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Table 1 Changes in the expression of estrogen receptor (ER) and progesterone receptor (PR) following treatment with pasireotide

From: Insulin-like growth factor-I inhibition with pasireotide decreases cell proliferation and increases apoptosis in pre-malignant lesions of the breast: a phase 1 proof of principle trial

  Number Change in percentage of positive cells P -value Number of lesions in which the percentage of positive cells decreased P -value
Proliferative lesions      
ER 9 –4.2 ± 9.9 0.13 7 (77.8%) 0.18
PR 7 –9.8 ± 30.7 0.81 3 (42.9%) 1.00
Atypical hyperplasia      
ER 5 –8.0 ± 15.0 0.31 2 (40%) 1.00
PR 4 –10.7 ± 54.3 0.88 2 (50%) 1.00
  1. Differences in the percentage of positive cells in core versus excision biopsies are presented as mean ± SD.
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