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  1. Research article

    Modification of the association between recreational physical activity and survival after breast cancer by promoter methylation in breast cancer-related genes

    Mechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role. We hypothesized that promoter methylation of breast...

    Lauren E. McCullough, Jia Chen, Yoon Hee Cho, Nikhil K. Khankari, Patrick T. Bradshaw, Alexandra J. White, Susan L. Teitelbaum, Mary Beth Terry, Alfred I. Neugut, Hanina Hibshoosh, Regina M. Santella and Marilie D. Gammon

    Breast Cancer Research 2017 19:19

    Published on: 21 February 2017

  2. Research article

    Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2 breast cancer that had progressed during or after prior endocrine therapy

    Overexpression of fibroblast growth factor receptor 1 (FGFR1), found in ≤8% of hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2) breast cancer cases, is correlated with de...

    Antonino Musolino, Mario Campone, Patrick Neven, Neelima Denduluri, Carlos H. Barrios, Javier Cortes, Kimberly Blackwell, Hatem Soliman, Zsuzsanna Kahan, Hervé Bonnefoi, Matthew Squires, Yong Zhang, Stephanie Deudon, Michael M. Shi and Fabrice André

    Breast Cancer Research 2017 19:18

    Published on: 10 February 2017

  3. Erratum

    Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

    Zhi Hu, Jian-Hua Mao, Christina Curtis, Ge Huang, Shenda Gu, Laura Heiser, Marc E. Lenburg, James E. Korkola, Nora Bayani, Shamith Samarajiwa, Jose A. Seoane, Mark A. Dane, Amanda Esch, Heidi S. Feiler, Nicholas J. Wang, Mary Ann Hardwicke…

    Breast Cancer Research 2017 19:17

    Published on: 9 February 2017

    The original article was published in Breast Cancer Research 2016 18:70

  4. Research article

    Biomarker analysis of the NeoSphere study: pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treatment of HER2-positive breast cancer

    NeoSphere showed significantly higher pathologic complete response (pCR) with neoadjuvant pertuzumab, trastuzumab, and docetaxel compared with trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuz...

    Giampaolo Bianchini, Astrid Kiermaier, Giulia Valeria Bianchi, Young-Hyuck Im, Tadeusz Pienkowski, Mei-Ching Liu, Ling-Ming Tseng, Mitch Dowsett, Lila Zabaglo, Sarah Kirk, Tania Szado, Jennifer Eng-Wong, Lukas C. Amler, Pinuccia Valagussa and Luca Gianni

    Breast Cancer Research 2017 19:16

    Published on: 9 February 2017

  5. Research article

    Thymosin beta 10 is a key regulator of tumorigenesis and metastasis and a novel serum marker in breast cancer

    Thymosin beta 10 (TMSB10) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to determine the biological roles and clinical significance of TMSB10 in b...

    Xin Zhang, Dong Ren, Ling Guo, Lan Wang, Shu Wu, Chuyong Lin, Liping Ye, Jinrong Zhu, Jun Li, Libing Song, Huanxin Lin and Zhenyu He

    Breast Cancer Research 2017 19:15

    Published on: 8 February 2017

  6. Research article

    Childhood body size and pubertal timing in relation to adult mammographic density phenotype

    An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or predi...

    Minouk J. Schoemaker, Michael E. Jones, Steven Allen, Jean Hoare, Alan Ashworth, Mitch Dowsett and Anthony J. Swerdlow

    Breast Cancer Research 2017 19:13

    Published on: 7 February 2017

  7. Research article

    Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

    The insulin-like growth factor 1 (IGF1) signaling axis plays a major role in tumorigenesis. In a previous experiment, we chronically treated mice with several agonists of the IGF1 receptor (IGF1R). We found th...

    Bas ter Braak, Christine L. Siezen, Joo S. Lee, Pooja Rao, Charlotte Voorhoeve, Eytan Ruppin, Jan Willem van der Laan and Bob van de Water

    Breast Cancer Research 2017 19:14

    Published on: 7 February 2017

  8. Research article

    Non-invasive optical spectroscopic monitoring of breast development during puberty

    Tanner staging (TS), a five-stage classification indicating no breast tissue (TS1) to full breast development (TS5), is used both in health research and clinical care to assess the onset of breast development ...

    Lothar Lilge, Mary Beth Terry, Jane Walter, Dushanthi Pinnaduwage, Gord Glendon, Danielle Hanna, Mai-Liis Tammemagi, Angela Bradbury, Saundra Buys, Mary Daly, Esther M. John, Julia A. Knight and Irene L. Andrulis

    Breast Cancer Research 2017 19:12

    Published on: 6 February 2017

  9. Research article

    Prevalence of preterm, low birthweight, and small for gestational age delivery after breast cancer diagnosis: a population-based study

    Black-white disparities in breast cancer incidence rates and birth outcomes raise concerns about potential disparities in the reproductive health of premenopausal breast cancer survivors. We examined the preva...

    Kristin Zeneé Black, Hazel B. Nichols, Eugenia Eng and Diane Louise Rowley

    Breast Cancer Research 2017 19:11

    Published on: 31 January 2017

  10. Research article

    Parity, hormones and breast cancer subtypes - results from a large nested case-control study in a national screening program

    Breast cancer comprises several molecular subtypes with different prognoses and possibly different etiology. Reproductive and hormonal factors are associated with breast cancer overall, and with luminal subtyp...

    Merete Ellingjord-Dale, Linda Vos, Steinar Tretli, Solveig Hofvind, Isabel dos-Santos-Silva and Giske Ursin

    Breast Cancer Research 2017 19:10

    Published on: 23 January 2017

  11. Research article

    Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients

    Postmenopausal obesity is associated with increased circulating levels of androgens and estrogens and elevated breast cancer risk. Crown-like structures (CLS; microscopic foci of dying adipocytes surrounded by...

    Maeve Mullooly, Hannah P. Yang, Roni T. Falk, Sarah J. Nyante, Renata Cora, Ruth M. Pfeiffer, Derek C. Radisky, Daniel W. Visscher, Lynn C. Hartmann, Jodi M. Carter, Amy C. Degnim, Frank Z. Stanczyk, Jonine D. Figueroa, Montserrat Garcia-Closas, Jolanta Lissowska, Melissa A. Troester…

    Breast Cancer Research 2017 19:8

    Published on: 19 January 2017

  12. Research article

    Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells

    The development and progression of estrogen receptor alpha positive (ERα+) breast cancer has been linked epidemiologically to prolactin. However, activation of the canonical mediator of prolactin, STAT5, is as...

    Craig E. Barcus, Kathleen A. O’Leary, Jennifer L. Brockman, Debra E. Rugowski, Yuming Liu, Nancy Garcia, Menggang Yu, Patricia J. Keely, Kevin W. Eliceiri and Linda A. Schuler

    Breast Cancer Research 2017 19:9

    Published on: 19 January 2017

  13. Research article

    PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression

    Lobular carcinoma in situ (LCIS) is a non-invasive breast lesion that is typically found incidentally on biopsy and is often associated with invasive lobular carcinoma (ILC). LCIS is considered by some to be a ri...

    Vandna Shah, Salpie Nowinski, Dina Levi, Irek Shinomiya, Narda Kebaier Ep Chaabouni, Cheryl Gillett, Anita Grigoriadis, Trevor A. Graham, Rebecca Roylance, Michael A. Simpson, Sarah E. Pinder and Elinor J. Sawyer

    Breast Cancer Research 2017 19:7

    Published on: 17 January 2017

  14. Research article

    Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis

    Early age at menarche, nulliparity, late age at first completed pregnancy, and never having breastfed, are established breast cancer risk factors. However, among breast cancer subtypes, it remains unclear whet...

    Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Lei Duan, Yani Lu, Kathleen E. Malone, Polly A. Marchbanks, Jill A. McDonald, Michael S. Simon, Suzanne G. Folger, Jane Sullivan-Halley, Dennis M. Deapen, Michael F. Press and Leslie Bernstein

    Breast Cancer Research 2017 19:6

    Published on: 13 January 2017

  15. Research article

    CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model

    Macrophages play diverse roles in mammary gland development and breast cancer. CC-chemokine ligand 2 (CCL2) is an inflammatory cytokine that recruits macrophages to sites of injury. Although CCL2 has been dete...

    Xuan Sun, Danielle J. Glynn, Leigh J. Hodson, Cecilia Huo, Kara Britt, Erik W. Thompson, Lucy Woolford, Andreas Evdokiou, Jeffrey W. Pollard, Sarah A. Robertson and Wendy V. Ingman

    Breast Cancer Research 2017 19:4

    Published on: 11 January 2017

  16. Research article

    18FDG-PET/CT for predicting the outcome in ER+/HER2- breast cancer patients: comparison of clinicopathological parameters and PET image-derived indices including tumor texture analysis

    This study investigated the value of some clinicopathological parameters and 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (18FDG-PET/CT) indices, including textural features, to predic...

    David Groheux, Antoine Martineau, Luis Teixeira, Marc Espié, Patricia de Cremoux, Philippe Bertheau, Pascal Merlet and Charles Lemarignier

    Breast Cancer Research 2017 19:3

    Published on: 5 January 2017

  17. Research article

    Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: a systematic review and meta-analysis

    The presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in several malignancies. Here, we quantify the effect of NLR on survival in patients with breast cancer,...

    Josee-Lyne Ethier, Danielle Desautels, Arnoud Templeton, Prakesh S. Shah and Eitan Amir

    Breast Cancer Research 2017 19:2

    Published on: 5 January 2017

  18. Erratum

    Erratum to: Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

    Serghei Malkov, John A. Shepherd, Christopher G. Scott, Rulla M. Tamimi, Lin Ma, Kimberly A. Bertrand, Fergus Couch, Matthew R. Jensen, Amir P. Mahmoudzadeh, Bo Fan, Aaron Norman, Kathleen R. Brandt, V. Shane Pankratz, Celine M. Vachon and Karla Kerlikowske

    Breast Cancer Research 2017 19:1

    Published on: 4 January 2017

    The original article was published in Breast Cancer Research 2016 18:122

  19. Research article

    Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort

    Obesity is a public health epidemic and an important breast cancer risk factor. The relationship between interrelated body measurements is complex and most studies fail to account for this complexity. We ident...

    Pamela L. Horn-Ross, Alison J. Canchola, Leslie Bernstein, Susan L. Neuhausen, David O. Nelson and Peggy Reynolds

    Breast Cancer Research 2016 18:132

    Published on: 21 December 2016

  20. Research article

    The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis

    Altered tumor cell metabolism is an emerging hallmark of cancer; however, the precise role for glucose in tumor initiation is not known. GLUT1 (SLC2A1) is expressed in breast cancer cells and is likely responsibl...

    Elizabeth A. Wellberg, Stevi Johnson, Jessica Finlay-Schultz, Andrew S. Lewis, Kristina L. Terrell, Carol A. Sartorius, E. Dale Abel, William J. Muller and Steven M. Anderson

    Breast Cancer Research 2016 18:131

    Published on: 20 December 2016

  21. Research article

    Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems

    Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening applications; however, MD measurements are influenced by mammography modality (screen film/di...

    Anya Burton, Graham Byrnes, Jennifer Stone, Rulla M. Tamimi, John Heine, Celine Vachon, Vahit Ozmen, Ana Pereira, Maria Luisa Garmendia, Christopher Scott, John H. Hipwell, Caroline Dickens, Joachim Schüz, Mustafa Erkin Aribal, Kimberly Bertrand, Ava Kwong…

    Breast Cancer Research 2016 18:130

    Published on: 19 December 2016

  22. Research article

    Circulating cell-free DNA-based epigenetic assay can detect early breast cancer

    Circulating cell-free DNA (cfDNA) has recently been recognized as a resource for biomarkers of cancer progression, treatment response, and drug resistance. However, few have demonstrated the usefulness of cfDN...

    Natsue Uehiro, Fumiaki Sato, Fengling Pu, Sunao Tanaka, Masahiro Kawashima, Kosuke Kawaguchi, Masahiro Sugimoto, Shigehira Saji and Masakazu Toi

    Breast Cancer Research 2016 18:129

    Published on: 19 December 2016

  23. Research article

    Involution of breast tissue and mammographic density

    Mammographic density decreases and involution of breast tissue increases with age; both are thought to be risk factors for breast cancer. The current study investigated the relationship between involution or h...

    Gertraud Maskarinec, Dan Ju, David Horio, Lenora W. M. Loo and Brenda Y. Hernandez

    Breast Cancer Research 2016 18:128

    Published on: 15 December 2016

  24. Research article

    Imaging the mammary gland and mammary tumours in 3D: optical tissue clearing and immunofluorescence methods

    High-resolution 3D imaging of intact tissue facilitates cellular and subcellular analyses of complex structures within their native environment. However, difficulties associated with immunolabelling and imagin...

    Bethan Lloyd-Lewis, Felicity M. Davis, Olivia B. Harris, Jessica R. Hitchcock, Filipe C. Lourenco, Mathias Pasche and Christine J. Watson

    Breast Cancer Research 2016 18:127

    Published on: 13 December 2016

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