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Breast Cancer Research


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  1. Content type: Research Article

    The Gail model has been widely used and validated with conflicting results. The current study aims to evaluate the performance of different versions of the Gail model by means of systematic review and meta-ana...

    Authors: Xin Wang, Yubei Huang, Lian Li, Hongji Dai, Fengju Song and Kexin Chen

    Citation: Breast Cancer Research 2018 20:18

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  2. Content type: Research Article

    Our purpose is to develop a testable biological hypothesis to explain the known increased risk of breast cancer associated with extensive percent mammographic density (PMD), and to reconcile the apparent parad...

    Authors: Norman Boyd, Hal Berman, Jie Zhu, Lisa J. Martin, Martin J. Yaffe, Sofia Chavez, Greg Stanisz, Greg Hislop, Anna M. Chiarelli, Salomon Minkin and Andrew D. Paterson

    Citation: Breast Cancer Research 2018 20:17

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  3. Content type: Research Article

    The clinical importance of tumor-infiltrating cluster of differentiation 4 (CD4) T cells is incompletely understood in early breast cancer. We investigated the clinical significance of CD4, forkhead box P3 (FO...

    Authors: Marcus Schmidt, Veronika Weyer-Elberich, Jan G. Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Aslihan Gerhold-Ay, Antje Lebrecht, Marco J. Battista, Annette Hasenburg, Ugur Sahin, Konstantine T. Kalogeras, Pirkko-Liisa Kellokumpu-Lehtinen, George Fountzilas, Ralph M. Wirtz and Heikki Joensuu

    Citation: Breast Cancer Research 2018 20:15

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  4. Content type: Research Article

    Mammographic breast density is one of the strongest risk factors for breast cancer, but molecular understanding of how breast density relates to cancer risk is less complete. Studies of proteins in blood plasm...

    Authors: Sanna Byström, Martin Eklund, Mun-Gwan Hong, Claudia Fredolini, Mikael Eriksson, Kamila Czene, Per Hall, Jochen M. Schwenk and Marike Gabrielson

    Citation: Breast Cancer Research 2018 20:14

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  5. Content type: Research Article

    Breast magnetic resonance imaging (MRI) has been reported to frequently result in false-positive diagnoses, limiting its positive predictive value (PPV). However, for PPV calculation, all nonmalignant tissue c...

    Authors: Christiane K. Kuhl, Annika Keulers, Kevin Strobel, Hannah Schneider, Nadine Gaisa and Simone Schrading

    Citation: Breast Cancer Research 2018 20:13

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  6. Content type: Research Article

    Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional ma...

    Authors: Emma H. Allott, Joseph Geradts, Stephanie M. Cohen, Thaer Khoury, Gary R. Zirpoli, Wiam Bshara, Warren Davis, Angela Omilian, Priya Nair, Rochelle P. Ondracek, Ting-Yuan David Cheng, C. Ryan Miller, Helena Hwang, Leigh B. Thorne, Siobhan O’Connor, Traci N. Bethea…

    Citation: Breast Cancer Research 2018 20:12

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  7. Content type: Research Article

    High mammographic density is associated with both risk of cancers being missed at mammography, and increased risk of developing breast cancer. Stratification of breast cancer prevention and screening requires ...

    Authors: Susan M. Astley, Elaine F. Harkness, Jamie C. Sergeant, Jane Warwick, Paula Stavrinos, Ruth Warren, Mary Wilson, Ursula Beetles, Soujanya Gadde, Yit Lim, Anil Jain, Sara Bundred, Nicola Barr, Valerie Reece, Adam R. Brentnall, Jack Cuzick…

    Citation: Breast Cancer Research 2018 20:10

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  8. Content type: Research Article

    As only a minor portion of the information present in histological sections is accessible by eye, recognition and quantification of complex patterns and relationships among constituents relies on digital image...

    Authors: I. Roxanis, R. Colling, C. Kartsonaki, A. R. Green and E A. Rakha

    Citation: Breast Cancer Research 2018 20:11

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  9. Content type: Research Article

    The Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1 increases protein stability and function. We identify a novel signaling axis...

    Authors: Matthew G. Annis, Veronique Ouellet, Jonathan P. Rennhack, Sylvain L’Esperance, Claudine Rancourt, Anne-Marie Mes-Masson, Eran R. Andrechek and Peter M. Siegel

    Citation: Breast Cancer Research 2018 20:9

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  10. Content type: Research Article

    Germline mutations in the BRIP1 gene have been described as conferring a moderate risk for ovarian cancer (OC), while the role of BRIP1 in breast cancer (BC) pathogenesis remains controversial.

    Authors: Nana Weber-Lassalle, Jan Hauke, Juliane Ramser, Lisa Richters, Eva Groß, Britta Blümcke, Andrea Gehrig, Anne-Karin Kahlert, Clemens R. Müller, Karl Hackmann, Ellen Honisch, Konstantin Weber-Lassalle, Dieter Niederacher, Julika Borde, Holger Thiele, Corinna Ernst…

    Citation: Breast Cancer Research 2018 20:7

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  11. Content type: Research article

    Preeclampsia is frequently linked to reduced breast cancer risk. However, little is known regarding the underlying genetic association and the association between preeclampsia and mammographic density.

    Authors: Haomin Yang, Wei He, Mikael Eriksson, Jingmei Li, Natalie Holowko, Flaminia Chiesa, Per Hall and Kamila Czene

    Citation: Breast Cancer Research 2018 20:6

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  12. Content type: Research article

    Although it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations d...

    Authors: Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Kathleen E. Malone, Polly A. Marchbanks, Jill A. McDonald, Michael S. Simon, Suzanne G. Folger, Yani Lu, Jane Sullivan-Halley, Dennis M. Deapen, Michael F. Press and Leslie Bernstein

    Citation: Breast Cancer Research 2018 20:5

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  13. Content type: Research Article

    Nearly 50% of breast cancer patients suffer from depression or anxiety. Selective serotonin reuptake inhibitors (SSRIs), the first-line pharmacological treatment for depression, have been implicated in breast ...

    Authors: John Busby, Ken Mills, Shu-Dong Zhang, Fabio Giuseppe Liberante and Chris R. Cardwell

    Citation: Breast Cancer Research 2018 20:4

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  14. Content type: Research Article

    Genome-wide association studies (GWASs) have identified numerous single-nucleotide polymorphisms (SNPs) associated with small increases in breast cancer risk. Studies to date suggest that some SNPs alter the e...

    Authors: Na Li, Simone M. Rowley, Ella R. Thompson, Simone McInerny, Lisa Devereux, Kaushalya C. Amarasinghe, Magnus Zethoven, Richard Lupat, David Goode, Jason Li, Alison H. Trainer, Kylie L. Gorringe, Paul A. James and Ian G. Campbell

    Citation: Breast Cancer Research 2018 20:3

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  15. Content type: Research Article

    It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) ...

    Authors: Linnea Huss, Salma Tunå Butt, Peter Almgren, Signe Borgquist, Jasmine Brandt, Asta Försti, Olle Melander and Jonas Manjer

    Citation: Breast Cancer Research 2018 20:1

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  16. Content type: Research Article

    Disseminated tumor cells (DTCs) found in the bone marrow (BM) of patients with breast cancer portend a poor prognosis and are thought to be intermediaries in the metastatic process. To assess the clinical rele...

    Authors: Sreeraj G. Pillai, Shunqiang Li, Chidananda M. Siddappa, Matthew J Ellis, Mark A. Watson and Rebecca Aft

    Citation: Breast Cancer Research 2018 20:2

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  17. Content type: Research Article

    Several frequently used prescription drugs may affect bleeding risk. We investigated use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), and statins ...

    Authors: Anne Marie L. Thomsen, Alma B. Pedersen, Nickolaj R. Kristensen, Bjarne Kuno Møller, Christian Erikstrup, Peer M. Christiansen, Mette Nørgaard and Deirdre Cronin-Fenton

    Citation: Breast Cancer Research 2017 19:135

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  18. Content type: Research Article

    Triple negative breast cancer (TNBC) lacks both early detection biomarkers and viable targeted therapeutics. Moreover, chemotherapy only produces 20–30% pathologic complete response. Because miRNAs are frequen...

    Authors: Hao-Yi Li, Jui-Lin Liang, Yao-Lung Kuo, Hao-Hsien Lee, Marcus J. Calkins, Hong-Tai Chang, Forn-Chia Lin, Yu-Chia Chen, Tai-I Hsu, Michael Hsiao, Luo-Ping Ger and Pei-Jung Lu

    Citation: Breast Cancer Research 2017 19:133

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  19. Content type: Research Article

    Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the ...

    Authors: Karthik Ghosh, Robert A. Vierkant, Ryan D. Frank, Stacey Winham, Daniel W. Visscher, Vernon S. Pankratz, Christopher G. Scott, Kathleen Brandt, Mark E. Sherman, Derek C. Radisky, Marlene H. Frost, Lynn C. Hartmann, Amy C. Degnim and Celine M. Vachon

    Citation: Breast Cancer Research 2017 19:134

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  20. Content type: Research Article

    Annexin-1 (ANXA1) plays pivotal roles in regulating various physiological processes including inflammation, proliferation and apoptosis, and deregulation of ANXA1 functions has been associated with tumorigenes...

    Authors: Asfa Alli-Shaik, Sheena Wee, Lina H. K. Lim and Jayantha Gunaratne

    Citation: Breast Cancer Research 2017 19:132

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  21. Content type: Research Article

    We examined racial differences in the expression of eight genes and their associations with risk of recurrence among 478 white and 495 black women who participated in the Carolina Breast Cancer Study Phase 3.

    Authors: Humberto Parada Jr, Xuezheng Sun, Jodie M. Fleming, ClarLynda R. Williams-DeVane, Erin L. Kirk, Linnea T. Olsson, Charles M. Perou, Andrew F. Olshan and Melissa A. Troester

    Citation: Breast Cancer Research 2017 19:131

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  22. Content type: Research Article

    The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor ...

    Authors: Ernestina M. De Francesco, Andrew H. Sims, Marcello Maggiolini, Federica Sotgia, Michael P. Lisanti and Robert B. Clarke

    Citation: Breast Cancer Research 2017 19:129

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  23. Content type: Research Article

    Patient-derived xenografts (PDXs) are increasingly used in cancer research as a tool to inform cancer biology and drug response. Most available breast cancer PDXs have been generated in the metastatic setting....

    Authors: Jia Yu, Bo Qin, Ann M. Moyer, Jason P. Sinnwell, Kevin J. Thompson, John A. Copland III, Laura A. Marlow, James L. Miller, Ping Yin, Bowen Gao, Katherine Minter-Dykhouse, Xiaojia Tang, Sarah A. McLaughlin, Alvaro Moreno-Aspitia, Anthony Schweitzer, Yan Lu…

    Citation: Breast Cancer Research 2017 19:130

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