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Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view

Mammographic density is known to be a strong risk factor for breast cancer. A particularly strong association with risk has been observed when density is measured using interactive threshold software. This, ho...

Authors: Stephen W Duffy, Iris D Nagtegaal, Susan M Astley, Maureen GC Gillan, Magnus A McGee, Caroline RM Boggis, Mary Wilson, Ursula M Beetles, Miriam A Griffiths, Anil K Jain, Jill Johnson, Rita Roberts, Heather Deans, Karen A Duncan, Geeta Iyengar, Pam M Griffiths…

Citation: Breast Cancer Research 2008 10:R64

Content type: Research article Published on: 23 July 2008
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Breast cancer stem cells: implications for therapy of breast cancer

The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells h...

Authors: Brian J Morrison, Chris W Schmidt, Sunil R Lakhani, Brent A Reynolds and J Alejandro Lopez

Citation: Breast Cancer Research 2008 10:210

Content type: Review Published on: 22 July 2008
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Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer

Preoperative chemotherapy is often used in patients with locally advanced breast cancer. However, commonly used clinical and pathological parameters are poor predictors of response to this type of therapy. Rec...

Authors: Shirly Davidovich, Ofer Ben-Izhak, Ma'anit Shapira, Boris Futerman and Dan D Hershko

Citation: Breast Cancer Research 2008 10:R63

Content type: Research article Published on: 21 July 2008
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Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays

Breast cancer metastasis is a complex, multi-step biological process. Genetic mutations along with epigenetic alterations in the form of DNA methylation patterns and histone modifications contribute to metasta...

Authors: David I Rodenhiser, Joseph Andrews, Wendy Kennette, Bekim Sadikovic, Ariel Mendlowitz, Alan B Tuck and Ann F Chambers

Citation: Breast Cancer Research 2008 10:R62

Content type: Research article Published on: 18 July 2008
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Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers

Oxidative stress can modify estrogen receptor (ER) structure and function, including induction of progesterone receptor (PR), altering the biology and clinical behavior of endocrine responsive (ER-positive) br...

Authors: Christina Yau and Christopher C Benz

Citation: Breast Cancer Research 2008 10:R61

Content type: Research article Published on: 17 July 2008
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Continuing trastuzumab beyond disease progression: outcomes analysis in patients with metastatic breast cancer

We performed a retrospective analysis of HER2-overexpressing metastatic breast cancer patients to describe clinical outcomes of those who, despite progression of the disease (PD), maintained trastuzumab for mu...

Authors: Giuseppe Cancello, Emilia Montagna, Diego D'Agostino, Mario Giuliano, Antonio Giordano, Giuseppe Di Lorenzo, Monica Plaitano, Sabino De Placido and Michele De Laurentiis

Citation: Breast Cancer Research 2008 10:R60

Content type: Research article Published on: 16 July 2008
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Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer

The cost of genetic testing and the limited knowledge about the BRCA1 and BRCA2 genes in different ethnic groups has limited its availability in medium- and low-resource countries, including Malaysia. In addition...

Authors: E Thirthagiri, SY Lee, P Kang, DS Lee, GT Toh, S Selamat, S-Y Yoon, NA Mohd Taib, MK Thong, CH Yip and SH Teo

Citation: Breast Cancer Research 2008 10:R59

Content type: Research article Published on: 16 July 2008
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The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer

ISG15 is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. However, alterations in the ISG15 signalling pathway...

Authors: Nuran Bektas, Erik Noetzel, Jürgen Veeck, Michael F Press, Glen Kristiansen, Amjad Naami, Arndt Hartmann, Arno Dimmler, Matthias W Beckmann, Ruth Knüchel, Peter A Fasching and Edgar Dahl

Citation: Breast Cancer Research 2008 10:R58

Content type: Research article Published on: 15 July 2008
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Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II

Obesity has consistently been associated with postmenopausal breast cancer risk. Proteins that are secreted by adipose tissue or are involved in regulating body mass may play a role in breast tumor development.

Authors: Heather Spencer Feigelson, Lauren R Teras, W Ryan Diver, Weining Tang, Alpa V Patel, Victoria L Stevens, Eugenia E Calle, Michael J Thun and Mark Bouzyk

Citation: Breast Cancer Research 2008 10:R57

Content type: Research article Published on: 8 July 2008
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The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer

Endocrine-dependent, estrogen receptor positive breast cancer cells proliferate in response to estrogens, synthesized by the cytochrome p450 aromatase enzyme. Letrozole is a potent nonsteroidal aromatase inhib...

Authors: Joanna Lisztwan, Astrid Pornon, Bin Chen, Shiuan Chen and Dean B Evans

Citation: Breast Cancer Research 2008 10:R56

Content type: Research article Published on: 8 July 2008
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The scope for a rapid digitiser of mammograms and other large-file, high-resolution images

Authors: R Grant and M Alsewan

Citation: Breast Cancer Research 2008 10(Suppl 3):P88

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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A review of breast cancers found in the Welsh Family History screening programme

Authors: S Bolt, J Jones, M Rogers, J Evans and K Gower Thomas

Citation: Breast Cancer Research 2008 10(Suppl 3):P86

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Eliciting requirements for a mammography training application

Authors: PM Taylor, M Hartswood, L Blot, S Anderson, L Wilkinson, E Anderson and R Proctor

Citation: Breast Cancer Research 2008 10(Suppl 3):P84

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Does size matter? A review of screen-detected microcalcifications seen at breast screening assessment

Authors: LIG Haigh

Citation: Breast Cancer Research 2008 10(Suppl 3):P82

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Lateral-approach stereotactic vacuum-assisted 10 G breast biopsy using Vacora for indeterminate microcalcifications: results of a single-institution assessment of 172 procedures

Authors: EM Vanherreweghe, M Mortier, R Van den Broecke, H Depypere, M Praet and G Villeirs

Citation: Breast Cancer Research 2008 10(Suppl 3):P80

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Initial experience with a new ultrasound imaging technique to measure tissue viscoelasticity

Authors: J Souquet, A Athanasiou, M Fink, J Bercoff, M Tanter, A Tardivon, T Deffieux and JL Gennisson

Citation: Breast Cancer Research 2008 10(Suppl 3):P78

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Digital screening on a mobile unit: the Coventry experience

Authors: S Hoffmeister and A Stanton

Citation: Breast Cancer Research 2008 10(Suppl 3):P76

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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What makes a good mammographer? Looking at the homogeneity of those groups who perform best and least well on the PERFORMS self-assessment scheme

Authors: HJ Scott and AG Gale

Citation: Breast Cancer Research 2008 10(Suppl 3):P74

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Effectiveness of screening a small population

Authors: ML Gaunt and K Darley

Citation: Breast Cancer Research 2008 10(Suppl 3):P72

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Variations in excision biopsy rates for women with B3/C3 results do not account for high benign open biopsy rates in the NHS Breast Screening Programme: a regional study

Authors: RM Watkins, F Johnson, A Mayer, A Bennett, DJ Harker and D Parham

Citation: Breast Cancer Research 2008 10(Suppl 3):P70

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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An audit reviewing the management of fibroadenomas with the advent of Mammotome in the breast unit in Bradford

Authors: ST Dennis, P Carder, P Burrows and N Sharma

Citation: Breast Cancer Research 2008 10(Suppl 3):P68

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Study of the availability of digital mammography for premenopausal women in the Valencian Breast Cancer Early Detection Program

Authors: M Ramos, R Tortosa, V Gonzalez, G Verdú and JI Villaescusa

Citation: Breast Cancer Research 2008 10(Suppl 3):P66

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Radial scars: to excise or not to excise?

Authors: A Moorhead, JE Murray and AM Gilchrist

Citation: Breast Cancer Research 2008 10(Suppl 3):P63

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Large-volume Mammotome biopsy may reduce the need for surgery in screen-detected papillary lesions

Authors: PJ Carder, P Burrows, ST Dennis and N Sharma

Citation: Breast Cancer Research 2008 10(Suppl 3):P57

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Consensus approach to discrepancies arising from independent double reading of screening mammograms

Authors: R Hiscock and G Hurst

Citation: Breast Cancer Research 2008 10(Suppl 3):P53

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Predicting the presence of invasive carcinoma from the extent of mammographic malignant microcalcification and grade of ductal carcinoma in situon core biopsy: results from a National Health Service Screening Programme

Authors: EAM O'Flynn, JC Morel, J Gonzalez, H Purushothaman, D Evans, R Wasan and MJ Michell

Citation: Breast Cancer Research 2008 10(Suppl 3):P51

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Only skin deep: a pictorial review of skin and subcutaneous lesions

Authors: P Moyle, M Hunt and P Britton

Citation: Breast Cancer Research 2008 10(Suppl 3):P47

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Comparison between the NVQ Level 3 in Diagnostic and Therapeutic Care and the BTec Professional Development Certificate for assistant practitioners in imaging: the Derby experience

Authors: M Cross, R Riley, T Bluck and D Samra

Citation: Breast Cancer Research 2008 10(Suppl 3):P45

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Breast cancer in young identical twins

Authors: SA Willson and PA Middleton

Citation: Breast Cancer Research 2008 10(Suppl 3):P43

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Can computed tomography replace nuclear medicine scans in the staging of breast cancer?

Authors: N Ridley, S Taylor and R Young

Citation: Breast Cancer Research 2008 10(Suppl 3):P41

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Breast biopsy pathology request forms: are the radiologists completing them correctly and legibly?

Authors: L Neville, N Ridley, S Taylor, J Armstrong and J Cook

Citation: Breast Cancer Research 2008 10(Suppl 3):P39

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Vacuum-assisted breast biopsy: comparison of three systems

Authors: F Canavan, AR Wilson, MJ Michell, D Evans, C Peacock, R Wasan and A O'Grady

Citation: Breast Cancer Research 2008 10(Suppl 3):P37

Content type: Poster presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Breast tomosynthesis in practice

Authors: I Andersson

Citation: Breast Cancer Research 2008 10(Suppl 3):P35

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Full field digital mammography: which equipment?

Authors: KC Young

Citation: Breast Cancer Research 2008 10(Suppl 3):P33

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Comparison of vacuum biopsy systems

Authors: R Wilson

Citation: Breast Cancer Research 2008 10(Suppl 3):P31

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Assistant practitioner job satisfaction and retention

Authors: S Sellars

Citation: Breast Cancer Research 2008 10(Suppl 3):P29

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Comparison of practitioner and assistant practitioner mammograms

Authors: A-M Fretwell

Citation: Breast Cancer Research 2008 10(Suppl 3):P28

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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The future of breast radiography: UK perspective

Authors: P Whelehan

Citation: Breast Cancer Research 2008 10(Suppl 3):P27

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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The first two years of digital mammographic screening in New Zealand

Authors: J Walker, R Beedie and A Cave

Citation: Breast Cancer Research 2008 10(Suppl 3):P24

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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How does the location of a satellite screening site affect uptake?

Authors: LS Wilkinson, S Hudson and J Peterson

Citation: Breast Cancer Research 2008 10(Suppl 3):P22

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Two systematic reviews to compare effects of double reading and computer-aided detection on both cancer detection and recall rate

Authors: PM Taylor and HWW Potts

Citation: Breast Cancer Research 2008 10(Suppl 3):P20

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Medico-legal issues in breast imaging

Authors: HN Purushothaman, JC Morel, E O'Flynn, ARM Wilson and MJ Michell

Citation: Breast Cancer Research 2008 10(Suppl 3):P18

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Evaluation of the diagnostic value of high temporal and spatial resolution morphologic, dynamic, spectroscopic and diffusion-weighted magnetic resonance imaging in patients with breast lesions at 3 T

Authors: K Pinker, W Bogner, S Gruber, P Szomolanyi, G Grabner, G Heinz-Peer, T Helbich and S Trattnig

Citation: Breast Cancer Research 2008 10(Suppl 3):P16

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Lesion size is a major determinant of the mammographic features of ductal carcinoma in situ: findings from the Sloane Project

Authors: A Evans, K Clements, A Maxwell, H Bishop, A Hanby, G Lawrence, O Kearins and S Pinder

Citation: Breast Cancer Research 2008 10(Suppl 3):P14

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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CADET 2 results/computer-aided detection update

Authors: F Gilbert

Citation: Breast Cancer Research 2008 10(Suppl 3):P12

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Magnetic resonance imaging in breast cancer: results of the COMICE trial

Authors: L Turnbull

Citation: Breast Cancer Research 2008 10(Suppl 3):P10

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Magnetic resonance imaging of ductal carcinoma in situ

Authors: C Kuhl

Citation: Breast Cancer Research 2008 10(Suppl 3):P8

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Minimising oncological treatment of early breast cancer

Authors: J Yarnold

Citation: Breast Cancer Research 2008 10(Suppl 3):P6

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Ultrasound elastography

Authors: G Rizzatto

Citation: Breast Cancer Research 2008 10(Suppl 3):P4

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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Positron emission tomography in breast disease

Authors: B Sharma

Citation: Breast Cancer Research 2008 10(Suppl 3):P2

Content type: Oral presentation Published on: 7 July 2008

This article is part of a Supplement: Volume 10 Supplement 3
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