Taipale J, Beachy PA: The Hedgehog and Wnt signalling pathways in cancer. Nature. 2001, 411: 349-354. 10.1038/35077219.
Article
CAS
PubMed
Google Scholar
Cowin P, Wysolmerski J: Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harb Perspect Biol. 2010, 2: a003251-
Article
PubMed
PubMed Central
Google Scholar
Coussens LM, Pollard JW: Leukocytes in mammary development and cancer. Cold Spring Harb Perspect Biol. 2011, 3: pii: a003285-
Article
Google Scholar
Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD, Lau KW, Raine K, Jones D, Marshall J, Ramakrishna M, Shlien A, Cooke SL, Hinton J, Menzies A, Stebbings LA, Leroy C, Jia M, Rance R, Mudie LJ, Gamble SJ, Stephens PJ, McLaren S, Tarpey PS, Papaemmanuil E, Davies HR, Varela I, McBride DJ, Bignell GR, Leung K, Butler AP, et al: The life history of 21 breast cancers. Cell. 2012, 149: 994-1007. 10.1016/j.cell.2012.04.023.
Article
CAS
PubMed
PubMed Central
Google Scholar
Almendro V, Marusyk A, Polyak K: Cellular heterogeneity and molecular evolution in cancer. Ann Rev Pathol. 2013, 8: 277-302. 10.1146/annurev-pathol-020712-163923.
Article
CAS
Google Scholar
Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, Cook K, Stepansky A, Levy D, Esposito D, Muthuswamy L, Krasnitz A, McCombie WR, Hicks J, Wigler M: Tumour evolution inferred by single-cell sequencing. Nature. 2011, 472: 90-94. 10.1038/nature09807.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, Brown AM, Ng K, Ma J, Wienholds E, Dunant C, Pollett A, Gallinger S, McPherson J, Mullighan CG, Shibata D, Dick JE: Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science. 2013, 339: 543-548. 10.1126/science.1227670.
Article
CAS
PubMed
Google Scholar
Turner NC, Reis-Filho JS: Genetic heterogeneity and cancer drug resistance. Lancet Oncol. 2012, 13: e178-185. 10.1016/S1470-2045(11)70335-7.
Article
PubMed
Google Scholar
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM: Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006, 66: 9339-9344. 10.1158/0008-5472.CAN-06-3126.
Article
CAS
PubMed
Google Scholar
Rosen JM, Jordan CT: The increasing complexity of the cancer stem cell paradigm. Science. 2009, 324: 1670-1673. 10.1126/science.1171837.
Article
CAS
PubMed
PubMed Central
Google Scholar
Clarke RB, Howell A, Potten CS, Anderson E: Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res. 1997, 57: 4987-4991.
CAS
PubMed
Google Scholar
Russo J, Ao X, Grill C, Russo IH: Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland. Breast Cancer Res Treat. 1999, 53: 217-227. 10.1023/A:1006186719322.
Article
CAS
PubMed
Google Scholar
Seagroves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM: C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol Endocrinol. 2000, 14: 359-368.
CAS
PubMed
Google Scholar
Brisken C, Park S, Vass T, Lydon JP, O'Malley BW, Weinberg RA: A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A. 1998, 95: 5076-5081. 10.1073/pnas.95.9.5076.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mallepell S, Krust A, Chambon P, Brisken C: Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A. 2006, 103: 2196-2201. 10.1073/pnas.0510974103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mulac-Jericevic B, Lydon JP, DeMayo FJ, Conneely OM: Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci U S A. 2003, 100: 9744-9749. 10.1073/pnas.1732707100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Beleut M, Rajaram RD, Caikovski M, Ayyanan A, Germano D, Choi Y, Schneider P, Brisken C: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A. 2010, 107: 2989-2994. 10.1073/pnas.0915148107.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brisken C, Ayyannan A, Nguyen C, Heineman A, Reinhardt F, Tan J, Dey SK, Dotto GP, Weinberg RA: IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell. 2002, 3: 877-887. 10.1016/S1534-5807(02)00365-9.
Article
CAS
PubMed
Google Scholar
Brisken C, Heineman A, Chavarria T, Elenbaas B, Tan J, Dey SK, McMahon JA, McMahon AP, Weinberg RA: Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev. 2000, 14: 650-654.
CAS
PubMed
PubMed Central
Google Scholar
Ciarloni L, Mallepell S, Brisken C: Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A. 2007, 104: 5455-5460. 10.1073/pnas.0611647104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fernandez-Valdivia R, Mukherjee A, Ying Y, Li J, Paquet M, DeMayo FJ, Lydon JP: The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev Biol. 2009, 328: 127-139. 10.1016/j.ydbio.2009.01.019.
Article
CAS
PubMed
Google Scholar
Tanos T, Sflomos G, Echeverria PC, Ayyanan A, Gutierrez M, Delaloye JF, Raffoul W, Fiche M, Dougall W, Schneider P, Yalcin-Ozuysal O, Brisken C: Progesterone/RANKL is a major regulatory axis in the human breast. Sci Transl Med. 2013, 5: 182ra155-
Article
Google Scholar
Asselin-Labat ML, Vaillant F, Sheridan JM, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE: Control of mammary stem cell function by steroid hormone signalling. Nature. 2010, 465: 798-802. 10.1038/nature09027.
Article
CAS
PubMed
Google Scholar
Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, Stingl J, Waterhouse PD, Khokha R: Progesterone induces adult mammary stem cell expansion. Nature. 2010, 465: 803-807. 10.1038/nature09091.
Article
CAS
PubMed
Google Scholar
Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ: Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development. 2013, 140: 1397-1401. 10.1242/dev.088948.
Article
CAS
PubMed
Google Scholar
Moraes RC, Zhang X, Harrington N, Fung JY, Wu MF, Hilsenbeck SG, Allred DC, Lewis MT: Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. Development. 2007, 134: 1231-1242. 10.1242/dev.02797.
Article
CAS
PubMed
Google Scholar
Visbal AP, LaMarca HL, Villanueva H, Toneff MJ, Li Y, Rosen JM, Lewis MT: Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. Dev Biol. 2011, 352: 116-127. 10.1016/j.ydbio.2011.01.025.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pond AC, Bin X, Batts T, Roarty K, Hilsenbeck S, Rosen JM: Fibroblast growth factor receptor signaling is essential for normal mammary gland development and stem cell function. Stem Cells. 2013, 31: 178-189. 10.1002/stem.1266.
Article
CAS
PubMed
Google Scholar
Bade LK, Goldberg JE, Dehut HA, Hall MK, Schwertfeger KL: Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor. J Cell Sci. 2011, 124: 3106-3117. 10.1242/jcs.082651.
Article
CAS
PubMed
PubMed Central
Google Scholar
Balko JM, Miller TW, Morrison MM, Hutchinson K, Young C, Rinehart C, Sánchez V, Jee D, Polyak K, Prat A, Perou CM, Arteaga CL, Cook RS: The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium. Proc Natl Acad Sci U S A. 2012, 109: 221-226. 10.1073/pnas.1115802109.
Article
CAS
PubMed
Google Scholar
Clevers H, Nusse R: Wnt/beta-catenin signaling and disease. Cell. 2012, 149: 1192-1205. 10.1016/j.cell.2012.05.012.
Article
CAS
PubMed
Google Scholar
Alexander CM, Goel S, Fakhraldeen SA, Kim S: Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling. Cold Spring Harb Perspect Biol. 2012, 4: 1-28.
Article
Google Scholar
de Visser KE, Ciampricotti M, Michalak EM, Tan DW, Speksnijder EN, Hau CS, Clevers H, Barker N, Jonkers J: Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. J Pathol. 2012, 228: 300-309. 10.1002/path.4096.
Article
CAS
PubMed
Google Scholar
Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z: Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Reports. 2013, 3: 70-78. 10.1016/j.celrep.2012.12.017.
Article
CAS
PubMed
PubMed Central
Google Scholar
DiMeo TA, Anderson K, Phadke P, Fan C, Perou CM, Naber S, Kuperwasser C: A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res. 2009, 69: 5364-5373. 10.1158/0008-5472.CAN-08-4135.
Article
CAS
PubMed
PubMed Central
Google Scholar
Khramtsov AI, Khramtsova GF, Tretiakova M, Huo D, Olopade OI, Goss KH: Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol. 2010, 176: 2911-2920. 10.2353/ajpath.2010.091125.
Article
PubMed
PubMed Central
Google Scholar
van Amerongen R, Bowman AN, Nusse R: Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell. 2012, 11: 387-400. 10.1016/j.stem.2012.05.023.
Article
CAS
PubMed
Google Scholar
Zeng YA, Nusse R: Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell. 2010, 6: 568-577. 10.1016/j.stem.2010.03.020.
Article
CAS
PubMed
PubMed Central
Google Scholar
Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R: A localized Wnt signal orients asymmetric stem cell division in vitro. Science. 2013, 339: 1445-1448. 10.1126/science.1231077.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hernandez AR, Klein AM, Kirschner MW: Kinetic responses of beta-catenin specify the sites of Wnt control. Science. 2012, 338: 1337-1340. 10.1126/science.1228734.
Article
CAS
PubMed
Google Scholar
Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl GM: Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc Natl Acad Sci U S A. 2013, 110: 6991-6996. 10.1073/pnas.1303671110.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fillmore CM, Gupta PB, Rudnick JA, Caballero S, Keller PJ, Lander ES, Kuperwasser C: Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010, 107: 21737-21742. 10.1073/pnas.1007863107.
Article
CAS
PubMed
PubMed Central
Google Scholar
Harrison H, Simoes BM, Rogerson L, Howell SJ, Landberg G, Clarke RB: Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling. Breast Cancer Res. 2013, 15: R21-10.1186/bcr3396.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yamamoto M, Taguchi Y, Ito-Kureha T, Semba K, Yamaguchi N, Inoue J: NF-kappaB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype. Nat Commun. 2013, 4: 2299-
PubMed
Google Scholar
Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Rubin J, Richardson AL, Weinberg RA: Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell. 2011, 145: 926-940. 10.1016/j.cell.2011.04.029.
Article
CAS
PubMed
PubMed Central
Google Scholar