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  1. The limitations of mammography in the detection and evaluation of invasive lobular carcinoma (ILC) have long been recognized, presenting real clinical challenges in treatment planning for these tumors. However...

    Authors: Karen Johnson, Deba Sarma and E Shelley Hwang
    Citation: Breast Cancer Research 2015 17:94
    Content type: Review Published on:

  2. Mammographic density (MD) is one of the strongest determinants of sporadic breast cancer (BC). In this study, we compared MD in BRCA1/2 mutation carriers and non-carriers from BRCA1/2 mutation-positive families a...

    Authors: Teresa Ramón y Cajal, Isabel Chirivella, Josefa Miranda, Alexandre Teule, Ángel Izquierdo, Judith Balmaña, Ana Beatriz Sánchez-Heras, Gemma Llort, David Fisas, Virginia Lope, Elena Hernández-Agudo, María José Juan-Fita, Isabel Tena, Luis Robles, Carmen Guillén-Ponce, Pedro Pérez-Segura…
    Citation: Breast Cancer Research 2015 17:93
    Content type: Research article Published on:

  3. Transforming growth factor beta (TGF-β) readily suppresses the development of early-stage breast cancers, an activity that gives way to tumor promotion in their late-stage counterparts. The molecular mechanism...

    Authors: Chevaun D. Morrison and William P. Schiemann
    Citation: Breast Cancer Research 2015 17:92
    Content type: Viewpoint Published on:

  5. Chemotherapy remains the only available treatment for triple-negative (TN) breast cancer, and most patients exhibit an incomplete pathologic response. Half of patients exhibiting an incomplete pathologic respo...

    Authors: Shenduo Li, Sturgis Payne, Fang Wang, Peter Claus, Zuowei Su, Jeffrey Groth, Joseph Geradts, Gustaaf de Ridder, Rebeca Alvarez, Paul Kelly Marcom, Salvatore V. Pizzo and Robin E. Bachelder
    Citation: Breast Cancer Research 2015 17:91
    Content type: Research article Published on:

  7. Arthralgia is a common toxicity among women taking aromatase inhibitors (AIs) and can lead to premature discontinuation of therapy. We evaluated the association between arthralgia, co-morbid fatigue and/or ins...

    Authors: Joshua Bauml, Lu Chen, Jinbo Chen, Jean Boyer, Michael Kalos, Susan Q. Li, Angela DeMichele and Jun J. Mao
    Citation: Breast Cancer Research 2015 17:89
    Content type: Research article Published on:

  8. Metformin, a diabetes drug with well-established side effect and safety profiles, has been widely studied for its anti-tumor activities in a number of cancers, including breast cancer. But its mechanism of act...

    Authors: Laura Camacho, Atreyi Dasgupta and Sao Jiralerspong
    Citation: Breast Cancer Research 2015 17:88
    Content type: Editorial Published on:

  10. Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase that is highly expressed in Human Epidermal Growth Factor 2+ (Her2+) breast cancers. Overexpression of PTK6 enhances anchorage-independent surviv...

    Authors: Sun Hee Park, Koichi Ito, William Olcott, Igor Katsyv, Gwyneth Halstead-Nussloch and Hanna Y. Irie
    Citation: Breast Cancer Research 2015 17:86
    Content type: Research article Published on:

  11. MicroRNAs (miRNAs) have been implicated in governing lineage specification and differentiation in multiple organs; however, little is known about their specific roles in mammopoiesis. We have determined the gl...

    Authors: Bhupinder Pal, Yunshun Chen, Andrew Bert, Yifang Hu, Julie M. Sheridan, Tamara Beck, Wei Shi, Keith Satterley, Paul Jamieson, Gregory J. Goodall, Geoffrey J. Lindeman, Gordon K. Smyth and Jane E. Visvader
    Citation: Breast Cancer Research 2015 17:85
    Content type: Research article Published on:

  12. Ductal carcinoma in situ is a biologically diverse entity. Whereas some lesions are cured by local surgical excision, others recur as in situ disease or progress to invasive carcinoma with subsequent potential...

    Authors: Jia-Min B. Pang, Kylie L. Gorringe, Stephen Q. Wong, Alexander Dobrovic, Ian G. Campbell and Stephen B. Fox
    Citation: Breast Cancer Research 2015 17:80
    Content type: Review Published on:

  13. The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary devel...

    Authors: Yu Wei Phua, Akira Nguyen, Daniel L. Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea Mcfarland, Roslin Russell, Warren Kaplan, Mark J. Cowley, Radhika Nair, Elena Zotenko, Sandra O’Toole, Shi-xiong Tan, David E. James…
    Citation: Breast Cancer Research 2015 17:83
    Content type: Research article Published on:

  14. Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered on...

    Authors: Daniele Campa, Myrto Barrdahl, Mia M. Gaudet, Amanda Black, Stephen J. Chanock, W. Ryan Diver, Susan M. Gapstur, Christopher Haiman, Susan Hankinson, Aditi Hazra, Brian Henderson, Robert N. Hoover, David J. Hunter, Amit D. Joshi, Peter Kraft, Loic Le Marchand…
    Citation: Breast Cancer Research 2015 17:82
    Content type: Research article Published on:

  15. nab-Paclitaxel is approved for the treatment of metastatic breast cancer on an every-3-week schedule based on positive findings from a pivotal phase III trial in which nab-paclitaxel 260 mg/m2 every 3 weeks was ...

    Authors: Miguel Martín
    Citation: Breast Cancer Research 2015 17:81
    Content type: Review Published on:

  16. Mammographic density (MD), after adjustment for a women’s age and body mass index, is a strong and independent risk factor for breast cancer (BC). Although the BC risk attributable to increased MD is significa...

    Authors: Cecilia W. Huo, Grace Chew, Prue Hill, Dexing Huang, Wendy Ingman, Leigh Hodson, Kristy A. Brown, Astrid Magenau, Amr H. Allam, Ewan McGhee, Paul Timpson, Michael A. Henderson, Erik W. Thompson and Kara Britt
    Citation: Breast Cancer Research 2015 17:79
    Content type: Research article Published on:

  17. Breast tumors are comprised of distinct cancer cell populations which differ in their tumorigenic and metastatic capacity. Characterization of cell surface markers enables investigators to distinguish between ...

    Authors: Ran Rostoker, Sagi Abelson, Inna Genkin, Sarit Ben-Shmuel, Ravi Sachidanandam, Eyal J. Scheinman, Keren Bitton-Worms, Zila Shen Orr, Avishay Caspi, Maty Tzukerman and Derek LeRoith
    Citation: Breast Cancer Research 2015 17:78
    Content type: Research article Published on:

  18. During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent s...

    Authors: Seungyoun Jung, Brian L. Egleston, D. Walt Chandler, Linda Van Horn, Nola M. Hylton, Catherine C. Klifa, Norman L. Lasser, Erin S. LeBlanc, Kenneth Paris, John A. Shepherd, Linda G. Snetselaar, Frank Z. Stanczyk, Victor J. Stevens and Joanne F. Dorgan
    Citation: Breast Cancer Research 2015 17:77
    Content type: Research Published on:

  19. Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesi...

    Authors: Greg J. Logan, David J. Dabbs, Peter C. Lucas, Rachel C. Jankowitz, Daniel D. Brown, Beth Z. Clark, Steffi Oesterreich and Priscilla F. McAuliffe
    Citation: Breast Cancer Research 2015 17:76
    Content type: Review Published on:

  20. Mammographic density (MD) is a strong heritable and intermediate phenotype for breast cancer, but much of its genetic variation remains unexplained. We performed a large-scale genetic association study includi...

    Authors: Judith S Brand, Jingmei Li, Keith Humphreys, Robert Karlsson, Mikael Eriksson, Emma Ivansson, Per Hall and Kamila Czene
    Citation: Breast Cancer Research 2015 17:75
    Content type: Research article Published on:

  21. High weight and high percentage mammographic breast density are both breast cancer risk factors but are negatively correlated. Therefore, we wanted to obtain more insight into this apparent paradox.

    Authors: Johanna Olga Pauline Wanders, Marije Fokje Bakker, Wouter Bernard Veldhuis, Petra Huberdina Maria Peeters and Carla Henrica van Gils
    Citation: Breast Cancer Research 2015 17:74
    Content type: Research article Published on:

  22. The molecular biology involving neoadjuvant chemotherapy (NAC) response is poorly understood. To elucidate the impact of NAC on the breast cancer transcriptome and its association with clinical outcome, we ana...

    Authors: Mark Jesus M. Magbanua, Denise M. Wolf, Christina Yau, Sarah E. Davis, Julia Crothers, Alfred Au, Christopher M. Haqq, Chad Livasy, Hope S. Rugo, Laura Esserman, John W. Park and Laura J. van ’t Veer
    Citation: Breast Cancer Research 2015 17:73
    Content type: Research Published on:

  23. Non-invasive diffuse optical tomography (DOT) and diffuse correlation spectroscopy (DCS) can detect and characterize breast cancer and predict tumor responses to neoadjuvant chemotherapy, even in patients with...

    Authors: So Hyun Chung, Michael D. Feldman, Daniel Martinez, Helen Kim, Mary E. Putt, David R. Busch, Julia Tchou, Brian J. Czerniecki, Mitchell D. Schnall, Mark A. Rosen, Angela DeMichele, Arjun G. Yodh and Regine Choe
    Citation: Breast Cancer Research 2015 17:72
    Content type: Research article Published on:

  24. A progressive loss of circulating anti-human epidermal growth factor receptor-2/neu (HER2) CD4+ T-helper type 1 (Th1) immune responses is observed in HER2pos-invasive breast cancer (IBC) patients relative to heal...

    Authors: Jashodeep Datta, Erik Berk, Shuwen Xu, Elizabeth Fitzpatrick, Cinthia Rosemblit, Lea Lowenfeld, Noah Goodman, David A Lewis, Paul J Zhang, Carla Fisher, Robert E Roses, Angela DeMichele and Brian J Czerniecki
    Citation: Breast Cancer Research 2015 17:71
    Content type: Research article Published on:

  25. We previously demonstrated that HER2/neu-driven mammary carcinogenesis can be prevented by an interleukin-12 (IL-12)-adjuvanted allogeneic HER2/neu-expressing cell vaccine. Since IL-12 can induce the release o...

    Authors: Stefania Croci, Patrizia Nanni, Arianna Palladini, Giordano Nicoletti, Valentina Grosso, Giorgia Benegiamo, Lorena Landuzzi, Alessia Lamolinara, Marianna L. Ianzano, Dario Ranieri, Massimiliano Dall’Ora, Manuela Iezzi, Carla De Giovanni and Pier-Luigi Lollini
    Citation: Breast Cancer Research 2015 17:70
    Content type: Research article Published on:

  26. Acquired tamoxifen resistance remains the major obstacle to breast cancer endocrine therapy. β1-integrin was identified as one of the target genes of G protein-coupled estrogen receptor (GPER), a novel estroge...

    Authors: Jie Yuan, Manran Liu, Li Yang, Gang Tu, Qing Zhu, Maoshan Chen, Hong Cheng, Haojun Luo, Weijie Fu, Zhenhua Li and Guanglun Yang
    Citation: Breast Cancer Research 2015 17:69
    Content type: Research article Published on:

  28. We present a fully automated method for deriving quantitative measures of background parenchymal enhancement (BPE) from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and perform a preli...

    Authors: Shandong Wu, Susan P Weinstein, Michael J DeLeo III, Emily F Conant, Jinbo Chen, Susan M Domchek and Despina Kontos
    Citation: Breast Cancer Research 2015 17:67
    Content type: Research article Published on:

    The Erratum to this article has been published in Breast Cancer Research 2015 17:144

  29. Tumor cells can effectively be killed by heat, e.g. by using magnetic hyperthermia. The main challenge in the field, however, is the generation of therapeutic temperatures selectively in the whole tumor region...

    Authors: Susanne Kossatz, Julia Grandke, Pierre Couleaud, Alfonso Latorre, Antonio Aires, Kieran Crosbie-Staunton, Robert Ludwig, Heidi Dähring, Volker Ettelt, Ana Lazaro-Carrillo, Macarena Calero, Maha Sader, José Courty, Yuri Volkov, Adriele Prina-Mello, Angeles Villanueva…
    Citation: Breast Cancer Research 2015 17:66
    Content type: Research article Published on:

  30. Women with evidence of high intake ratios of the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to the omega-6 arachidonic acid have been found to have a reduced...

    Authors: Carol J Fabian, Bruce F Kimler and Stephen D Hursting
    Citation: Breast Cancer Research 2015 17:62
    Content type: Review Published on:

  31. The serine/threonine protein kinase ataxia telangiectasia mutated (ATM) is critical in maintaining genomic integrity. Upon DNA double-strand breaks, ATM phosphorylates key downstream proteins including p53 and...

    Authors: Xiaolan Feng, Haocheng Li, Michelle Dean, Holly E Wilson, Elizabeth Kornaga, Emeka K Enwere, Patricia Tang, Alexander Paterson, Susan P Lees-Miller, Anthony M Magliocco and Gwyn Bebb
    Citation: Breast Cancer Research 2015 17:65
    Content type: Research article Published on:

  32. Metformin use has recently been observed to decrease both the rate and mortality of breast cancer. Our study was aim to determine whether metformin use is associated with survival in diabetic breast cancer pat...

    Authors: Hee Jeong Kim, Hyunwook Kwon, Jong Won Lee, Hwa Jung Kim, Sae Byul Lee, Hee Sung Park, Guiyun Sohn, Yura Lee, Beom Seok Koh, Jong Han Yu, Byung Ho Son and Sei Hyun Ahn
    Citation: Breast Cancer Research 2015 17:64
    Content type: Research article Published on:

  33. Mammography screening for breast cancer is widely available in many countries. Initially praised as a universal achievement to improve women's health and to reduce the burden of breast cancer, the benefits and...

    Authors: Magnus Løberg, Mette Lise Lousdal, Michael Bretthauer and Mette Kalager
    Citation: Breast Cancer Research 2015 17:63
    Content type: Review Published on:

  34. Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be cause...

    Authors: Sophie Blein, Claire Bardel, Vincent Danjean, Lesley McGuffog, Sue Healey, Daniel Barrowdale, Andrew Lee, Joe Dennis, Karoline B Kuchenbaecker, Penny Soucy, Mary Beth Terry, Wendy K Chung, David E Goldgar, Saundra S Buys, Ramunas Janavicius, Laima Tihomirova…
    Citation: Breast Cancer Research 2015 17:61
    Content type: Research article Published on:

  35. Trastuzumab has been used in the treatment of human epidermal growth factor receptor 2 (HER2)-expressing breast cancer, but its efficacy is limited by de novo or acquired resistance. Although many mechanisms have...

    Authors: Minh Ngoc Duong, Aurore Cleret, Eva-Laure Matera, Kamel Chettab, Doriane Mathé, Sandrine Valsesia-Wittmann, Béatrice Clémenceau and Charles Dumontet
    Citation: Breast Cancer Research 2015 17:57
    Content type: Research article Published on:

  37. Breast cancer, the most common cause of cancer-related deaths worldwide among women, is a molecularly and clinically heterogeneous disease. Extensive genetic and epigenetic profiling of breast tumors has recen...

    Authors: Christy C Ong, Sarah Gierke, Cameron Pitt, Meredith Sagolla, Christine K Cheng, Wei Zhou, Adrian M Jubb, Laura Strickland, Maike Schmidt, Sergio G Duron, David A Campbell, Wei Zheng, Seameen Dehdashti, Min Shen, Nora Yang, Mark L Behnke…
    Citation: Breast Cancer Research 2015 17:59
    Content type: Research article Published on:

  38. Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was ...

    Authors: Ailith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana M Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan Tyrer, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Alison M Dunning…
    Citation: Breast Cancer Research 2015 17:58
    Content type: Research article Published on:

  39. Worldwide, many patients with HER2+ (human epidermal growth factor receptor 2-positive) early breast cancer (BC) do not receive adjuvant trastuzumab. Hazards of recurrence of these patients with respect to hor...

    Authors: Kathrin Strasser-Weippl, Nora Horick, Ian E Smith, Joyce O’Shaughnessy, Bent Ejlertsen, Frances Boyle, Aman U Buzdar, Pierre Fumoleau, William Gradishar, Miguel Martin, Beverly Moy, Martine Piccart-Gebhart, Kathleen I Pritchard, Deborah Lindquist, Erica Rappold, Dianne M Finkelstein…
    Citation: Breast Cancer Research 2015 17:56
    Content type: Research article Published on:

  40. Patients with clinically and pathologically similar breast tumors often have very different outcomes and treatment responses. Current prognostic markers allocate the majority of breast cancer patients to the h...

    Authors: Kristina P Sørensen, Mads Thomassen, Qihua Tan, Martin Bak, Søren Cold, Mark Burton, Martin J Larsen and Torben A Kruse
    Citation: Breast Cancer Research 2015 17:55
    Content type: Research article Published on:

  42. The clinical success of trastuzumab in breast cancer taught us that appropriate tumor evaluation is mandatory for the correct identification of patients eligible for targeted therapies. Although HER2 protein e...

    Authors: Paolo Nuciforo, Nina Radosevic-Robin, Tony Ng and Maurizio Scaltriti
    Citation: Breast Cancer Research 2015 17:53
    Content type: Review Published on:

  44. With tremendous advances in sequencing and analysis in recent years, a wealth of genetic information has become available to identify and classify breast cancer into five main subtypes - luminal A, luminal B, ...

    Authors: Leonard B Maggi Jr and Jason D Weber
    Citation: Breast Cancer Research 2015 17:51
    Content type: Editorial Published on:

  45. High physical activity has been shown to decrease the risk of breast cancer, potentially by a mechanism that also reduces mammographic density. We tested the hypothesis that the risk of developing breast cance...

    Authors: Thang Trinh, Mikael Eriksson, Hatef Darabi, Stephanie E Bonn, Judith S Brand, Jack Cuzick, Kamila Czene, Arvid Sjölander, Katarina Bälter and Per Hall
    Citation: Breast Cancer Research 2015 17:50
    Content type: Research article Published on:

  46. The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention.

    Authors: Kaja Tikk, Disorn Sookthai, Renée T Fortner, Theron Johnson, Sabina Rinaldi, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Françoise Clavel-Chapelon, Laura Baglietto, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Giovanna Masala…
    Citation: Breast Cancer Research 2015 17:49
    Content type: Research article Published on:

  47. Cancer vaccines have the potential to induce curative anti-tumor immune responses and better adjuvants may improve vaccine efficacy. We have previously shown that Hp91, a peptide derived from the B box domain ...

    Authors: Diahnn F Campbell, Rebecca Saenz, Ila S Bharati, Daniel Seible, Liangfang Zhang, Sadik Esener, Bradley Messmer, Marie Larsson and Davorka Messmer
    Citation: Breast Cancer Research 2015 17:48
    Content type: Research article Published on:

  48. Focal adhesion kinase (FAK) controls cell growth and survival downstream of integrin-matrix receptors. Upon adhesion loss or FAK inhibition, FAK can translocate to the nucleus. The nucleolus is a non-membrane ...

    Authors: Isabelle Tancioni, Nichol LG Miller, Sean Uryu, Christine Lawson, Christine Jean, Xiao Lei Chen, Elizabeth G Kleinschmidt and David D Schlaepfer
    Citation: Breast Cancer Research 2015 17:47
    Content type: Research article Published on:

  49. Podocalyxin (gene name PODXL) is a CD34-related sialomucin implicated in the regulation of cell adhesion, migration and polarity. Upregulated expression of podocalyxin is linked to poor patient survival in epithe...

    Authors: Kimberly A Snyder, Michael R Hughes, Bradley Hedberg, Jill Brandon, Diana Canals Hernaez, Peter Bergqvist, Frederic Cruz, Kelvin Po, Marcia L Graves, Michelle E Turvey, Julie S Nielsen, John A Wilkins, Shaun R McColl, John S Babcook, Calvin D Roskelley and Kelly M McNagny
    Citation: Breast Cancer Research 2015 17:46
    Content type: Research article Published on:

  50. Breast cancer cells display preferences for specific metastatic sites including the bone, lung and liver. Metastasis is a complex process that relies, in part, on interactions between disseminated cancer cells...

    Authors: Sébastien Tabariès, Véronique Ouellet, Brian E Hsu, Matthew G Annis, April AN Rose, Liliane Meunier, Euridice Carmona, Christine E Tam, Anne-Marie Mes-Masson and Peter M Siegel
    Citation: Breast Cancer Research 2015 17:45
    Content type: Research article Published on:
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