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Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a c...
PARP-1 (polyADP-ribose polymerase-1) is known to be activated in response to DNA damage, and activated PARP-1 promotes DNA repair. However, a recently disclosed alternative mechanism of PARP-1 activation by ph...
Hes-6 is a member of the basic helix-loop-helix (bHLH) family of transcription factors, and its overexpression has been reported in metastatic cancers of different origins. Hes-6 has been described as an inhib...
Androgens have important physiological effects in women while at the same time they may be implicated in breast cancer pathologies. However, data on the effects of androgens on mammary epithelial proliferation...
Alterations in cell cycle regulators have been implicated in human malignancies including breast cancer. PD 0332991 is an orally active, highly selective inhibitor of the cyclin D kinases (CDK)4 and CDK6 with ...
Aromatase inhibitors are currently included in the 'optimal' management of early-stage breast cancer. Uncertainty remains, however, as to the most appropriate treatment strategy, particularly for newly diagnos...
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 11 Supplement 2
Women who carry mutations in BRCA1 and BRCA2 have a substantially increased risk of developing breast cancer as compared with the general population. However, risk estimates range from 20 to 80%, suggesting the p...
Myc has been intensely studied since its discovery more than 25 years ago. Insight has been gained into Myc's function in normal physiology, where its role appears to be organ specific, and in cancer where man...
γ-Secretase inhibitors are new anti-cancer agents targeting Notch signaling. Their specificity for Notch is as yet unclear. Han and colleagues investigated the effects of Z-LeuLeuNleu-CHO on growth of breast c...
Previous studies in mouse models and pilot epidemiology studies have demonstrated that inherited polymorphisms are associated with inherited risk of tumor progression and poor outcome in human breast cancer. T...
Proteasome inhibition provides an attractive approach to cancer therapy and may have application in the treatment of breast cancer. However, results of recent clinical trials to evaluate the effect of the prot...
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