Borowsky AD. Choosing a mouse model: experimental biology in context—the utility and limitations of mouse models of breast cancer. Cold Spring Harb Perspect Biol. 2011;3(9):a009670.
Article
PubMed
PubMed Central
Google Scholar
Chan SR, Vermi W, Luo J, Lucini L, Rickert C, Fowler AM, Lonardi S, Arthur C, Young LJ, Levy DE, et al. STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas. Breast Cancer Res. 2012;14(1):R16.
Article
CAS
PubMed
PubMed Central
Google Scholar
van Bragt MP, Hu X, Xie Y, Li Z. RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells. Elife. 2014;3, e03881.
PubMed
PubMed Central
Google Scholar
Cardiff RD, Anver MR, Gusterson BA, Hennighausen L, Jensen RA, Merino MJ, Rehm S, Russo J, Tavassoli FA, Wakefield LM, et al. The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene. 2000;19(8):968–88.
Article
CAS
PubMed
Google Scholar
Cardiff RD, Munn RJ, Galvez JJ. The tumor pathology of genetically engineered mice: a new approach to molecular pathology. In: Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, editors. The mouse in biomedical research. Vol. II: Diseases. 2nd ed. San Diego: Academic Press/Elsevier; 2007. p. 581–622.
Chapter
Google Scholar
Cardiff RD, Wellings SR. The comparative pathology of human and mouse mammary glands. J Mammary Gland Biol Neoplasia. 1999;4(1):105–22.
Article
CAS
PubMed
Google Scholar
Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE, Engelberg JA, Tepper CG, Willis BJ, Khan IH, et al. Abnormal mammary development in 129:STAT1-null mice is stroma-dependent. PLoS One. 2015;10(6), e0129895.
Article
PubMed
PubMed Central
Google Scholar
LaBarge MA, Mora-Blanco EL, Samson S, Miyano M. Breast cancer beyond the age of mutation. Gerontology. 2016;62(4):434–42.
Article
CAS
PubMed
Google Scholar
Cardiff RD. How to phenotype a mouse. Dis Model Mech. 2009;2(7-8):317–21.
Article
PubMed
Google Scholar
Cardiff RD, Miller CH, Munn RJ, Galvez JJ. Structured reporting in anatomic pathology for coclinical trials: the caELMIR model. Cold Spring Harb Protoc. 2014;2014(1):32–43.
Article
PubMed
Google Scholar
Cardiff RD, Miller CH, Munn RJ. Limited mouse necropsy. Cold Spring Harb Protoc. doi:10.1101/pdb.prot073395.
Cardiff RD, Miller CH, Munn RJ. Analysis of mouse model pathology: a primer for studying the anatomic pathology of genetically engineered mice. Cold Spring Harb Protoc. 2014;2014(6):561–80.
PubMed
Google Scholar
Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, Schreiber RD. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A. 1998;95(13):7556–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996;84(3):431–42.
Article
CAS
PubMed
Google Scholar
Späth GF, Schlesinger P, Schreiber R, Beverley SM. A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major. PLoS Pathog. 2009;5(4), e1000381.
Article
PubMed
PubMed Central
Google Scholar
Chan SR, Rickert CG, Vermi W, Sheehan KC, Arthur C, Allen JA, White JM, Archambault J, Lonardi S, McDevitt TM, et al. Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα+ tumorigenesis. Cell Death Differ. 2014;21(2):234–46.
Article
CAS
PubMed
Google Scholar
Griffith OL, Chan SR, Griffith M, Krysiak K, Skidmore ZL, Hundal J, Allen JA, Arthur CD, Runci D, Bugatti M, et al. Truncating prolactin receptor mutations promote tumor growth in murine estrogen receptor-α mammary carcinomas. Cell Rep. 2016;17(1):249–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Klover PJ, Muller WJ, Robinson GW, Pfeiffer RM, Yamaji D, Hennighausen L. Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. Neoplasia. 2010;12(11):899–905.
Article
CAS
PubMed
PubMed Central
Google Scholar
Koromilas AE, Sexl V. The tumor suppressor function of STAT1 in breast cancer. JAKSTAT. 2013;2(2), e23353.
PubMed
PubMed Central
Google Scholar
Raven JF, Williams V, Wang S, Tremblay ML, Muller WJ, Durbin JE, Koromilas AE. Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle. 2011;10(5):794–804.
Article
CAS
PubMed
Google Scholar
Schneckenleithner C, Bago-Horvath Z, Dolznig H, Neugebauer N, Kollmann K, Kolbe T, Decker T, Kerjaschki D, Wagner KU, Muller M, et al. Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias. Oncotarget. 2011;2(12):1043–54.
Article
PubMed
PubMed Central
Google Scholar
Borowsky AD, Namba R, Young LJ, Hunter KW, Hodgson JG, Tepper CG, McGoldrick ET, Muller WJ, Cardiff RD, Gregg JP. Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior. Clin Exp Metastasis. 2005;22(1):47–59.
Article
CAS
PubMed
Google Scholar
Shao Y, Shen Y, Chen T, Xu F, Chen X, Zheng S. The functions and clinical applications of tumor-derived exosomes. Oncotarget. 2016;7(37):60736–51.
Article
PubMed
PubMed Central
Google Scholar
Mori H, Soonsawad P, Schuetter L, Chen Q, Hubbard NE, Cardiff RD, Borowsky AD. Introduction of zinc-salt fixation for effective detection of immune cell-related markers by immunohistochemistry. Toxicol Pathol. 2015;43(6):883–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Stack EC, Wang C, Roman KA, Hoyt CC. Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of tyramide signal amplification, multispectral imaging and multiplex analysis. Methods. 2014;70(1):46–58.
Article
CAS
PubMed
Google Scholar
Miller JK, Shattuck DL, Ingalla EQ, Yen L, Borowsky AD, Young LJ, Cardiff RD. Carraway 3rd KL, Sweeney C. Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer. Cancer Res. 2008;68(20):8286–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cardiff RD, Hubbard NE, Engelberg JA, Munn RJ, Miller CH, Walls JE, Chen JQ, Velasquez-Garcia HA, Galvez JJ, Bell KJ, et al. Quantitation of fixative-induced morphologic and antigenic variation in mouse and human breast cancers. Lab Invest. 2013;93(4):480–97.
Article
CAS
PubMed
Google Scholar
Kanda T, Sullivan KF, Wahl GM. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol. 1998;8(7):377–85.
Article
CAS
PubMed
Google Scholar
Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainier DY, et al. The perivascular niche regulates breast tumour dormancy. Nat Cell Biol. 2013;15(7):807–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mori H, Bhat R, Bruni-Cardoso A, Chen EI, Jorgens DM, Coutinho K, Louie K, Bowen BB, Inman JL, Tecca V, et al. New insight into the role of MMP14 in metabolic balance. PeerJ. 2016;4, e2142.
Article
PubMed
PubMed Central
Google Scholar
Cardiff RD, Sinn E, Muller W, Leder P. Transgenic oncogene mice: tumor phenotype predicts genotype. Am J Pathol. 1991;139(3):495–501.
CAS
PubMed
PubMed Central
Google Scholar
Veltmaat JM, Ramsdell AF, Sterneck E. Positional variations in mammary gland development and cancer. J Mammary Gland Biol Neoplasia. 2013;18(2):179–88.
Article
PubMed
PubMed Central
Google Scholar
Brayton CF, Treuting PM, Ward JM. Pathobiology of aging mice and GEM: background strains and experimental design. Vet Pathol. 2012;49(1):85–105.
Article
CAS
PubMed
Google Scholar
Nieto AI, Shyamala G, Galvez JJ, Thordarson G, Wakefield LM, Cardiff RD. Persistent mammary hyperplasia in FVB/N mice. Comp Med. 2003;53(4):433–8.
CAS
PubMed
Google Scholar
Lee SH, Ichii O, Otsuka S, Elewa YH, Namiki Y, Hashimoto Y, Kon Y. Ovarian cysts in MRL/MpJ mice are derived from the extraovarian rete: a developmental study. J Anat. 2011;219(6):743–55.
Article
PubMed
PubMed Central
Google Scholar
Long GG. Apparent mesonephric duct (rete anlage) origin for cysts and proliferative epithelial lesions in the mouse ovary. Toxicol Pathol. 2002;30(5):592–8.
Article
PubMed
Google Scholar
Cardiff RD, Anver MR, Boivin GP, Bosenberg MW, Maronpot RR, Molinolo AA, Nikitin AY, Rehg JE, Thomas GV, Russell RG, et al. Precancer in mice: animal models used to understand, prevent, and treat human precancers. Toxicol Pathol. 2006;34(6):699–707.
Article
PubMed
Google Scholar
Rosner A, Miyoshi K, Landesman-Bollag E, Xu X, Seldin DC, Moser AR, MacLeod CL, Shyamala G, Gillgrass AE, Cardiff RD. Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am J Pathol. 2002;161(3):1087–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hegde PS, Karanikas V, Evers S. The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition. Clin Cancer Res. 2016;22(8):1865–74.
Article
CAS
PubMed
Google Scholar
Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol. 2015;17(6):816–26.
Article
CAS
PubMed
Google Scholar
Henry CJ, Marusyk A, DeGregori J. Aging-associated changes in hematopoiesis and leukemogenesis: what’s the connection? Aging (Albany NY). 2011;3(6):643–56.
Article
CAS
Google Scholar
DeGregori J. Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age? Oncogene. 2013;32(15):1869–75.
Article
CAS
PubMed
Google Scholar
Rozhok AI, Salstrom JL, DeGregori J. Stochastic modeling indicates that aging and somatic evolution in the hematopoietic system are driven by non-cell-autonomous processes. Aging (Albany NY). 2014;6(12):1033–48.
Article
Google Scholar
Flurkey K, Currer JM, Harrison DE. The mouse in aging research. In: Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, editors. The mouse in biomedical research. Volume III: Normative biology, husbandry, and models. 2nd ed. San Diego: Academic Press/Elsevier; 2007. p. 637–72.
Chapter
Google Scholar
Hovey RC, Trott JF, Ginsburg E, Goldhar A, Sasaki MM, Fountain SJ, Sundararajan K, Vonderhaar BK. Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland. Dev Dyn. 2001;222(2):192–205.
Article
CAS
PubMed
Google Scholar
Arendt LM, Rugowski DE, Grafwallner-Huseth TA, Garcia-Barchino MJ, Rui H, Schuler LA. Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer. Breast Cancer Res. 2011;13(1):R11.
Article
PubMed
PubMed Central
Google Scholar
Horigan KC, Trott JF, Barndollar AS, Scudder JM, Blauwiekel RM, Hovey RC. Hormone interactions confer specific proliferative and histomorphogenic responses in the porcine mammary gland. Domest Anim Endocrinol. 2009;37(2):124–38.
Article
CAS
PubMed
Google Scholar
Rose-Hellekant TA, Arendt LM, Schroeder MD, Gilchrist K, Sandgren EP, Schuler LA. Prolactin induces ERα-positive and ERα-negative mammary cancer in transgenic mice. Oncogene. 2003;22(30):4664–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ormandy CJ, Hall RE, Manning DL, Robertson JF, Blamey RW, Kelly PA, Nicholson RI, Sutherland RL. Coexpression and cross-regulation of the prolactin receptor and sex steroid hormone receptors in breast cancer. J Clin Endocrinol Metab. 1997;82(11):3692–9.
CAS
PubMed
Google Scholar
Barcus CE, Holt EC, Keely PJ, Eliceiri KW, Schuler LA. Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells. PLoS One. 2015;10(1), e0116891.
Article
PubMed
PubMed Central
Google Scholar
Jozwik KM, Carroll JS. Pioneer factors in hormone-dependent cancers. Nat Rev Cancer. 2012;12(6):381–5.
Article
CAS
PubMed
Google Scholar
Zaret KS, Carroll JS. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 2011;25(21):2227–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang G, Zhao Y, Liu Y, Kao LP, Wang X, Skerry B, Li Z. FOXA1 defines cancer cell specificity. Sci Adv. 2016;2(3), e1501473.
Article
PubMed
PubMed Central
Google Scholar
Liu Y, Zhao Y, Skerry B, Wang X, Colin-Cassin C, Radisky DC, Kaestner KH, Li Z. Foxa1 is essential for mammary duct formation. Genesis. 2016;54(5):277–85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bernardo GM, Keri RA. FOXA1: a transcription factor with parallel functions in development and cancer. Biosci Rep. 2012;32(2):113–30.
Article
CAS
PubMed
Google Scholar
Tarulli GA, Laven-Law G, Shakya R, Tilley WD, Hickey TE. Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation. J Mammary Gland Biol Neoplasia. 2015;20(1-2):75–91.
Article
PubMed
Google Scholar
Smith GH, Medina D. A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J Cell Sci. 1988;90(Pt 1):173–83.
PubMed
Google Scholar
Chepko G, Smith GH. Mammary epithelial stem cells: our current understanding. J Mammary Gland Biol Neoplasia. 1999;4(1):35–52.
Article
CAS
PubMed
Google Scholar
Smith CA, Monaghan P, Neville AM. Basal clear cells of the normal human breast. Virchows Arch A Pathol Anat Histopathol. 1984;402(3):319–29.
Article
CAS
PubMed
Google Scholar
Stirling JW, Chandler JA. The fine structure of the normal, resting terminal ductal-lobular unit of the female breast. Virchows Arch A Pathol Anat Histol. 1976;372(3):205–26.
Article
CAS
PubMed
Google Scholar
Stirling JW, Chandler JA. The fine structure of ducts and subareolar ducts in the resting gland of the female breast. Virchows Arch A Pathol Anat Histol. 1977;373(2):119–32.
Article
CAS
PubMed
Google Scholar
Toker C. Observations on the ultrastructure of a mammary ductule. J Ultrastruct Res. 1967;21(1):9–25.
Article
CAS
PubMed
Google Scholar
Shehata M, Teschendorff A, Sharp G, Novcic N, Russell IA, Avril S, Prater M, Eirew P, Caldas C, Watson CJ, et al. Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res. 2012;14(5):R134.
Article
CAS
PubMed
PubMed Central
Google Scholar
Taylor RA, Wang H, Wilkinson SE, Richards MG, Britt KL, Vaillant F, Lindeman GJ, Visvader JE, Cunha GR, St John J, et al. Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers. Stem Cells. 2009;27(12):3032–42.
CAS
PubMed
Google Scholar
Andrechek ER, Hardy WR, Siegel PM, Rudnicki MA, Cardiff RD, Muller WJ. Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc Natl Acad Sci U S A. 2000;97(7):3444–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jensen HM, Rice JR, Wellings SR. Preneoplastic lesions in the human breast. Science. 1976;191(4224):295–7.
Article
CAS
PubMed
Google Scholar
Wellings SR, Jensen HM. On the origin and progression of ductal carcinoma in the human breast. J Natl Cancer Inst. 1973;50(5):1111–8.
Article
CAS
PubMed
Google Scholar
Wellings SR, Jensen HM, DeVault MR. Persistent and atypical lobules in the human breast may be precancerous. Experientia. 1976;32(11):1463–5.
Article
CAS
PubMed
Google Scholar
Wellings SR, Jensen HM, Marcum RG. An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J Natl Cancer Inst. 1975;55(2):231–73.
CAS
PubMed
Google Scholar
Going JJ. Lobar anatomy of human breast and its importance for breast cancer. In: Tot T, editor. Breast cancer: a lobar disease. London: Springer; 2011. p. 19–37.
Google Scholar
Going JJ, Mohun TJ. Human breast duct anatomy, the ‘sick lobe’ hypothesis and intraductal approaches to breast cancer. Breast Cancer Res Treat. 2006;97(3):285–91.
Article
PubMed
Google Scholar
Tot T. Subgross morphology, the sick lobe hypothesis, and the success of breast conservation. Int J Breast Cancer. 2011;2011:634021.
Article
PubMed
PubMed Central
Google Scholar
Sanders ME, Schuyler PA, Simpson JF, Page DL, Dupont WD. Continued observation of the natural history of low-grade ductal carcinoma in situ reaffirms proclivity for local recurrence even after more than 30 years of follow-up. Mod Pathol. 2015;28(5):662–9.
Article
PubMed
Google Scholar
Haricharan S, Hein SM, Dong J, Toneff MJ, Aina OH, Rao PH, Cardiff RD, Li Y. Contribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer. Oncogene. 2014;33(50):5729–39.
Article
CAS
PubMed
Google Scholar
Turpin J, Ling C, Crosby EJ, Hartman ZC, Simond AM, Chodosh LA, Rennhack JP, Andrechek ER, Ozcelik J, Hallett M, et al. The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment. Oncogene. 2016;35(47):6053–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Molyneux G, Smalley MJ. The cell of origin of BRCA1 mutation-associated breast cancer: a cautionary tale of gene expression profiling. J Mammary Gland Biol Neoplasia. 2011;16(1):51–5.
Article
PubMed
Google Scholar
Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med. 2009;15(8):907–13.
Article
CAS
PubMed
Google Scholar
Santagata S, Thakkar A, Ergonul A, Wang B, Woo T, Hu R, Harrell JC, McNamara G, Schwede M, Culhane AC, et al. Taxonomy of breast cancer based on normal cell phenotype predicts outcome. J Clin Invest. 2014;124(2):859–70.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fantozzi A, Christofori G. Mouse models of breast cancer metastasis. Breast Cancer Res. 2006;8(4):212.
Article
PubMed
PubMed Central
Google Scholar
Koren S, Reavie L, Couto JP, De Silva D, Stadler MB, Roloff T, Britschgi A, Eichlisberger T, Kohler H, Aina O, et al. PIK3CA
H1047R induces multipotency and multi-lineage mammary tumours. Nature. 2015;525(7567):114–8.
Article
CAS
PubMed
Google Scholar