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  1. We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no a...

    Authors: Christopher A Haiman, Susan E Hankinson, Donna Spiegelman, Graham A Colditz, Walter C Willett, Frank E Speizer, Myles Brown and David J Hunter
    Citation: Breast Cancer Research 2000 2:378
  2. Estrogen receptors are members of the nuclear receptor steroid family that exhibit specific structural features, ligand-binding domain sequence identity and dimeric interactions, that single them out. The crys...

    Authors: Marc Ruff, Monique Gangloff, Jean Marie Wurtz and Dino Moras
    Citation: Breast Cancer Research 2000 2:353
  3. Natural, synthetic and environmental estrogens have numerous effects on the development and physiology of mammals. Estrogen is primarily known for its role in the development and functioning of the female repr...

    Authors: Sylvia Curtis Hewitt, John F Couse and Kenneth S Korach
    Citation: Breast Cancer Research 2000 2:345
  4. Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone ...

    Authors: Benita S Katzenellenbogen and John A Katzenellenbogen
    Citation: Breast Cancer Research 2000 2:335
  5. Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and hi...

    Authors: Gloria H Heppner, Fred R Miller and PV Malathy Shekhar
    Citation: Breast Cancer Research 2000 2:331
  6. An association between protein glycosylation and tumorigenesis has been recognized for over 10 years. Associations linking the importance of glycosylation events to tumor biology, especially the progression to...

    Authors: Christine Couldrey and Jeffrey E Green
    Citation: Breast Cancer Research 2000 2:321
  7. Mammography is an effective screening modality for the early detection of breast cancer. The reduction in breast cancer mortality is greater for women aged over 50 at screening than for women aged under 50. Ma...

    Authors: Nick Day and Ruth Warren
    Citation: Breast Cancer Research 2000 2:247
  8. The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrat...

    Authors: Andrew C Phillips and Karen H Vousden
    Citation: Breast Cancer Research 2000 2:244
  9. New guidelines for the collection and use of human tissues for research will impose new requirements on researchers to seek ethical approval and patient consent. This extends to the use of surplus tissue, such...

    Authors: Mitch Dowsett
    Citation: Breast Cancer Research 2000 2:241
  10. The use of human tissue, and material derived from such tissue, for research purposes is currently the subject of much debate. This debate needs to address several issues, including: the principle of abandonme...

    Authors: Wendy Prime, Mark E Sobel and C Simon Herrington
    Citation: Breast Cancer Research 2000 2:237

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