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  1. The ability of growth factors and their cognate receptors to induce mammary epithelial proliferation and differentiation is dependent on their ability to activate a number of specific signal transduction pathw...

    Authors: Eran R Andrechek and William J Muller
    Citation: Breast Cancer Research 2000 2:211
  2. Both the non-receptor tyrosine kinase, c-Src, and members of the epidermal growth factor (EGF) receptor family are overexpressed in high percentages of human breast cancers. Because these molecules are plasma ...

    Authors: Jacqueline S Biscardi, Rumey C Ishizawar, Corinne M Silva and Sarah J Parsons
    Citation: Breast Cancer Research 2000 2:203
  3. The past decade has seen the definition of key signalling pathways downstream of receptor tyrosine kinases (RTKs) in terms of their components and the protein-protein interactions that facilitate signal transd...

    Authors: Rania Kairouz and Roger J Daly
    Citation: Breast Cancer Research 2000 2:197
  4. The fibroblast growth factors [Fgfs (murine), FGFs (human)] constitute a large family of ligands that signal through a class of cell-surface tyrosine kinase receptors. Fgf signalling has been associated in vitro ...

    Authors: Clive Dickson, Bradley Spencer-Dene, Christian Dillon and Vera Fantl
    Citation: Breast Cancer Research 2000 2:191
  5. Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has b...

    Authors: Norbert Prenzel, Esther Zwick, Michael Leserer and Axel Ullrich
    Citation: Breast Cancer Research 2000 2:184
  6. Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and paracrine factors to signalling molecules on neighbouring cells. Receptors of the tyrosine kinase family play an important r...

    Authors: Nancy E Hynes
    Citation: Breast Cancer Research 2000 2:154
  7. The mammary epithelium undergoes cyclical periods of cellular proliferation, differentiation and regression. These processes are under the control of the hormones secreted during pregnancy, lactation and invol...

    Authors: Bernd Groner and Lothar Hennighausen
    Citation: Breast Cancer Research 2000 2:149
  8. We previously reported that ductal infiltrating carcinomas (DIC) of the human breast display profound modifications of the stromal architecture, associated with anomalous collagen composition. The major altera...

    Authors: Ida Pucci-Minafra, Cintia Carella, Rosalia Cirincione, Silvana Chimenti, Salvatore Minafra and Claudio Luparello
    Citation: Breast Cancer Research 2000 2:E008
  9. Altered responsiveness to extracellular signals and cell cycle dysregulation are hallmarks of cancer. The cell cycle is governed by cyclin-dependent kinases (cdks) that integrate mitogenic and growth inhibitor...

    Authors: Jeffrey Donovan and Joyce Slingerland
    Citation: Breast Cancer Research 2000 2:116

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