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  1. Basal-like breast cancers (BLBCs) are very aggressive, and present serious clinical challenges as there are currently no targeted therapies available. We determined the regulatory role of Y-box binding protein...

    Authors: Anna L Stratford, Golareh Habibi, Arezoo Astanehe, Helen Jiang, Kaiji Hu, Eugene Park, Ashleen Shadeo, Timon PH Buys, Wan Lam, Trevor Pugh, Marco Marra, Torsten O Nielsen, Uwe Klinge, Peter R Mertens, Samuel Aparicio and Sandra E Dunn
    Citation: Breast Cancer Research 2007 9:R61
    Content type: Research article Published on:

  2. We have previously shown that the Beta Protein 1 (BP1) homeodomain protein is expressed in 81% of invasive ductal breast carcinomas, and that increased BP1 expression correlates with tumor progression. The pur...

    Authors: Holly S Stevenson, Sidney W Fu, Joseph J Pinzone, Jinguen Rheey, Samuel J Simmens and Patricia E Berg
    Citation: Breast Cancer Research 2007 9:R60
    Content type: Research article Published on:

  3. There are two main questions when assessing a woman for interventions to reduce her risks of developing or dying from breast cancer, the answers of which will determine her access: What are her chances of carr...

    Authors: D Gareth R Evans and Anthony Howell
    Citation: Breast Cancer Research 2007 9:213
    Content type: Review Published on:

  4. Neoadjuvant chemotherapy for breast cancer has a well-established role in the management of patients with locally advanced or early stage disease. Multiple trials have demonstrated superior survival outcomes i...

    Authors: Erica L Mayer, Lisa A Carey and Harold J Burstein
    Citation: Breast Cancer Research 2007 9:110
    Content type: Commentary Published on:

  5. Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age at diagnosis has been shown to be an independent indicator of breast cancer prognosis. Except for...

    Authors: Christina Yau, Vita Fedele, Ritu Roydasgupta, Jane Fridlyand, Alan Hubbard, Joe W Gray, Karen Chew, Shanaz H Dairkee, Dan H Moore, Francesco Schittulli, Stefania Tommasi, Angelo Paradiso, Donna G Albertson and Christopher C Benz
    Citation: Breast Cancer Research 2007 9:R59
    Content type: Research article Published on:

  6. HGFIN, previously identified as nmb, and its homolog osteoactivin are single transmembrane proteins that are expressed in differentiated immune cells. These proteins exhibit properties that could potentiate tu...

    Authors: Rebecca L Metz, Prem S Patel, Meera Hameed, Margaret Bryan and Pranela Rameshwar
    Citation: Breast Cancer Research 2007 9:R58
    Content type: Research article Published on:

  7. Aberrant DNA methylation has been found frequently in human breast cancers, associated with the loss of expression of a number of regulatory genes for growth and correlated to clinical outcomes. The present st...

    Authors: Weiwei Feng, Lanlan Shen, Sijin Wen, Daniel G Rosen, Jaroslav Jelinek, Xin Hu, Shaoyi Huan, Miao Huang, Jinsong Liu, Aysegul A Sahin, Kelly K Hunt, Robert C Bast Jr, Yu Shen, Jean-Pierre J Issa and Yinhua Yu
    Citation: Breast Cancer Research 2007 9:R57
    Content type: Research article Published on:

  8. 1,1-Bis (3'-indolyl)-1-(p-biphenyl) methane (CDIM9) has been identified as a new peroxisome proliferator-activated receptor (PPAR)-γ agonist that exhibits both receptor dependent and independent antitumor acti...

    Authors: Yunpeng Su, Kathryn Vanderlaag, Courtney Ireland, Janelle Ortiz, Henry Grage, Stephen Safe and Arthur E Frankel
    Citation: Breast Cancer Research 2007 9:R56
    Content type: Research article Published on:

  9. Deregulation of Polycomb member Bmi-1 is involved in cell proliferation and human oncogenesis. Modulation of Bmi-1 is found in several tumor tissues, including primary breast carcinomas; however, analysis of B...

    Authors: Javier Silva, Vanesa García, José M García, Cristina Peña, Gemma Domínguez, Raquel Díaz, Yolanda Lorenzo, Alicia Hurtado, Antonio Sánchez and Félix Bonilla
    Citation: Breast Cancer Research 2007 9:R55
    Content type: Research article Published on:

  10. This article highlights a recent study by Holst et al. in Nature Genetics that finds estrogen receptor-alpha (ER-α) amplification in early benign lesions and more advanced invasive carcinomas of the breast, and d...

    Authors: Amy M Fowler and Elaine T Alarid
    Citation: Breast Cancer Research 2007 9:305
    Content type: Viewpoint Published on:

  11. BRCA1 is involved in numerous essential processes in the cell, and the effects of BRCA1 dysfunction in breast cancer carcinogenesis are well described. Many of the breast cancer susceptibility genes such as BRCA2

    Authors: Felicity Lose, Jeremy Arnold, David B Young, Carolyn J Brown, Graham J Mann, Gulietta M Pupo, Kum Kum Khanna, Georgia Chenevix-Trench and Amanda B Spurdle
    Citation: Breast Cancer Research 2007 9:R54
    Content type: Research article Published on:

    The Erratum to this article has been published in Breast Cancer Research 2008 10:406

  12. Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Moreover, accumulat...

    Authors: David G DeNardo and Lisa M Coussens
    Citation: Breast Cancer Research 2007 9:212
    Content type: Review Published on:

  13. High breast density is associated with increased breast cancer risk. Epidemiologic studies have shown an increase in breast cancer risk in postmenopausal women with high levels of sex steroids. Hence, sex ster...

    Authors: Martijn Verheus, Petra HM Peeters, Paulus AH van Noord, Yvonne T van der Schouw, Diederick E Grobbee and Carla H van Gils
    Citation: Breast Cancer Research 2007 9:R53
    Content type: Research article Published on:

  14. This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) on...

    Authors: Raffaele Adolfo Calogero, Francesca Cordero, Guido Forni and Federica Cavallo
    Citation: Breast Cancer Research 2007 9:211
    Content type: Review Published on:

  15. In contrast to nonsteroidal aromatase inhibitors, the steroidal aromatase inactivator exemestane does not have detrimental effects on bone in animal models. This study was designed to compare the effects of ex...

    Authors: Paul E Goss, Peyman Hadji, Milayna Subar, Paula Abreu, Torben Thomsen and Jose Banke-Bochita
    Citation: Breast Cancer Research 2007 9:R52
    Content type: Research article Published on:

  16. Breast cancer development and progression are dependent on estrogen activity. In premenopausal women, estrogen production is mainly regulated through the hypothalamic-pituitary-gonadal (HPG) axis.

    Authors: Djura Piersma, Axel PN Themmen, Maxime P Look, Jan GM Klijn, John A Foekens, André G Uitterlinden, Huibert AP Pols and Els MJJ Berns
    Citation: Breast Cancer Research 2007 9:R51
    Content type: Research article Published on:

  17. Resistance to anti-epidermal growth factor receptor (anti-EGFR) therapies is an emerging clinical problem. The efficacy of anti-EGFR therapies can be influenced by the presence of heregulins (HRGs), which can ...

    Authors: Iain R Hutcheson, Janice M Knowlden, Steve E Hiscox, Denise Barrow, Julia MW Gee, John F Robertson, Ian O Ellis and Robert I Nicholson
    Citation: Breast Cancer Research 2007 9:R50
    Content type: Research article Published on:

    The Correction to this article has been published in Breast Cancer Research 2018 20:98

  20. The purpose of the present investigation is to determine whether centrosome amplifications are present in breast tumor cells, whether there are differences of centrosome amplification between benign breast les...

    Authors: Hui-qin Guo, Meixia Gao, Jinfang Ma, Ting Xiao, Lin-lin Zhao, Yanning Gao and Qin-jing Pan
    Citation: Breast Cancer Research 2007 9:R48
    Content type: Research article Published on:

  21. Increased versican expression has been associated with local breast cancer invasiveness and a more aggressive tumor phenotype. The cellular mechanisms are not fully understood and this study evaluated versican...

    Authors: Albert JM Yee, Margarete Akens, Bing L Yang, Joel Finkelstein, Peng-Sheng Zheng, Zhaoqiong Deng and Burton Yang
    Citation: Breast Cancer Research 2007 9:R47
    Content type: Research article Published on:

  22. Combination estrogen plus progestin causes breast cancer. In light of this causal relation, the rapid decline in breast cancer incidence noted in 2003, following an earlier and slower reduction in incidence fr...

    Authors: Graham A Colditz
    Citation: Breast Cancer Research 2007 9:108
    Content type: Editorial Published on:

    The Erratum to this article has been published in Breast Cancer Research 2007 9:401

  23. Cancer-testis antigens (CTAGs) are expressed solely in germ cells and in malignant tissues. They are targets of immune responses mediated by cytotoxic T cells in some cancers, and there is much interest in dev...

    Authors: Mark Taylor, Louise M Bolton, Peter Johnson, Tim Elliott and Nick Murray
    Citation: Breast Cancer Research 2007 9:R46
    Content type: Research article Published on:

  24. Positron emission tomography (PET) is suggested for early monitoring of treatment response, assuming that effective anticancer treatment induces metabolic changes that precede morphology alterations and change...

    Authors: Azita Monazzam, Raymond Josephsson, Carl Blomqvist, Jörgen Carlsson, Bengt Långström and Mats Bergström
    Citation: Breast Cancer Research 2007 9:R45
    Content type: Research article Published on:

  28. There is growing evidence that the Wilms' tumor 1 suppressor gene (WT1) behaves as an oncogene in some forms of breast cancer. Previous studies have demonstrated that the N-terminal domain of WT1 can act as a ...

    Authors: Youqi Han, Serban San-Marina, Lin Yang, Haytham Khoury and Mark D Minden
    Citation: Breast Cancer Research 2007 9:R43
    Content type: Research article Published on:

  29. Int6 has been shown to be an interactive participant with the protein translation initiation complex eIF3, the COP9 signalosome and the regulatory lid of the 26S proteasome. Insertion of mouse mammary tumor vi...

    Authors: David L Mack, Corinne A Boulanger, Robert Callahan and Gilbert H Smith
    Citation: Breast Cancer Research 2007 9:R42
    Content type: Research article Published on:

  30. Suppression of Bcl-2 expression can overcome cellular resistance to apoptosis induced by the adenovirus type 5 gene E1A in models of ovarian and breast cancer. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is ...

    Authors: Takeshi Sugimoto, Chandra Bartholomeusz, Ana M Tari and Naoto T Ueno
    Citation: Breast Cancer Research 2007 9:R41
    Content type: Research article Published on:

  31. The purpose of this study was to evaluate the diagnostic accuracy of computed tomography (CT) perfusion in differentiating metastatic from inflammatory enlarged axillary lymph nodes in patients with breast can...

    Authors: Yun Liu, Massimo Bellomi, Giovanna Gatti and Xuejun Ping
    Citation: Breast Cancer Research 2007 9:R40
    Content type: Research article Published on:

  34. A genetic component is well established in the etiology of breast cancer. It is not well known, however, whether genetic traits also influence prognostic features of the malignant phenotype.

    Authors: Mikael Hartman, Linda Lindström, Paul W Dickman, Hans-Olov Adami, Per Hall and Kamila Czene
    Citation: Breast Cancer Research 2007 9:R39
    Content type: Research article Published on:
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