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  1. Content type: Research article

    Body size in early life is inversely associated with adult breast cancer (BC) risk, but it is unclear whether the associations differ by tumor characteristics.

    Authors: Md. Shajedur Rahman Shawon, Mikael Eriksson and Jingmei Li

    Citation: Breast Cancer Research 2017 19:84

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  2. Content type: Research article

    Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer (CBC) risk. However, information on influential covaria...

    Authors: Anne S. Reiner, Charles F. Lynch, Julia S. Sisti, Esther M. John, Jennifer D. Brooks, Leslie Bernstein, Julia A. Knight, Li Hsu, Patrick Concannon, Lene Mellemkjær, Marc Tischkowitz, Robert W. Haile, Ronglai Shen, Kathleen E. Malone, Meghan Woods, Xiaolin Liang…

    Citation: Breast Cancer Research 2017 19:83

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  3. Content type: Research article

    Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones.

    Authors: Renée T. Fortner, Eglé Tolockiene, Helena Schock, Husam Oda, Hans-Åke Lakso, Göran Hallmans, Rudolf Kaaks, Paolo Toniolo, Anne Zeleniuch-Jacquotte, Kjell Grankvist and Eva Lundin

    Citation: Breast Cancer Research 2017 19:82

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  4. Content type: Research article

    The underlying biological mechanisms through which epidemiologically defined breast cancer risk factors contribute to disease risk remain poorly understood. Identification of the molecular changes associated w...

    Authors: Kevin C. Johnson, E. Andres Houseman, Jessica E. King and Brock C. Christensen

    Citation: Breast Cancer Research 2017 19:81

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  5. Content type: Erratum

    Authors: Nathaniel M. Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Plecha and Anant Madabhushi

    Citation: Breast Cancer Research 2017 19:80

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    The original article was published in Breast Cancer Research 2017 19:57

  6. Content type: Research article

    Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time ...

    Authors: Nguyen M. Nguyen, Fabia de Oliveira Andrade, Lu Jin, Xiyuan Zhang, Madisa Macon, M. Idalia Cruz, Carlos Benitez, Bryan Wehrenberg, Chao Yin, Xiao Wang, Jianhua Xuan, Sonia de Assis and Leena Hilakivi-Clarke

    Citation: Breast Cancer Research 2017 19:77

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  7. Content type: Research article

    Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been o...

    Authors: Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson and Christoforos Thomas

    Citation: Breast Cancer Research 2017 19:79

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  8. Content type: Research article

    Tumours are not only composed of malignant cells but also consist of a stromal micro-environment, which has been shown to influence cancer cell behaviour. Because the ageing process induces accumulation of sen...

    Authors: Barbara Brouwers, Debora Fumagalli, Sylvain Brohee, Sigrid Hatse, Olivier Govaere, Giuseppe Floris, Kathleen Van den Eynde, Yacine Bareche, Patrick Schöffski, Ann Smeets, Patrick Neven, Diether Lambrechts, Christos Sotiriou and Hans Wildiers

    Citation: Breast Cancer Research 2017 19:78

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  9. Content type: Research article

    Natural killer (NK) cells play a critical role in cancer immunosurveillance. Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of activated NK cells from a small volume of...

    Authors: Mira M. Shenouda, Amy Gillgrass, Tina Nham, Richard Hogg, Amanda J. Lee, Marianne V. Chew, Mahsa Shafaei, Craig Aarts, Dean A. Lee, John Hassell, Anita Bane, Sukhbinder Dhesy-Thind and Ali A. Ashkar

    Citation: Breast Cancer Research 2017 19:76

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  10. Content type: Research article

    The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor ...

    Authors: Meghan Morrison Joly, Michelle M. Williams, Donna J. Hicks, Bayley Jones, Violeta Sanchez, Christian D. Young, Dos D. Sarbassov, William J. Muller, Dana Brantley-Sieders and Rebecca S. Cook

    Citation: Breast Cancer Research 2017 19:74

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  11. Content type: Research article

    Compared with surgery alone, postoperative adjuvant radiotherapy (RT) improves relapse-free survival of patients with early-stage breast cancer. We evaluated the long-term overall and disease-free survival rat...

    Authors: Jan Poleszczuk, Kimberly Luddy, Lu Chen, Jae K. Lee, Louis B. Harrison, Brian J. Czerniecki, Hatem Soliman and Heiko Enderling

    Citation: Breast Cancer Research 2017 19:75

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  12. Content type: Research article

    Members of the microRNA (miR)-200 family, which are involved in tumor metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain elusive.

    Authors: Guangxin Zhang, Wei Zhang, Bingjin Li, Erica Stringer-Reasor, Chengjing Chu, Liyan Sun, Sejong Bae, Dongquan Chen, Shi Wei, Kenneth Jiao, Wei-Hsiung Yang, Ranji Cui, Runhua Liu and Lizhong Wang

    Citation: Breast Cancer Research 2017 19:73

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  13. Content type: Research article

    Breast adipocytes play important roles in both the development and function of mammary epithelial cells. Therefore, carcinoma–adipose stromal cell (ASC) interactions have been considered pivotal in supporting ...

    Authors: Minako Sakurai, Yasuhiro Miki, Kiyoshi Takagi, Takashi Suzuki, Takanori Ishida, Noriaki Ohuchi and Hironobu Sasano

    Citation: Breast Cancer Research 2017 19:70

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  14. Content type: Research article

    Different breast cancer subtypes show distinct tropisms for sites of metastasis. Notably, the lung is the most common site for the first distant recurrence in triple-negative breast cancer (TNBC). The identifi...

    Authors: Jin Wang, Cailu Song, Hailin Tang, Chao Zhang, Jun Tang, Xing Li, Bo Chen and Xiaoming Xie

    Citation: Breast Cancer Research 2017 19:72

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  15. Content type: Research article

    A unique 12-chemokine gene expression score (CS) accurately predicted the presence of tumor-localized, ectopic lymph node-like structures (TL-ELNs) and improved overall survival (OS) in primary colorectal canc...

    Authors: Sangeetha Prabhakaran, Victoria T. Rizk, Zhenjun Ma, Chia-Ho Cheng, Anders E. Berglund, Dominico Coppola, Farah Khalil, James J. Mulé and Hatem H. Soliman

    Citation: Breast Cancer Research 2017 19:71

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  16. Content type: Research article

    Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-deg...

    Authors: Mary Beth Terry, Theresa H. M. Keegan, Lauren C. Houghton, Mandy Goldberg, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Ying Wei, Alice S. Whittemore, Angeline Protacio, Angela R. Bradbury, Wendy K. Chung, Julia A. Knight and Esther M. John

    Citation: Breast Cancer Research 2017 19:69

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  17. Content type: Research article

    In the light of the breast density legislation in the USA, it is important to know a woman’s breast cancer risk, but particularly her risk of a tumor that is not detected through mammographic screening (interv...

    Authors: Johanna O. P. Wanders, Katharina Holland, Nico Karssemeijer, Petra H. M. Peeters, Wouter B. Veldhuis, Ritse M. Mann and Carla H. van Gils

    Citation: Breast Cancer Research 2017 19:67

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  18. Content type: Research article

    Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer ...

    Authors: Shari E. Smith, Paul Mellor, Alison K. Ward, Stephanie Kendall, Megan McDonald, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Scott Napper and Deborah H. Anderson

    Citation: Breast Cancer Research 2017 19:65

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  19. Content type: Research article

    Follistatin (FST) is an intrinsic inhibitor of activin, a member of the transforming growth factor-β superfamily of ligands. The prognostic value of FST and its family members, the follistatin-like (FSTL) prot...

    Authors: Darcie D. Seachrist, Steven T. Sizemore, Emhonta Johnson, Fadi W. Abdul-Karim, Kristen L. Weber Bonk and Ruth A. Keri

    Citation: Breast Cancer Research 2017 19:66

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  20. Content type: Research article

    The landscape of cancer-predisposing genes has been extensively investigated in the last 30 years with various methodologies ranging from candidate gene to genome-wide association studies. However, sequencing ...

    Authors: Giorgio E. M. Melloni, Luca Mazzarella, Loris Bernard, Margherita Bodini, Anna Russo, Lucilla Luzi, Pier Giuseppe Pelicci and Laura Riva

    Citation: Breast Cancer Research 2017 19:63

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  21. Content type: Research article

    In breast cancer, BRCA promoter hypermethylation and BRCA germline mutations are said to occur together rarely, but this property has not yet been translated into a clinical test. Our aim in this study was to inv...

    Authors: Shoko Vos, Cathy Beatrice Moelans and Paul Joannes van Diest

    Citation: Breast Cancer Research 2017 19:64

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  22. Content type: Research article

    Recent genome-wide profiling by sequencing and distinctive chromatin signatures has identified thousands of long non-coding RNA (lncRNA) species (>200 nt). LncRNAs have emerged as important regulators of gene ...

    Authors: Zhengyu Jiang, Carolyn M. Slater, Yan Zhou, Karthik Devarajan, Karen J. Ruth, Yueran Li, Kathy Q. Cai, Mary Daly and Xiaowei Chen

    Citation: Breast Cancer Research 2017 19:62

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  23. Content type: Research article

    Terminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, research...

    Authors: Changyuan Guo, Hyuna Sung, Shan Zheng, Jennifer Guida, Erni Li, Jing Li, Nan Hu, Joseph Deng, Jonine D. Figueroa, Mark E. Sherman, Gretchen L. Gierach, Ning Lu and Xiaohong R. Yang

    Citation: Breast Cancer Research 2017 19:61

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  24. Content type: Research article

    Re-operation for positive resection margins following breast-conserving surgery occurs frequently (average = 20–25%), is cost-inefficient, and leads to physical and psychological morbidity. Current margin asse...

    Authors: Edward R. St John, Julia Balog, James S. McKenzie, Merja Rossi, April Covington, Laura Muirhead, Zsolt Bodai, Francesca Rosini, Abigail V. M. Speller, Sami Shousha, Rathi Ramakrishnan, Ara Darzi, Zoltan Takats and Daniel R. Leff

    Citation: Breast Cancer Research 2017 19:59

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  25. Content type: Research article

    Mutations in the estrogen receptor alpha (ERα) 1 gene (ESR1) are frequently detected in ER+ metastatic breast cancer, and there is increasing evidence that these mutations confer endocrine resistance in breast ca...

    Authors: Amir Bahreini, Zheqi Li, Peilu Wang, Kevin M. Levine, Nilgun Tasdemir, Lan Cao, Hazel M. Weir, Shannon L. Puhalla, Nancy E. Davidson, Andrew M. Stern, David Chu, Ben Ho Park, Adrian V. Lee and Steffi Oesterreich

    Citation: Breast Cancer Research 2017 19:60

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  26. Content type: Research article

    PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case series, but PREDICT has been shown to underestimate...

    Authors: Francisco J. Candido dos Reis, Gordon C. Wishart, Ed M. Dicks, David Greenberg, Jem Rashbass, Marjanka K. Schmidt, Alexandra J. van den Broek, Ian O. Ellis, Andrew Green, Emad Rakha, Tom Maishman, Diana M. Eccles and Paul D. P. Pharoah

    Citation: Breast Cancer Research 2017 19:58

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  27. Content type: Research article

    In this study, we evaluated the ability of radiomic textural analysis of intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to pre...

    Authors: Nathaniel M. Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Plecha and Anant Madabhushi

    Citation: Breast Cancer Research 2017 19:57

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    The Erratum to this article has been published in Breast Cancer Research 2017 19:80

  28. Content type: Research article

    The breast tumor microenvironment regulates progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). However, it is unclear how interactions between breast epithelial and stromal cell...

    Authors: Mansoureh Sameni, Dora Cavallo-Medved, Omar E. Franco, Anita Chalasani, Kyungmin Ji, Neha Aggarwal, Arulselvi Anbalagan, Xuequn Chen, Raymond R. Mattingly, Simon W. Hayward and Bonnie F. Sloane

    Citation: Breast Cancer Research 2017 19:56

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  29. Content type: Research article

    Accurate determination of the predictive markers human epidermal growth factor receptor 2 (HER2/ERBB2), estrogen receptor (ER/ESR1), progesterone receptor (PgR/PGR), and marker of proliferation Ki67 (MKI67) is in...

    Authors: Zsuzsanna Varga, Annette Lebeau, Hong Bu, Arndt Hartmann, Frederique Penault-Llorca, Elena Guerini-Rocco, Peter Schraml, Fraser Symmans, Robert Stoehr, Xiaodong Teng, Andreas Turzynski, Reinhard von Wasielewski, Claudia Gürtler, Mark Laible, Kornelia Schlombs, Heikki Joensuu…

    Citation: Breast Cancer Research 2017 19:55

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  30. Content type: Research article

    Breast cancer is the most common malignancy and the leading cause of cancer death among women. TIMELESS (TIM), a circadian rhythm regulator, has been recently implicated in the progression of human cancer. How...

    Authors: Limin Chi, Yujiao Zou, Ling Qin, Weifeng Ma, Yanyan Hao, Yao Tang, Rongcheng Luo and Ziqing Wu

    Citation: Breast Cancer Research 2017 19:53

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  31. Content type: Research article

    The mechanisms of resistance to anti-human epidermal growth factor receptor 2 (HER 2) therapies are unclear but may include the tyrosine-protein kinase Met (c-Met), vascular endothelial growth factor (VEGF) an...

    Authors: Stephen K. Chia, Susan L. Ellard, Mihaela Mates, Stephen Welch, Catalin Mihalcioiu, Wilson H. Miller Jr, Karen Gelmon, Caroline Lohrisch, Vikaash Kumar, Sara Taylor, Linda Hagerman, Rachel Goodwin, Tao Wang, Shingo Sakashita, Ming S. Tsao, Elizabeth Eisenhauer…

    Citation: Breast Cancer Research 2017 19:54

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  32. Content type: Research article

    Regular users of aspirin may have reduced risk of breast cancer. Few studies have addressed whether risk reduction pertains to specific breast cancer subtypes defined jointly by hormone receptor (estrogen and ...

    Authors: Christina A. Clarke, Alison J. Canchola, Lisa M. Moy, Susan L. Neuhausen, Nadia T. Chung, James V. Lacey Jr and Leslie Bernstein

    Citation: Breast Cancer Research 2017 19:52

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  33. Content type: Research article

    Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of developing metastases in the brain. Despite gains with systemic control of Her2+ di...

    Authors: Cecilia Choy, Khairul I. Ansari, Josh Neman, Sarah Hsu, Matthew J. Duenas, Hubert Li, Nagarajan Vaidehi and Rahul Jandial

    Citation: Breast Cancer Research 2017 19:51

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  34. Content type: Research article

    3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming established for a number of cancers,...

    Authors: Edward P. Carter, James A. Gopsill, Jennifer. J. Gomm, J. Louise Jones and Richard P. Grose

    Citation: Breast Cancer Research 2017 19:50

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  35. Content type: Erratum

    Authors: Preeti Putcha, Jiyang Yu, Ruth Rodriguez-Barrueco, Laura Saucedo-Cuevas, Patricia Villagrasa, Eva Murga-Penas, Steven N. Quayle, Min Yang, Veronica Castro, David Llobet-Navas, Daniel Birnbaum, Pascal Finetti, Wendy A. Woodward, François Bertucci, Mary L. Alpaugh, Andrea Califano…

    Citation: Breast Cancer Research 2017 19:49

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    The original article was published in Breast Cancer Research 2015 17:149

  36. Content type: Research article

    Cancer is a mosaic of tumor cell subpopulations, where only a minority is responsible for disease recurrence and cancer invasiveness. We focused on one of the most aggressive circulating tumor cells (CTCs) whi...

    Authors: Iole Cordone, Serena Masi, Valentina Summa, Mariantonia Carosi, Antonello Vidiri, Alessandra Fabi, Alessia Pasquale, Laura Conti, Immacolata Rosito, Carmine Maria Carapella, Veronica Villani and Andrea Pace

    Citation: Breast Cancer Research 2017 19:46

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  37. Content type: Research article

    The current exploratory analysis was performed to evaluate the efficacy and safety of everolimus for treatment of human epidermal growth factor receptor 2-positive (HER2+) advanced breast cancer in the Asian s...

    Authors: Masakazu Toi, Zhimin Shao, Sara Hurvitz, Ling-Ming Tseng, Qingyuan Zhang, Kunwei Shen, Donggeng Liu, Jifeng Feng, Binghe Xu, Xiaojia Wang, Keun Seok Lee, Ting Ying Ng, Antonia Ridolfi, Florence Noel-baron, Francois Ringeisen and Zefei Jiang

    Citation: Breast Cancer Research 2017 19:47

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  38. Content type: Research article

    Mammographic breast density is a well-established strong risk factor for breast cancer. The environmental contributors to geographic variation in breast density in urban and rural areas are poorly understood. ...

    Authors: Lusine Yaghjyan, Robert Arao, Cole Brokamp, Ellen S. O’Meara, Brian L. Sprague, Gabriela Ghita and Patrick Ryan

    Citation: Breast Cancer Research 2017 19:36

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  39. Content type: Research article

    Aside from chemotherapy utilization, limited data are available on the relationship between gene expression profiling (GEP) testing and breast cancer care. We assessed the relationship between GEP testing and ...

    Authors: Suzanne C. O’Neill, Claudine Isaacs, Filipa Lynce, Deena Mary Atieh Graham, Calvin Chao, Vanessa B. Sheppard, Yingjun Zhou, Chunfu Liu, Nandini Selvam, Marc D. Schwartz and Arnold L. Potosky

    Citation: Breast Cancer Research 2017 19:45

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  40. Content type: Research article

    Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated subtypes.

    Authors: Miriam Ragle Aure, Valeria Vitelli, Sandra Jernström, Surendra Kumar, Marit Krohn, Eldri U. Due, Tonje Husby Haukaas, Suvi-Katri Leivonen, Hans Kristian Moen Vollan, Torben Lüders, Einar Rødland, Charles J. Vaske, Wei Zhao, Elen K. Møller, Silje Nord, Guro F. Giskeødegård…

    Citation: Breast Cancer Research 2017 19:44

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