Brenner H: Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis. Lancet. 2002, 360: 1131-1135. 10.1016/S0140-6736(02)11199-8.
Article
PubMed
Google Scholar
Pantel K, Cote RJ, Fodstad O: Detection and clinical importance of micrometastatic disease. J Natl Cancer Inst. 1999, 91: 1113-1124. 10.1093/jnci/91.13.1113.
Article
CAS
PubMed
Google Scholar
Braun S, Pantel K, Muller P, Janni W, Hepp F, Kentenich CR, Gastroph S, Wischnik A, Dimpfl T, Kindermann G, Riethmuller G, Schlimok G: Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med. 2000, 342: 525-533. 10.1056/NEJM200002243420801.
Article
CAS
PubMed
Google Scholar
Janni W, Gastroph S, Hepp F, Kentenich C, Rjosk D, Schindlbeck C, Dimpfl T, Sommer H, Braun S: Prognostic significance of an increased number of micrometastatic tumor cells in the bone marrow of patients with first recurrence of breast carcinoma. Cancer. 2000, 88: 2252-2259. 10.1002/(SICI)1097-0142(20000515)88:10<2252::AID-CNCR8>3.0.CO;2-Q.
Article
CAS
PubMed
Google Scholar
Braun S, Cevatli BS, Assemi C, Janni W, Kentenich CRM, Schindlbeck C, Rjosk D, Hepp F: Comparative analysis of micrometastasis to the bone marrow and lymph nodes of node-negative breast cancer patients receiving no adjuvant therapy. J Clin Oncol. 2001, 19: 1468-1475.
Article
CAS
PubMed
Google Scholar
Ikeda N, Miyoshi Y, Motomura K, Inaji H, Koyama H, Noguchi S: Prognostic significance of occult bone marrow micrometastases of breast cancer detected by quantitative polymerase chain reaction for cytokeratin 19 mRNA. Jpn J Cancer Res. 2000, 91: 918-924.
Article
CAS
PubMed
Google Scholar
Aerts J, Wynendaele W, Paridaens R, Christiaens MR, vandenBogaert W, vanOosterom AT, Vandekerckhove F: A real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect breast carcinoma cells in peripheral blood. Ann Oncol. 2001, 12: 39-46. 10.1023/A:1008317512253.
Article
CAS
PubMed
Google Scholar
Leers MPG, Schoffelen R, Hoop JGM, Theunissen P, Oosterhuis JWA, Bijl HV, Rahmy A, Tan W, Nap M: Multiparameter flow cytometry as a tool for the detection of micrometastatic tumour cells in the sentinel lymph node procedure of patients with breast cancer. J Clin Pathol. 2002, 55: 359-366.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zoli W, Barzanti F, Dal Susino M, De Paola F, Tesei A, Ricotti L, Padovani F, Reno F, Amadori D: Flow-cytometric determination of tumor cells in lymph nodes. Oncology. 2002, 62: 128-135. 10.1159/000048258.
Article
CAS
PubMed
Google Scholar
Forus A, Hoifodt HK, Overli GE, Myklebost O, Fodstad O: Sensitive fluorescent in situ hybridisation method for the characterisation of breast cancer cells in bone marrow aspirates. Mol Pathol. 1999, 52: 68-74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hosch S, Kraus J, Scheunemann P, Izbicki JR, Schneider C, Schumacher U, Witter K, Speicher MR, Pantel K: Malignant potential and cytogenetic characteristics of occult disseminated tumor cells in esophageal cancer. Cancer Res. 2000, 60: 6836-6840.
CAS
PubMed
Google Scholar
Zhong XY, Kaul S, Lin YS, Eichler A, Bastert G: Sensitive detection of micrometastases in bone marrow from patients with breast cancer using immunomagnetic isolation of tumor cells in combination with reverse transcriptase/polymerase chain reaction for cytokeratin-19. J Cancer Res Clin Oncol. 2000, 126: 212-218. 10.1007/s004320050035.
Article
CAS
PubMed
Google Scholar
Flatmark K, Bjornland K, Johannessen HO, Hegstad E, Rosales R, Harklau L, Solhaug JH, Faye RS, Soreide O, Fodstad O: Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients. Clin Cancer Res. 2002, 8: 444-449.
PubMed
Google Scholar
Ree AH, Engerbraaten O, Hovig E, Fodstad O: Differential display analysis of breast carcinoma cells enriched by immunomagnetic target cell selection: gene expression profiles in bone marrow target cells. Int J Cancer. 2002, 97: 28-33. 10.1002/ijc.1564.
Article
CAS
PubMed
Google Scholar
Weihrauch MR, Skibowski E, Koslowsky TC, Voiss W, Re D, KuhnRegnier F, Bannwarth C, Siedek M, Diehl V, Bohlen H: Immunomagnetic enrichment and detection of micrometastases in colorectal cancer: correlation with established clinical parameters. J Clin Oncol. 2002, 20: 4338-4343. 10.1200/JCO.2002.02.152.
Article
CAS
PubMed
Google Scholar
Choesmel V, Anract P, Høifødt H, Thiery JP, Blin N: A relevant immunomagnetic assay to detect and characterize EpCAM-positive cells in bone marrow from breast cancer patients. Cancer. 2004,
Google Scholar
Pierga JY, Bonneton C, Vincent-Salomon A, de Cremoux P, Nos C, Blin N, Pouillard P, Thiery JP, Magdelenat H: Clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancer patients. Clin Cancer Res. 2000, 10: 1392-1400.
Article
Google Scholar
Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, MacDonald S, Pulford KA, Stein H, Mason DY: Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984, 32: 219-229.
Article
CAS
PubMed
Google Scholar
Singletary SE, Allred C, Ashley P, Bassett LW, Berry D, Bland KI, Borgen PI, Clark G, Edge SB, Hayes DF, Hughes LL, Hutter RV, Morrow M, Page DL, Recht A, Theriault RL, Thor A, Weaver DL, Wieand HS, Greene FL: Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol. 2002, 20: 3628-3636. 10.1200/JCO.2002.02.026.
Article
PubMed
Google Scholar
Rosenberg R, Gertler R, Friederichs J, Fuehrer K, Dahm M, Phelps R, Thorban S, Nekarda H, Siewert JR: Comparison of two density gradient centrifugation systems for the enrichment of disseminated tumor cells in blood. Cytometry. 2002, 49: 150-158. 10.1002/cyto.10161.
Article
CAS
PubMed
Google Scholar
Borgen E, Naume B, Nestland JM, Kvalheim G, Beiske K, Fodstad O, Diel IJ, Solomayer EF, Theocharous P, Coombes RC, Smith BM, Wunder E, Marolleau JP, Garcia J, Pantel K: Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. establishment of objective criteria for the evaluation of immunostained cells. Cytotherapy. 1999, 1: 377-388. 10.1080/0032472031000141283.
Article
CAS
PubMed
Google Scholar
Gerber B, Krause A, Muller H, Richter D, Reimer T, Makovitzky J, Herrnring C, Jeschke U, Kundt G, Friese K: Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors. J Clin Oncol. 2001, 19: 960-971.
Article
CAS
PubMed
Google Scholar
Bostick PJ, Chatterjee S, Chi DD, Huynh KT, Giuliano AE, Cote R, Hoon DS: Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients. J Clin Oncol. 1998, 16: 2632-2640.
Article
CAS
PubMed
Google Scholar
Witzig TE, Bossy B, Kimlinger T, Roche PC, Ingle JN, Grant C, Donohue J, Suman VJ, Harrington D, Torre-Bueno J, Bauer KD: Detection of circulating cytokeratin-positive cells in the blood of breast cancer patients using immunomagnetic enrichment and digital microscopy. Clin Cancer Res. 2002, 8: 1085-1091.
PubMed
Google Scholar
Diel IJ, Kaufmann M, Costa SD, Holle R, von Minckwitz G, Solomayer EF, Kaul S, Bastert G: Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. J Natl Cancer Inst. 1996, 88: 1652-1658. 10.1093/jnci/88.22.1652.
Article
CAS
PubMed
Google Scholar
Mansi JL, Gogas H, Bliss JM, Gazet JC, Berger U, Coombes RC: Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study. Lancet. 1999, 354: 197-202. 10.1016/S0140-6736(98)10175-7.
Article
CAS
PubMed
Google Scholar
Naume B, Borgen E, Kvalheim G, Karesen R, Qvist H, Sauer T, Kumar T, Nesland JM: Detection of isolated tumor cells in bone marrow in early-stage breast carcinoma patients: comparison with preoperative clinical parameters and primary tumor characteristics. Clin Cancer Res. 2001, 7: 4122-4129.
CAS
PubMed
Google Scholar
Gebauer G, Fehm T, Merkle E, Beck EP, Lang N, Jager W: Epithelial cells in bone marrow of breast cancer patients at time of primary surgery: clinical outcome during long-term follow-up. J Clin Oncol. 2001, 19: 3669-3674.
Article
CAS
PubMed
Google Scholar
Wiedswang G, Borgen E, Karesen R, Kvalheim G, Nesland JM, Schlichting HQE, Sauer T, Janbu J, Harbitz T, Naume B: Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J Clin Oncol. 2003, 21: 3469-3478. 10.1200/JCO.2003.02.009.
Article
CAS
PubMed
Google Scholar
Thurm H, Ebel S, Kentenich C, Hemsen A, Riethdorf S, Coith C, Wallwiener D, Braun S, Oberhoff C, Janicke F, Pantel K: Rare expression of epithelial cell adhesion molecule on residual micrometastatic breast cancer cells after adjuvant chemotherapy. Clin Cancer Res. 2003, 9: 2598-2604.
CAS
PubMed
Google Scholar
Baker MK, Mikhitarian K, Osta W, Callahan K, Hoda R, Brescia F, Kneuper-Hall R, Mitas M, Cole DJ, Gillanders WE: Molecular detection of breast cancer cells in the peripheral blood of advanced-stage breast cancer patients using multimarker real-time reverse transcription-polymerase chain reaction and a novel porous barrier density gradient centrifugation technology. Clin Cancer Res. 2003, 9: 4865-4871.
CAS
PubMed
Google Scholar
Borgen E, Beiske K, Trachsel S, Nesland JM, Kvalheim G, Herstad TK, Schlichting E, Qvist H, Naume B: Immunocytochemical detection of isolated epithelial cells in bone marrow: non-specific staining and contribution by plasma cells directly reactive to alkaline phosphatase. J Pathol. 1998, 185: 427-434. 10.1002/(SICI)1096-9896(199808)185:4<427::AID-PATH127>3.0.CO;2-7.
Article
CAS
PubMed
Google Scholar
Braun S, Hepp F, Kentenich CR, Janni W, Pantel K, Riethmuller G, Willgeroth F, Sommer HL: Monoclonal antibody therapy with edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow. Clin Cancer Res. 1999, 5: 3999-4004.
CAS
PubMed
Google Scholar
Schroder CP, Ruiters MH, de Jong S, Tiebosch AT, Wesseling J, Veenstra R, de Vries J, Hoekstra HJ, de Leij LF, de Vries EG: Detection of micrometastatic breast cancer by means of real time quantitative RT-PCR and immunostaining in perioperative blood samples and sentinel nodes. Int J Cancer. 2003, 106: 611-618. 10.1002/ijc.11295.
Article
PubMed
Google Scholar
Packeisen J, Kaup-Franzen C, Knieriem HJ: Detection of surface antigen 17-1A in breast and colorectal cancer. Hybridoma. 1999, 18: 37-40.
Article
CAS
PubMed
Google Scholar
Gastl G, Spizzo G, Obrist P, Dunser M, Mikuz G: Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet. 2000, 356: 1981-1982. 10.1016/S0140-6736(00)03312-2.
Article
CAS
PubMed
Google Scholar
Braun S, Hepp F, Sommer HL, Pantel K: Tumor-antigen heterogeneity of disseminated breast cancer cells: implications for immunotherapy of minimal residual disease. Int J Cancer. 1999, 84: 1-5. 10.1002/(SICI)1097-0215(19990219)84:1<1::AID-IJC1>3.0.CO;2-A.
Article
CAS
PubMed
Google Scholar
Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO: Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol. 1994, 125: 437-446. 10.1083/jcb.125.2.437.
Article
CAS
PubMed
Google Scholar
Balzar M, Winter MJ, de Boer CJ, Litvinov SV: The biology of the 17-1A antigen (Ep-CAM). J Mol Med. 1999, 77: 699-712. 10.1007/s001099900038.
Article
CAS
PubMed
Google Scholar
Jojovic M, Adam E, Zangemeister-Wittke U, Schumacher U: Epithelial glycoprotein-2 expression is subject to regulatory processes in epithelial-mesenchymal transitions during metastases: an investigation of human cancers transplanted into severe combined immunodeficient mice. Histochem J. 1998, 30: 723-729. 10.1023/A:1003486630314.
Article
CAS
PubMed
Google Scholar
Gires O, Kieu C, Fix P, Schmitt B, Munz M, Wollenberg B, Zeidler R: Tumor necrosis factor alpha negatively regulates the expression of the carcinoma-associated antigen epithelial cell adhesion molecule. Cancer. 2001, 92: 620-628. 10.1002/1097-0142(20010801)92:3<620::AID-CNCR1362>3.0.CO;2-F.
Article
CAS
PubMed
Google Scholar
Ferrero M, Spyratos F, Le Doussal V, Desplaces A, Rouesse J: Flow cytometric analysis of DNA content and keratins by using CK7, CK8, CK18, CK19, and KL1 monoclonal antibodies in benign and malignant human breast tumors. Cytometry. 1990, 11: 716-724.
Article
CAS
PubMed
Google Scholar
Franzen B, Linder S, Alaiya AA, Eriksson E, Uruy K, Hirano T, Okuzawa K, Auer G: Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins. Br J Cancer. 1996, 74: 1632-1638.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brotherick I, Robson CN, Browell DA, Shenfine J, White MD, Cunliffe WJ, Shenton BK, Egan M, Webb LA, Lunt LG, Young JR, Higgs MJ: Cytokeratin expression in breast cancer: phenotypic changes associated with disease progression. Cytometry. 1998, 32: 301-308. 10.1002/(SICI)1097-0320(19980801)32:4<301::AID-CYTO7>3.3.CO;2-R.
Article
CAS
PubMed
Google Scholar
Su L, Morgan PR, Lane EB: Expression of cytokeratin messenger RNA versus protein in the normal mammary gland and in breast cancer. Hum Pathol. 1996, 27: 800-806. 10.1016/S0046-8177(96)90452-9.
Article
CAS
PubMed
Google Scholar