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  1. Content type: Research article

    Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC).

    Authors: Daniele Campa, Myrto Barrdahl, Aurelia Santoro, Gianluca Severi, Laura Baglietto, Hanane Omichessan, Rosario Tumino, H. B(as). Bueno-de-Mesquita, Petra H. Peeters, Elisabete Weiderpass, Maria-Dolores Chirlaque, Miguel Rodríguez-Barranco, Antonio Agudo, Marc Gunter, Laure Dossus, Vittorio Krogh…

    Citation: Breast Cancer Research 2018 20:29

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  2. Content type: Research Article

    The ataxia telangiectasia mutated (ATM) gene is a moderate-risk breast cancer susceptibility gene; germline loss-of-function variants are found in up to 3% of hereditary breast and ovarian cancer (HBOC) families ...

    Authors: Anne-Laure Renault, Noura Mebirouk, Laetitia Fuhrmann, Guillaume Bataillon, Eve Cavaciuti, Dorothée Le Gal, Elodie Girard, Tatiana Popova, Philippe La Rosa, Juana Beauvallet, Séverine Eon-Marchais, Marie-Gabrielle Dondon, Catherine Dubois d’Enghien, Anthony Laugé, Walid Chemlali, Virginie Raynal…

    Citation: Breast Cancer Research 2018 20:28

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  3. Content type: Research Article

    Patients with breast cancer who have a pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) have improved survival. We hypothesize that once pCR has been achieved, there is no difference in subse...

    Authors: Anna Weiss, Sami I. Bashour, Kenneth Hess, Alastair M. Thompson and Nuhad K. Ibrahim

    Citation: Breast Cancer Research 2018 20:27

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  4. Content type: Research article

    The recommendation for chemotherapy in early-stage breast cancer patients has been refined by the 21-gene Recurrence Score. However, uncertainty remains whether patients in the Intermediate Risk category benef...

    Authors: Jonathan Chen, Xian Wu, Paul J. Christos, Silvia Formenti and Himanshu Nagar

    Citation: Breast Cancer Research 2018 20:26

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  5. Content type: Research Article

    The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. ...

    Authors: Wen-Shan Liu, Shih-Hsuan Chan, Hong-Tai Chang, Guan-Cheng Li, Ya-Ting Tu, Hui-Hwa Tseng, Ting-Ying Fu, Hui-Yu Chang, Huei-Han Liou, Luo-Ping Ger and Kuo-Wang Tsai

    Citation: Breast Cancer Research 2018 20:25

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  6. Content type: Research article

    The interaction of breast cancer cells with other cells in the tumor microenvironment plays an important role in metastasis. Invasion and intravasation, two critical steps in the metastatic process, are influe...

    Authors: Ramon M. Cabrera, Serena P. H. Mao, Chinmay R. Surve, John S. Condeelis and Jeffrey E. Segall

    Citation: Breast Cancer Research 2018 20:24

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  7. Content type: Research Article

    Mammographic density (MD) is an established predictor of risk of a first breast cancer, but the relationship of MD to contralateral breast cancer (CBC) risk is not clear, including the roles of age, mammogram ...

    Authors: Julia A. Knight, Kristina M. Blackmore, Jing Fan, Kathleen E. Malone, Esther M. John, Charles F. Lynch, Celine M. Vachon, Leslie Bernstein, Jennifer D. Brooks, Anne S. Reiner, Xiaolin Liang, Meghan Woods and Jonine L. Bernstein

    Citation: Breast Cancer Research 2018 20:23

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  8. Content type: Research Article

    Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressors in breast cancer. While PTEN itself is not considered a druggable target, PTEN synthetic-sick or synthetic-leth...

    Authors: Yew Chung Tang, Szu-Chi Ho, Elisabeth Tan, Alvin Wei Tian Ng, John R. McPherson, Germaine Yen Lin Goh, Bin Tean Teh, Frederic Bard and Steven G. Rozen

    Citation: Breast Cancer Research 2018 20:22

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  9. Content type: Research Article

    Breast cancer (BC) is a heterogeneous disease characterised by variant biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC although its impact on patient outcome in different BC...

    Authors: Rokaya El Ansari, Madeleine L. Craze, Islam Miligy, Maria Diez-Rodriguez, Christopher C. Nolan, Ian O. Ellis, Emad A. Rakha and Andrew R. Green

    Citation: Breast Cancer Research 2018 20:21

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  10. Content type: Research Article

    Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy. In order to identify abnormalities and possibl...

    Authors: Anne Sofie Froelunde, Marit Ohlenbusch, Kristoffer B. Hansen, Nicolai Jessen, Sukhan Kim and Ebbe Boedtkjer

    Citation: Breast Cancer Research 2018 20:20

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  11. Content type: Research Article

    Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer. This study explored novel serum proteins as surrog...

    Authors: Bashar Zeidan, Antigoni Manousopoulou, Diana J. Garay-Baquero, Cory H. White, Samantha E. T. Larkin, Kathleen N. Potter, Theodoros I. Roumeliotis, Evangelia K. Papachristou, Ellen Copson, Ramsey I. Cutress, Stephen A. Beers, Diana Eccles, Paul A. Townsend and Spiros D. Garbis

    Citation: Breast Cancer Research 2018 20:19

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  12. Content type: Research Article

    The Gail model has been widely used and validated with conflicting results. The current study aims to evaluate the performance of different versions of the Gail model by means of systematic review and meta-ana...

    Authors: Xin Wang, Yubei Huang, Lian Li, Hongji Dai, Fengju Song and Kexin Chen

    Citation: Breast Cancer Research 2018 20:18

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  13. Content type: Research Article

    Our purpose is to develop a testable biological hypothesis to explain the known increased risk of breast cancer associated with extensive percent mammographic density (PMD), and to reconcile the apparent parad...

    Authors: Norman Boyd, Hal Berman, Jie Zhu, Lisa J. Martin, Martin J. Yaffe, Sofia Chavez, Greg Stanisz, Greg Hislop, Anna M. Chiarelli, Salomon Minkin and Andrew D. Paterson

    Citation: Breast Cancer Research 2018 20:17

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  14. Content type: Research Article

    The clinical importance of tumor-infiltrating cluster of differentiation 4 (CD4) T cells is incompletely understood in early breast cancer. We investigated the clinical significance of CD4, forkhead box P3 (FO...

    Authors: Marcus Schmidt, Veronika Weyer-Elberich, Jan G. Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Aslihan Gerhold-Ay, Antje Lebrecht, Marco J. Battista, Annette Hasenburg, Ugur Sahin, Konstantine T. Kalogeras, Pirkko-Liisa Kellokumpu-Lehtinen, George Fountzilas, Ralph M. Wirtz and Heikki Joensuu

    Citation: Breast Cancer Research 2018 20:15

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  15. Content type: Research Article

    Mammographic breast density is one of the strongest risk factors for breast cancer, but molecular understanding of how breast density relates to cancer risk is less complete. Studies of proteins in blood plasm...

    Authors: Sanna Byström, Martin Eklund, Mun-Gwan Hong, Claudia Fredolini, Mikael Eriksson, Kamila Czene, Per Hall, Jochen M. Schwenk and Marike Gabrielson

    Citation: Breast Cancer Research 2018 20:14

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  16. Content type: Research Article

    Breast magnetic resonance imaging (MRI) has been reported to frequently result in false-positive diagnoses, limiting its positive predictive value (PPV). However, for PPV calculation, all nonmalignant tissue c...

    Authors: Christiane K. Kuhl, Annika Keulers, Kevin Strobel, Hannah Schneider, Nadine Gaisa and Simone Schrading

    Citation: Breast Cancer Research 2018 20:13

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  17. Content type: Research Article

    Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional ma...

    Authors: Emma H. Allott, Joseph Geradts, Stephanie M. Cohen, Thaer Khoury, Gary R. Zirpoli, Wiam Bshara, Warren Davis, Angela Omilian, Priya Nair, Rochelle P. Ondracek, Ting-Yuan David Cheng, C. Ryan Miller, Helena Hwang, Leigh B. Thorne, Siobhan O’Connor, Traci N. Bethea…

    Citation: Breast Cancer Research 2018 20:12

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  18. Content type: Research Article

    As only a minor portion of the information present in histological sections is accessible by eye, recognition and quantification of complex patterns and relationships among constituents relies on digital image...

    Authors: I. Roxanis, R. Colling, C. Kartsonaki, A. R. Green and E A. Rakha

    Citation: Breast Cancer Research 2018 20:11

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  19. Content type: Research Article

    High mammographic density is associated with both risk of cancers being missed at mammography, and increased risk of developing breast cancer. Stratification of breast cancer prevention and screening requires ...

    Authors: Susan M. Astley, Elaine F. Harkness, Jamie C. Sergeant, Jane Warwick, Paula Stavrinos, Ruth Warren, Mary Wilson, Ursula Beetles, Soujanya Gadde, Yit Lim, Anil Jain, Sara Bundred, Nicola Barr, Valerie Reece, Adam R. Brentnall, Jack Cuzick…

    Citation: Breast Cancer Research 2018 20:10

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  20. Content type: Research Article

    The Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1 increases protein stability and function. We identify a novel signaling axis...

    Authors: Matthew G. Annis, Veronique Ouellet, Jonathan P. Rennhack, Sylvain L’Esperance, Claudine Rancourt, Anne-Marie Mes-Masson, Eran R. Andrechek and Peter M. Siegel

    Citation: Breast Cancer Research 2018 20:9

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  21. Content type: Research Article

    Germline mutations in the BRIP1 gene have been described as conferring a moderate risk for ovarian cancer (OC), while the role of BRIP1 in breast cancer (BC) pathogenesis remains controversial.

    Authors: Nana Weber-Lassalle, Jan Hauke, Juliane Ramser, Lisa Richters, Eva Groß, Britta Blümcke, Andrea Gehrig, Anne-Karin Kahlert, Clemens R. Müller, Karl Hackmann, Ellen Honisch, Konstantin Weber-Lassalle, Dieter Niederacher, Julika Borde, Holger Thiele, Corinna Ernst…

    Citation: Breast Cancer Research 2018 20:7

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  22. Content type: Research article

    Preeclampsia is frequently linked to reduced breast cancer risk. However, little is known regarding the underlying genetic association and the association between preeclampsia and mammographic density.

    Authors: Haomin Yang, Wei He, Mikael Eriksson, Jingmei Li, Natalie Holowko, Flaminia Chiesa, Per Hall and Kamila Czene

    Citation: Breast Cancer Research 2018 20:6

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  23. Content type: Research article

    Although it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations d...

    Authors: Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Kathleen E. Malone, Polly A. Marchbanks, Jill A. McDonald, Michael S. Simon, Suzanne G. Folger, Yani Lu, Jane Sullivan-Halley, Dennis M. Deapen, Michael F. Press and Leslie Bernstein

    Citation: Breast Cancer Research 2018 20:5

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  24. Content type: Research Article

    Nearly 50% of breast cancer patients suffer from depression or anxiety. Selective serotonin reuptake inhibitors (SSRIs), the first-line pharmacological treatment for depression, have been implicated in breast ...

    Authors: John Busby, Ken Mills, Shu-Dong Zhang, Fabio Giuseppe Liberante and Chris R. Cardwell

    Citation: Breast Cancer Research 2018 20:4

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  25. Content type: Research Article

    Genome-wide association studies (GWASs) have identified numerous single-nucleotide polymorphisms (SNPs) associated with small increases in breast cancer risk. Studies to date suggest that some SNPs alter the e...

    Authors: Na Li, Simone M. Rowley, Ella R. Thompson, Simone McInerny, Lisa Devereux, Kaushalya C. Amarasinghe, Magnus Zethoven, Richard Lupat, David Goode, Jason Li, Alison H. Trainer, Kylie L. Gorringe, Paul A. James and Ian G. Campbell

    Citation: Breast Cancer Research 2018 20:3

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  26. Content type: Research Article

    Disseminated tumor cells (DTCs) found in the bone marrow (BM) of patients with breast cancer portend a poor prognosis and are thought to be intermediaries in the metastatic process. To assess the clinical rele...

    Authors: Sreeraj G. Pillai, Shunqiang Li, Chidananda M. Siddappa, Matthew J Ellis, Mark A. Watson and Rebecca Aft

    Citation: Breast Cancer Research 2018 20:2

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  27. Content type: Research Article

    It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) ...

    Authors: Linnea Huss, Salma Tunå Butt, Peter Almgren, Signe Borgquist, Jasmine Brandt, Asta Försti, Olle Melander and Jonas Manjer

    Citation: Breast Cancer Research 2018 20:1

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  28. Content type: Research Article

    Several frequently used prescription drugs may affect bleeding risk. We investigated use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), and statins ...

    Authors: Anne Marie L. Thomsen, Alma B. Pedersen, Nickolaj R. Kristensen, Bjarne Kuno Møller, Christian Erikstrup, Peer M. Christiansen, Mette Nørgaard and Deirdre Cronin-Fenton

    Citation: Breast Cancer Research 2017 19:135

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  29. Content type: Research Article

    Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the ...

    Authors: Karthik Ghosh, Robert A. Vierkant, Ryan D. Frank, Stacey Winham, Daniel W. Visscher, Vernon S. Pankratz, Christopher G. Scott, Kathleen Brandt, Mark E. Sherman, Derek C. Radisky, Marlene H. Frost, Lynn C. Hartmann, Amy C. Degnim and Celine M. Vachon

    Citation: Breast Cancer Research 2017 19:134

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  30. Content type: Research Article

    Triple negative breast cancer (TNBC) lacks both early detection biomarkers and viable targeted therapeutics. Moreover, chemotherapy only produces 20–30% pathologic complete response. Because miRNAs are frequen...

    Authors: Hao-Yi Li, Jui-Lin Liang, Yao-Lung Kuo, Hao-Hsien Lee, Marcus J. Calkins, Hong-Tai Chang, Forn-Chia Lin, Yu-Chia Chen, Tai-I Hsu, Michael Hsiao, Luo-Ping Ger and Pei-Jung Lu

    Citation: Breast Cancer Research 2017 19:133

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  31. Content type: Research Article

    Annexin-1 (ANXA1) plays pivotal roles in regulating various physiological processes including inflammation, proliferation and apoptosis, and deregulation of ANXA1 functions has been associated with tumorigenes...

    Authors: Asfa Alli-Shaik, Sheena Wee, Lina H. K. Lim and Jayantha Gunaratne

    Citation: Breast Cancer Research 2017 19:132

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  32. Content type: Research Article

    We examined racial differences in the expression of eight genes and their associations with risk of recurrence among 478 white and 495 black women who participated in the Carolina Breast Cancer Study Phase 3.

    Authors: Humberto Parada Jr, Xuezheng Sun, Jodie M. Fleming, ClarLynda R. Williams-DeVane, Erin L. Kirk, Linnea T. Olsson, Charles M. Perou, Andrew F. Olshan and Melissa A. Troester

    Citation: Breast Cancer Research 2017 19:131

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  33. Content type: Research Article

    Patient-derived xenografts (PDXs) are increasingly used in cancer research as a tool to inform cancer biology and drug response. Most available breast cancer PDXs have been generated in the metastatic setting....

    Authors: Jia Yu, Bo Qin, Ann M. Moyer, Jason P. Sinnwell, Kevin J. Thompson, John A. Copland III, Laura A. Marlow, James L. Miller, Ping Yin, Bowen Gao, Katherine Minter-Dykhouse, Xiaojia Tang, Sarah A. McLaughlin, Alvaro Moreno-Aspitia, Anthony Schweitzer, Yan Lu…

    Citation: Breast Cancer Research 2017 19:130

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  34. Content type: Research Article

    The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor ...

    Authors: Ernestina M. De Francesco, Andrew H. Sims, Marcello Maggiolini, Federica Sotgia, Michael P. Lisanti and Robert B. Clarke

    Citation: Breast Cancer Research 2017 19:129

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  35. Content type: Research Article

    Obesity is correlated with an increased risk for developing postmenopausal breast cancer. Since obesity rates continue to rise worldwide, it is important to understand how the obese microenvironment influences...

    Authors: Tamara Chamberlin, Joseph V. D’Amato and Lisa M. Arendt

    Citation: Breast Cancer Research 2017 19:128

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  36. Content type: Research Article

    Laboratory assays evaluating the effect of DNA sequence variants on BRCA1 mRNA splicing may contribute to classification by providing molecular evidence. However, our knowledge of normal and aberrant BRCA1 splici...

    Authors: Lucy C. de Jong, Simone Cree, Vanessa Lattimore, George A. R. Wiggins, Amanda B. Spurdle, Allison Miller, Martin A. Kennedy and Logan C. Walker

    Citation: Breast Cancer Research 2017 19:127

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  37. Content type: Research Article

    In mammography, breast compression is applied to reduce the thickness of the breast. While it is widely accepted that firm breast compression is needed to ensure acceptable image quality, guidelines remain vag...

    Authors: Katharina Holland, Ioannis Sechopoulos, Ritse M. Mann, Gerard J. den Heeten, Carla H. van Gils and Nico Karssemeijer

    Citation: Breast Cancer Research 2017 19:126

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  38. Content type: Research

    Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in patients using adjuvant tamoxifen. Direct measurement...

    Authors: Thomas Helland, Nina Henne, Ersilia Bifulco, Bjørn Naume, Elin Borgen, Vessela N. Kristensen, Jan T. Kvaløy, Timothy L. Lash, Grethe I. G. Alnæs, Ron H. van Schaik, Emiel A. M. Janssen, Steinar Hustad, Ernst A. Lien, Gunnar Mellgren and Håvard Søiland

    Citation: Breast Cancer Research 2017 19:125

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  39. Content type: Research Article

    High mammographic density is a strong, well-established breast cancer risk factor. Three studies conducted in various smaller geographic settings reported inconsistent findings between air pollution and mammog...

    Authors: Natalie C. DuPre, Jaime E. Hart, Kimberly A. Bertrand, Peter Kraft, Francine Laden and Rulla M. Tamimi

    Citation: Breast Cancer Research 2017 19:124

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  40. Content type: Research Article

    Thymidine kinase 1 (TK1) is a cell cycle-regulated enzyme with peak expression in the S phase during DNA synthesis, and it is an attractive biomarker of cell proliferation. Serum TK1 activity has demonstrated ...

    Authors: Nusayba Bagegni, Shana Thomas, Ning Liu, Jingqin Luo, Jeremy Hoog, Donald W. Northfelt, Matthew P. Goetz, Andres Forero, Mattias Bergqvist, Jakob Karen, Magnus Neumüller, Edward M. Suh, Zhanfang Guo, Kiran Vij, Souzan Sanati, Matthew Ellis…

    Citation: Breast Cancer Research 2017 19:123

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  41. Content type: Research Article

    Proper repair and restart of stressed replication forks requires intact homologous recombination (HR). HR at stressed replication forks can be initiated by the 5′ endonuclease EEPD1, which cleaves the stalled ...

    Authors: Robert Hromas, Hyun-Suk Kim, Gurjit Sidhu, Elizabeth Williamson, Aruna Jaiswal, Taylor A. Totterdale, Jocelyn Nole, Suk-Hee Lee, Jac A. Nickoloff and Kimi Y. Kong

    Citation: Breast Cancer Research 2017 19:122

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  42. Content type: Research Article

    Approximately 70% of all breast cancers express the estrogen receptor, and are regulated by estrogen. While the ovaries are the primary source of estrogen in premenopausal women, most breast cancer is diagnose...

    Authors: Derek F. Amanatullah, John S. Tamaresis, Pauline Chu, Michael H. Bachmann, Nhat M. Hoang, Deborah Collyar, Aaron T. Mayer, Robert B. West, William J. Maloney, Christopher H. Contag and Bonnie L. King

    Citation: Breast Cancer Research 2017 19:121

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  43. Content type: Research Article

    The aim of this study was to investigate the prognostic value of the PAM50 intrinsic subtypes and risk of recurrence (ROR) score in patients with early breast cancer and long-term follow-up. A special focus wa...

    Authors: Hege O. Ohnstad, Elin Borgen, Ragnhild S. Falk, Tonje G. Lien, Marit Aaserud, My Anh T. Sveli, Jon A. Kyte, Vessela N. Kristensen, Gry A. Geitvik, Ellen Schlichting, Erik A. Wist, Therese Sørlie, Hege G. Russnes and Bjørn Naume

    Citation: Breast Cancer Research 2017 19:120

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  44. Content type: Research Article

    Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors ...

    Authors: Olivier Brouckaert, Anja Rudolph, Annouschka Laenen, Renske Keeman, Manjeet K. Bolla, Qin Wang, Adelheid Soubry, Hans Wildiers, Irene L. Andrulis, Volker Arndt, Matthias W. Beckmann, Javier Benitez, Carl Blomqvist, Stig E. Bojesen, Hiltrud Brauch, Paul Brennan…

    Citation: Breast Cancer Research 2017 19:119

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  45. Content type: Research article

    While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) co...

    Authors: Jinchao Feng, Junqing Xu, Shudong Jiang, Hong Yin, Yan Zhao, Jiang Gui, Ke Wang, Xiuhua Lv, Fang Ren, Brian W. Pogue and Keith D. Paulsen

    Citation: Breast Cancer Research 2017 19:117

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