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  1. Content type: Research article

    Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, is not only essential for proper mammary ductal development, but also associated with breast cancer proliferation and growth. In the absen...

    Authors: Serena P. H. Mao, Minji Park, Ramon M. Cabrera, John R. Christin, George S. Karagiannis, Maja H. Oktay, Dietmar M. W. Zaiss, Scott I. Abrams, Wenjun Guo, John S. Condeelis, Paraic A. Kenny and Jeffrey E. Segall

    Citation: Breast Cancer Research 2018 20:131

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  2. Content type: Research article

    De novo or acquired resistance in breast cancer leads to treatment failures and disease progression. In human epidermal growth factor receptor 2 (HER2)-positive (HER2+) breast cancer, Src, a non-receptor tyros...

    Authors: Brooke N. McKnight and Nerissa T. Viola-Villegas

    Citation: Breast Cancer Research 2018 20:130

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  3. Content type: Research article

    Stem cells are precursors for all mammary epithelia, including ductal and alveolar epithelia, and myoepithelial cells. In vivo mammary epithelia reside in a tissue context and interact with their milieu via re...

    Authors: Safiah Olabi, Ahmet Ucar, Keith Brennan and Charles H. Streuli

    Citation: Breast Cancer Research 2018 20:128

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  4. Content type: Research article

    Bone is one of the most frequent metastatic sites of advanced breast cancer. Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have palliative effects. During normal bone r...

    Authors: Xuxiang Liu, Minghui Cao, Melanie Palomares, Xiwei Wu, Arthur Li, Wei Yan, Miranda Y. Fong, Wing-Chung Chan and Shizhen Emily Wang

    Citation: Breast Cancer Research 2018 20:127

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  5. Content type: Research article

    Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current...

    Authors: Sruthi Ravindranathan, Khue G. Nguyen, Samantha L. Kurtz, Haven N. Frazier, Sean G. Smith, Bhanu prasanth Koppolu, Narasimhan Rajaram and David A. Zaharoff

    Citation: Breast Cancer Research 2018 20:126

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  6. Content type: Research article

    Circadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA damage responses and metabolism. Circadian disruptio...

    Authors: Eleanor Broadberry, James McConnell, Jack Williams, Nan Yang, Egor Zindy, Angela Leek, Rachel Waddington, Leena Joseph, Miles Howe, Qing-Jun Meng and Charles H Streuli

    Citation: Breast Cancer Research 2018 20:125

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  7. Content type: Research article

    Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive...

    Authors: Christina M Dieli-Conwright, Kerry S Courneya, Wendy Demark-Wahnefried, Nathalie Sami, Kyuwan Lee, Frank C Sweeney, Christina Stewart, Thomas A Buchanan, Darcy Spicer, Debu Tripathy, Leslie Bernstein and Joanne E Mortimer

    Citation: Breast Cancer Research 2018 20:124

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  8. Content type: Review

    Endocrine therapy is recommended for patients with hormone receptor-positive (HR+) advanced and metastatic breast cancer without visceral crisis (symptomatic visceral disease). However, many patients experience d...

    Authors: Gabriel N. Hortobagyi

    Citation: Breast Cancer Research 2018 20:123

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  9. Content type: Short report

    The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent sta...

    Authors: Elin Borgen, Maria C. Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E. Lønning, Marit Synnestvedt, Julio A. Aguirre-Ghiso and Bjørn Naume

    Citation: Breast Cancer Research 2018 20:120

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  10. Content type: Research article

    Standard three-dimensional (3D) in vitro culture techniques, such as those used for mammary epithelial cells, rely on random distribution of cells within hydrogels. Although these systems offer advantages over tr...

    Authors: John A. Reid, Peter A. Mollica, Robert D. Bruno and Patrick C. Sachs

    Citation: Breast Cancer Research 2018 20:122

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    The Correction to this article has been published in Breast Cancer Research 2018 20:136

  11. Content type: Research article

    Exposure to road traffic noise was associated with increased risk of estrogen receptor (ER)-negative (ER-) breast cancer in a previous cohort study, but not with overall or ER-positive (ER+) breast cancer, or ...

    Authors: Zorana Jovanovic Andersen, Jeanette Therming Jørgensen, Lea Elsborg, Søren Nymand Lophaven, Claus Backalarz, Jens Elgaard Laursen, Torben Holm Pedersen, Mette Kildevæld Simonsen, Elvira Vaclavik Bräuner and Elsebeth Lynge

    Citation: Breast Cancer Research 2018 20:119

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  12. Content type: Research article

    The most life-threatening step during malignant tumor progression is reached when cancer cells leave the primary tumor mass and seed metastasis in distant organs. To infiltrate the surrounding tissue and disse...

    Authors: Nathalie Meyer-Schaller, Chantal Heck, Stefanie Tiede, Mahmut Yilmaz and Gerhard Christofori

    Citation: Breast Cancer Research 2018 20:118

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  13. Content type: Research article

    Metastasis is responsible for a significant number of breast cancer-related deaths. Hypoxia, a primary driving force of cancer metastasis, induces the expression of BHLHE40, a transcription regulator. This stu...

    Authors: Aarti Sethuraman, Martin Brown, Raya Krutilina, Zhao-Hui Wu, Tiffany N. Seagroves, Lawrence M. Pfeffer and Meiyun Fan

    Citation: Breast Cancer Research 2018 20:117

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  14. Content type: Research article

    Increased collagen expression and deposition are associated with cancer progression and poor prognosis in breast cancer patients. However, function and regulation of membrane-associated collagen in breast canc...

    Authors: Hui Zhang, Tricia Fredericks, Gaofeng Xiong, Yifei Qi, Piotr G. Rychahou, Jia-Da Li, Taina Pihlajaniemi, Wei Xu and Ren Xu

    Citation: Breast Cancer Research 2018 20:116

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  15. Content type: Research article

    Previous studies on the role of TP53 mutation in breast cancer treatment response and survival are contradictory and inconclusive, limited by the use of different endpoints to determine clinical significance and ...

    Authors: Nathan A. Ungerleider, Sonia G. Rao, Ashkan Shahbandi, Douglas Yee, Tianhua Niu, Wesley D. Frey and James G. Jackson

    Citation: Breast Cancer Research 2018 20:115

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  16. Content type: Research article

    Limited evidence, mostly from studies in Western populations, suggests that the prognostic effects of lifestyle-related risk factors may be molecular subtype-dependent. Here, we examined whether pre-diagnostic...

    Authors: Mustapha Abubakar, Hyuna Sung, Devi BCR, Jennifer Guida, Tieng Swee Tang, Ruth M. Pfeiffer and Xiaohong R. Yang

    Citation: Breast Cancer Research 2018 20:114

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  17. Content type: Research article

    Drug resistance of paclitaxel (TAX), the first-line chemotherapy drug for breast cancer, was reported to develop in 90% of patients with breast cancer, especially metastatic breast cancer. Investigating the me...

    Authors: Liu Yang, Yanhua Tian, Wei Sun Leong, Heng Song, Wei Yang, Meiqi Wang, Xinle Wang, Jing Kong, Baoen Shan and Zhengchuan Song

    Citation: Breast Cancer Research 2018 20:113

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  18. Content type: Research article

    Tamoxifen is typically used to treat patients with estrogen receptor alpha (ERα)-positive breast cancer. However, 30% of these patients gain acquired resistance to tamoxifen during or after tamoxifen treatment...

    Authors: Pin Gao, Xiang Wang, Ying Jin, Wenquan Hu, Yajun Duan, Aiping Shi, Ye Du, Dong Song, Ming Yang, Sijie Li, Bing Han, Gang Zhao, Hongquan Zhang, Zhimin Fan and Qing Robert Miao

    Citation: Breast Cancer Research 2018 20:112

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  19. Content type: Research article

    Antimicrobial T cells play key roles in the disease progression of cancers arising in mucosal epithelial tissues, such as the colon. However, little is known about microbe-reactive T cells within human breast ...

    Authors: Nicholas A. Zumwalde, Jill D. Haag, Michael N. Gould and Jenny E. Gumperz

    Citation: Breast Cancer Research 2018 20:111

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  20. Content type: Research article

    This phase Ib study (NCT00960960) evaluated pictilisib (GDC-0941; pan-phosphatidylinositol 3-kinase inhibitor) plus paclitaxel, with and without bevacizumab or trastuzumab, or in combination with letrozole, in...

    Authors: Patrick Schöffski, Sara Cresta, Ingrid A. Mayer, Hans Wildiers, Silvia Damian, Steven Gendreau, Isabelle Rooney, Kari M. Morrissey, Jill M. Spoerke, Vivian W. Ng, Stina M. Singel and Eric Winer

    Citation: Breast Cancer Research 2018 20:109

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  21. Content type: Research article

    Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined t...

    Authors: Roberto R. Rosato, Daniel Dávila-González, Dong Soon Choi, Wei Qian, Wen Chen, Anthony J. Kozielski, Helen Wong, Bhuvanesh Dave and Jenny C. Chang

    Citation: Breast Cancer Research 2018 20:108

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  22. Content type: Correction

    After the publication of this article [1], we noticed that in Fig. 2, the survival curve images (C and D, lower panel) were incorrect. The corrected Fig. 2 is presented below. The correction does not affect in...

    Authors: Aya Asano, Shigeto Ueda, Ichiei Kuji, Tomohiko Yamane, Hideki Takeuchi, Eiko Hirokawa, Ikuko Sugitani, Hiroko Shimada, Takahiro Hasebe, Akihiko Osaki and Toshiaki Saeki

    Citation: Breast Cancer Research 2018 20:107

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    The original article was published in Breast Cancer Research 2018 20:78

  23. Content type: Research article

    Invasive lobular breast carcinoma (ILC) is a histological subtype of breast cancer that is characterized by loss of E-cadherin and high expression of estrogen receptor alpha (ERα). In many cases, ILC is effect...

    Authors: Tian Du, Matthew J. Sikora, Kevin M. Levine, Nilgun Tasdemir, Rebecca B. Riggins, Stacy G. Wendell, Bennett Van Houten and Steffi Oesterreich

    Citation: Breast Cancer Research 2018 20:106

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  24. Content type: Research article

    Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. N...

    Authors: Alexey A. Leontovich, Mohammad Jalalirad, Jeffrey L. Salisbury, Lisa Mills, Candace Haddox, Mark Schroeder, Ann Tuma, Maria E. Guicciardi, Luca Zammataro, Mario W. Gambino, Angela Amato, Aldo Di Leonardo, James McCubrey, Carol A. Lange, Minetta Liu, Tufia Haddad…

    Citation: Breast Cancer Research 2018 20:105

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  25. Content type: Research article

    Obesity is a strong predictor of poor prognosis in breast cancer, especially in postmenopausal women. In particular, tumors in obese patients tend to seed more distant metastases, although the biology behind t...

    Authors: Mélanie Bousquenaud, Flavia Fico, Giovanni Solinas, Curzio Rüegg and Albert Santamaria-Martínez

    Citation: Breast Cancer Research 2018 20:104

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  26. Content type: Research article

    Several prognostic signatures for early oestrogen receptor-positive (ER+) breast cancer have been established with a 10-year follow-up. We tested the hypothesis that signatures optimised for 0–5-year and 5–10-...

    Authors: Richard Buus, Belinda Yeo, Adam R. Brentnall, Marie Klintman, Maggie Chon U. Cheang, Komel Khabra, Ivana Sestak, Qiong Gao, Jack Cuzick and Mitch Dowsett

    Citation: Breast Cancer Research 2018 20:103

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  27. Content type: Meeting report

    The European Network for Breast Development and Cancer (ENBDC), a worldwide network (http://​www.​enbdc.​org/​), celebrated its tenth anniversary with a fantasti...

    Authors: Zuzana Koledova, Beatrice A. Howard, Johanna Englund, Karsten Bach, Mohammed Bentires-Alj and Eva Gonzalez-Suarez

    Citation: Breast Cancer Research 2018 20:102

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  28. Content type: Research article

    We sought to investigate associations between dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) features and tumor-infiltrating lymphocytes (TILs) in breast cancer, as well as to study if MRI fe...

    Authors: Jia Wu, Xuejie Li, Xiaodong Teng, Daniel L. Rubin, Sandy Napel, Bruce L. Daniel and Ruijiang Li

    Citation: Breast Cancer Research 2018 20:101

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  29. Content type: Review

    Differentiation of stem cells into highly specialised cells requires gene expression changes brought about by remodelling of the chromatin architecture. During this lineage-commitment process, the majority of ...

    Authors: Holly Holliday, Laura A. Baker, Simon R. Junankar, Susan J. Clark and Alexander Swarbrick

    Citation: Breast Cancer Research 2018 20:100

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  30. Content type: Research article

    While many studies have shown that maternal factors in pregnancy affect the cancer risk for offspring, few studies have investigated the impact of paternal exposures on their progeny’s risk of this disease. Po...

    Authors: Raquel Santana da Cruz, Elissa J. Carney, Johan Clarke, Hong Cao, M. Idalia Cruz, Carlos Benitez, Lu Jin, Yi Fu, Zuolin Cheng, Yue Wang and Sonia de Assis

    Citation: Breast Cancer Research 2018 20:99

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  31. Content type: Correction

    After the publication of this work [1], an error was noticed in Fig. 2b and Fig. 4b as well as Fig. 4b. and Fig. 5d. Images of the ERK1/2 blots were accidentally duplicated. In Fig. 5a. and Fig. 5c., the last ...

    Authors: Iain R. Hutcheson, Janice M. Knowlden, Steve E. Hiscox, Denise Barrow, Julia M. W. Gee, John F. Robertson, Ian O. Ellis and Robert I. Nicholson

    Citation: Breast Cancer Research 2018 20:98

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    The original article was published in Breast Cancer Research 2007 9:R50

  32. Content type: Research article

    Although ductal carcinoma in situ (DCIS) is a non-invasive breast cancer, many DCIS lesions may progress to invasive cancer and the genes and pathways responsible for its progression are largely unknown. FGFR1...

    Authors: Mao Yang, Xiaobin Yu, Xuesen Li, Bo Luo, Wenli Yang, Yan Lin, Dabing Li, Zhonglin Gan, Jianming Xu and Tao He

    Citation: Breast Cancer Research 2018 20:97

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  33. Content type: Research article

    Molecular classification of tumour clonality is currently not evaluated in multiple invasive breast carcinomas, despite evidence suggesting common clonal origins. There is no consensus about which type of data...

    Authors: Jana Biermann, Toshima Z. Parris, Szilárd Nemes, Anna Danielsson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson and Khalil Helou

    Citation: Breast Cancer Research 2018 20:96

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  34. Content type: Research article

    We evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode.

    Authors: Donella Puliti, Marco Zappa, Paolo Giorgi Rossi, Elena Pierpaoli, Gianfranco Manneschi, Daniela Ambrogetti, Leonardo Ventura and Paola Mantellini

    Citation: Breast Cancer Research 2018 20:95

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  35. Content type: Research article

    Thyroxine (T4) has been positively associated with tumor cell proliferation, while the effect of triiodothyronine (T3) on cell proliferation has not been well-established because it differs according to the ty...

    Authors: Carolina Ortega-Olvera, Alfredo Ulloa-Aguirre, Angélica Ángeles-Llerenas, Fernando Enrique Mainero-Ratchelous, Claudia Elena González-Acevedo, Ma. de Lourdes Hernández-Blanco, Elad Ziv, Larissa Avilés-Santa, Edelmiro Pérez-Rodríguez and Gabriela Torres-Mejía

    Citation: Breast Cancer Research 2018 20:94

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  36. Content type: Research article

    Long-term insulin exposure has been implicated in breast cancer etiology, but epidemiological evidence remains inconclusive. The aims of this study were to investigate the association of insulin therapy with m...

    Authors: Signe Borgquist, Ann H. Rosendahl, Kamila Czene, Nirmala Bhoo-Pathy, Mozhgan Dorkhan, Per Hall and Judith S. Brand

    Citation: Breast Cancer Research 2018 20:93

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  37. Content type: Research article

    Epidemiological studies have consistently shown that increased mammographic density (MD) is a strong risk factor for breast cancer. We previously observed an elevated number of vimentin+/CD45+ leukocytes in high ...

    Authors: Cecilia W. Huo, Prue Hill, Grace Chew, Paul J. Neeson, Heloise Halse, Elizabeth D. Williams, Michael A. Henderson, Erik W. Thompson and Kara L. Britt

    Citation: Breast Cancer Research 2018 20:92

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  38. Content type: Research article

    Fibroadenomas are common benign breast lesions, and studies of European American women indicate a persistent, increased risk of breast cancer after diagnosing a fibroadenoma on biopsy. This association has not...

    Authors: Asra N. Shaik, Julie J. Ruterbusch, Eman Abdulfatah, Resha Shrestha, M. H. D. Fayez Daaboul, Visakha Pardeshi, Daniel W. Visscher, Sudeshna Bandyopadhyay, Rouba Ali-Fehmi and Michele L. Cote

    Citation: Breast Cancer Research 2018 20:91

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  39. Content type: Research article

    Upregulation of human epidermal growth factor receptor 3 (HER3) is a major mechanism of acquired resistance to therapies targeting its heterodimerization partners epidermal growth factor receptor (EGFR) and hu...

    Authors: Takuya Osada, Zachary C. Hartman, Junping Wei, Gangjun Lei, Amy C. Hobeika, William R. Gwin, Marcio A. Diniz, Neil Spector, Timothy M. Clay, Wei Chen, Michael A. Morse and H. Kim Lyerly

    Citation: Breast Cancer Research 2018 20:90

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  40. Content type: Correction

    After the publication of this work [1], an error was noticed in Fig. 4a. The micrograph image sh528 was accidentally duplicated.

    Authors: Benjamin A. Katchman, I. Tolgay Ocal, Heather E. Cunliffe, Yu-Hui Chang, Galen Hostetter, Aprill Watanabe, Janine LoBello and Douglas F. Lake

    Citation: Breast Cancer Research 2018 20:89

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    The original article was published in Breast Cancer Research 2013 15:R28

  41. Content type: Research article

    Inflammatory breast cancer (IBC) is the most aggressive form of primary breast cancer. Using a custom-made breast cancer gene sequencing panel, we investigated somatic mutations in IBC to better understand the...

    Authors: Xu Liang, Sophie Vacher, Anais Boulai, Virginie Bernard, Sylvain Baulande, Mylene Bohec, Ivan Bièche, Florence Lerebours and Céline Callens

    Citation: Breast Cancer Research 2018 20:88

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  42. Content type: Research article

    Breast cancer is the most prevalent tumor entity in Li-Fraumeni syndrome. Up to 80% of individuals with a Li-Fraumeni-like phenotype do not harbor detectable causative germline TP53 variants. Yet, no systematic p...

    Authors: Judith Penkert, Gunnar Schmidt, Winfried Hofmann, Stephanie Schubert, Maximilian Schieck, Bernd Auber, Tim Ripperger, Karl Hackmann, Marc Sturm, Holger Prokisch, Ursula Hille-Betz, Dorothea Mark, Thomas Illig, Brigitte Schlegelberger and Doris Steinemann

    Citation: Breast Cancer Research 2018 20:87

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  43. Content type: Research article

    Mesenchymal transformation of pulmonary endothelial cells contributes to the formation of a metastatic microenvironment, but it is not known whether this precedes or follows early metastasis formation. In the ...

    Authors: Marta Smeda, Anna Kieronska, Mateusz G. Adamski, Bartosz Proniewski, Magdalena Sternak, Tasnim Mohaissen, Kamil Przyborowski, Katarzyna Derszniak, Dawid Kaczor, Marta Stojak, Elzbieta Buczek, Agnieszka Jasztal, Joanna Wietrzyk and Stefan Chlopicki

    Citation: Breast Cancer Research 2018 20:86

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  44. Content type: Research article

    Breast magnetic resonance imaging (MRI) is the most sensitive imaging method for breast cancer detection and is therefore offered as a screening technique to women at increased risk of developing breast cancer...

    Authors: Suzan Vreemann, Jan C. M. van Zelst, Margrethe Schlooz-Vries, Peter Bult, Nicoline Hoogerbrugge, Nico Karssemeijer, Albert Gubern-Mérida and Ritse M. Mann

    Citation: Breast Cancer Research 2018 20:84

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  45. Content type: Research article

    Although numerous studies have reported that tricho-rhino-phalangeal syndrome type I (TRPS1) protein, the only reported atypical GATA transcription factor, is overexpressed in various carcinomas, the underlyin...

    Authors: Yuzhi Wang, Jun Zhang, Lele Wu, Weiguang Liu, Guanyun Wei, Xue Gong, Yan Liu, Zhifang Ma, Fei Ma, Jean Paul Thiery and Liming Chen

    Citation: Breast Cancer Research 2018 20:83

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  46. Content type: Research article

    Triple-negative breast cancer (TNBC) remains an aggressive breast cancer subtype with limited treatment options. ENMD-2076 is a small-molecule inhibitor of Aurora and angiogenic kinases with proapoptotic and a...

    Authors: Jennifer R. Diamond, S. G. Eckhardt, Todd M. Pitts, Adrie van Bokhoven, Dara Aisner, Daniel L. Gustafson, Anna Capasso, Sharon Sams, Peter Kabos, Kathryn Zolman, Tiffany Colvin, Anthony D. Elias, Anna M. Storniolo, Bryan P. Schneider, Dexiang Gao, John J. Tentler…

    Citation: Breast Cancer Research 2018 20:82

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  47. Content type: Review

    Physical inactivity and being overweight are modifiable lifestyle risk factors that consistently have been associated with a higher risk of postmenopausal breast cancer in observational studies. One biologic h...

    Authors: Martijn de Roon, Anne M. May, Anne McTiernan, Rob J. P. M. Scholten, Petra H. M. Peeters, Christine M. Friedenreich and Evelyn M. Monninkhof

    Citation: Breast Cancer Research 2018 20:81

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