Woo Chang, Lihua Li, Laura Martincich, Savannah C. Partridge, Jin You Kim, Hans Jonas Meyer and Andreas Wienke

    Citation: Breast Cancer Research 2018 20:58

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  20. Content type: Research article

    Altered lipid metabolism is an emerging hallmark of aggressive breast cancers. The N-myc downstream regulated gene (NDRG1) gene plays a critical role in peripheral nervous system myelination, as inactivating m...

    Authors: Christopher J. Sevinsky, Faiza Khan, Leila Kokabee, Anza Darehshouri, Krishna Rao Maddipati and Douglas S. Conklin

    Citation: Breast Cancer Research 2018 20:55

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  21. Content type: Research article

    Breast cancer pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) varies with tumor subtype. The purpose of this study was to identify an early treatment window for predicting pCR based on tum...

    Authors: Quing Zhu, Susan Tannenbaum, Scott H. Kurtzman, Patricia DeFusco, Andrew Ricci Jr, Hamed Vavadi, Feifei Zhou, Chen Xu, Alex Merkulov, Poornima Hegde, Mark Kane, Liqun Wang and Kert Sabbath

    Citation: Breast Cancer Research 2018 20:56

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  22. Content type: Research article

    Metastatic triple-negative breast cancer (TNBC) is a heterogeneous and incurable disease. Numerous studies have been conducted to seek molecular targets to treat TNBC effectively, but chemotherapy is still the...

    Authors: Kideok Jin, Niranjan B. Pandey and Aleksander S. Popel

    Citation: Breast Cancer Research 2018 20:54

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  23. Content type: Research article

    Obesity and type II diabetes are linked to increased breast cancer risk in postmenopausal women. Patients treated with the antidiabetic drug metformin for diabetes or metabolic syndrome have reduced breast can...

    Authors: Erin D. Giles, Sonali Jindal, Elizabeth A. Wellberg, Troy Schedin, Steven M. Anderson, Ann D. Thor, Dean P. Edwards, Paul S. MacLean and Pepper Schedin

    Citation: Breast Cancer Research 2018 20:50

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  24. Content type: Research article

    The purpose of this work was to investigate noninvasive early detection of treatment response of breast cancer patients to neoadjuvant chemotherapy (NAC) using chemical exchange saturation transfer (CEST) meas...

    Authors: Erwin Krikken, Vitaliy Khlebnikov, Moritz Zaiss, Rajni A. Jibodh, Paul J. van Diest, Peter R. Luijten, Dennis W. J. Klomp, Hanneke W. M. van Laarhoven and Jannie P. Wijnen

    Citation: Breast Cancer Research 2018 20:51

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  25. Content type: Correction

    After the publication of this work [1] an error was noticed in Fig. 3a and Fig. 5a.

    Authors: Joan S. Lewis-Wambi, Helen R. Kim, Chris Wambi, Roshani Patel, Jennifer R. Pyle, Andres J. Klein-Szanto and V. Craig Jordan

    Citation: Breast Cancer Research 2018 20:57

    Published on:

    The original article was published in Breast Cancer Research 2008 10:R104

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