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  1. Research article

    Hormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population

    Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer (CBC) risk. However, information on influential covaria...

    Anne S. Reiner, Charles F. Lynch, Julia S. Sisti, Esther M. John, Jennifer D. Brooks, Leslie Bernstein, Julia A. Knight, Li Hsu, Patrick Concannon, Lene Mellemkjær, Marc Tischkowitz, Robert W. Haile, Ronglai Shen, Kathleen E. Malone, Meghan Woods, Xiaolin Liang…

    Breast Cancer Research 2017 19:83

    Published on: 19 July 2017

  2. Research article

    Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort

    Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones.

    Renée T. Fortner, Eglé Tolockiene, Helena Schock, Husam Oda, Hans-Åke Lakso, Göran Hallmans, Rudolf Kaaks, Paolo Toniolo, Anne Zeleniuch-Jacquotte, Kjell Grankvist and Eva Lundin

    Breast Cancer Research 2017 19:82

    Published on: 18 July 2017

  3. Research article

    Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age

    The underlying biological mechanisms through which epidemiologically defined breast cancer risk factors contribute to disease risk remain poorly understood. Identification of the molecular changes associated w...

    Kevin C. Johnson, E. Andres Houseman, Jessica E. King and Brock C. Christensen

    Breast Cancer Research 2017 19:81

    Published on: 10 July 2017

  4. Research article

    Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice

    Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time ...

    Nguyen M. Nguyen, Fabia de Oliveira Andrade, Lu Jin, Xiyuan Zhang, Madisa Macon, M. Idalia Cruz, Carlos Benitez, Bryan Wehrenberg, Chao Yin, Xiao Wang, Jianhua Xuan, Sonia de Assis and Leena Hilakivi-Clarke

    Breast Cancer Research 2017 19:77

    Published on: 3 July 2017

  5. Research article

    Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

    Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been o...

    Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson and Christoforos Thomas

    Breast Cancer Research 2017 19:79

    Published on: 3 July 2017

  6. Research article

    The footprint of the ageing stroma in older patients with breast cancer

    Tumours are not only composed of malignant cells but also consist of a stromal micro-environment, which has been shown to influence cancer cell behaviour. Because the ageing process induces accumulation of sen...

    Barbara Brouwers, Debora Fumagalli, Sylvain Brohee, Sigrid Hatse, Olivier Govaere, Giuseppe Floris, Kathleen Van den Eynde, Yacine Bareche, Patrick Schöffski, Ann Smeets, Patrick Neven, Diether Lambrechts, Christos Sotiriou and Hans Wildiers

    Breast Cancer Research 2017 19:78

    Published on: 3 July 2017

  7. Research article

    Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours

    Natural killer (NK) cells play a critical role in cancer immunosurveillance. Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of activated NK cells from a small volume of...

    Mira M. Shenouda, Amy Gillgrass, Tina Nham, Richard Hogg, Amanda J. Lee, Marianne V. Chew, Mahsa Shafaei, Craig Aarts, Dean A. Lee, John Hassell, Anita Bane, Sukhbinder Dhesy-Thind and Ali A. Ashkar

    Breast Cancer Research 2017 19:76

    Published on: 1 July 2017

  8. Research article

    Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis

    The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor ...

    Meghan Morrison Joly, Michelle M. Williams, Donna J. Hicks, Bayley Jones, Violeta Sanchez, Christian D. Young, Dos D. Sarbassov, William J. Muller, Dana Brantley-Sieders and Rebecca S. Cook

    Breast Cancer Research 2017 19:74

    Published on: 30 June 2017

  9. Research article

    Neoadjuvant radiotherapy of early-stage breast cancer and long-term disease-free survival

    Compared with surgery alone, postoperative adjuvant radiotherapy (RT) improves relapse-free survival of patients with early-stage breast cancer. We evaluated the long-term overall and disease-free survival rat...

    Jan Poleszczuk, Kimberly Luddy, Lu Chen, Jae K. Lee, Louis B. Harrison, Brian J. Czerniecki, Hatem Soliman and Heiko Enderling

    Breast Cancer Research 2017 19:75

    Published on: 30 June 2017

  10. Research article

    MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer

    Members of the microRNA (miR)-200 family, which are involved in tumor metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain elusive.

    Guangxin Zhang, Wei Zhang, Bingjin Li, Erica Stringer-Reasor, Chengjing Chu, Liyan Sun, Sejong Bae, Dongquan Chen, Shi Wei, Kenneth Jiao, Wei-Hsiung Yang, Ranji Cui, Runhua Liu and Lizhong Wang

    Breast Cancer Research 2017 19:73

    Published on: 21 June 2017

  11. Research article

    Interaction with adipocyte stromal cells induces breast cancer malignancy via S100A7 upregulation in breast cancer microenvironment

    Breast adipocytes play important roles in both the development and function of mammary epithelial cells. Therefore, carcinoma–adipose stromal cell (ASC) interactions have been considered pivotal in supporting ...

    Minako Sakurai, Yasuhiro Miki, Kiyoshi Takagi, Takashi Suzuki, Takanori Ishida, Noriaki Ohuchi and Hironobu Sasano

    Breast Cancer Research 2017 19:70

    Published on: 19 June 2017

  12. Research article

    miR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer

    Different breast cancer subtypes show distinct tropisms for sites of metastasis. Notably, the lung is the most common site for the first distant recurrence in triple-negative breast cancer (TNBC). The identifi...

    Jin Wang, Cailu Song, Hailin Tang, Chao Zhang, Jun Tang, Xing Li, Bo Chen and Xiaoming Xie

    Breast Cancer Research 2017 19:72

    Published on: 19 June 2017

  13. Research article

    Evaluation of invasive breast cancer samples using a 12-chemokine gene expression score: correlation with clinical outcomes

    A unique 12-chemokine gene expression score (CS) accurately predicted the presence of tumor-localized, ectopic lymph node-like structures (TL-ELNs) and improved overall survival (OS) in primary colorectal canc...

    Sangeetha Prabhakaran, Victoria T. Rizk, Zhenjun Ma, Chia-Ho Cheng, Anders E. Berglund, Dominico Coppola, Farah Khalil, James J. Mulé and Hatem H. Soliman

    Breast Cancer Research 2017 19:71

    Published on: 19 June 2017

  14. Research article

    Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

    Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-deg...

    Mary Beth Terry, Theresa H. M. Keegan, Lauren C. Houghton, Mandy Goldberg, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Ying Wei, Alice S. Whittemore, Angeline Protacio, Angela R. Bradbury, Wendy K. Chung, Julia A. Knight and Esther M. John

    Breast Cancer Research 2017 19:69

    Published on: 8 June 2017

  15. Research article

    The effect of volumetric breast density on the risk of screen-detected and interval breast cancers: a cohort study

    In the light of the breast density legislation in the USA, it is important to know a woman’s breast cancer risk, but particularly her risk of a tumor that is not detected through mammographic screening (interv...

    Johanna O. P. Wanders, Katharina Holland, Nico Karssemeijer, Petra H. M. Peeters, Wouter B. Veldhuis, Ritse M. Mann and Carla H. van Gils

    Breast Cancer Research 2017 19:67

    Published on: 5 June 2017

  16. Research article

    Molecular characterization of breast cancer cell lines through multiple omic approaches

    Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer ...

    Shari E. Smith, Paul Mellor, Alison K. Ward, Stephanie Kendall, Megan McDonald, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Scott Napper and Deborah H. Anderson

    Breast Cancer Research 2017 19:65

    Published on: 5 June 2017

  17. Research article

    Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer

    Follistatin (FST) is an intrinsic inhibitor of activin, a member of the transforming growth factor-β superfamily of ligands. The prognostic value of FST and its family members, the follistatin-like (FSTL) prot...

    Darcie D. Seachrist, Steven T. Sizemore, Emhonta Johnson, Fadi W. Abdul-Karim, Kristen L. Weber Bonk and Ruth A. Keri

    Breast Cancer Research 2017 19:66

    Published on: 5 June 2017

  18. Research article

    A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data

    The landscape of cancer-predisposing genes has been extensively investigated in the last 30 years with various methodologies ranging from candidate gene to genome-wide association studies. However, sequencing ...

    Giorgio E. M. Melloni, Luca Mazzarella, Loris Bernard, Margherita Bodini, Anna Russo, Lucilla Luzi, Pier Giuseppe Pelicci and Laura Riva

    Breast Cancer Research 2017 19:63

    Published on: 31 May 2017

  19. Research article

    LincIN, a novel NF90-binding long non-coding RNA, is overexpressed in advanced breast tumors and involved in metastasis

    Recent genome-wide profiling by sequencing and distinctive chromatin signatures has identified thousands of long non-coding RNA (lncRNA) species (>200 nt). LncRNAs have emerged as important regulators of gene ...

    Zhengyu Jiang, Carolyn M. Slater, Yan Zhou, Karthik Devarajan, Karen J. Ruth, Yueran Li, Kathy Q. Cai, Mary Daly and Xiaowei Chen

    Breast Cancer Research 2017 19:62

    Published on: 30 May 2017

  20. Research article

    Age-related terminal duct lobular unit involution in benign tissues from Chinese breast cancer patients with luminal and triple-negative tumors

    Terminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, research...

    Changyuan Guo, Hyuna Sung, Shan Zheng, Jennifer Guida, Erni Li, Jing Li, Nan Hu, Joseph Deng, Jonine D. Figueroa, Mark E. Sherman, Gretchen L. Gierach, Ning Lu and Xiaohong R. Yang

    Breast Cancer Research 2017 19:61

    Published on: 25 May 2017

  21. Research article

    Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery

    Re-operation for positive resection margins following breast-conserving surgery occurs frequently (average = 20–25%), is cost-inefficient, and leads to physical and psychological morbidity. Current margin asse...

    Edward R. St John, Julia Balog, James S. McKenzie, Merja Rossi, April Covington, Laura Muirhead, Zsolt Bodai, Francesca Rosini, Abigail V. M. Speller, Sami Shousha, Rathi Ramakrishnan, Ara Darzi, Zoltan Takats and Daniel R. Leff

    Breast Cancer Research 2017 19:59

    Published on: 23 May 2017

  22. Research article

    Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models

    Mutations in the estrogen receptor alpha (ERα) 1 gene (ESR1) are frequently detected in ER+ metastatic breast cancer, and there is increasing evidence that these mutations confer endocrine resistance in breast ca...

    Amir Bahreini, Zheqi Li, Peilu Wang, Kevin M. Levine, Nilgun Tasdemir, Lan Cao, Hazel M. Weir, Shannon L. Puhalla, Nancy E. Davidson, Andrew M. Stern, David Chu, Ben Ho Park, Adrian V. Lee and Steffi Oesterreich

    Breast Cancer Research 2017 19:60

    Published on: 23 May 2017

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