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We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no a...
Estrogen signaling has turned out to be much more complex and exciting than previously thought; the paradigm shift in our understanding of estrogen action came in 1996, when the presence of a new estrogen rece...
Estrogen receptors are members of the nuclear receptor steroid family that exhibit specific structural features, ligand-binding domain sequence identity and dimeric interactions, that single them out. The crys...
Natural, synthetic and environmental estrogens have numerous effects on the development and physiology of mammals. Estrogen is primarily known for its role in the development and functioning of the female repr...
Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone ...
Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and hi...
Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major hereditary bre...
An association between protein glycosylation and tumorigenesis has been recognized for over 10 years. Associations linking the importance of glycosylation events to tumor biology, especially the progression to...
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
This article is part of a Supplement: Volume 2 Supplement 2
The fibroblast growth factor receptor (FGFR)2 gene has been shown to be amplified in 5-10% of breast cancer patients. A breast cancer cell line developed in our laboratory, SUM-52PE, was shown to have a 12-fol...
Protein truncation test (PTT) and single-strand conformation polymorphism (SSCP) assay were used to scan the BRCA1 and BRCA2 genes in 136 unrelated Italian breast/ovarian cancer patients. In the sample tested, BR...
The development of intervention strategies for carriers of mutations in the BRCA1 and BRCA2 genes has several considerations. The first are primary prevention and secondary prevention in unaffected carriers using...
Risk factors for breast cancer are related to endogenous hormonesand reproductive events. As such, traditional cancer prevention strategies arenot easily applicable. Tamoxifen and other selective estrogen rece...
The potential for a reduction in dietary fat or for an increase in dietary fiber to reduce breast cancer risk has been debated for some years. It is argued here that available research data, even though extens...
The cyclic production of estrogen and progesterone by the premenopausal ovary accounts for the steep rise in breast cancer risk in premenopausal women. These hormones are breast cell mitogens. By reducing expo...
The available results from breast cancer chemoprevention trials are reviewed. Four trials using tamoxifen have been performed, of which three have reported efficacy results. A fifth trial using raloxifene has ...
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases. Their primary function is degradation of proteins in the extracellular matrix. Currently, at least 19 members of this family ...
Mammography is an effective screening modality for the early detection of breast cancer. The reduction in breast cancer mortality is greater for women aged over 50 at screening than for women aged under 50. Ma...
The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrat...
New guidelines for the collection and use of human tissues for research will impose new requirements on researchers to seek ethical approval and patient consent. This extends to the use of surplus tissue, such...
The use of human tissue, and material derived from such tissue, for research purposes is currently the subject of much debate. This debate needs to address several issues, including: the principle of abandonme...
We describe here the expression pattern of the breast cell growthinhibitor Mammastatin in normal and breast cancer cells. Normal Cells (NHMC)over-express Mammastatin in low calcium media. Mammastatin has been ...
Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and paracrine factors to signalling molecules on neighbouring cells. Receptors of the tyrosine kinase family play an important r...
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