Insulin-like growth factor-I inhibition with pasireotide decreases cell proliferation and increases apoptosis in pre-malignant lesions of the breast: a phase 1 proof of principle trial

Table 1 Changes in the expression of estrogen receptor (ER) and progesterone receptor (PR) following treatment with pasireotide

	Number	Change in percentage of positive cells	P -value	Number of lesions in which the percentage of positive cells decreased	P -value
Proliferative lesions
ER	9	–4.2 ± 9.9	0.13	7 (77.8%)	0.18
PR	7	–9.8 ± 30.7	0.81	3 (42.9%)	1.00
Atypical hyperplasia
ER	5	–8.0 ± 15.0	0.31	2 (40%)	1.00
PR	4	–10.7 ± 54.3	0.88	2 (50%)	1.00

Differences in the percentage of positive cells in core versus excision biopsies are presented as mean ± SD.

ISSN: 1465-542X