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  1. Content type: Research article

    Systemic and chronic inflammatory conditions in patients with breast cancer have been associated with reduced patient survival and increased breast cancer aggressiveness. This paper characterizes the role of a...

    Authors: Ken Tawara, Celeste Bolin, Jordan Koncinsky, Sujatha Kadaba, Hunter Covert, Caleb Sutherland, Laura Bond, Joseph Kronz, Joel R. Garbow and Cheryl L. Jorcyk

    Citation: Breast Cancer Research 2018 20:53

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  2. Content type: Research article

    Endocrine therapies are the mainstay of treatment for oestrogen receptor (ER)-positive (ER+) breast cancer (BC). However, resistance remains problematic largely due to enhanced cross-talk between ER and growth fa...

    Authors: Ricardo Ribas, Sunil Pancholi, Aradhana Rani, Eugene Schuster, Stephanie K. Guest, Joanna Nikitorowicz-Buniak, Nikiana Simigdala, Allan Thornhill, Francesca Avogadri-Connors, Richard E. Cutler Jr, Alshad S. Lalani, Mitch Dowsett, Stephen R. Johnston and Lesley-Ann Martin

    Citation: Breast Cancer Research 2018 20:44

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  3. Content type: Research article

    Circulating tumor cells (CTCs) carry independent prognostic information in patients with metastatic breast cancer (MBC) on different lines of therapy. Moreover, CTC clusters are suggested to add prognostic inf...

    Authors: Anna-Maria Larsson, Sara Jansson, Pär-Ola Bendahl, Charlotte Levin Tykjaer Jörgensen, Niklas Loman, Cecilia Graffman, Lotta Lundgren, Kristina Aaltonen and Lisa Rydén

    Citation: Breast Cancer Research 2018 20:48

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  4. Content type: Research article

    The percentage of mammographic dense tissue (PD) defined by pixel value threshold is a well-established risk factor for breast cancer. Recently there has been some evidence to suggest that an increased thresho...

    Authors: Chao Wang, Adam R. Brentnall, Jack Cuzick, Elaine F. Harkness, D. Gareth Evans and Susan Astley

    Citation: Breast Cancer Research 2018 20:49

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  5. Content type: Correction

    After the publication of this article [1] we noticed that in Fig. 1, the gel images (1A and 1B lower panel) were incorrect.

    Authors: Anastasios D. Papanastasiou, Chaido Sirinian and Haralabos P. Kalofonos

    Citation: Breast Cancer Research 2018 20:47

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    The original article was published in Breast Cancer Research 2012 14:R112

  6. Content type: Research article

    MicroRNAs (miRNAs) regulate gene expression and influence cancer. Primary transcripts of miRNAs (pri-miRNAs) are poorly annotated and little is known about the role of germline variation in miRNA genes and bre...

    Authors: Jeannette T. Bensen, Mariaelisa Graff, Kristin L. Young, Praveen Sethupathy, Joel Parker, Chad V. Pecot, Kevin Currin, Stephen A. Haddad, Edward A. Ruiz-Narváez, Christopher A. Haiman, Chi-Chen Hong, Lara E. Sucheston-Campbell, Qianqian Zhu, Song Liu, Song Yao, Elisa V. Bandera…

    Citation: Breast Cancer Research 2018 20:45

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  7. Content type: Research article

    Background parenchymal uptake (BPU), which refers to the level of Tc-99m sestamibi uptake within normal fibroglandular tissue on molecular breast imaging (MBI), has been identified as a breast cancer risk fact...

    Authors: Carrie B. Hruska, Jennifer R. Geske, Tiffinee N. Swanson, Alyssa N. Mammel, David S. Lake, Armando Manduca, Amy Lynn Conners, Dana H. Whaley, Christopher G. Scott, Rickey E. Carter, Deborah J. Rhodes, Michael K. O’Connor and Celine M. Vachon

    Citation: Breast Cancer Research 2018 20:46

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  8. Content type: Research article

    Proteolytic impairment of the Fc effector functions of therapeutic monoclonal antibodies (mAbs) can compromise their antitumor efficacy in the tumor microenvironment and may represent an unappreciated mechanis...

    Authors: Hao-Ching Hsiao, Xuejun Fan, Robert E. Jordan, Ningyan Zhang and Zhiqiang An

    Citation: Breast Cancer Research 2018 20:43

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  9. Content type: Research article

    Psychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transc...

    Authors: A. N. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. G. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia and Y. Li

    Citation: Breast Cancer Research 2018 20:42

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  10. Content type: Research article

    The RhoA activating protein Net1 contributes to breast cancer cell proliferation, motility, and invasion in vitro, yet little is known about its roles in mammary gland tumorigenesis and metastasis.

    Authors: Yan Zuo, Arzu Ulu, Jeffrey T. Chang and Jeffrey A. Frost

    Citation: Breast Cancer Research 2018 20:41

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  11. Content type: Short report

    Detection of circulating ESR1 mutations is associated with acquired resistance to aromatase inhibitor (AI) in metastatic breast cancer. Until now, the presence of circulating ESR1 mutations at the end of adjuvant...

    Authors: Violette Allouchery, Ludivine Beaussire, Anne Perdrix, David Sefrioui, Laetitia Augusto, Cécile Guillemet, Nasrin Sarafan-Vasseur, Frédéric Di Fiore and Florian Clatot

    Citation: Breast Cancer Research 2018 20:40

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  12. Content type: Review

    Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and treatment. After a diagnosis of ADH on biopsy a proportio...

    Authors: Tanjina Kader, Prue Hill, Emad A. Rakha, Ian G. Campbell and Kylie L. Gorringe

    Citation: Breast Cancer Research 2018 20:39

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  13. Content type: Research article

    Texture patterns have been shown to improve breast cancer risk segregation in addition to area-based mammographic density. The additional value of texture pattern scores on top of volumetric mammographic densi...

    Authors: Johanna O. P. Wanders, Carla H. van Gils, Nico Karssemeijer, Katharina Holland, Michiel Kallenberg, Petra H. M. Peeters, Mads Nielsen and Martin Lillholm

    Citation: Breast Cancer Research 2018 20:36

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  14. Content type: Research article

    The majority of estrogen receptor-positive (ERα+) breast cancers respond to endocrine therapies. However, resistance to endocrine therapies is common in 30% of cases, which may be due to altered ERα signaling and...

    Authors: Maria B. Padua, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Mayuri S. Prasad, Yangyang Hao, Xi Rao, Sheng Liu, Jun Wan, Yunlong Liu, Kyle McElyea, Max Jacobsen, George Sandusky, Sandra Althouse, Susan Perkins and Harikrishna Nakshatri

    Citation: Breast Cancer Research 2018 20:35

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  15. Content type: Research article

    Cognitive decline is among the most feared treatment-related outcomes of older adults with cancer. The majority of older patients with breast cancer self-report cognitive problems during and after chemotherapy...

    Authors: Bihong T. Chen, Sean K. Sethi, Taihao Jin, Sunita K. Patel, Ningrong Ye, Can-Lan Sun, Russell C. Rockne, E. Mark Haacke, James C. Root, Andrew J. Saykin, Tim A. Ahles, Andrei I. Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan…

    Citation: Breast Cancer Research 2018 20:38

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  16. Content type: Research article

    Rapidly evolving understanding of cancer biology has presented novel opportunities to translate that understanding into clinically relevant therapy. Palbociclib, a novel, first-in-class cyclin-dependent kinase...

    Authors: J. K. Kish, M. A. Ward, D. Garofalo, H. V. Ahmed, L. McRoy, J. Laney, G. Zanotti, J. Braverman, H. Yu and B. A. Feinberg

    Citation: Breast Cancer Research 2018 20:37

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  17. Content type: Research Article

    The main purpose was to investigate the correlation between magnetic resonance imaging (MRI)-based response patterns halfway through neoadjuvant chemotherapy and immunotherapy (NAC) and pathological tumor resp...

    Authors: Briete Goorts, Kelly M. A. Dreuning, Janneke B. Houwers, Loes F. S. Kooreman, Evert-Jan G. Boerma, Ritse M. Mann, Marc B. I. Lobbes and Marjolein L. Smidt

    Citation: Breast Cancer Research 2018 20:34

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  18. Content type: Research article

    Long noncoding RNAs (LncRNAs) represent a class of widespread and diverse endogenous RNAs that can posttranscriptionally regulate gene expression through the interaction with RNA-binding proteins and micro RNA...

    Authors: Yanchun Zhou, Xiuhua Meng, Shaoying Chen, Wei Li, Delin Li, Robert Singer and Wei Gu

    Citation: Breast Cancer Research 2018 20:32

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  19. Content type: Research article

    Breast cancer prognosis is strongly associated with tumor size at diagnosis. We aimed to identify factors associated with diagnosis of large (> 2 cm) compared to small tumors, and to examine implications for l...

    Authors: Fredrik Strand, Keith Humphreys, Johanna Holm, Mikael Eriksson, Sven Törnberg, Per Hall, Edward Azavedo and Kamila Czene

    Citation: Breast Cancer Research 2018 20:31

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  20. Content type: Research Article

    Younger age at onset of breast development, which has been declining in recent decades, is associated with increased breast cancer risk independent of age at menarche. Given the need to study the drivers of th...

    Authors: Lauren C. Houghton, Julia A. Knight, Mary Jane De Souza, Mandy Goldberg, Melissa L. White, Karen O’Toole, Wendy K. Chung, Angela R. Bradbury, Mary B. Daly, Irene L. Andrulis, Esther M. John, Saundra S. Buys and Mary Beth Terry

    Citation: Breast Cancer Research 2018 20:33

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  21. Content type: Research Article

    The ataxia telangiectasia mutated (ATM) gene is a moderate-risk breast cancer susceptibility gene; germline loss-of-function variants are found in up to 3% of hereditary breast and ovarian cancer (HBOC) families ...

    Authors: Anne-Laure Renault, Noura Mebirouk, Laetitia Fuhrmann, Guillaume Bataillon, Eve Cavaciuti, Dorothée Le Gal, Elodie Girard, Tatiana Popova, Philippe La Rosa, Juana Beauvallet, Séverine Eon-Marchais, Marie-Gabrielle Dondon, Catherine Dubois d’Enghien, Anthony Laugé, Walid Chemlali, Virginie Raynal…

    Citation: Breast Cancer Research 2018 20:28

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  22. Content type: Research article

    Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC).

    Authors: Daniele Campa, Myrto Barrdahl, Aurelia Santoro, Gianluca Severi, Laura Baglietto, Hanane Omichessan, Rosario Tumino, H. B(as). Bueno-de-Mesquita, Petra H. Peeters, Elisabete Weiderpass, Maria-Dolores Chirlaque, Miguel Rodríguez-Barranco, Antonio Agudo, Marc Gunter, Laure Dossus, Vittorio Krogh…

    Citation: Breast Cancer Research 2018 20:29

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  23. Content type: Research Article

    Patients with breast cancer who have a pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) have improved survival. We hypothesize that once pCR has been achieved, there is no difference in subse...

    Authors: Anna Weiss, Sami I. Bashour, Kenneth Hess, Alastair M. Thompson and Nuhad K. Ibrahim

    Citation: Breast Cancer Research 2018 20:27

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  24. Content type: Research article

    The recommendation for chemotherapy in early-stage breast cancer patients has been refined by the 21-gene Recurrence Score. However, uncertainty remains whether patients in the Intermediate Risk category benef...

    Authors: Jonathan Chen, Xian Wu, Paul J. Christos, Silvia Formenti and Himanshu Nagar

    Citation: Breast Cancer Research 2018 20:26

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  25. Content type: Research Article

    The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. ...

    Authors: Wen-Shan Liu, Shih-Hsuan Chan, Hong-Tai Chang, Guan-Cheng Li, Ya-Ting Tu, Hui-Hwa Tseng, Ting-Ying Fu, Hui-Yu Chang, Huei-Han Liou, Luo-Ping Ger and Kuo-Wang Tsai

    Citation: Breast Cancer Research 2018 20:25

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  26. Content type: Research article

    The interaction of breast cancer cells with other cells in the tumor microenvironment plays an important role in metastasis. Invasion and intravasation, two critical steps in the metastatic process, are influe...

    Authors: Ramon M. Cabrera, Serena P. H. Mao, Chinmay R. Surve, John S. Condeelis and Jeffrey E. Segall

    Citation: Breast Cancer Research 2018 20:24

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  27. Content type: Research Article

    Mammographic density (MD) is an established predictor of risk of a first breast cancer, but the relationship of MD to contralateral breast cancer (CBC) risk is not clear, including the roles of age, mammogram ...

    Authors: Julia A. Knight, Kristina M. Blackmore, Jing Fan, Kathleen E. Malone, Esther M. John, Charles F. Lynch, Celine M. Vachon, Leslie Bernstein, Jennifer D. Brooks, Anne S. Reiner, Xiaolin Liang, Meghan Woods and Jonine L. Bernstein

    Citation: Breast Cancer Research 2018 20:23

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  28. Content type: Research Article

    Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy. In order to identify abnormalities and possibl...

    Authors: Anne Sofie Froelunde, Marit Ohlenbusch, Kristoffer B. Hansen, Nicolai Jessen, Sukhan Kim and Ebbe Boedtkjer

    Citation: Breast Cancer Research 2018 20:20

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  29. Content type: Research Article

    Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer. This study explored novel serum proteins as surrog...

    Authors: Bashar Zeidan, Antigoni Manousopoulou, Diana J. Garay-Baquero, Cory H. White, Samantha E. T. Larkin, Kathleen N. Potter, Theodoros I. Roumeliotis, Evangelia K. Papachristou, Ellen Copson, Ramsey I. Cutress, Stephen A. Beers, Diana Eccles, Paul A. Townsend and Spiros D. Garbis

    Citation: Breast Cancer Research 2018 20:19

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  30. Content type: Research Article

    Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressors in breast cancer. While PTEN itself is not considered a druggable target, PTEN synthetic-sick or synthetic-leth...

    Authors: Yew Chung Tang, Szu-Chi Ho, Elisabeth Tan, Alvin Wei Tian Ng, John R. McPherson, Germaine Yen Lin Goh, Bin Tean Teh, Frederic Bard and Steven G. Rozen

    Citation: Breast Cancer Research 2018 20:22

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  31. Content type: Research Article

    Breast cancer (BC) is a heterogeneous disease characterised by variant biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC although its impact on patient outcome in different BC...

    Authors: Rokaya El Ansari, Madeleine L. Craze, Islam Miligy, Maria Diez-Rodriguez, Christopher C. Nolan, Ian O. Ellis, Emad A. Rakha and Andrew R. Green

    Citation: Breast Cancer Research 2018 20:21

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  32. Content type: Research Article

    The Gail model has been widely used and validated with conflicting results. The current study aims to evaluate the performance of different versions of the Gail model by means of systematic review and meta-ana...

    Authors: Xin Wang, Yubei Huang, Lian Li, Hongji Dai, Fengju Song and Kexin Chen

    Citation: Breast Cancer Research 2018 20:18

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  33. Content type: Research Article

    Our purpose is to develop a testable biological hypothesis to explain the known increased risk of breast cancer associated with extensive percent mammographic density (PMD), and to reconcile the apparent parad...

    Authors: Norman Boyd, Hal Berman, Jie Zhu, Lisa J. Martin, Martin J. Yaffe, Sofia Chavez, Greg Stanisz, Greg Hislop, Anna M. Chiarelli, Salomon Minkin and Andrew D. Paterson

    Citation: Breast Cancer Research 2018 20:17

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  34. Content type: Research Article

    The clinical importance of tumor-infiltrating cluster of differentiation 4 (CD4) T cells is incompletely understood in early breast cancer. We investigated the clinical significance of CD4, forkhead box P3 (FO...

    Authors: Marcus Schmidt, Veronika Weyer-Elberich, Jan G. Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Aslihan Gerhold-Ay, Antje Lebrecht, Marco J. Battista, Annette Hasenburg, Ugur Sahin, Konstantine T. Kalogeras, Pirkko-Liisa Kellokumpu-Lehtinen, George Fountzilas, Ralph M. Wirtz and Heikki Joensuu

    Citation: Breast Cancer Research 2018 20:15

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  35. Content type: Research Article

    Mammographic breast density is one of the strongest risk factors for breast cancer, but molecular understanding of how breast density relates to cancer risk is less complete. Studies of proteins in blood plasm...

    Authors: Sanna Byström, Martin Eklund, Mun-Gwan Hong, Claudia Fredolini, Mikael Eriksson, Kamila Czene, Per Hall, Jochen M. Schwenk and Marike Gabrielson

    Citation: Breast Cancer Research 2018 20:14

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  36. Content type: Research Article

    Breast magnetic resonance imaging (MRI) has been reported to frequently result in false-positive diagnoses, limiting its positive predictive value (PPV). However, for PPV calculation, all nonmalignant tissue c...

    Authors: Christiane K. Kuhl, Annika Keulers, Kevin Strobel, Hannah Schneider, Nadine Gaisa and Simone Schrading

    Citation: Breast Cancer Research 2018 20:13

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  37. Content type: Research Article

    Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional ma...

    Authors: Emma H. Allott, Joseph Geradts, Stephanie M. Cohen, Thaer Khoury, Gary R. Zirpoli, Wiam Bshara, Warren Davis, Angela Omilian, Priya Nair, Rochelle P. Ondracek, Ting-Yuan David Cheng, C. Ryan Miller, Helena Hwang, Leigh B. Thorne, Siobhan O’Connor, Traci N. Bethea…

    Citation: Breast Cancer Research 2018 20:12

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  38. Content type: Research Article

    High mammographic density is associated with both risk of cancers being missed at mammography, and increased risk of developing breast cancer. Stratification of breast cancer prevention and screening requires ...

    Authors: Susan M. Astley, Elaine F. Harkness, Jamie C. Sergeant, Jane Warwick, Paula Stavrinos, Ruth Warren, Mary Wilson, Ursula Beetles, Soujanya Gadde, Yit Lim, Anil Jain, Sara Bundred, Nicola Barr, Valerie Reece, Adam R. Brentnall, Jack Cuzick…

    Citation: Breast Cancer Research 2018 20:10

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  39. Content type: Research Article

    As only a minor portion of the information present in histological sections is accessible by eye, recognition and quantification of complex patterns and relationships among constituents relies on digital image...

    Authors: I. Roxanis, R. Colling, C. Kartsonaki, A. R. Green and E A. Rakha

    Citation: Breast Cancer Research 2018 20:11

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  40. Content type: Research Article

    The Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1 increases protein stability and function. We identify a novel signaling axis...

    Authors: Matthew G. Annis, Veronique Ouellet, Jonathan P. Rennhack, Sylvain L’Esperance, Claudine Rancourt, Anne-Marie Mes-Masson, Eran R. Andrechek and Peter M. Siegel

    Citation: Breast Cancer Research 2018 20:9

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  41. Content type: Research Article

    Germline mutations in the BRIP1 gene have been described as conferring a moderate risk for ovarian cancer (OC), while the role of BRIP1 in breast cancer (BC) pathogenesis remains controversial.

    Authors: Nana Weber-Lassalle, Jan Hauke, Juliane Ramser, Lisa Richters, Eva Groß, Britta Blümcke, Andrea Gehrig, Anne-Karin Kahlert, Clemens R. Müller, Karl Hackmann, Ellen Honisch, Konstantin Weber-Lassalle, Dieter Niederacher, Julika Borde, Holger Thiele, Corinna Ernst…

    Citation: Breast Cancer Research 2018 20:7

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  42. Content type: Research article

    Preeclampsia is frequently linked to reduced breast cancer risk. However, little is known regarding the underlying genetic association and the association between preeclampsia and mammographic density.

    Authors: Haomin Yang, Wei He, Mikael Eriksson, Jingmei Li, Natalie Holowko, Flaminia Chiesa, Per Hall and Kamila Czene

    Citation: Breast Cancer Research 2018 20:6

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  43. Content type: Research article

    Although it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations d...

    Authors: Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Kathleen E. Malone, Polly A. Marchbanks, Jill A. McDonald, Michael S. Simon, Suzanne G. Folger, Yani Lu, Jane Sullivan-Halley, Dennis M. Deapen, Michael F. Press and Leslie Bernstein

    Citation: Breast Cancer Research 2018 20:5

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  44. Content type: Research Article

    Nearly 50% of breast cancer patients suffer from depression or anxiety. Selective serotonin reuptake inhibitors (SSRIs), the first-line pharmacological treatment for depression, have been implicated in breast ...

    Authors: John Busby, Ken Mills, Shu-Dong Zhang, Fabio Giuseppe Liberante and Chris R. Cardwell

    Citation: Breast Cancer Research 2018 20:4

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  45. Content type: Research Article

    Genome-wide association studies (GWASs) have identified numerous single-nucleotide polymorphisms (SNPs) associated with small increases in breast cancer risk. Studies to date suggest that some SNPs alter the e...

    Authors: Na Li, Simone M. Rowley, Ella R. Thompson, Simone McInerny, Lisa Devereux, Kaushalya C. Amarasinghe, Magnus Zethoven, Richard Lupat, David Goode, Jason Li, Alison H. Trainer, Kylie L. Gorringe, Paul A. James and Ian G. Campbell

    Citation: Breast Cancer Research 2018 20:3

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  46. Content type: Research Article

    It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) ...

    Authors: Linnea Huss, Salma Tunå Butt, Peter Almgren, Signe Borgquist, Jasmine Brandt, Asta Försti, Olle Melander and Jonas Manjer

    Citation: Breast Cancer Research 2018 20:1

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  47. Content type: Research Article

    Disseminated tumor cells (DTCs) found in the bone marrow (BM) of patients with breast cancer portend a poor prognosis and are thought to be intermediaries in the metastatic process. To assess the clinical rele...

    Authors: Sreeraj G. Pillai, Shunqiang Li, Chidananda M. Siddappa, Matthew J Ellis, Mark A. Watson and Rebecca Aft

    Citation: Breast Cancer Research 2018 20:2

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