Volume 12 Supplement 1
Breast calcification: the 'Cinderella' breast element?
© BioMed Central Ltd. 2010
Published: 18 May 2010
There is currently extensive diagnostic use of breast tissue calcifications through their differential mammographic appearance, albeit with relatively low specificity. However, the details of the calcification chemical and structural composition remain somewhat vague. Thus any associated clinical significance, such as indications of tumour type, grade and stage, have not previously been explored.
The biochemical composition and incorporation of carbonate into the hydroxyapatite lattice of type II microcalcifications was studied by infrared microspectroscopy, allowing spectral information to be directly correlated with associated histopathology of the surrounding tissue.
This study a greater significance for microcalcification chemistry in mechanisms associated with cancer progression, and especially for the future diagnosis and classification of breast pathology.