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Breast Cancer Research

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  1. Content type: Research Article

    Genome-wide association studies (GWASs) have identified numerous single-nucleotide polymorphisms (SNPs) associated with small increases in breast cancer risk. Studies to date suggest that some SNPs alter the e...

    Authors: Na Li, Simone M. Rowley, Ella R. Thompson, Simone McInerny, Lisa Devereux, Kaushalya C. Amarasinghe, Magnus Zethoven, Richard Lupat, David Goode, Jason Li, Alison H. Trainer, Kylie L. Gorringe, Paul A. James and Ian G. Campbell

    Citation: Breast Cancer Research 2018 20:3

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  2. Content type: Research Article

    It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) ...

    Authors: Linnea Huss, Salma Tunå Butt, Peter Almgren, Signe Borgquist, Jasmine Brandt, Asta Försti, Olle Melander and Jonas Manjer

    Citation: Breast Cancer Research 2018 20:1

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  3. Content type: Research Article

    Disseminated tumor cells (DTCs) found in the bone marrow (BM) of patients with breast cancer portend a poor prognosis and are thought to be intermediaries in the metastatic process. To assess the clinical rele...

    Authors: Sreeraj G. Pillai, Shunqiang Li, Chidananda M. Siddappa, Matthew J Ellis, Mark A. Watson and Rebecca Aft

    Citation: Breast Cancer Research 2018 20:2

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  4. Content type: Research Article

    Several frequently used prescription drugs may affect bleeding risk. We investigated use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), and statins ...

    Authors: Anne Marie L. Thomsen, Alma B. Pedersen, Nickolaj R. Kristensen, Bjarne Kuno Møller, Christian Erikstrup, Peer M. Christiansen, Mette Nørgaard and Deirdre Cronin-Fenton

    Citation: Breast Cancer Research 2017 19:135

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  5. Content type: Research Article

    Triple negative breast cancer (TNBC) lacks both early detection biomarkers and viable targeted therapeutics. Moreover, chemotherapy only produces 20–30% pathologic complete response. Because miRNAs are frequen...

    Authors: Hao-Yi Li, Jui-Lin Liang, Yao-Lung Kuo, Hao-Hsien Lee, Marcus J. Calkins, Hong-Tai Chang, Forn-Chia Lin, Yu-Chia Chen, Tai-I Hsu, Michael Hsiao, Luo-Ping Ger and Pei-Jung Lu

    Citation: Breast Cancer Research 2017 19:133

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  6. Content type: Research Article

    Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the ...

    Authors: Karthik Ghosh, Robert A. Vierkant, Ryan D. Frank, Stacey Winham, Daniel W. Visscher, Vernon S. Pankratz, Christopher G. Scott, Kathleen Brandt, Mark E. Sherman, Derek C. Radisky, Marlene H. Frost, Lynn C. Hartmann, Amy C. Degnim and Celine M. Vachon

    Citation: Breast Cancer Research 2017 19:134

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  7. Content type: Research Article

    Annexin-1 (ANXA1) plays pivotal roles in regulating various physiological processes including inflammation, proliferation and apoptosis, and deregulation of ANXA1 functions has been associated with tumorigenes...

    Authors: Asfa Alli-Shaik, Sheena Wee, Lina H. K. Lim and Jayantha Gunaratne

    Citation: Breast Cancer Research 2017 19:132

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  8. Content type: Research Article

    We examined racial differences in the expression of eight genes and their associations with risk of recurrence among 478 white and 495 black women who participated in the Carolina Breast Cancer Study Phase 3.

    Authors: Humberto Parada Jr, Xuezheng Sun, Jodie M. Fleming, ClarLynda R. Williams-DeVane, Erin L. Kirk, Linnea T. Olsson, Charles M. Perou, Andrew F. Olshan and Melissa A. Troester

    Citation: Breast Cancer Research 2017 19:131

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  9. Content type: Research Article

    The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor ...

    Authors: Ernestina M. De Francesco, Andrew H. Sims, Marcello Maggiolini, Federica Sotgia, Michael P. Lisanti and Robert B. Clarke

    Citation: Breast Cancer Research 2017 19:129

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  10. Content type: Research Article

    Patient-derived xenografts (PDXs) are increasingly used in cancer research as a tool to inform cancer biology and drug response. Most available breast cancer PDXs have been generated in the metastatic setting....

    Authors: Jia Yu, Bo Qin, Ann M. Moyer, Jason P. Sinnwell, Kevin J. Thompson, John A. Copland III, Laura A. Marlow, James L. Miller, Ping Yin, Bowen Gao, Katherine Minter-Dykhouse, Xiaojia Tang, Sarah A. McLaughlin, Alvaro Moreno-Aspitia, Anthony Schweitzer, Yan Lu…

    Citation: Breast Cancer Research 2017 19:130

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  11. Content type: Research Article

    Obesity is correlated with an increased risk for developing postmenopausal breast cancer. Since obesity rates continue to rise worldwide, it is important to understand how the obese microenvironment influences...

    Authors: Tamara Chamberlin, Joseph V. D’Amato and Lisa M. Arendt

    Citation: Breast Cancer Research 2017 19:128

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  12. Content type: Research Article

    In mammography, breast compression is applied to reduce the thickness of the breast. While it is widely accepted that firm breast compression is needed to ensure acceptable image quality, guidelines remain vag...

    Authors: Katharina Holland, Ioannis Sechopoulos, Ritse M. Mann, Gerard J. den Heeten, Carla H. van Gils and Nico Karssemeijer

    Citation: Breast Cancer Research 2017 19:126

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  13. Content type: Research Article

    Laboratory assays evaluating the effect of DNA sequence variants on BRCA1 mRNA splicing may contribute to classification by providing molecular evidence. However, our knowledge of normal and aberrant BRCA1 splici...

    Authors: Lucy C. de Jong, Simone Cree, Vanessa Lattimore, George A. R. Wiggins, Amanda B. Spurdle, Allison Miller, Martin A. Kennedy and Logan C. Walker

    Citation: Breast Cancer Research 2017 19:127

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  14. Content type: Research

    Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in patients using adjuvant tamoxifen. Direct measurement...

    Authors: Thomas Helland, Nina Henne, Ersilia Bifulco, Bjørn Naume, Elin Borgen, Vessela N. Kristensen, Jan T. Kvaløy, Timothy L. Lash, Grethe I. G. Alnæs, Ron H. van Schaik, Emiel A. M. Janssen, Steinar Hustad, Ernst A. Lien, Gunnar Mellgren and Håvard Søiland

    Citation: Breast Cancer Research 2017 19:125

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  15. Content type: Research Article

    High mammographic density is a strong, well-established breast cancer risk factor. Three studies conducted in various smaller geographic settings reported inconsistent findings between air pollution and mammog...

    Authors: Natalie C. DuPre, Jaime E. Hart, Kimberly A. Bertrand, Peter Kraft, Francine Laden and Rulla M. Tamimi

    Citation: Breast Cancer Research 2017 19:124

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  16. Content type: Research Article

    Thymidine kinase 1 (TK1) is a cell cycle-regulated enzyme with peak expression in the S phase during DNA synthesis, and it is an attractive biomarker of cell proliferation. Serum TK1 activity has demonstrated ...

    Authors: Nusayba Bagegni, Shana Thomas, Ning Liu, Jingqin Luo, Jeremy Hoog, Donald W. Northfelt, Matthew P. Goetz, Andres Forero, Mattias Bergqvist, Jakob Karen, Magnus Neumüller, Edward M. Suh, Zhanfang Guo, Kiran Vij, Souzan Sanati, Matthew Ellis…

    Citation: Breast Cancer Research 2017 19:123

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  17. Content type: Research Article

    Proper repair and restart of stressed replication forks requires intact homologous recombination (HR). HR at stressed replication forks can be initiated by the 5′ endonuclease EEPD1, which cleaves the stalled ...

    Authors: Robert Hromas, Hyun-Suk Kim, Gurjit Sidhu, Elizabeth Williamson, Aruna Jaiswal, Taylor A. Totterdale, Jocelyn Nole, Suk-Hee Lee, Jac A. Nickoloff and Kimi Y. Kong

    Citation: Breast Cancer Research 2017 19:122

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  18. Content type: Research Article

    Approximately 70% of all breast cancers express the estrogen receptor, and are regulated by estrogen. While the ovaries are the primary source of estrogen in premenopausal women, most breast cancer is diagnose...

    Authors: Derek F. Amanatullah, John S. Tamaresis, Pauline Chu, Michael H. Bachmann, Nhat M. Hoang, Deborah Collyar, Aaron T. Mayer, Robert B. West, William J. Maloney, Christopher H. Contag and Bonnie L. King

    Citation: Breast Cancer Research 2017 19:121

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  19. Content type: Research Article

    The aim of this study was to investigate the prognostic value of the PAM50 intrinsic subtypes and risk of recurrence (ROR) score in patients with early breast cancer and long-term follow-up. A special focus wa...

    Authors: Hege O. Ohnstad, Elin Borgen, Ragnhild S. Falk, Tonje G. Lien, Marit Aaserud, My Anh T. Sveli, Jon A. Kyte, Vessela N. Kristensen, Gry A. Geitvik, Ellen Schlichting, Erik A. Wist, Therese Sørlie, Hege G. Russnes and Bjørn Naume

    Citation: Breast Cancer Research 2017 19:120

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  20. Content type: Research Article

    Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors ...

    Authors: Olivier Brouckaert, Anja Rudolph, Annouschka Laenen, Renske Keeman, Manjeet K. Bolla, Qin Wang, Adelheid Soubry, Hans Wildiers, Irene L. Andrulis, Volker Arndt, Matthias W. Beckmann, Javier Benitez, Carl Blomqvist, Stig E. Bojesen, Hiltrud Brauch, Paul Brennan…

    Citation: Breast Cancer Research 2017 19:119

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  21. Content type: Research article

    While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) co...

    Authors: Jinchao Feng, Junqing Xu, Shudong Jiang, Hong Yin, Yan Zhao, Jiang Gui, Ke Wang, Xiuhua Lv, Fang Ren, Brian W. Pogue and Keith D. Paulsen

    Citation: Breast Cancer Research 2017 19:117

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  22. Content type: Research article

    The percentage of mammographic dense tissue (PD) is an important risk factor for breast cancer, and there is some evidence that texture features may further improve predictive ability. However, relatively litt...

    Authors: Chao Wang, Adam R. Brentnall, Jack Cuzick, Elaine F. Harkness, D. Gareth Evans and Susan Astley

    Citation: Breast Cancer Research 2017 19:114

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  23. Content type: Research article

    Dysregulated DNA repair and cell proliferation controls are essential driving forces in mammary tumorigenesis. BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated...

    Authors: Roberto Droz-Rosario, Huimei Lu, Jingmei Liu, Ning-Ang Liu, Shridar Ganesan, Bing Xia, Bruce G. Haffty and Zhiyuan Shen

    Citation: Breast Cancer Research 2017 19:115

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