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  1. Research article

    Alcohol consumption and breast tumor gene expression

    Alcohol consumption is an established risk factor for breast cancer and the association generally appears stronger among estrogen receptor (ER)-positive tumors. However, the biological mechanisms underlying th...

    Jun Wang, Yujing J. Heng, A. Heather Eliassen, Rulla M. Tamimi, Aditi Hazra, Vincent J. Carey, Christine B. Ambrosone, Victor P. de Andrade, Adam Brufsky, Fergus J. Couch, Tari A. King, Francesmary Modugno, Celine M. Vachon, David J. Hunter, Andrew H. Beck and Susan E. Hankinson

    Breast Cancer Research 2017 19:108

    Published on: 12 September 2017

  2. Research article

    Contrast-enhanced spectral mammography in neoadjuvant chemotherapy monitoring: a comparison with breast magnetic resonance imaging

    Neoadjuvant-chemotherapy (NAC) is considered the standard treatment for locally advanced breast carcinomas. Accurate assessment of disease response is fundamental to increase the chances of successful breast-c...

    Valentina Iotti, Sara Ravaioli, Rita Vacondio, Chiara Coriani, Sabrina Caffarri, Roberto Sghedoni, Andrea Nitrosi, Moira Ragazzi, Elisa Gasparini, Cristina Masini, Giancarlo Bisagni, Giuseppe Falco, Guglielmo Ferrari, Luca Braglia, Alberto Del Prato, Ivana Malavolti…

    Breast Cancer Research 2017 19:106

    Published on: 11 September 2017

  3. Research article

    Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors

    Poly(ADP-ribose) polymerase inhibitors (PARPi), coupled to a DNA damaging agent is a promising approach to treating triple negative breast cancer (TNBC). However, not all patients respond; we hypothesize that ...

    Imke H. Bartelink, Brendan Prideaux, Gregor Krings, Lisa Wilmes, Pei Rong Evelyn Lee, Pan Bo, Byron Hann, Jean-Philippe Coppé, Diane Heditsian, Lamorna Swigart-Brown, Ella F. Jones, Sergey Magnitsky, Ron J Keizer, Niels de Vries, Hilde Rosing, Nela Pawlowska…

    Breast Cancer Research 2017 19:107

    Published on: 11 September 2017

  4. Research article

    ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation

    During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues ...

    Michelle M. Williams, David B. Vaught, Meghan Morrison Joly, Donna J. Hicks, Violeta Sanchez, Philip Owens, Bushra Rahman, David L. Elion, Justin M. Balko and Rebecca S. Cook

    Breast Cancer Research 2017 19:105

    Published on: 8 September 2017

  5. Research Article

    Breast Tissue Organisation and its Association with Breast Cancer Risk

    Mammographic percentage density is an established and important risk factor for breast cancer. In this paper, we investigate the role of the spatial organisation of (dense vs. fatty) regions of the breast defi...

    Maya Alsheh Ali, Kamila Czene, Louise Eriksson, Per Hall and Keith Humphreys

    Breast Cancer Research 2017 19:103

    Published on: 6 September 2017

  6. Research article

    Pathobiology of the 129:Stat1 −/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype

    Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1 tm1Rds) develop estrogen receptor-positive (ER+), luminal-type mammary carcinomas at an advanced age. ...

    Hidetoshi Mori, Jane Q. Chen, Robert D. Cardiff, Zsófia Pénzváltó, Neil E. Hubbard, Louis Schuetter, Russell C. Hovey, Josephine F. Trott and Alexander D. Borowsky

    Breast Cancer Research 2017 19:102

    Published on: 2 September 2017

  7. Research article

    Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer

    Chemotherapy decreases the risk of relapse and mortality in early-stage breast cancer (BC), but it comes with the risk of toxicity. Chemotherapy efficacy depends on relative dose intensity (RDI), and an RDI < ...

    Yuan Yuan, Nilesh Vora, Can-Lan Sun, Daneng Li, Enrique Soto-Perez-de-Celis, Joanne Mortimer, The-hang Luu, George Somlo, James Waisman, David Smith, Joseph Chao, Vani Katheria, Timothy Synold, Vivi Tran, Shu Mi, Abrahm Levi…

    Breast Cancer Research 2017 19:101

    Published on: 29 August 2017

  8. Research article

    Tissue-based associations of mammographic breast density with breast stem cell markers

    Mammographic breast density is a well-established, strong breast cancer risk factor but the biology underlying this association remains unclear. Breast density may reflect underlying alterations in the size an...

    Lusine Yaghjyan, Ethan Stoll, Karthik Ghosh, Christopher G. Scott, Matthew R. Jensen, Kathleen R. Brandt, Daniel Visscher and Celine M. Vachon

    Breast Cancer Research 2017 19:100

    Published on: 29 August 2017

  9. Research article

    The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting

    Patients with BRCA1-like tumors correlate with improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed to distinguish between BRCA1-like and non-BRCA1-like ...

    Tesa M. Severson, Denise M. Wolf, Christina Yau, Justine Peeters, Diederik Wehkam, Philip C. Schouten, Suet-Feung Chin, Ian J. Majewski, Magali Michaut, Astrid Bosma, Bernard Pereira, Tycho Bismeijer, Lodewyk Wessels, Carlos Caldas, René Bernards, Iris M. Simon…

    Breast Cancer Research 2017 19:99

    Published on: 25 August 2017

  10. Research article

    Assessment of the prognostic role of a 94-single nucleotide polymorphisms risk score in early breast cancer in the SIGNAL/PHARE prospective cohort: no correlation with clinico-pathological characteristics and outcomes

    Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effec...

    Elsa Curtit, Xavier Pivot, Julie Henriques, Sophie Paget-Bailly, Pierre Fumoleau, Maria Rios, Hervé Bonnefoi, Thomas Bachelot, Patrick Soulié, Christelle Jouannaud, Hugues Bourgeois, Thierry Petit, Isabelle Tennevet, David Assouline, Marie-Christine Mathieu, Jean-Philippe Jacquin…

    Breast Cancer Research 2017 19:98

    Published on: 22 August 2017

  11. Research article

    Combining quantitative and qualitative breast density measures to assess breast cancer risk

    Accurately identifying women with dense breasts (Breast Imaging Reporting and Data System [BI-RADS] heterogeneously or extremely dense) who are at high breast cancer risk will facilitate discussions of supplem...

    Karla Kerlikowske, Lin Ma, Christopher G. Scott, Amir P. Mahmoudzadeh, Matthew R. Jensen, Brian L. Sprague, Louise M. Henderson, V. Shane Pankratz, Steven R. Cummings, Diana L. Miglioretti, Celine M. Vachon and John A. Shepherd

    Breast Cancer Research 2017 19:97

    Published on: 22 August 2017

  12. Meeting report

    The ninth ENBDC Weggis meeting: growth and in-depth characterisation of normal and neoplastic breast cells

    Mammary gland biologists gathered for the ninth annual workshop of the European Network for Breast Development and Cancer (ENBDC) at Weggis on the shores of Lake Lucerne in March 2017. The main themes were oes...

    Katrin E. Wiese, Romain J. Amante, Maria dM. Vivanco, Mohamed Bentires-Alj and Richard D. Iggo

    Breast Cancer Research 2017 19:96

    Published on: 22 August 2017

  13. Research article

    White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)

    Several studies have suggested that global DNA methylation in circulating white blood cells (WBC) is associated with breast cancer risk.

    Susan R. Sturgeon, J. Richard Pilsner, Kathleen F. Arcaro, Kaoru Ikuma, Haotian Wu, Soon-Mi Kim, Nayha Chopra-Tandon, Adam R. Karpf, Regina G. Ziegler, Catherine Schairer, Raji Balasubramanian and David A. Reckhow

    Breast Cancer Research 2017 19:94

    Published on: 18 August 2017

  14. Research article

    Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

    We previously performed a case–control genome-wide association study in women treated with selective estrogen receptor modulators (SERMs) for breast cancer prevention and identified single nucleotide polymorph...

    Sisi Qin, James N. Ingle, Mohan Liu, Jia Yu, D. Lawrence Wickerham, Michiaki Kubo, Richard M. Weinshilboum and Liewei Wang

    Breast Cancer Research 2017 19:95

    Published on: 18 August 2017

  15. Research article

    Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer

    Selinexor (KPT-330) is an oral agent that has been shown to inhibit the nuclear exporter XPO1. Given the pressing need for novel therapies for triple-negative breast cancer (TNBC), we sought to determine the a...

    Natalia Paez Arango, Erkan Yuca, Ming Zhao, Kurt W. Evans, Stephen Scott, Charissa Kim, Ana Maria Gonzalez-Angulo, Filip Janku, Naoto T. Ueno, Debu Tripathy, Argun Akcakanat, Aung Naing and Funda Meric-Bernstam

    Breast Cancer Research 2017 19:93

    Published on: 15 August 2017

  16. Research article

    Concurrent antitumor and bone-protective effects of everolimus in osteotropic breast cancer

    The mammalian target of rapamycin inhibitor everolimus is approved as an antitumor agent in advanced estrogen receptor-positive breast cancer. Surrogate bone marker data from clinical trials suggest effects on...

    Andrew J. Browne, Marie L. Kubasch, Andy Göbel, Peyman Hadji, David Chen, Martina Rauner, Friedrich Stölzel, Lorenz C. Hofbauer and Tilman D. Rachner

    Breast Cancer Research 2017 19:92

    Published on: 9 August 2017

  17. Research article

    Effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes and PD-L1 expression in breast cancer and its clinical significance

    The effects of neoadjuvant chemotherapy on immune markers remain largely unknown. The specific aim of this study was to assess stromal tumor-infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1...

    Vasiliki Pelekanou, Daniel E. Carvajal-Hausdorf, Mehmet Altan, Brad Wasserman, Cristobal Carvajal-Hausdorf, Hallie Wimberly, Jason Brown, Donald Lannin, Lajos Pusztai and David L. Rimm

    Breast Cancer Research 2017 19:91

    Published on: 7 August 2017

  18. Research article

    Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade

    New molecular targets are needed for women with triple-negative breast cancer (TNBC). This pre-clinical study investigated the combination of the EGFR inhibitor gefitinib with the sphingosine kinase (SphK) inh...

    Janet L. Martin, Sohel M. Julovi, Mike Z. Lin, Hasanthi C. de Silva, Frances M. Boyle and Robert C. Baxter

    Breast Cancer Research 2017 19:90

    Published on: 4 August 2017

  19. Research article

    A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer

    Targeted therapies in HER2-positive metastatic breast cancer significantly improve outcomes but efficacy is limited by therapeutic resistance. HER2 is an acutely sensitive Heat Shock Protein 90 (HSP90) client ...

    Komal Jhaveri, Rui Wang, Eleonora Teplinsky, Sarat Chandarlapaty, David Solit, Karen Cadoo, James Speyer, Gabriella D’Andrea, Sylvia Adams, Sujata Patil, Sofia Haque, Tara O’Neill, Kent Friedman, Francisco J. Esteva, Clifford Hudis and Shanu Modi

    Breast Cancer Research 2017 19:89

    Published on: 2 August 2017

  20. Research article

    AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

    Absence of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) correlates with poor long-term survival in patients with triple negative breast cancer (TNBC). These incomplete treatment respon...

    Sheheryar Kabraji, Xavier Solé, Ying Huang, Clyde Bango, Michaela Bowden, Aditya Bardia, Dennis Sgroi, Massimo Loda and Sridhar Ramaswamy

    Breast Cancer Research 2017 19:88

    Published on: 1 August 2017

  21. Research article

    Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies

    The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations...

    Sinead Toomey, Alexander J. Eustace, Joanna Fay, Katherine M. Sheehan, Aoife Carr, Malgorzata Milewska, Stephen F. Madden, Ausra Teiserskiene, Elaine W. Kay, Norma O’Donovan, William Gallagher, Liam Grogan, Oscar Breathnach, Janice Walshe, Catherine Kelly, Brian Moulton…

    Breast Cancer Research 2017 19:87

    Published on: 27 July 2017

  22. Research article

    Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

    Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased proliferation. Proliferation may be restored in secondary metastases by mesenchymal-to-epith...

    H. J. Hugo, N. P. A. D. Gunasinghe, B. G. Hollier, T. Tanaka, T. Blick, A. Toh, P. Hill, C. Gilles, M. Waltham and E. W. Thompson

    Breast Cancer Research 2017 19:86

    Published on: 27 July 2017

  23. Research article

    Body size in early life and risk of breast cancer

    Body size in early life is inversely associated with adult breast cancer (BC) risk, but it is unclear whether the associations differ by tumor characteristics.

    Md. Shajedur Rahman Shawon, Mikael Eriksson and Jingmei Li

    Breast Cancer Research 2017 19:84

    Published on: 21 July 2017

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