Retraction Note: Loss of pigment epithelium-derived factor: a novel mechanism for the development of endocrine resistance in breast cancer
Breast Cancer Research volume 25, Article number: 107 (2023)
Retraction Note to: Breast Cancer Research 2012, 14:R146 https://doi.org/10.1186/bcr3356
The Editor-in-Chief has retracted this article at the Corresponding Author's request. After publication, concerns were raised regarding the western blot images presented in the figures. Specifically:
Figure 1a beta-actin bands appear highly similar to Fig. 5b in the corresponding author's earlier article .
Figure 7d pSer167-ER-alpha blot appears highly similar to the MCF:2A BCL-2 blot in Fig. 4a in the authors' earlier article .
Figure 2b pER-Ser118 blot appears to contain an “invisible” band in lane 3.
Figure 3b PEDF blot appears to have a vertical straight line break in the backgrounds between lanes 2 and 3.
Figure 4a PEDF lanes 2 and 3 appear highly similar to p70S6K lanes 1 and 2, respectively.
Figure 7d pAKT blot appears highly similar to Fig. 4d mitochondria Cyt c in .
Figure 6d PBS and rPEDF images appear highly similar to Fig. 6d BSO and E2, respectively, in .
The Corresponding Author has stated that some of the blots from their other projects were mistakenly used in this article. The Editor-in-Chief therefore no longer has confidence in the presented data.
The authors have been offered to submit a revised manuscript with the correct data for further peer review.
Min Huang and Joan Lewis-Wambi agree to this retraction. The publisher has not been able to obtain a current email address for Rifat Jan.
Lewis-Wambi JS, Cunliffe HE, Kim HR, Willis AL, Jordan VC. Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer. 2008;44(12):1770–9. https://doi.org/10.1016/j.ejca.2008.05.016.
Lewis-Wambi JS, Kim HR, Wambi C, et al. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Res. 2008;10:R104. https://doi.org/10.1186/bcr2208.
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Jan, R., Huang, M. & Lewis-Wambi, J. Retraction Note: Loss of pigment epithelium-derived factor: a novel mechanism for the development of endocrine resistance in breast cancer. Breast Cancer Res 25, 107 (2023). https://doi.org/10.1186/s13058-023-01711-7