Skip to main content

Articles

425 result(s) for 'Breast expansion' within Breast Cancer Research

Page 7 of 9

  1. Despite significant advances in research, breast cancer is still the most common form of cancer, with 50,000 cases diagnosed and 12,000 dying of the disease each year in the UK. In October 2013, Breast Cancer ...

    Authors: Delyth Morgan
    Citation: Breast Cancer Research 2013 15:107
    Content type: Editorial Published on:

  2. Selinexor (KPT-330) is an oral agent that has been shown to inhibit the nuclear exporter XPO1. Given the pressing need for novel therapies for triple-negative breast cancer (TNBC), we sought to determine the a...

    Authors: Natalia Paez Arango, Erkan Yuca, Ming Zhao, Kurt W. Evans, Stephen Scott, Charissa Kim, Ana Maria Gonzalez-Angulo, Filip Janku, Naoto T. Ueno, Debu Tripathy, Argun Akcakanat, Aung Naing and Funda Meric-Bernstam
    Citation: Breast Cancer Research 2017 19:93
    Content type: Research article Published on:

  3. Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined t...

    Authors: Roberto R. Rosato, Daniel Dávila-González, Dong Soon Choi, Wei Qian, Wen Chen, Anthony J. Kozielski, Helen Wong, Bhuvanesh Dave and Jenny C. Chang
    Citation: Breast Cancer Research 2018 20:108
    Content type: Research article Published on:

  4. The organisation of the mammary epithelial hierarchy is poorly understood. Our hypothesis is that the luminal cell compartment is more complex than initially described, and that an understanding of the develop...

    Authors: Mona Shehata, Andrew Teschendorff, Gemma Sharp, Nikola Novcic, I Alasdair Russell, Stefanie Avril, Michael Prater, Peter Eirew, Carlos Caldas, Christine J Watson and John Stingl
    Citation: Breast Cancer Research 2012 14:R134
    Content type: Research article Published on:

  5. Menopausal hormone therapies vary widely in their effects on breast cancer risk, and the mechanisms underlying these differences are unclear. The primary goals of this study were to characterize the mammary gl...

    Authors: Charles E Wood, Daniel Branstetter, Allison P Jacob, J Mark Cline, Thomas C Register, Kathy Rohrbach, Li-Ya Huang, Hermina Borgerink and William C Dougall
    Citation: Breast Cancer Research 2013 15:R62
    Content type: Research article Published on:

  6. Several innate immunity genes are overexpressed in human cancers and their roles remain controversial. Bone marrow stromal antigen 2 (BST-2) is one such gene whose role in cancer is not clear. BST-2 is a uniqu...

    Authors: Wadie D Mahauad-Fernandez, Kris A DeMali, Alicia K Olivier and Chioma M Okeoma
    Citation: Breast Cancer Research 2014 16:493
    Content type: Research article Published on:

  7. Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with poor survival in patients with breast c...

    Authors: Sergio Granados-Principal, Yi Liu, Maria L Guevara, Elvin Blanco, Dong Soon Choi, Wei Qian, Tejal Patel, Angel A Rodriguez, Joseph Cusimano, Heidi L Weiss, Hong Zhao, Melissa D Landis, Bhuvanesh Dave, Steven S Gross and Jenny C Chang
    Citation: Breast Cancer Research 2015 17:25
    Content type: Research article Published on:

  8. Breast cancer is a heterogeneous disease. Hence, stratification of patients based on the subtype of breast cancer is key to its successful treatment. Among all the breast cancer subtypes, basal-like breast can...

    Authors: Ritama Paul, Ming Luo, Xueying Mo, Jason Lu, Syn Kok Yeo and Jun-Lin Guan
    Citation: Breast Cancer Research 2020 22:59
    Content type: Research article Published on:

    The Correction to this article has been published in Breast Cancer Research 2020 22:71

  9. Obesity is correlated with an increased risk for developing postmenopausal breast cancer. Since obesity rates continue to rise worldwide, it is important to understand how the obese microenvironment influences...

    Authors: Tamara Chamberlin, Joseph V. D’Amato and Lisa M. Arendt
    Citation: Breast Cancer Research 2017 19:128
    Content type: Research Article Published on:

  11. Human models of noninvasive breast tumors are limited, and the existing in vivo models do not mimic inter- and intratumoral heterogeneity. Ductal carcinoma in situ (DCIS) is the most common type (80%) of noninvas...

    Authors: Fariba Behbod, Frances S Kittrell, Heather LaMarca, David Edwards, Sofia Kerbawy, Jessica C Heestand, Evelin Young, Purna Mukhopadhyay, Hung-Wen Yeh, D Craig Allred, Min Hu, Kornelia Polyak, Jeffrey M Rosen and Daniel Medina
    Citation: Breast Cancer Research 2009 11:R66
    Content type: Research article Published on:

  12. Women who had children at a young age (less than 25) show a reduced overall risk of breast cancer. However, epidemiological studies showed that for all other women, pregnancy increases the risk of breast cance...

    Authors: Elizabeth Slocum, Amanda Craig, Augusto Villanueva and Doris Germain
    Citation: Breast Cancer Research 2019 21:56
    Content type: Research article Published on:

  13. Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic decision-making and predicting outcomes; however, these subtypes may not be as distinct as previously thought. Patie...

    Authors: Gadisti Aisha Mohamed, Sundis Mahmood, Nevena B. Ognjenovic, Min Kyung Lee, Owen M. Wilkins, Brock C. Christensen, Kristen E. Muller and Diwakar R. Pattabiraman
    Citation: Breast Cancer Research 2023 25:23
    Content type: Research Published on:

  14. Protein tyrosine kinases (PTKs) are frequently overexpressed and/or activated in human malignancies, and regulate cancer cell proliferation, cellular survival, and migration. As such, they have become promisin...

    Authors: Kristopher A Lofgren, Julie H Ostrander, Daniel Housa, Gregory K Hubbard, Alessia Locatelli, Robin L Bliss, Kathryn L Schwertfeger and Carol A Lange
    Citation: Breast Cancer Research 2011 13:R89
    Content type: Research article Published on:

  15. The transcription factor TRPS1 is a context-dependent oncogene in breast cancer. In the mammary gland, TRPS1 activity is restricted to the luminal population and is critical during puberty and pregnancy. Its f...

    Authors: Marie Tollot-Wegner, Marco Jessen, KyungMok Kim, Adrián Sanz-Moreno, Nadine Spielmann, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis and Björn von Eyss
    Citation: Breast Cancer Research 2024 26:74
    Content type: Research Published on:

  16. The introduction of next-generation sequencing has resulted in testing multiple genes simultaneously to identify inherited pathogenic variants (PVs) in cancer susceptibility genes. PVs with low minor allele fr...

    Authors: Felipe Batalini, Ellie G. Peacock, Lindsey Stobie, Alison Robertson, Judy Garber, Jeffrey N. Weitzel and Nadine M. Tung
    Citation: Breast Cancer Research 2019 21:107
    Content type: Review Published on:

  17. The diversity of human breast cancer subtypes has led to the hypothesis that breast cancer is actually a number of different diseases arising from cells at various stages of differentiation. The elusive nature...

    Authors: Lei Bao, Robert D. Cardiff, Paul Steinbach, Karen S. Messer and Lesley G. Ellies
    Citation: Breast Cancer Research 2015 17:137
    Content type: Research article Published on:

  18. RHAMM is a multifunctional protein that is upregulated in breast tumors, and the presence of strongly RHAMM+ve cancer cell subsets associates with elevated risk of peripheral metastasis. Experimentally, RHAMM imp...

    Authors: Cornelia Tolg, Maja Milojevic, Freda W. Qi, Hailie A. Pavanel, M. Elizabeth O. Locke, Jenny Ma, Mathew Price, Andrew C. Nelson, James B. McCarthy, Kathleen A. Hill and Eva A. Turley
    Citation: Breast Cancer Research 2023 25:74
    Content type: Research Published on:

  19. We propose that even partial loss of BRCA1...leads to an overall increase in EGFR expression in MECs and to an expansion of the highly EGFR-expressing, ALDH1-positive...BRCA1...at the earliest stages of transform...

    Authors: Laura N Burga, Hai Hu, Ashish Juvekar, Nadine M Tung, Susan L Troyan, Erin W Hofstatter and Gerburg M Wulf
    Citation: Breast Cancer Research 2011 13:R30
    Content type: Research article Published on:

  20. Breast cancer mortality is principally due to tumor recurrence, which can occur following extended periods of clinical remission that may last decades. While clinical latency has been postulated to reflect the...

    Authors: Jason R. Ruth, Dhruv K. Pant, Tien-chi Pan, Hans E. Seidel, Sanjeethan C. Baksh, Blaine A. Keister, Rita Singh, Christopher J. Sterner, Suzanne J. Bakewell, Susan E. Moody, George K. Belka and Lewis A. Chodosh
    Citation: Breast Cancer Research 2021 23:63
    Content type: Research article Published on:

  21. Parathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when it is produced by alveolar epithelial cells and secreted into the mat...

    Authors: Diego Y. Grinman, Kata Boras-Granic, Farzin M. Takyar, Pamela Dann, Julie R. Hens, Christina Marmol, Jongwon Lee, Jungmin Choi, Lewis A. Chodosh, Martin E. Garcia Sola and John J. Wysolmerski
    Citation: Breast Cancer Research 2022 24:30
    Content type: Research Published on:

  22. The interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its effects. Using N-ethyl-N-nitrosourea mutagenesis, we foun...

    Authors: Wing-Hong Jonathan Ho, Andrew M. K. Law, Etienne Masle-Farquhar, Lesley E. Castillo, Amanda Mawson, Moira K. O’Bryan, Christopher C. Goodnow, David Gallego-Ortega, Samantha R. Oakes and Christopher J. Ormandy
    Citation: Breast Cancer Research 2022 24:31
    Content type: Research article Published on:

  26. One of the best-characterized oncogenic mechanisms in breast cancer is the aberrant activation of phosphatidylinositol-3-kinase, protein kinase B, and mammalian target of rapamycin signaling. In both endocrine...

    Authors: Andrew Stone and Elizabeth A Musgrove
    Citation: Breast Cancer Research 2014 16:101
    Content type: Editorial Published on:

  29. Breast cancer cells invading the connective tissues outside the mammary lobule or duct immerse in a reservoir of extracellular matrix (ECM) that is structurally and biochemically distinct from that of their si...

    Authors: Kelsey F. Ruud, William C. Hiscox, Ilhan Yu, Roland K. Chen and Weimin Li
    Citation: Breast Cancer Research 2020 22:82
    Content type: Research article Published on:

  30. The cell of origin for estrogen receptor α (ERα) positive breast cancer is probably a luminal stem cell in the terminal duct lobular units. To model these cells we have used the murine myoepithelial layer in t...

    Authors: Stephanie Verbeke, Elodie Richard, Elodie Monceau, Xenia Schmidt, Benoit Rousseau, Valerie Velasco, David Bernard, Herve Bonnefoi, Gaetan MacGrogan and Richard D Iggo
    Citation: Breast Cancer Research 2014 16:504
    Content type: Research article Published on:

    The Erratum to this article has been published in Breast Cancer Research 2015 17:126

  32. NOTCH activation has been recently implicated in human breast cancers, associated with a poor prognosis, and tumor-initiating cells are hypothesized to mediate resistance to treatment and disease relapse. To a...

    Authors: Matthew J Simmons, Ryan Serra, Nicole Hermance and Michelle A Kelliher
    Citation: Breast Cancer Research 2012 14:R126
    Content type: Research article Published on:

  33. Percent mammographic density (PMD) adjusted for age and body mass index is one of the strongest risk factors for breast cancer and is known to be approximately 60% heritable. Here we report a finding of an ass...

    Authors: Jennifer L Caswell, Karla Kerlikowske, John A Shepherd, Steven R Cummings, Donglei Hu, Scott Huntsman and Elad Ziv
    Citation: Breast Cancer Research 2013 15:R40
    Content type: Research article Published on:

  38. The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (E...

    Authors: Tamara Tanos, Lucia Jimenez Rojo, Pablo Echeverria and Cathrin Brisken
    Citation: Breast Cancer Research 2012 14:210
    Content type: Review Published on:

  39. Retinoic acid signaling plays key roles in embryonic development and in maintaining the differentiated status of adult tissues. Recently, the nuclear retinoic acid receptor (RAR) isotypes α, β and γ were found...

    Authors: Almudena Bosch, Silvina P Bertran, Yongke Lu, Avalon Garcia, Alexis M Jones, Marcia I Dawson and Eduardo F Farias
    Citation: Breast Cancer Research 2012 14:R121
    Content type: Research article Published on:

  40. Molecular characterization of the normal epithelial cell types that reside in the mammary gland is an important step toward understanding pathways that regulate self-renewal, lineage commitment, and differenti...

    Authors: Elgene Lim, Di Wu, Bhupinder Pal, Toula Bouras, Marie-Liesse Asselin-Labat, François Vaillant, Hideo Yagita, Geoffrey J Lindeman, Gordon K Smyth and Jane E Visvader
    Citation: Breast Cancer Research 2010 12:R21
    Content type: Research article Published on:

  42. The tumour-suppressive effects of transforming growth factor-beta (TGF-β) are well documented; however, the mechanistic basis of these effects is not fully understood. Previously, we showed that a non-canonica...

    Authors: Kevin Roarty, Sarah E Baxley, Michael R Crowley, Andra R Frost and Rosa Serra
    Citation: Breast Cancer Research 2009 11:R19
    Content type: Research article Published on:

  43. Although estrogen and progesterone play a key role in normal mammary development and in breast cancer, the potential for proliferation and lineage differentiation as well as origin of cells that express the es...

    Authors: Gabriella Honeth, Sara Lombardi, Christophe Ginestier, Minhee Hur, Rebecca Marlow, Bharath Buchupalli, Ireneusz Shinomiya, Patrycja Gazinska, Silvia Bombelli, Vernie Ramalingam, Anand D Purushotham, Sarah E Pinder and Gabriela Dontu
    Citation: Breast Cancer Research 2014 16:R52
    Content type: Research article Published on:

  44. In recent years, the mammary gland epithelium has been shown to be a mixture of differentiated cell populations in a hierarchical relationship with their stem and progenitor cells. However, the mechanisms that re...

    Authors: Lorenzo Melchor and Matthew J Smalley
    Citation: Breast Cancer Research 2008 10:305
    Content type: Viewpoint Published on:

  46. The mammary gland epithelial components are thought to arise from stem cells that undergo both self-renewal and differentiation. Self-renewal has been shown to be regulated by the Hedgehog, Notch, and Wnt path...

    Authors: Suling Liu, Gabriela Dontu and Max S Wicha
    Citation: Breast Cancer Research 2005 7:86
    Content type: Review Published on:

  49. The European Network for Breast Development and Cancer (ENBDC) Workshop on ‘Methods in Mammary Gland Development and Cancer’ has grown into the essential, international technical discussion forum for scientist...

    Authors: Robert B Clarke, John Stingl, Maria Vivanco and Mohamed Bentires-Alj
    Citation: Breast Cancer Research 2013 15:313
    Content type: Meeting report Published on:
Submit manuscript

Follow

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 6.1
    5-year Journal Impact Factor: 7.1
    Source Normalized Impact per Paper (SNIP): 1.865
    SCImago Journal Rank (SJR): 2.578

    Speed 2023
    Submission to first editorial decision (median days): 14
    Submission to acceptance (median days): 129

    Usage 2023
    Downloads: 2,432,781
    Altmetric mentions: 1,561

Breast Cancer Research

ISSN: 1465-542X

Contact us