Nelson HD, Smith ME, Griffin JC, Fu R: Use of medications to reduce risk for primary breast cancer: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2013, 158: 604-614. 10.7326/0003-4819-158-8-201304160-00005.
Article
PubMed
Google Scholar
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N: Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998, 90: 1371-1388. 10.1093/jnci/90.18.1371.
Article
CAS
PubMed
Google Scholar
Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, Norton L, Nickelsen T, Bjarnason NH, Morrow M, Lippman ME, Black D, Glusman JE, Costa A, Jordan VC: The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA. 1999, 281: 2189-2197. 10.1001/jama.281.23.2189.
Article
CAS
PubMed
Google Scholar
Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim EM, Polubriaginof F, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi AJ, Roche CA, Hughes KS: The role of chemoprevention in modifying the risk of breast cancer in women with atypical breast lesions. Breast Cancer Res Treat. 2012, 136: 627-633. 10.1007/s10549-012-2318-8.
Article
CAS
PubMed
Google Scholar
Ruan W, Catanese V, Wieczorek R, Feldman M, Kleinberg DL: Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid. Endocrinology. 1995, 136: 1296-1302.
Article
CAS
PubMed
Google Scholar
Ruan W, Monaco ME, Kleinberg DL: Progesterone stimulates mammary gland ductal morphogenesis by synergizing with and enhancing insulin-like growth factor-I action. Endocrinology. 2005, 146: 1170-1178. 10.1210/en.2004-1360.
Article
CAS
PubMed
Google Scholar
Ruan W, Kleinberg DL: Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. Endocrinology. 1999, 140: 5075-5081.
Article
CAS
PubMed
Google Scholar
Kleinberg DL, Wood TL, Furth PA, Lee AV: Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocr Rev. 2009, 30: 51-74. 10.1210/er.2008-0022.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kleinberg DL, Ameri P, Singh B: Pasireotide, an IGF-I action inhibitor, prevents growth hormone and estradiol-induced mammary hyperplasia. Pituitary. 2011, 14: 44-52. 10.1007/s11102-010-0257-0.
Article
CAS
PubMed
Google Scholar
Carboni JM, Lee AV, Hadsell DL, Rowley BR, Lee FY, Bol DK, Camuso AE, Gottardis M, Greer AF, Ho CP, Hurlburt W, Li A, Saulnier M, Velaparthi U, Wang C, Wen ML, Westhouse RA, Wittman M, Zimmermann K, Rupnow BA, Wong TW: Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor. Cancer Res. 2005, 65: 3781-3787. 10.1158/0008-5472.CAN-04-4602.
Article
CAS
PubMed
Google Scholar
Hadsell DL, Bonnette SG: IGF and insulin action in the mammary gland: lessons from transgenic and knockout models. J Mammary Gland Biol Neoplasia. 2000, 5: 19-30. 10.1023/A:1009559014703.
Article
CAS
PubMed
Google Scholar
Ruan W, Fahlbusch F, Clemmons DR, Monaco ME, Walden PD, Silva AP, Schmid HA, Kleinberg DL: SOM230 inhibits insulin-like growth factor-I action in mammary gland development by pituitary independent mechanism: mediated through somatostatin subtype receptor 3?. Mol Endocrinol. 2006, 20: 426-436. 10.1210/me.2005-0283.
Article
CAS
PubMed
Google Scholar
Tap WD, Demetri G, Barnette P, Desai J, Kavan P, Tozer R, Benedetto PW, Friberg G, Deng H, McCaffery I, Leitch I, Badola S, Chang S, Zhu M, Tolcher A: Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors. J Clin Oncol. 2012, 30: 1849-1856. 10.1200/JCO.2011.37.2359.
Article
CAS
PubMed
Google Scholar
Yang Y, Yee D: Targeting insulin and insulin-like growth factor signaling in breast cancer. J Mammary Gland Biol Neoplasia. 2012, 17: 251-261. 10.1007/s10911-012-9268-y.
Article
PubMed
PubMed Central
Google Scholar
Bruchim I, Werner H: Targeting IGF-1 signaling pathways in gynecologic malignancies. Expert Opin Ther Targets. 2013, 17: 307-320. 10.1517/14728222.2013.749863.
Article
CAS
PubMed
Google Scholar
Murakami H, Doi T, Yamamoto N, Watanabe J, Boku N, Fuse N, Yoshino T, Ohtsu A, Otani S, Shibayama K, Takubo T, Loh E: Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012, 70: 407-414. 10.1007/s00280-012-1924-9.
Article
CAS
PubMed
PubMed Central
Google Scholar
McKian KP, Haluska P: Cixutumumab. Expert Opin Investig Drugs. 2009, 18: 1025-1033. 10.1517/13543780903055049.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yee D: Insulin-like growth factor receptor inhibitors: baby or the bathwater?. J Natl Cancer Inst. 2012, 104: 975-981. 10.1093/jnci/djs258.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kleinberg DL: Early mammary development: Growth hormone and IGF-1. J Mammary Gland Biol Neoplasia. 1997, 2: 49-57. 10.1023/A:1026373513521.
Article
CAS
PubMed
Google Scholar
Ma XJ, Salunga R, Tuggle JT, Gaudet J, Enright E, McQuary P, Payette T, Pistone M, Stecker K, Zhang BM, Zhou YX, Varnholt H, Smith B, Gadd M, Chatfield E, Kessler J, Baer TM, Erlander MG, Sgroi DC: Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci U S A. 2003, 100: 5974-5979. 10.1073/pnas.0931261100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tisty T, Vachon CM, Melton LJ, Visscher DW: Benign breast disease and the risk of breast cancer. N Engl J Med. 2005, 353: 229-237. 10.1056/NEJMoa044383.
Article
CAS
PubMed
Google Scholar
Cichon MA, Degnim AC, Visscher DW, Radisky DC: Microenvironmental influences that drive progression from benign breast disease to invasive breast cancer. J Mammary Gland Biol Neoplasia. 2010, 15: 389-397. 10.1007/s10911-010-9195-8.
Article
PubMed
PubMed Central
Google Scholar
Uehara J, Nazario AC, Rodrigues de Lima G, Simoes MJ, Juliano Y, Gebrim LH: Effects of tamoxifen on the breast in the luteal phase of the menstrual cycle. Int J Gynaecol Obstet. 1998, 62: 77-82. 10.1016/S0020-7292(98)00050-2.
Article
CAS
PubMed
Google Scholar
Bernardes JR, Seixas MT, Lima GR, Marinho LC, Gebrim LH: The effect of tamoxifen on PCNA expression in fibroadenomas. Breast J. 2003, 9: 302-306. 10.1046/j.1524-4741.2003.09410.x.
Article
CAS
PubMed
Google Scholar
Dowsett M, Bundred NJ, Decensi A, Sainsbury RC, Lu Y, Hills MJ, Cohen FJ, Veronesi P, O'Brien ME, Scott T, Muchmore DB: Effect of raloxifene on breast cancer cell Ki67 and apoptosis: a double-blind, placebo-controlled, randomized clinical trial in postmenopausal patients. Cancer Epidemiol Biomarkers Prev. 2001, 10: 961-966.
CAS
PubMed
Google Scholar
Iwata H, Masuda N, Sagara Y, Kinoshita T, Nakamura S, Yanagita Y, Nishimura R, Iwase H, Kamigaki S, Takei H, Tsuda H, Hayashi N, Noguchi S: Analysis of Ki-67 expression with neoadjuvant anastrozole or tamoxifen in patients receiving goserelin for premenopausal breast cancer. Cancer. 2013, 119: 704-713. 10.1002/cncr.27818.
Article
CAS
PubMed
Google Scholar
Polley MY, Leung SC, McShane LM, Gao D, Hugh JC, Mastropasqua MG, Viale G, Zabaglo LA, Penault-Llorca F, Bartlett JM, Gown AM, Symmans WF, Piper T, Mehl E, Enos RA, Hayes DF, Dowsett M, Nielsen TO: An international Ki67 reproducibility study. J Natl Cancer Inst. 2013, 105: 1897-1906. 10.1093/jnci/djt306.
Article
PubMed
PubMed Central
Google Scholar
Theodoropoulou M, Zhang J, Laupheimer S, Paez-Pereda M, Erneux C, Florio T, Pagotto U, Stalla G: Octreotide, a Somatostatin Analogue, mediates its Antiproliferative Action in Pituitary Tumor Cells by Altering Phosphatidylinositol 3-Kinase Signaling and Inducing Zac1 Expression. Cancer Res. 2006, 66: 1576-1582. 10.1158/0008-5472.CAN-05-1189.
Article
CAS
PubMed
Google Scholar
Christov K, Ikui A, Shilkaitis A, Green A, Yao R, You M, Grubbs C, Steele V, Lubet R, Weinstein IB: Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors. Breast Cancer Res Treat. 2003, 77: 253-264. 10.1023/A:1021804121171.
Article
CAS
PubMed
Google Scholar
Zhang GJ, Kimijima I, Onda M, Kanno M, Sato H, Watanabe T, Tsuchiya A, Abe R, Takenoshita S: Tamoxifen-induced apoptosis in breast cancer cells relates to down-regulation of bcl-2, but not bax and bcl-X(L), without alteration of p53 protein levels. Clin Cancer Res. 1999, 5: 2971-2977.
CAS
PubMed
Google Scholar
Farczadi E, Kaszas I, Baki M, Szende B: Changes in apoptosis, mitosis, Her-2, p53 and Bcl2 expression in breast carcinomas after short-term tamoxifen treatment. Neoplasma. 2002, 49: 101-103.
CAS
PubMed
Google Scholar
Alvarez RH, Valero V, Hortobagyi GN: Emerging targeted therapies for breast cancer. J Clin Oncol. 2010, 28: 3366-3379. 10.1200/JCO.2009.25.4011.
Article
CAS
PubMed
Google Scholar
Colao A, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, Schoenherr U, Mills D, Salgado LR, Biller BM: A 12-month phase 3 study of pasireotide in Cushing’s disease. N Engl J Med. 2012, 366: 914-924. 10.1056/NEJMoa1105743.
Article
CAS
PubMed
Google Scholar
Henry RRMS, Wetli-Hermosillo K, Ligueros-Saylan M, Chenji S, Golor G: Mechanism and Management of Hyperglycemia Associated with Pasireotide: Results from Studies in Healthy volunteers. Endocr Rev. 2011, 32: 3-274. 10.1210/er.2009-0043.
Article
Google Scholar
Colao A, De Block C, Gaztambide MS, Kumar S, Seufert J, Casanueva FF: Managing hyperglycemia in patients with Cushing’s disease treated with pasireotide: medical expert recommendations. Pituitary. 2014, 2013: 180-186. 10.1007/s11102-013-0483-3.
Article
Google Scholar