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  1. Research article

    MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer

    Members of the microRNA (miR)-200 family, which are involved in tumor metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain elusive.

    Guangxin Zhang, Wei Zhang, Bingjin Li, Erica Stringer-Reasor, Chengjing Chu, Liyan Sun, Sejong Bae, Dongquan Chen, Shi Wei, Kenneth Jiao, Wei-Hsiung Yang, Ranji Cui, Runhua Liu and Lizhong Wang

    Breast Cancer Research 2017 19:73

    Published on: 21 June 2017

  2. Research article

    Evaluation of invasive breast cancer samples using a 12-chemokine gene expression score: correlation with clinical outcomes

    A unique 12-chemokine gene expression score (CS) accurately predicted the presence of tumor-localized, ectopic lymph node-like structures (TL-ELNs) and improved overall survival (OS) in primary colorectal canc...

    Sangeetha Prabhakaran, Victoria T. Rizk, Zhenjun Ma, Chia-Ho Cheng, Anders E. Berglund, Dominico Coppola, Farah Khalil, James J. Mulé and Hatem H. Soliman

    Breast Cancer Research 2017 19:71

    Published on: 19 June 2017

  3. Research article

    miR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer

    Different breast cancer subtypes show distinct tropisms for sites of metastasis. Notably, the lung is the most common site for the first distant recurrence in triple-negative breast cancer (TNBC). The identifi...

    Jin Wang, Cailu Song, Hailin Tang, Chao Zhang, Jun Tang, Xing Li, Bo Chen and Xiaoming Xie

    Breast Cancer Research 2017 19:72

    Published on: 19 June 2017

  4. Research article

    Interaction with adipocyte stromal cells induces breast cancer malignancy via S100A7 upregulation in breast cancer microenvironment

    Breast adipocytes play important roles in both the development and function of mammary epithelial cells. Therefore, carcinoma–adipose stromal cell (ASC) interactions have been considered pivotal in supporting ...

    Minako Sakurai, Yasuhiro Miki, Kiyoshi Takagi, Takashi Suzuki, Takanori Ishida, Noriaki Ohuchi and Hironobu Sasano

    Breast Cancer Research 2017 19:70

    Published on: 19 June 2017

  5. Research article

    Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

    Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-deg...

    Mary Beth Terry, Theresa H. M. Keegan, Lauren C. Houghton, Mandy Goldberg, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Ying Wei, Alice S. Whittemore, Angeline Protacio, Angela R. Bradbury, Wendy K. Chung, Julia A. Knight and Esther M. John

    Breast Cancer Research 2017 19:69

    Published on: 8 June 2017

  6. Research article

    Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer

    Follistatin (FST) is an intrinsic inhibitor of activin, a member of the transforming growth factor-β superfamily of ligands. The prognostic value of FST and its family members, the follistatin-like (FSTL) prot...

    Darcie D. Seachrist, Steven T. Sizemore, Emhonta Johnson, Fadi W. Abdul-Karim, Kristen L. Weber Bonk and Ruth A. Keri

    Breast Cancer Research 2017 19:66

    Published on: 5 June 2017

  7. Research article

    Molecular characterization of breast cancer cell lines through multiple omic approaches

    Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer ...

    Shari E. Smith, Paul Mellor, Alison K. Ward, Stephanie Kendall, Megan McDonald, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Scott Napper and Deborah H. Anderson

    Breast Cancer Research 2017 19:65

    Published on: 5 June 2017

  8. Research article

    The effect of volumetric breast density on the risk of screen-detected and interval breast cancers: a cohort study

    In the light of the breast density legislation in the USA, it is important to know a woman’s breast cancer risk, but particularly her risk of a tumor that is not detected through mammographic screening (interv...

    Johanna O. P. Wanders, Katharina Holland, Nico Karssemeijer, Petra H. M. Peeters, Wouter B. Veldhuis, Ritse M. Mann and Carla H. van Gils

    Breast Cancer Research 2017 19:67

    Published on: 5 June 2017

  9. Research article

    A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data

    The landscape of cancer-predisposing genes has been extensively investigated in the last 30 years with various methodologies ranging from candidate gene to genome-wide association studies. However, sequencing ...

    Giorgio E. M. Melloni, Luca Mazzarella, Loris Bernard, Margherita Bodini, Anna Russo, Lucilla Luzi, Pier Giuseppe Pelicci and Laura Riva

    Breast Cancer Research 2017 19:63

    Published on: 31 May 2017

  10. Research article

    LincIN, a novel NF90-binding long non-coding RNA, is overexpressed in advanced breast tumors and involved in metastasis

    Recent genome-wide profiling by sequencing and distinctive chromatin signatures has identified thousands of long non-coding RNA (lncRNA) species (>200 nt). LncRNAs have emerged as important regulators of gene ...

    Zhengyu Jiang, Carolyn M. Slater, Yan Zhou, Karthik Devarajan, Karen J. Ruth, Yueran Li, Kathy Q. Cai, Mary Daly and Xiaowei Chen

    Breast Cancer Research 2017 19:62

    Published on: 30 May 2017

  11. Research article

    Age-related terminal duct lobular unit involution in benign tissues from Chinese breast cancer patients with luminal and triple-negative tumors

    Terminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, research...

    Changyuan Guo, Hyuna Sung, Shan Zheng, Jennifer Guida, Erni Li, Jing Li, Nan Hu, Joseph Deng, Jonine D. Figueroa, Mark E. Sherman, Gretchen L. Gierach, Ning Lu and Xiaohong R. Yang

    Breast Cancer Research 2017 19:61

    Published on: 25 May 2017

  12. Research article

    Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models

    Mutations in the estrogen receptor alpha (ERα) 1 gene (ESR1) are frequently detected in ER+ metastatic breast cancer, and there is increasing evidence that these mutations confer endocrine resistance in breast ca...

    Amir Bahreini, Zheqi Li, Peilu Wang, Kevin M. Levine, Nilgun Tasdemir, Lan Cao, Hazel M. Weir, Shannon L. Puhalla, Nancy E. Davidson, Andrew M. Stern, David Chu, Ben Ho Park, Adrian V. Lee and Steffi Oesterreich

    Breast Cancer Research 2017 19:60

    Published on: 23 May 2017

  13. Research article

    Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery

    Re-operation for positive resection margins following breast-conserving surgery occurs frequently (average = 20–25%), is cost-inefficient, and leads to physical and psychological morbidity. Current margin asse...

    Edward R. St John, Julia Balog, James S. McKenzie, Merja Rossi, April Covington, Laura Muirhead, Zsolt Bodai, Francesca Rosini, Abigail V. M. Speller, Sami Shousha, Rathi Ramakrishnan, Ara Darzi, Zoltan Takats and Daniel R. Leff

    Breast Cancer Research 2017 19:59

    Published on: 23 May 2017

  14. Research article

    An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation

    PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case series, but PREDICT has been shown to underestimate...

    Francisco J. Candido dos Reis, Gordon C. Wishart, Ed M. Dicks, David Greenberg, Jem Rashbass, Marjanka K. Schmidt, Alexandra J. van den Broek, Ian O. Ellis, Andrew Green, Emad Rakha, Tom Maishman, Diana M. Eccles and Paul D. P. Pharoah

    Breast Cancer Research 2017 19:58

    Published on: 22 May 2017

  15. Research article

    Intratumoral and peritumoral radiomics for the pretreatment prediction of pathological complete response to neoadjuvant chemotherapy based on breast DCE-MRI

    In this study, we evaluated the ability of radiomic textural analysis of intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to pre...

    Nathaniel M. Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Plecha and Anant Madabhushi

    Breast Cancer Research 2017 19:57

    Published on: 18 May 2017

  16. Research article

    Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

    The breast tumor microenvironment regulates progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). However, it is unclear how interactions between breast epithelial and stromal cell...

    Mansoureh Sameni, Dora Cavallo-Medved, Omar E. Franco, Anita Chalasani, Kyungmin Ji, Neha Aggarwal, Arulselvi Anbalagan, Xuequn Chen, Raymond R. Mattingly, Simon W. Hayward and Bonnie F. Sloane

    Breast Cancer Research 2017 19:56

    Published on: 15 May 2017

  17. Research article

    An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®

    Accurate determination of the predictive markers human epidermal growth factor receptor 2 (HER2/ERBB2), estrogen receptor (ER/ESR1), progesterone receptor (PgR/PGR), and marker of proliferation Ki67 (MKI67) is in...

    Zsuzsanna Varga, Annette Lebeau, Hong Bu, Arndt Hartmann, Frederique Penault-Llorca, Elena Guerini-Rocco, Peter Schraml, Fraser Symmans, Robert Stoehr, Xiaodong Teng, Andreas Turzynski, Reinhard von Wasielewski, Claudia Gürtler, Mark Laible, Kornelia Schlombs, Heikki Joensuu…

    Breast Cancer Research 2017 19:55

    Published on: 11 May 2017

  18. Research article

    A phase-I study of lapatinib in combination with foretinib, a c-MET, AXL and vascular endothelial growth factor receptor inhibitor, in human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer

    The mechanisms of resistance to anti-human epidermal growth factor receptor 2 (HER 2) therapies are unclear but may include the tyrosine-protein kinase Met (c-Met), vascular endothelial growth factor (VEGF) an...

    Stephen K. Chia, Susan L. Ellard, Mihaela Mates, Stephen Welch, Catalin Mihalcioiu, Wilson H. Miller, Karen Gelmon, Caroline Lohrisch, Vikaash Kumar, Sara Taylor, Linda Hagerman, Rachel Goodwin, Tao Wang, Shingo Sakashita, Ming S. Tsao, Elizabeth Eisenhauer…

    Breast Cancer Research 2017 19:54

    Published on: 2 May 2017

  19. Research article

    TIMELESS contributes to the progression of breast cancer through activation of MYC

    Breast cancer is the most common malignancy and the leading cause of cancer death among women. TIMELESS (TIM), a circadian rhythm regulator, has been recently implicated in the progression of human cancer. How...

    Limin Chi, Yujiao Zou, Ling Qin, Weifeng Ma, Yanyan Hao, Yao Tang, Rongcheng Luo and Ziqing Wu

    Breast Cancer Research 2017 19:53

    Published on: 2 May 2017

  20. Research article

    Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study

    Regular users of aspirin may have reduced risk of breast cancer. Few studies have addressed whether risk reduction pertains to specific breast cancer subtypes defined jointly by hormone receptor (estrogen and ...

    Christina A. Clarke, Alison J. Canchola, Lisa M. Moy, Susan L. Neuhausen, Nadia T. Chung, James V. Lacey and Leslie Bernstein

    Breast Cancer Research 2017 19:52

    Published on: 1 May 2017

  21. Research article

    Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases

    Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of developing metastases in the brain. Despite gains with systemic control of Her2+ di...

    Cecilia Choy, Khairul I. Ansari, Josh Neman, Sarah Hsu, Matthew J. Duenas, Hubert Li, Nagarajan Vaidehi and Rahul Jandial

    Breast Cancer Research 2017 19:51

    Published on: 26 April 2017

  22. Research article

    A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer

    3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming established for a number of cancers,...

    Edward P. Carter, James A. Gopsill, Jennifer. J. Gomm, J. Louise Jones and Richard P. Grose

    Breast Cancer Research 2017 19:50

    Published on: 21 April 2017

  23. Erratum

    Erratum to: HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers

    Preeti Putcha, Jiyang Yu, Ruth Rodriguez-Barrueco, Laura Saucedo-Cuevas, Patricia Villagrasa, Eva Murga-Penas, Steven N. Quayle, Min Yang, Veronica Castro, David Llobet-Navas, Daniel Birnbaum, Pascal Finetti, Wendy A. Woodward, François Bertucci, Mary L. Alpaugh, Andrea Califano…

    Breast Cancer Research 2017 19:49

    Published on: 19 April 2017

    The original article was published in Breast Cancer Research 2015 17:149

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