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  1. In breast cancer, circulating tumor cells (CTCs)/disseminated tumor cells (DTCs) may serve as independent adverse prognostic variables, to monitor the course of the disease and to predict response or failure t...

    Authors: Manfred Schmitt and John A Foekens
    Citation: Breast Cancer Research 2009 11:109
    Content type: Editorial Published on:

  2. MUC1 is a cell-surface glycoprotein that establishes a molecular barrier at the epithelial surface and engages in morphogenetic signal transduction. Alterations in MUC1 glycosylation accompany the development ...

    Authors: Mark D Pegram, Virginia F Borges, Nuhad Ibrahim, Jyotsna Fuloria, Charles Shapiro, Susan Perez, Karen Wang, Franziska Schaedli Stark and Nigel Courtenay Luck
    Citation: Breast Cancer Research 2009 11:R73
    Content type: Research article Published on:

  3. Seven classes of mitogen-activated protein kinase (MAPK) intracellular signalling cascades exist, four of which are implicated in breast disease and function in mammary epithelial cells. These are the extracel...

    Authors: Jacqueline Whyte, Orla Bergin, Alessandro Bianchi, Sara McNally and Finian Martin
    Citation: Breast Cancer Research 2009 11:209
    Content type: Review Published on:

  4. Expression of the A and B forms of progesterone receptor (PR) in an appropriate ratio is critical for mammary development. Mammary glands of PR-A transgenic mice, carrying an additional A form of PR as a trans...

    Authors: Marina Simian, Mina J Bissell, Mary Helen Barcellos-Hoff and Gopalan Shyamala
    Citation: Breast Cancer Research 2009 11:R72
    Content type: Research article Published on:

  6. The origin and clinical relevance of circulating cell-free tumor DNA in the blood of cancer patients is still unclear. Here we investigated whether the detection of this DNA is related to bone marrow (BM) micr...

    Authors: Heidi Schwarzenbach, Klaus Pantel, Birthe Kemper, Cord Beeger, Friedrich Otterbach, Rainer Kimmig and Sabine Kasimir-Bauer
    Citation: Breast Cancer Research 2009 11:R71
    Content type: Research article Published on:

  7. Previous studies indicate that overexpression of the membrane-associated mucin MUC4 is potently anti-adhesive to cultured tumor cells, and suppresses cellular apoptotic response to a variety of insults. Such o...

    Authors: Heather C Workman, Jamie K Miller, Ellen Q Ingalla, Rouminder P Kaur, Diane I Yamamoto, Laurel A Beckett, Lawrence JT Young, Robert D Cardiff, Alexander D Borowsky, Kermit L Carraway, Colleen Sweeney and Kermit L Carraway III
    Citation: Breast Cancer Research 2009 11:R70
    Content type: Research article Published on:

  8. Reliable predictive and prognostic markers for routine diagnostic purposes are needed for breast cancer patients treated with neoadjuvant chemotherapy. We evaluated protein biomarkers in a cohort of 116 partic...

    Authors: Silvia Darb-Esfahani, Sibylle Loibl, Berit M Müller, Marc Roller, Carsten Denkert, Martina Komor, Karsten Schlüns, Jens Uwe Blohmer, Jan Budczies, Bernd Gerber, Aurelia Noske, Andreas du Bois, Wilko Weichert, Christian Jackisch, Manfred Dietel, Klaus Richter…
    Citation: Breast Cancer Research 2009 11:R69
    Content type: Research article Published on:

  10. The steroid receptor RNA activator is a functional RNA suspected to participate in the mechanisms underlying breast tumor progression. This RNA is also able to encode for a protein, Steroid Receptor RNA Activa...

    Authors: Yi Yan, George P Skliris, Carla Penner, Shilpa Chooniedass-Kothari, Charlton Cooper, Zoann Nugent, Anne Blanchard, Peter H Watson, Yvonne Myal, Leigh C Murphy and Etienne Leygue
    Citation: Breast Cancer Research 2009 11:R67
    Content type: Research article Published on:

  11. Human models of noninvasive breast tumors are limited, and the existing in vivo models do not mimic inter- and intratumoral heterogeneity. Ductal carcinoma in situ (DCIS) is the most common type (80%) of noninvas...

    Authors: Fariba Behbod, Frances S Kittrell, Heather LaMarca, David Edwards, Sofia Kerbawy, Jessica C Heestand, Evelin Young, Purna Mukhopadhyay, Hung-Wen Yeh, D Craig Allred, Min Hu, Kornelia Polyak, Jeffrey M Rosen and Daniel Medina
    Citation: Breast Cancer Research 2009 11:R66
    Content type: Research article Published on:

  12. Because of the small size of in situ mammary cancers in mouse models, high-resolution imaging techniques are required to effectively observe how lesions develop, grow and progress over time. The purpose of this s...

    Authors: Sanaz A Jansen, Suzanne D Conzen, Xiaobing Fan, Erica J Markiewicz, Gillian M Newstead and Gregory S Karczmar
    Citation: Breast Cancer Research 2009 11:R65
    Content type: Research article Published on:

  14. Physical activity improves quality of life after a breast cancer diagnosis, and a beneficial effect on survival would be particularly welcome. Four observational studies have now reported decreased total morta...

    Authors: Adeyemi A Ogunleye and Michelle D Holmes
    Citation: Breast Cancer Research 2009 11:106
    Content type: Commentary Published on:

  17. Vitamin D status measured during adulthood has been inversely associated with breast cancer risk in some, but not all, studies. Vitamin D has been hypothesized to prevent breast cancer through genomic and non-...

    Authors: Marjorie L McCullough, Victoria L Stevens, Roshni Patel, Eric J Jacobs, Elizabeth B Bain, Ronald L Horst, Susan M Gapstur, Michael J Thun and Eugenia E Calle
    Citation: Breast Cancer Research 2009 11:R64
    Content type: Research article Published on:

  18. Treatment of breast cancer is becoming more individualized with the recognition of tumor subgroups that respond differently to available therapies. Breast cancer 1 gene (BRCA1)-deficient tumors are usually of ...

    Authors: Julian Puppe, Rinske Drost, Xiaoling Liu, Simon A Joosse, Bastiaan Evers, Paulien Cornelissen-Steijger, Petra Nederlof, Qiang Yu, Jos Jonkers, Maarten van Lohuizen and Alexandra M Pietersen
    Citation: Breast Cancer Research 2009 11:R63
    Content type: Research article Published on:

  19. Macrophages in the mammary gland are essential for morphogenesis of the ductal epithelial tree and have been implicated in promoting breast tumor metastasis. Although it is well established that macrophages in...

    Authors: David E Gyorki, Marie-Liesse Asselin-Labat, Nico van Rooijen, Geoffrey J Lindeman and Jane E Visvader
    Citation: Breast Cancer Research 2009 11:R62
    Content type: Research article Published on:

  20. Rho signaling regulates key cellular processes including proliferation, survival, and migration, and it has been implicated in the development of many types of cancer including breast cancer. P190B Rho GTPase ...

    Authors: Brandy M Heckman-Stoddard, Tracy Vargo-Gogola, Peter R McHenry, Vivian Jiang, Matthew P Herrick, Susan G Hilsenbeck, Jeffrey Settleman and Jeffrey M Rosen
    Citation: Breast Cancer Research 2009 11:R61
    Content type: Research article Published on:

  21. The inaugural European Network for Breast Development and Cancer (ENBDC) meeting on 'Methods in Mammary Gland Development and Cancer' was held in Weggis, Switzerland last April. The goal was to discuss the det...

    Authors: Mohamed Bentires-Alj, Robert B Clarke, Jos Jonkers, Matthew Smalley and Torsten Stein
    Citation: Breast Cancer Research 2009 11:305
    Content type: Meeting report Published on:

  22. Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the developme...

    Authors: Mark R Pickard, Andrew R Green, Ian O Ellis, Carlos Caldas, Vanessa L Hedge, Mirna Mourtada-Maarabouni and Gwyn T Williams
    Citation: Breast Cancer Research 2009 11:R60
    Content type: Research article Published on:

  23. The role of circulating tumor cells (CTCs) in blood of primary breast cancer patients is still under investigation. We evaluated the incidence of CTCs in blood, we evaluated the correlation between CTCs and di...

    Authors: Tanja Fehm, Oliver Hoffmann, Bahriye Aktas, Sven Becker, Erich F Solomayer, Diethelm Wallwiener, Rainer Kimmig and Sabine Kasimir-Bauer
    Citation: Breast Cancer Research 2009 11:R59
    Content type: Research article Published on:

  24. MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved...

    Authors: Matteo Fassan, Raffaele Baffa, Juan P Palazzo, Joshua Lloyd, Marco Crosariol, Chang-Gong Liu, Stefano Volinia, Hannes Alder, Massimo Rugge, Carlo M Croce and Anne Rosenberg
    Citation: Breast Cancer Research 2009 11:R58
    Content type: Research article Published on:

  25. Notch is a family of transmembrane protein receptors whose activation requires proteolytic cleavage by γ-secretase. Since aberrant Notch signaling can induce mammary carcinomas in transgenic mice and high expr...

    Authors: Jianxun Han, Ivy Ma, Michael J Hendzel and Joan Allalunis-Turner
    Citation: Breast Cancer Research 2009 11:R57
    Content type: Research article Published on:

  27. Sites of chronic inflammation are often associated with the establishment and growth of various malignancies including breast cancer. A common inflammatory condition in humans is autoimmune arthritis (AA) that...

    Authors: Lopamudra Das Roy, Latha B Pathangey, Teresa L Tinder, Jorge L Schettini, Helen E Gruber and Pinku Mukherjee
    Citation: Breast Cancer Research 2009 11:R56
    Content type: Research article Published on:

  28. Perhaps the major challenge in developing more effective therapeutic strategies for the treatment of breast cancer patients is confronting the heterogeneity of the disease, recognizing that breast cancer is no...

    Authors: Andrea H Bild, Joel S Parker, Adam M Gustafson, Chaitanya R Acharya, Katherine A Hoadley, Carey Anders, P Kelly Marcom, Lisa A Carey, Anil Potti, Joseph R Nevins and Charles M Perou
    Citation: Breast Cancer Research 2009 11:R55
    Content type: Research article Published on:

    The Erratum to this article has been published in Breast Cancer Research 2011 13:406

  29. We sought to determine whether the levels of expression of 17 candidate genes were associated with locoregional control after breast-conserving treatments of early-stage breast cancers in young, premenopausal ...

    Authors: Marc A Bollet, Alexia Savignoni, Leanne De Koning, Carine Tran-Perennou, Catherine Barbaroux, Armelle Degeorges, Brigitte Sigal-Zafrani, Geneviève Almouzni, Paul Cottu, Rémy Salmon, Nicolas Servant, Alain Fourquet and Patricia de Cremoux
    Citation: Breast Cancer Research 2009 11:R54
    Content type: Research article Published on:

  30. How and when a tumor acquires metastatic properties remain largely unknown. Recent work has uncovered an intricate new mechanism through which transforming growth factor-beta (TGFβ) acts in concert with oncoge...

    Authors: Jean-Christophe Marine and Geert Berx
    Citation: Breast Cancer Research 2009 11:304
    Content type: Viewpoint Published on:

  31. The sodium iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells. This in turn allows radioiodine imaging and therapy for thyroid cancer. To extend the use of NIS-mediated radi...

    Authors: Miguel A Trujillo, Michael J Oneal, Julia Davydova, Elizabeth Bergert, Masato Yamamoto and John C Morris III
    Citation: Breast Cancer Research 2009 11:R53
    Content type: Research article Published on:

  32. We examined the association between mammographic density and single-nucleotide polymorphisms (SNPs) in genes encoding CYP1A1, CYP1B1, aromatase, 17β-HSD, ESR1, and ESR2 in pre- and early perimenopausal white, ...

    Authors: Carolyn J Crandall, Mary E Sehl, Sybil L Crawford, Ellen B Gold, Laurel A Habel, Lesley M Butler, MaryFran R Sowers, Gail A Greendale and Janet S Sinsheimer
    Citation: Breast Cancer Research 2009 11:R51
    Content type: Research article Published on:

  33. Signal transducer and activator of transcription (STAT) 5b is a transcription factor involved in pro-proliferative and pro-survival signaling in a number of solid tumors, including breast cancer. The contribut...

    Authors: Teresa M Bernaciak, Jessica Zareno, J Thomas Parsons and Corinne M Silva
    Citation: Breast Cancer Research 2009 11:R52
    Content type: Research article Published on:

  34. HER2 overexpression, or rather HER2 gene amplification, is indicative for Herceptin therapy in both metastatic and pre-metastatic breast cancer patients. Patient's individual sensitivity to Herceptin treatment, h...

    Authors: Andrea Sassen, Simone Diermeier-Daucher, Manuela Sieben, Olaf Ortmann, Ferdinand Hofstaedter, Stephan Schwarz and Gero Brockhoff
    Citation: Breast Cancer Research 2009 11:R50
    Content type: Research article Published on:

  35. Assessments by the handful of prospective studies of the association of serum antioxidants and breast cancer risk have yielded inconsistent results. This multiethnic nested case-control study sought to examine...

    Authors: Meira Epplein, Yurii B Shvetsov, Lynne R Wilkens, Adrian A Franke, Robert V Cooney, Loïc Le Marchand, Brian E Henderson, Laurence N Kolonel and Marc T Goodman
    Citation: Breast Cancer Research 2009 11:R49
    Content type: Research article Published on:

  36. Human epidermal growth factor receptor (HER)2 over-expression is associated with a shortened disease-free interval and poor survival. Although the addition of trastuzumab to chemotherapy in the first-line sett...

    Authors: Phuong Khanh H Morrow, Francisco Zambrana and Francisco J Esteva
    Citation: Breast Cancer Research 2009 11:207
    Content type: Review Published on:

  37. Peripherally localized aromatase, which converts circulating androgens into estrogens, is important in the pathogenesis of postmenopausal breast carcinomas. We have previously shown that aromatase mRNA levels ...

    Authors: Naoko Honma, Kaiyo Takubo, Motoji Sawabe, Tomio Arai, Futoshi Akiyama, Goi Sakamoto, Toshiaki Utsumi, Noriko Yoshimura and Nobuhiro Harada
    Citation: Breast Cancer Research 2009 11:R48
    Content type: Research article Published on:

  38. Germline mutations in the BRCA1 and BRCA2 genes account for a considerable fraction of familial predisposition to breast cancer. Somatic mutations in BRCA1 and BRCA2 have not been found and the involvement of the...

    Authors: Olafur Andri Stefansson, Jon Gunnlaugur Jonasson, Oskar Thor Johannsson, Kristrun Olafsdottir, Margret Steinarsdottir, Sigridur Valgeirsdottir and Jorunn Erla Eyfjord
    Citation: Breast Cancer Research 2009 11:R47
    Content type: Research article Published on:

    The Erratum to this article has been published in Breast Cancer Research 2009 11:404

  39. The persistence of circulating tumor cells (CTC) in breast cancer patients might be associated with stem cell like tumor cells which have been suggested to be the active source of metastatic spread in primary ...

    Authors: Bahriye Aktas, Mitra Tewes, Tanja Fehm, Siegfried Hauch, Rainer Kimmig and Sabine Kasimir-Bauer
    Citation: Breast Cancer Research 2009 11:R46
    Content type: Research article Published on:

  40. Mounting molecular evidence suggests that invasive lobular carcinoma (ILC) is developing from in situ lesions, atypical lobular hyperplasia (ALH), and lobular carcinoma in situ (LCIS). However, little is known ab...

    Authors: Donghui Zou, Han-Seung Yoon, Ahmad Anjomshoaa, David Perez, Ryuji Fukuzawa, Parry Guilford and Bostjan Humar
    Citation: Breast Cancer Research 2009 11:R45
    Content type: Research article Published on:

  41. Mammography screening reduces breast cancer mortality through earlier diagnosis but may convey further benefit if screening is associated with optimized treatment through multidisciplinary medical care. In Nor...

    Authors: Mette Kalager, Tor Haldorsen, Michael Bretthauer, Geir Hoff, Steinar O Thoresen and Hans-Olov Adami
    Citation: Breast Cancer Research 2009 11:R44
    Content type: Research article Published on:

  42. Recent anticancer drugs have been made larger to pass selectively through tumor vessels and stay in the interstitium. Understanding drug movement in association with its size at the single-molecule level and e...

    Authors: Masaaki Kawai, Hideo Higuchi, Motohiro Takeda, Yoshio Kobayashi and Noriaki Ohuchi
    Citation: Breast Cancer Research 2009 11:R43
    Content type: Research article Published on:

  43. Heterochromatin protein 1 (HP1) associates with chromatin by binding to histone H3 and contributes to gene silencing. There are three isoforms of HP1 in mammals: HP1α, β, and γ. Studies have shown that the lev...

    Authors: Jason G Lieberthal, Marissa Kaminsky, Christopher N Parkhurst and Naoko Tanese
    Citation: Breast Cancer Research 2009 11:R42
    Content type: Research article Published on:

  44. Research that classifies breast tumors into homogenous subgroups could ultimately help to define public health prevention strategies for aggressive breast cancer subtypes. However, etiologic research on molecu...

    Authors: Melissa A Troester and Theresa Swift-Scanlan
    Citation: Breast Cancer Research 2009 11:104
    Content type: Editorial Published on:

  45. Inhibitor of apoptosis (IAPs) proteins are a family of proteins that can block apoptosis in normal cells and have been suggested to cause resistance to apoptosis in cancer. Overexpression of oncogenic receptor...

    Authors: Fiona M Foster, Thomas W Owens, Jolanta Tanianis-Hughes, Robert B Clarke, Keith Brennan, Nigel J Bundred and Charles H Streuli
    Citation: Breast Cancer Research 2009 11:R41
    Content type: Research article Published on:
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