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Positron emitting ¹⁸F-2-deoxy-2-fluoro-D-glucose: potential 'hot' new therapy

Preclinical studies suggest that ¹⁸F-2-deoxy-2-fluoro-D-glucose (¹⁸F-FDG) kills breast cancer cells without significant marrow toxicity or parenchymal toxicity. Radiation dose calculations estimated from fluorode...

Authors: Joanne E Mortimer and Marie E Taylor

Citation: Breast Cancer Research 2003 5:329

Content type: Commentary Published on: 13 October 2003
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Breast Cancer Therapy Annual – today's drug treatment of cancer?

Authors: David Cameron

Citation: Breast Cancer Research 2003 6:12

Content type: Book report Published on: 13 October 2003
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The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions

Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were originally evaluated bec...

Authors: Stefanie S Jeffrey and Jonathan R Pollack

Citation: Breast Cancer Research 2003 5:320

Content type: Review Published on: 9 October 2003
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The diagnosis and management of pre-invasive breast disease Genetic alterations in pre-invasive lesions

The development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative geno...

Authors: Jorge S Reis-Filho and Sunil R Lakhani

Citation: Breast Cancer Research 2003 5:313

Content type: Review Published on: 9 October 2003
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The diagnosis and management of pre-invasive breast disease Problems associated with management of pre-invasive lesions

The treatment of ductal carcinoma in situ (DCIS) involves adequate surgical excision with adjuvant radiotherapy where appropriate. An inadequate excision margin and young age are independent risk factors for loca...

Authors: Anand D Purushotham

Citation: Breast Cancer Research 2003 5:309

Content type: Review Published on: 9 October 2003
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The diagnosis and management of pre-invasive breast disease: The role of new diagnostic techniques

In recent years we have seen significantly increased use of minimally invasive diagnostic techniques in the management of breast disease. There is wide recognition of fine needle aspiration and core biopsy as ...

Authors: Ashutosh Nerurkar and Peter Osin

Citation: Breast Cancer Research 2003 5:305

Content type: Review Published on: 9 October 2003
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Microarray technology and its effect on breast cancer (re)classification and prediction of outcome

Authors: Fatima Cardoso

Citation: Breast Cancer Research 2003 5:303

Content type: Viewpoint Published on: 9 October 2003
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Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast

Estrogen is a mitogenic factor that is implicated in the genesis and progression of breast cancer via its binding to estrogen receptor (ER)-α. Synthesis of estrogen in situ is believed to be catalyzed mainly by a...

Authors: Zhenhuan Zhang, Hiroko Yamashita, Tatsuya Toyama, Yoko Omoto, Hiroshi Sugiura, Yasuo Hara, Xueqing Wu, Shunzo Kobayashi and Hirotaka Iwase

Citation: Breast Cancer Research 2003 5:R250

Content type: Research article Published on: 9 October 2003
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Are herbal remedies and dietary supplements safe and effective for breast cancer patients?

There remains limited scientific evidence on the efficacy and safety of 'natural' therapies such as herbal remedies and dietary supplements. Nevertheless, breast cancer patients are particularly prone to purch...

Authors: Aedin Cassidy

Citation: Breast Cancer Research 2003 5:300

Content type: Commentary Published on: 7 October 2003
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Cytoplasmic p21^WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis

HER-2 (c-erbB2/Neu) predicts the prognosis of and may influence treatment responses in breast cancer. HER-2 activity induces the cytoplasmic location of p21^WAFI/CIPI in cell culture, accompanied by resistance to ...

Authors: Zoë E Winters, Russell D Leek, Mike J Bradburn, Chris J Norbury and Adrian L Harris

Citation: Breast Cancer Research 2003 5:R242

Content type: Research article Published on: 3 October 2003
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Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion

Our previous studies detected focal disruptions in myoepithelial cell layers of several ducts with carcinoma in situ. The cell cluster overlying each of the myoepithelial disruptions showed a marked reduction in ...

Authors: Yan-gao Man, Lisa Tai, Ross Barner, Russell Vang, Jeffrey S Saenger, Kris M Shekitka, Gary L Bratthauer, Darren T Wheeler, Chang Y Liang, Tuyethoa N Vinh and Brian L Strauss

Citation: Breast Cancer Research 2003 5:R231

Content type: Research article Published on: 3 October 2003
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CTLA-4 based therapy (MDX-010)

Authors: A Korman

Citation: Breast Cancer Research 2003 5(Suppl 1):63

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Combined hormonal therapy for advanced breast cancer in postmenopausal patients

Authors: P Langecker, W Lang, D Blanchett, P Bailey, C Scribner and P Goss

Citation: Breast Cancer Research 2003 5(Suppl 1):62

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Clinical applications of Affymetrix Genechip arrays for RNA and DNA analysis

Authors: I Russell

Citation: Breast Cancer Research 2003 5(Suppl 1):61

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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From gene expression patterns to antibody diagnostics

Authors: DT Ross, BZ Ring, S Chang, Y Wang, C McDaniel, S Defoe, R Beck and R Seitz

Citation: Breast Cancer Research 2003 5(Suppl 1):60

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Rational engineering of Fc/Fc receptor interactions to improve antibody potency

Authors: S Doberstein, G Lazar and R Hayes

Citation: Breast Cancer Research 2003 5(Suppl 1):59

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Target discovery in the postgenomic era

Authors: L Friedman, L Johnson, H Francis-Lang, M Costa, D Baly, G Duyk and G Plowman

Citation: Breast Cancer Research 2003 5(Suppl 1):58

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Genomic approaches to drug target discovery using mouse models

Authors: DW Morris

Citation: Breast Cancer Research 2003 5(Suppl 1):57

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Meta-analyses of transcriptional information: impact of data integration in understanding human breast cancers

Authors: ET Liu

Citation: Breast Cancer Research 2003 5(Suppl 1):55

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Immunotherapy of cancer

Authors: I McKenzie

Citation: Breast Cancer Research 2003 5(Suppl 1):53

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Functional characterization of mammary stem cells in development and breast cancer

Authors: JM Rosen, BE Welm, SB Tepera, F Behbod, SL Grimm, T Venezia, MA Goodell, TA Graubert, Z Werb, Y Li and HE Varmus

Citation: Breast Cancer Research 2003 5(Suppl 1):51

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Characterization, isolation and cultivation of distinctive human breast cell populations

Authors: R Villadsen, T Gudjonsson, A Fridriksdottir, M Wissing, L Rønnov-Jessen, MJ Bissell and OW Petersen

Citation: Breast Cancer Research 2003 5(Suppl 1):49

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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In situ to invasive carcinoma transition: escape or release

Authors: K Polyak

Citation: Breast Cancer Research 2003 5(Suppl 1):47

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Mammary intraepithelial neoplasia outgrowths (MINO): MINO and human ductal carcinoma in situ

Authors: AD Borowsky

Citation: Breast Cancer Research 2003 5(Suppl 1):45

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Advanced imaging and detection R&D in the Center for Biophotonics

Authors: DL Matthews

Citation: Breast Cancer Research 2003 5(Suppl 1):43

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Imaging angiogenesis in early stages of breast cancer using a standardized radiolabeled adapter protein docked to vascular endothelial growth factor

Authors: S Mandl, FG Blankenberg, Y-A Cao, C O'Connell-Rodwell, C Mari, TI Gaynutdinov, J-L Vanderheyden, MV Backer, JM Backer and C Contag

Citation: Breast Cancer Research 2003 5(Suppl 1):41

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Imaging mouse models of breast cancer with positron emission tomography

Authors: S Cherry, C Abbey, S Borowsky, J Gregg and R Cardiff

Citation: Breast Cancer Research 2003 5(Suppl 1):40

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Using genomic similarities and differences to interpret mouse models of human development and cancer

Authors: L Stubbs, C Elso, G Loots, A Hamilton and I Ovcharenko

Citation: Breast Cancer Research 2003 5(Suppl 1):38

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Expression profiling of breast cancer, influence of tumor genotype and patient genotype

Authors: A-L Borresen-Dale

Citation: Breast Cancer Research 2003 5(Suppl 1):36

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Hormonal interactions during mammary gland development

Authors: BK Vonderhaar

Citation: Breast Cancer Research 2003 5(Suppl 1):34

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Genetic determinants of susceptibility to estrogen-induced mammary cancer in the rat

Authors: JD Shull, BS Schaffer, LM Bartsch, LK Buckles, KA Gould, M Tochacek, B Xie, CM Lachel, KL Pennington, TE Strecker and KK Hansen

Citation: Breast Cancer Research 2003 5(Suppl 1):32

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Role of differentiation in carcinogenesis and cancer prevention

Authors: J Russo and IH Russo

Citation: Breast Cancer Research 2003 5(Suppl 1):31

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Genetically engineered mouse models of human breast cancer

Authors: RA Jensen

Citation: Breast Cancer Research 2003 5(Suppl 1):30

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Transgenic models are predictive: the herceptin and flavopiridol experience

Authors: E Schmidt

Citation: Breast Cancer Research 2003 5(Suppl 1):28

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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The mouse in preclinical trials: transgenic, carcinogen-induced, or xenograph models – which to use?

Authors: P Brown

Citation: Breast Cancer Research 2003 5(Suppl 1):27

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Synergy between the erbB and transforming growth factor beta signaling networks: implications for molecular therapeutics in human neoplasia

Authors: CL Arteaga

Citation: Breast Cancer Research 2003 5(Suppl 1):26

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Proof-of-concept in vivo evaluation of targeted therapeutics: lessons from immunoliposomes

Authors: CC Benz

Citation: Breast Cancer Research 2003 5(Suppl 1):25

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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The comparative genetics and genomics of cancer: of mice and men

Authors: G Hodgson, J Hager, K Chin, CA Lapuk, S Volik, C Collins, A Balmain, F Waldman, D Hanahan and J Gray

Citation: Breast Cancer Research 2003 5(Suppl 1):24

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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The molecular biology of mammary intraepithelial neoplasia outgrowths

Authors: L Namba, SY Liu, ET McGoldrick, LJT Young, AD Borowsky, RD Cardiff and JP Gregg

Citation: Breast Cancer Research 2003 5(Suppl 1):23

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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The ErbB receptor tyrosine kinases and their roles in cancer

Authors: NE Hynes

Citation: Breast Cancer Research 2003 5(Suppl 1):21

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Pregnancy levels of estrogen prevents breast cancer

Authors: S Nandi, RC Guzman, G Thordarson and L Rajkumar

Citation: Breast Cancer Research 2003 5(Suppl 1):19

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Development of a transgenic mouse line for the evaluation of the androgen receptor activity in vivo

Authors: R Attar, C Cullinan, C-P Ho, M Swerdel, J Dell, RB Rowley, DJ Bol, J Ostrowski, K Mookhtiar, M Gottardis and R Weinmann

Citation: Breast Cancer Research 2003 5(Suppl 1):17

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Role of animal models in oncology drug discovery

Authors: R Kumar

Citation: Breast Cancer Research 2003 5(Suppl 1):15

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Genetically modified cancer models: the value of luciferase-tagged tumors and in vivo luciferase-based reporter assays in oncology drug discovery

Authors: W Yang, C Kowal, E Sorensen and P Lassota

Citation: Breast Cancer Research 2003 5(Suppl 1):13

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Mammary pathology of the genetically engineered mouse

Authors: AD Borowsky

Citation: Breast Cancer Research 2003 5(Suppl 1):11

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Advanced immunophenotyping: more is better!

Authors: N Baumgarth

Citation: Breast Cancer Research 2003 5(Suppl 1):9

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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The Mutant Mouse Regional Resource Center Program

Authors: KCK Lloyd

Citation: Breast Cancer Research 2003 5(Suppl 1):7

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Reversibility and progression in conditional transgenic mouse models of breast cancer

Authors: LA Chodosh, RB Boxer, SE Moody, BA Keister, CJ Sarkisian, JW Jang, GK Belka, CM Blakely, CP Portocarero, CJ Sterner, KL Notarfrancesco and EA Kauh

Citation: Breast Cancer Research 2003 5(Suppl 1):5

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Mouse models for BRCA1-associated breast cancer

Authors: R-H Wang, W Li, X Xu and C Deng

Citation: Breast Cancer Research 2003 5(Suppl 1):3

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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Mouse models of human breast cancer: evolution or convolution?

Authors: JE Green

Citation: Breast Cancer Research 2003 5(Suppl 1):1

Content type: Oral presentation Published on: 1 October 2003

This article is part of a Supplement: Volume 5 Supplement 1
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