Representative images of proliferation (Ki67) and apoptosis (terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)) from patients treated with pasireotide. Representative examples showing Ki67 immunostaining of atypical hyperplasia (A) and one case of ductal carcinoma in situ (DCIS) (B) from pasireotide-treated patients (top panel). (C) TUNEL staining of an atypical lobular hyperplasia (ALH) lesion before and after treatment with pasireotide. Positive cells are brown. (D) A small increase in the number of apoptotic cells (arrows) was also observed after treatment in one case of DCIS.