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  1. Content type: Research article

    The early detection of metastasis based on biomarkers in plasma may improve cancer prognosis and guide treatment. The aim of this work was to characterize alterations in metabolites of the arginine pathway, en...

    Authors: Kamil Kus, Agnieszka Kij, Agnieszka Zakrzewska, Agnieszka Jasztal, Marta Stojak, Maria Walczak and Stefan Chlopicki

    Citation: Breast Cancer Research 2018 20:148

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  2. Content type: Research article

    Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, ...

    Authors: Kuanrong Li, Garnet Anderson, Vivian Viallon, Patrick Arveux, Marina Kvaskoff, Agnès Fournier, Vittorio Krogh, Rosario Tumino, Maria-Jose Sánchez, Eva Ardanaz, María-Dolores Chirlaque, Antonio Agudo, David C. Muller, Todd Smith, Ioanna Tzoulaki, Timothy J. Key…

    Citation: Breast Cancer Research 2018 20:147

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  3. Content type: Research article

    A combination of entinostat, all-trans retinoic acid, and doxorubicin (EAD) induces cell death and differentiation and causes significant regression of xenografts of triple-negative breast cancer (TNBC).

    Authors: Vanessa F. Merino, Soonweng Cho, Nguyen Nguyen, Helen Sadik, Athira Narayan, Conover Talbot Jr, Leslie Cope, Xian C. Zhou, Zhe Zhang, Balázs Győrffy and Saraswati Sukumar

    Citation: Breast Cancer Research 2018 20:145

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  4. Content type: Research article

    The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatm...

    Authors: Jennifer M. Mongiovi, Gary R. Zirpoli, Rikki Cannioto, Lara E. Sucheston-Campbell, Dawn L. Hershman, Joseph M. Unger, Halle C. F. Moore, James A. Stewart, Claudine Isaacs, Timothy J. Hobday, Muhammad Salim, Gabriel N. Hortobagyi, Julie R. Gralow, G. Thomas Budd, Kathy S. Albain, Christine B. Ambrosone…

    Citation: Breast Cancer Research 2018 20:146

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  5. Content type: Research article

    Junctional adhesion molecule-A (JAM-A) is an adhesion molecule whose overexpression on breast tumor tissue has been associated with aggressive cancer phenotypes, including human epidermal growth factor recepto...

    Authors: Astrid O. Leech, Sri HariKrishna Vellanki, Emily J. Rutherford, Aoife Keogh, Hanne Jahns, Lance Hudson, Norma O’Donovan, Siham Sabri, Bassam Abdulkarim, Katherine M. Sheehan, Elaine W. Kay, Leonie S. Young, Arnold D. K. Hill, Yvonne E. Smith and Ann M. Hopkins

    Citation: Breast Cancer Research 2018 20:140

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  6. Content type: Review

    Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for the treatment of high cholesterol ...

    Authors: Colin H. Beckwitt, Adam Brufsky, Zoltán N. Oltvai and Alan Wells

    Citation: Breast Cancer Research 2018 20:144

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  7. Content type: Review

    Lymph node (LN) metastasis is an important prognostic parameter in breast carcinoma, a crucial site for tumour–immune cell interaction and a gateway for further dissemination of tumour cells to other metastati...

    Authors: Gaurav Chatterjee, Trupti Pai, Thomas Hardiman, Kelly Avery-Kiejda, Rodney J. Scott, Jo Spencer, Sarah E. Pinder and Anita Grigoriadis

    Citation: Breast Cancer Research 2018 20:143

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  8. Content type: Research article

    Early analyses of human breast cancer identified high expression of the insulin-like growth factor type 1 receptor (IGF-1R) correlated with hormone receptor positive breast cancer and associated with a favorab...

    Authors: Alison E. Obr, Sushil Kumar, Yun-Juan Chang, Joseph J. Bulatowicz, Betsy J. Barnes, Raymond B. Birge, Deborah A. Lazzarino, Emily Gallagher, Derek LeRoith and Teresa L. Wood

    Citation: Breast Cancer Research 2018 20:138

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  9. Content type: Research article

    Cancer progression is influenced by genetic aberrations in the cancer cell population as well as by other factors including the microenvironment present within a tumour. Direct interactions between various cel...

    Authors: Sara Rhost, Éamon Hughes, Hannah Harrison, Svanheidur Rafnsdottir, Hanna Jacobsson, Pernilla Gregersson, Ylva Magnusson, Paul Fitzpatrick, Daniel Andersson, Karoline Berger, Anders Ståhlberg and Göran Landberg

    Citation: Breast Cancer Research 2018 20:137

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  10. Content type: Research article

    The sensitivity of estrogen receptor-positive breast cancers to tamoxifen treatment varies considerably, and the molecular mechanisms affecting the response rates are manifold. The human epidermal growth facto...

    Authors: Anja Kathrin Wege, Dominik Chittka, Stefan Buchholz, Monika Klinkhammer-Schalke, Simone Diermeier-Daucher, Florian Zeman, Olaf Ortmann and Gero Brockhoff

    Citation: Breast Cancer Research 2018 20:139

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  11. Content type: Research article

    Results from previous studies indicate that use of low-dose aspirin may improve breast cancer prognosis. We evaluated aspirin use and breast cancer outcomes in relation to clinical characteristics as well as d...

    Authors: Gabriella Frisk, Sara Ekberg, Elisabet Lidbrink, Sandra Eloranta, Malin Sund, Irma Fredriksson, Mats Lambe and Karin E. Smedby

    Citation: Breast Cancer Research 2018 20:142

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  12. Content type: Research article

    The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive breast cancer, and factors ...

    Authors: Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz and Nicola Aceto

    Citation: Breast Cancer Research 2018 20:141

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  13. Content type: Correction

    Following publication of the original article [1], the authors reported a typesetting error in the spelling of the second author’s name.

    Authors: John A. Reid, Peter A. Mollica, Robert D. Bruno and Patrick C. Sachs

    Citation: Breast Cancer Research 2018 20:136

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    The original article was published in Breast Cancer Research 2018 20:122

  14. Content type: Research article

    Inflammation is an important candidate mechanism underlying cancer and cancer treatment-related cognitive impairment. We investigated levels of blood cell–based inflammatory markers in breast cancer survivors ...

    Authors: Kimberly D. van der Willik, Vincent Koppelmans, Michael Hauptmann, Annette Compter, M. Arfan Ikram and Sanne B. Schagen

    Citation: Breast Cancer Research 2018 20:135

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  15. Content type: Research article

    Osteoporosis, an indicator of significant bone loss, has been consistently reported among older breast cancer survivors. Data are limited on the incidence of osteopenia, an earlier indicator of bone loss, and ...

    Authors: Cody Ramin, Betty J. May, Richard B. S. Roden, Mikiaila M. Orellana, Brenna C. Hogan, Michelle S. McCullough, Dana Petry, Deborah K. Armstrong and Kala Visvanathan

    Citation: Breast Cancer Research 2018 20:134

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  16. Content type: Research article

    We have previously shown that galactosylceramide (GalCer) affects the tumourigenic and metastatic properties of breast cancer cells by acting as an anti-apoptotic molecule. Since GalCer is a precursor molecule...

    Authors: Jaroslaw Suchanski, Jedrzej Grzegrzolka, Tomasz Owczarek, Pawel Pasikowski, Aleksandra Piotrowska, Bartlomiej Kocbach, Aleksandra Nowak, Piotr Dziegiel, Andrzej Wojnar and Maciej Ugorski

    Citation: Breast Cancer Research 2018 20:133

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  17. Content type: Research article

    The association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman’s familial risk.

    Authors: John L. Hopper, Gillian S. Dite, Robert J. MacInnis, Yuyan Liao, Nur Zeinomar, Julia A. Knight, Melissa C. Southey, Roger L. Milne, Wendy K. Chung, Graham G. Giles, Jeanine M. Genkinger, Sue-Anne McLachlan, Michael L. Friedlander, Antonis C. Antoniou, Prue C. Weideman, Gord Glendon…

    Citation: Breast Cancer Research 2018 20:132

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  18. Content type: Research article

    Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, is not only essential for proper mammary ductal development, but also associated with breast cancer proliferation and growth. In the absen...

    Authors: Serena P. H. Mao, Minji Park, Ramon M. Cabrera, John R. Christin, George S. Karagiannis, Maja H. Oktay, Dietmar M. W. Zaiss, Scott I. Abrams, Wenjun Guo, John S. Condeelis, Paraic A. Kenny and Jeffrey E. Segall

    Citation: Breast Cancer Research 2018 20:131

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  19. Content type: Research article

    De novo or acquired resistance in breast cancer leads to treatment failures and disease progression. In human epidermal growth factor receptor 2 (HER2)-positive (HER2+) breast cancer, Src, a non-receptor tyros...

    Authors: Brooke N. McKnight and Nerissa T. Viola-Villegas

    Citation: Breast Cancer Research 2018 20:130

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  20. Content type: Research article

    Bone is one of the most frequent metastatic sites of advanced breast cancer. Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have palliative effects. During normal bone r...

    Authors: Xuxiang Liu, Minghui Cao, Melanie Palomares, Xiwei Wu, Arthur Li, Wei Yan, Miranda Y. Fong, Wing-Chung Chan and Shizhen Emily Wang

    Citation: Breast Cancer Research 2018 20:127

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  21. Content type: Research article

    Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current...

    Authors: Sruthi Ravindranathan, Khue G. Nguyen, Samantha L. Kurtz, Haven N. Frazier, Sean G. Smith, Bhanu prasanth Koppolu, Narasimhan Rajaram and David A. Zaharoff

    Citation: Breast Cancer Research 2018 20:126

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  22. Content type: Research article

    Circadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA damage responses and metabolism. Circadian disruptio...

    Authors: Eleanor Broadberry, James McConnell, Jack Williams, Nan Yang, Egor Zindy, Angela Leek, Rachel Waddington, Leena Joseph, Miles Howe, Qing-Jun Meng and Charles H Streuli

    Citation: Breast Cancer Research 2018 20:125

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  23. Content type: Research article

    Stem cells are precursors for all mammary epithelia, including ductal and alveolar epithelia, and myoepithelial cells. In vivo mammary epithelia reside in a tissue context and interact with their milieu via re...

    Authors: Safiah Olabi, Ahmet Ucar, Keith Brennan and Charles H. Streuli

    Citation: Breast Cancer Research 2018 20:128

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  24. Content type: Research article

    Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive...

    Authors: Christina M Dieli-Conwright, Kerry S Courneya, Wendy Demark-Wahnefried, Nathalie Sami, Kyuwan Lee, Frank C Sweeney, Christina Stewart, Thomas A Buchanan, Darcy Spicer, Debu Tripathy, Leslie Bernstein and Joanne E Mortimer

    Citation: Breast Cancer Research 2018 20:124

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  25. Content type: Review

    Endocrine therapy is recommended for patients with hormone receptor-positive (HR+) advanced and metastatic breast cancer without visceral crisis (symptomatic visceral disease). However, many patients experience d...

    Authors: Gabriel N. Hortobagyi

    Citation: Breast Cancer Research 2018 20:123

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  26. Content type: Short report

    The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent sta...

    Authors: Elin Borgen, Maria C. Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E. Lønning, Marit Synnestvedt, Julio A. Aguirre-Ghiso and Bjørn Naume

    Citation: Breast Cancer Research 2018 20:120

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  27. Content type: Research article

    Standard three-dimensional (3D) in vitro culture techniques, such as those used for mammary epithelial cells, rely on random distribution of cells within hydrogels. Although these systems offer advantages over tr...

    Authors: John A. Reid, Peter A. Mollica, Robert D. Bruno and Patrick C. Sachs

    Citation: Breast Cancer Research 2018 20:122

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    The Correction to this article has been published in Breast Cancer Research 2018 20:136

  28. Content type: Research article

    Exposure to road traffic noise was associated with increased risk of estrogen receptor (ER)-negative (ER-) breast cancer in a previous cohort study, but not with overall or ER-positive (ER+) breast cancer, or ...

    Authors: Zorana Jovanovic Andersen, Jeanette Therming Jørgensen, Lea Elsborg, Søren Nymand Lophaven, Claus Backalarz, Jens Elgaard Laursen, Torben Holm Pedersen, Mette Kildevæld Simonsen, Elvira Vaclavik Bräuner and Elsebeth Lynge

    Citation: Breast Cancer Research 2018 20:119

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  29. Content type: Research article

    Metastasis is responsible for a significant number of breast cancer-related deaths. Hypoxia, a primary driving force of cancer metastasis, induces the expression of BHLHE40, a transcription regulator. This stu...

    Authors: Aarti Sethuraman, Martin Brown, Raya Krutilina, Zhao-Hui Wu, Tiffany N. Seagroves, Lawrence M. Pfeffer and Meiyun Fan

    Citation: Breast Cancer Research 2018 20:117

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  30. Content type: Research article

    Increased collagen expression and deposition are associated with cancer progression and poor prognosis in breast cancer patients. However, function and regulation of membrane-associated collagen in breast canc...

    Authors: Hui Zhang, Tricia Fredericks, Gaofeng Xiong, Yifei Qi, Piotr G. Rychahou, Jia-Da Li, Taina Pihlajaniemi, Wei Xu and Ren Xu

    Citation: Breast Cancer Research 2018 20:116

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  31. Content type: Research article

    The most life-threatening step during malignant tumor progression is reached when cancer cells leave the primary tumor mass and seed metastasis in distant organs. To infiltrate the surrounding tissue and disse...

    Authors: Nathalie Meyer-Schaller, Chantal Heck, Stefanie Tiede, Mahmut Yilmaz and Gerhard Christofori

    Citation: Breast Cancer Research 2018 20:118

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  32. Content type: Research article

    Previous studies on the role of TP53 mutation in breast cancer treatment response and survival are contradictory and inconclusive, limited by the use of different endpoints to determine clinical significance and ...

    Authors: Nathan A. Ungerleider, Sonia G. Rao, Ashkan Shahbandi, Douglas Yee, Tianhua Niu, Wesley D. Frey and James G. Jackson

    Citation: Breast Cancer Research 2018 20:115

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  33. Content type: Research article

    Drug resistance of paclitaxel (TAX), the first-line chemotherapy drug for breast cancer, was reported to develop in 90% of patients with breast cancer, especially metastatic breast cancer. Investigating the me...

    Authors: Liu Yang, Yanhua Tian, Wei Sun Leong, Heng Song, Wei Yang, Meiqi Wang, Xinle Wang, Jing Kong, Baoen Shan and Zhengchuan Song

    Citation: Breast Cancer Research 2018 20:113

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  34. Content type: Research article

    Limited evidence, mostly from studies in Western populations, suggests that the prognostic effects of lifestyle-related risk factors may be molecular subtype-dependent. Here, we examined whether pre-diagnostic...

    Authors: Mustapha Abubakar, Hyuna Sung, Devi BCR, Jennifer Guida, Tieng Swee Tang, Ruth M. Pfeiffer and Xiaohong R. Yang

    Citation: Breast Cancer Research 2018 20:114

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  35. Content type: Research article

    Tamoxifen is typically used to treat patients with estrogen receptor alpha (ERα)-positive breast cancer. However, 30% of these patients gain acquired resistance to tamoxifen during or after tamoxifen treatment...

    Authors: Pin Gao, Xiang Wang, Ying Jin, Wenquan Hu, Yajun Duan, Aiping Shi, Ye Du, Dong Song, Ming Yang, Sijie Li, Bing Han, Gang Zhao, Hongquan Zhang, Zhimin Fan and Qing Robert Miao

    Citation: Breast Cancer Research 2018 20:112

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  36. Content type: Research article

    Antimicrobial T cells play key roles in the disease progression of cancers arising in mucosal epithelial tissues, such as the colon. However, little is known about microbe-reactive T cells within human breast ...

    Authors: Nicholas A. Zumwalde, Jill D. Haag, Michael N. Gould and Jenny E. Gumperz

    Citation: Breast Cancer Research 2018 20:111

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  37. Content type: Research article

    This phase Ib study (NCT00960960) evaluated pictilisib (GDC-0941; pan-phosphatidylinositol 3-kinase inhibitor) plus paclitaxel, with and without bevacizumab or trastuzumab, or in combination with letrozole, in...

    Authors: Patrick Schöffski, Sara Cresta, Ingrid A. Mayer, Hans Wildiers, Silvia Damian, Steven Gendreau, Isabelle Rooney, Kari M. Morrissey, Jill M. Spoerke, Vivian W. Ng, Stina M. Singel and Eric Winer

    Citation: Breast Cancer Research 2018 20:109

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  38. Content type: Research article

    Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined t...

    Authors: Roberto R. Rosato, Daniel Dávila-González, Dong Soon Choi, Wei Qian, Wen Chen, Anthony J. Kozielski, Helen Wong, Bhuvanesh Dave and Jenny C. Chang

    Citation: Breast Cancer Research 2018 20:108

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  39. Content type: Correction

    After the publication of this article [1], we noticed that in Fig. 2, the survival curve images (C and D, lower panel) were incorrect. The corrected Fig. 2 is presented below. The correction does not affect in...

    Authors: Aya Asano, Shigeto Ueda, Ichiei Kuji, Tomohiko Yamane, Hideki Takeuchi, Eiko Hirokawa, Ikuko Sugitani, Hiroko Shimada, Takahiro Hasebe, Akihiko Osaki and Toshiaki Saeki

    Citation: Breast Cancer Research 2018 20:107

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    The original article was published in Breast Cancer Research 2018 20:78

  40. Content type: Research article

    Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. N...

    Authors: Alexey A. Leontovich, Mohammad Jalalirad, Jeffrey L. Salisbury, Lisa Mills, Candace Haddox, Mark Schroeder, Ann Tuma, Maria E. Guicciardi, Luca Zammataro, Mario W. Gambino, Angela Amato, Aldo Di Leonardo, James McCubrey, Carol A. Lange, Minetta Liu, Tufia Haddad…

    Citation: Breast Cancer Research 2018 20:105

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  41. Content type: Research article

    Invasive lobular breast carcinoma (ILC) is a histological subtype of breast cancer that is characterized by loss of E-cadherin and high expression of estrogen receptor alpha (ERα). In many cases, ILC is effect...

    Authors: Tian Du, Matthew J. Sikora, Kevin M. Levine, Nilgun Tasdemir, Rebecca B. Riggins, Stacy G. Wendell, Bennett Van Houten and Steffi Oesterreich

    Citation: Breast Cancer Research 2018 20:106

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  42. Content type: Research article

    Several prognostic signatures for early oestrogen receptor-positive (ER+) breast cancer have been established with a 10-year follow-up. We tested the hypothesis that signatures optimised for 0–5-year and 5–10-...

    Authors: Richard Buus, Belinda Yeo, Adam R. Brentnall, Marie Klintman, Maggie Chon U. Cheang, Komel Khabra, Ivana Sestak, Qiong Gao, Jack Cuzick and Mitch Dowsett

    Citation: Breast Cancer Research 2018 20:103

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  43. Content type: Research article

    Obesity is a strong predictor of poor prognosis in breast cancer, especially in postmenopausal women. In particular, tumors in obese patients tend to seed more distant metastases, although the biology behind t...

    Authors: Mélanie Bousquenaud, Flavia Fico, Giovanni Solinas, Curzio Rüegg and Albert Santamaria-Martínez

    Citation: Breast Cancer Research 2018 20:104

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  44. Content type: Meeting report

    The European Network for Breast Development and Cancer (ENBDC), a worldwide network (http://​www.​enbdc.​org/​), celebrated its tenth anniversary with a fantasti...

    Authors: Zuzana Koledova, Beatrice A. Howard, Johanna Englund, Karsten Bach, Mohammed Bentires-Alj and Eva Gonzalez-Suarez

    Citation: Breast Cancer Research 2018 20:102

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  45. Content type: Review

    Differentiation of stem cells into highly specialised cells requires gene expression changes brought about by remodelling of the chromatin architecture. During this lineage-commitment process, the majority of ...

    Authors: Holly Holliday, Laura A. Baker, Simon R. Junankar, Susan J. Clark and Alexander Swarbrick

    Citation: Breast Cancer Research 2018 20:100

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  46. Content type: Research article

    We sought to investigate associations between dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) features and tumor-infiltrating lymphocytes (TILs) in breast cancer, as well as to study if MRI fe...

    Authors: Jia Wu, Xuejie Li, Xiaodong Teng, Daniel L. Rubin, Sandy Napel, Bruce L. Daniel and Ruijiang Li

    Citation: Breast Cancer Research 2018 20:101

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  47. Content type: Correction

    After the publication of this work [1], an error was noticed in Fig. 2b and Fig. 4b as well as Fig. 4b. and Fig. 5d. Images of the ERK1/2 blots were accidentally duplicated. In Fig. 5a. and Fig. 5c., the last ...

    Authors: Iain R. Hutcheson, Janice M. Knowlden, Steve E. Hiscox, Denise Barrow, Julia M. W. Gee, John F. Robertson, Ian O. Ellis and Robert I. Nicholson

    Citation: Breast Cancer Research 2018 20:98

    Published on:

    The original article was published in Breast Cancer Research 2007 9:R50

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