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  1. Breast cancer is a heterogeneous disease, with several intrinsic subtypes differing by hormone receptor (HR) status, molecular profiles, and prognosis. However, the role of DNA methylation in breast cancer dev...

    Authors: Kathleen Conway, Sharon N Edmiston, Ryan May, Pei Fen Kuan, Haitao Chu, Christopher Bryant, Chiu-Kit Tse, Theresa Swift-Scanlan, Joseph Geradts, Melissa A Troester and Robert C Millikan
    Citation: Breast Cancer Research 2014 16:450
    Content type: Research article Published on:

  2. Transforming growth factor beta (TGFβ) plays a major role in the regulation of tumor initiation, progression, and metastasis. It is depended on the type II TGFβ receptor (TβRII) for signaling. Previously, we h...

    Authors: Sergey V Novitskiy, Elizabeth Forrester, Michael W Pickup, Agnieszka E Gorska, Anna Chytil, Mary Aakre, Dina Polosukhina, Philip Owens, Dilyara R Yusupova, Zhiguo Zhao, Fei Ye, Yu Shyr and Harold L Moses
    Citation: Breast Cancer Research 2014 16:425
    Content type: Research article Published on:

  3. Hormone receptor (HR) status has become an established target in treatment strategies of breast cancer. Population-based estimates of contralateral breast cancer (CBC) incidence by HR subtype in particular are...

    Authors: Carsten Rusner, Katharina Wolf, Ulrike Bandemer-Greulich, Jutta Engel, Christa Stegmaier, Bernd Holleczek, Gabriele Schubert-Fritschle, Anett Tillack and Andreas Stang
    Citation: Breast Cancer Research 2014 16:452
    Content type: Research article Published on:

  4. Recurrence or early metastasis remains the predominant cause of mortality in patients with estrogen receptor positive (ER+) mammary carcinoma (MC). However, the molecular mechanisms underlying the initial prog...

    Authors: Vijay Pandey, Zheng-Sheng Wu, Min Zhang, Rui Li, Jian Zhang, Tao Zhu and Peter E Lobie
    Citation: Breast Cancer Research 2014 16:429
    Content type: Research article Published on:

  5. The DDX21 RNA helicase has been shown to be a nucleolar and nuclear protein involved in ribosome RNA processing and AP-1 transcription. DDX21 is highly expressed in colon cancer, lymphomas, and some breast can...

    Authors: Yandong Zhang, Kathleen C Baysac, Lian-Fai Yee, Anthony J Saporita and Jason D Weber
    Citation: Breast Cancer Research 2014 16:449
    Content type: Research article Published on:

  6. Breast cancer is an increasing public health problem. Substantial advances have been made in the treatment of breast cancer, but the introduction of methods to predict women at elevated risk and prevent the di...

    Authors: Anthony Howell, Annie S Anderson, Robert B Clarke, Stephen W Duffy, D Gareth Evans, Montserat Garcia-Closas, Andy J Gescher, Timothy J Key, John M Saxton and Michelle N Harvie
    Citation: Breast Cancer Research 2014 16:446
    Content type: Research article Published on:

  7. The recently identified claudin-low subtype of breast cancer is enriched for cells with stem-like and mesenchymal-like characteristics. This subtype is most often triple-negative (lacking the estrogen and prog...

    Authors: Sierra A Colavito, Mike R Zou, Qin Yan, Don X Nguyen and David F Stern
    Citation: Breast Cancer Research 2014 16:444
    Content type: Research article Published on:

  8. The members of the Cas protein family (p130Cas/BCAR1, Nedd9/HEF1, EFS and CASS4) are scaffold proteins required for the assembly of signal transduction complexes in response to several stimuli, such as growth ...

    Authors: Giusy Tornillo, Paola Defilippi and Sara Cabodi
    Citation: Breast Cancer Research 2014 16:443
    Content type: Review Published on:

  9. The Rac-GEF P-REX1 is a key mediator of ErbB signaling in breast cancer recently implicated in mammary tumorigenesis and metastatic dissemination. Although P-REX1 is essentially undetectable in normal human ma...

    Authors: Laura Barrio-Real, Lorena G Benedetti, Nora Engel, Yaping Tu, Soonweng Cho, Saraswati Sukumar and Marcelo G Kazanietz
    Citation: Breast Cancer Research 2014 16:441
    Content type: Research article Published on:

  11. Mammographic density is a strong breast cancer risk factor and a major determinant of screening sensitivity. However, there is currently no validated estimation method for full-field digital mammography (FFDM).

    Authors: Amanda Eng, Zoe Gallant, John Shepherd, Valerie McCormack, Jingmei Li, Mitch Dowsett, Sarah Vinnicombe, Steve Allen and Isabel dos-Santos-Silva
    Citation: Breast Cancer Research 2014 16:439
    Content type: Research article Published on:

  12. It is frequent for news items to lead to a short lived temporary increase in interest in a particular health related service, however it is rare for this to have a long lasting effect. In 2013, in the UK in pa...

    Authors: D Gareth R Evans, Julian Barwell, Diana M Eccles, Amanda Collins, Louise Izatt, Chris Jacobs, Alan Donaldson, Angela F Brady, Andrew Cuthbert, Rachel Harrison, Sue Thomas, Anthony Howell, Zosia Miedzybrodzka and Alex Murray
    Citation: Breast Cancer Research 2014 16:442
    Content type: Research article Published on:

    The Letter to this article has been published in Breast Cancer Research 2015 17:143

  13. Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced...

    Authors: Abdi Ghaffari, Victoria Hoskin, Alvin Szeto, Maaike Hum, Navid Liaghati, Kanji Nakatsu, Yolanda Madarnas, Sandip Sengupta and Bruce E Elliott
    Citation: Breast Cancer Research 2014 16:438
    Content type: Research article Published on:

    The Erratum to this article has been published in Breast Cancer Research 2015 17:9

  14. Triple-negative breast cancer (TNBC) represents 15 to 20% of all types of breast cancer; however, it accounts for a large number of metastatic cases and deaths, and there is still no effective treatment. The d...

    Authors: Xiaohui Tan, Jin Peng, Yebo Fu, Shejuan An, Katayoon Rezaei, Sana Tabbara, Christine B Teal, Yan-gao Man, Rachel F Brem and Sidney W Fu
    Citation: Breast Cancer Research 2014 16:435
    Content type: Research article Published on:

  15. Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell survival through mechanisms other than ER antagonism. In the present study, we tested the efficacy of tamoxifen in a panel of ER-...

    Authors: Chun-Yu Liu, Man-Hsin Hung, Duen-Shian Wang, Pei-Yi Chu, Jung-Chen Su, Tsung-Han Teng, Chun-Teng Huang, Ting-Ting Chao, Cheng-Yi Wang, Chung-Wai Shiau, Ling-Ming Tseng and Kuen-Feng Chen
    Citation: Breast Cancer Research 2014 16:431
    Content type: Research article Published on:

  16. Traditional factors currently used for prognostic stratification do not always adequately predict treatment response and disease evolution in advanced breast cancer patients. Therefore, the use of blood-based ...

    Authors: Mario Giuliano, Antonio Giordano, Summer Jackson, Ugo De Giorgi, Michal Mego, Evan N Cohen, Hui Gao, Simone Anfossi, Beverly C Handy, Naoto T Ueno, Ricardo H Alvarez, Sabino De Placido, Vicente Valero, Gabriel N Hortobagyi, James M Reuben and Massimo Cristofanilli
    Citation: Breast Cancer Research 2014 16:440
    Content type: Research article Published on:

  17. The forkhead transcription factor FOXM1 coordinates expression of cell cycle-related genes and plays a pivotal role in tumorigenesis and cancer progression. We previously showed that FOXM1 acts downstream of 1...

    Authors: Anna Bergamaschi, Zeynep Madak-Erdogan, Yu Jin Kim, Yoon-La Choi, Hailing Lu and Benita S Katzenellenbogen
    Citation: Breast Cancer Research 2014 16:436
    Content type: Research article Published on:

  18. Triple-negative breast cancer (TNBC) is a subtype of highly malignant breast cancer with poor prognosis. TNBC is not amenable to endocrine therapy and often exhibit resistance to current chemotherapeutic agent...

    Authors: Hélène Pelicano, Wan Zhang, Jinyun Liu, Naima Hammoudi, Jiale Dai, Rui-Hua Xu, Lajos Pusztai and Peng Huang
    Citation: Breast Cancer Research 2014 16:434
    Content type: Research article Published on:

  19. Activation of the phosphatidylinositol 3-kinase (PI3K) pathway in estrogen receptor α (ER)-positive breast cancer is associated with reduced ER expression and activity, luminal B subtype, and poor outcome. Pho...

    Authors: Xiaoyong Fu, Chad J Creighton, Nrusingh C Biswal, Vijetha Kumar, Martin Shea, Sabrina Herrera, Alejandro Contreras, Carolina Gutierrez, Tao Wang, Sarmistha Nanda, Mario Giuliano, Gladys Morrison, Agostina Nardone, Kristen L Karlin, Thomas F Westbrook, Laura M Heiser…
    Citation: Breast Cancer Research 2014 16:430
    Content type: Research article Published on:

  20. Although aberrant tyrosine kinase signalling characterises particular breast cancer subtypes, a global analysis of tyrosine phosphorylation in mouse models of breast cancer has not been undertaken to date. Thi...

    Authors: Naveid A Ali, Jianmin Wu, Falko Hochgräfe, Howard Chan, Radhika Nair, Sunny Ye, Luxi Zhang, Ruth J Lyons, Mark Pinese, Hong Ching Lee, Nicola Armstrong, Christopher J Ormandy, Susan J Clark, Alexander Swarbrick and Roger J Daly
    Citation: Breast Cancer Research 2014 16:437
    Content type: Research article Published on:

  21. Interleukin-like epithelial-to-mesenchymal transition inducer (ILEI) is an essential cytokine in tumor progression that is upregulated in several cancers, and its altered subcellular localization is a predicto...

    Authors: Agnes Csiszar, Betül Kutay, Silvia Wirth, Ulrike Schmidt, Sabine Macho-Maschler, Martin Schreiber, Memetcan Alacakaptan, Georg F Vogel, Karin Aumayr, Lukas A Huber and Hartmut Beug
    Citation: Breast Cancer Research 2014 16:433
    Content type: Research article Published on:

  22. The infiltration of FOXP3+ regulatory T cells into invasive tumors has been reported to be associated with survival in a variety of cancers. The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (T...

    Authors: Shuzhen Liu, William D Foulkes, Samuel Leung, Dongxia Gao, Sherman Lau, Zuzana Kos and Torsten O Nielsen
    Citation: Breast Cancer Research 2014 16:432
    Content type: Research article Published on:

  23. Human epidermal growth factor receptor 2 (HER2) amplification is frequent in ductal carcinoma in situ (DCIS) of the breast and is associated with poorly differentiated tumors and adverse prognosis features. Th...

    Authors: Laura G Estévez, Ana Suarez-Gauthier, Elena García, Cristina Miró, Isabel Calvo, María Fernández-Abad, Mercedes Herrero, Manuel Marcos, Cristina Márquez, Fernando Lopez Ríos, Sofía Perea and Manuel Hidalgo
    Citation: Breast Cancer Research 2014 16:R76
    Content type: Research article Published on:

  24. Breast cancer arising at a young age is relatively uncommon, particularly in the developed world. Several studies have demonstrated that younger patients often experience a more aggressive disease course and h...

    Authors: Hatem A Azim and Ann H Partridge
    Citation: Breast Cancer Research 2014 16:427
    Content type: Review Published on:

  25. Percent mammographic density (PMD) is associated with an increased risk of interval breast cancer in screening programs, as are younger age, pre-menopausal status, lower body mass index and hormone therapy. Th...

    Authors: Norman F Boyd, Ella Huszti, Olga Melnichouk, Lisa J Martin, Greg Hislop, Anna Chiarelli, Martin J Yaffe and Salomon Minkin
    Citation: Breast Cancer Research 2014 16:417
    Content type: Research article Published on:

  26. Extracellular nucleotides are released and detectable in a high concentration within the tumor microenvironment. G protein-coupled P2Y2 nucleotide receptor (P2Y2R) is activated equipotently by adenosine triphosph...

    Authors: Hana Jin, So Young Eun, Jong Sil Lee, Sang Won Park, Jae Heun Lee, Ki Churl Chang and Hye Jung Kim
    Citation: Breast Cancer Research 2014 16:R77
    Content type: Research article Published on:

  27. Mammographic density is similar among women at risk of either sporadic or BRCA1/2-related breast cancer. It has been suggested that digitized mammographic images contain computer-extractable information within th...

    Authors: Gretchen L Gierach, Hui Li, Jennifer T Loud, Mark H Greene, Catherine K Chow, Li Lan, Sheila A Prindiville, Jennifer Eng-Wong, Peter W Soballe, Claudia Giambartolomei, Phuong L Mai, Claudia E Galbo, Kathryn Nichols, Kathleen A Calzone, Olufunmilayo I Olopade, Mitchell H Gail…
    Citation: Breast Cancer Research 2014 16:424
    Content type: Research article Published on:

  28. Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease involved in cancer invasion and metastasis, interacting with plasminogen activator inhibitor-1 (PAI-1), which was originally ...

    Authors: Michael J Duffy, Patricia M McGowan, Nadia Harbeck, Christoph Thomssen and Manfred Schmitt
    Citation: Breast Cancer Research 2014 16:428
    Content type: Review Published on:

  29. Lymphedema is a potentially debilitating condition that occurs among breast cancer survivors. This study examines the incidence of self-reported lymphedema, timing of lymphedema onset, and associations between...

    Authors: Kayo Togawa, Huiyan Ma, Jane Sullivan-Halley, Marian L Neuhouser, Ikuyo Imayama, Kathy B Baumgartner, Ashley Wilder Smith, Catherine M Alfano, Anne McTiernan, Rachel Ballard-Barbash and Leslie Bernstein
    Citation: Breast Cancer Research 2014 16:414
    Content type: Research article Published on:

  30. Single-nucleotide polymorphisms (SNPs) at 6q25.1 that are associated with breast cancer susceptibility have been identified in several genome-wide association studies (GWASs). However, the exact causal variant...

    Authors: Yanru Wang, Yisha He, Zhenzhen Qin, Yue Jiang, Guangfu Jin, Hongxia Ma, Juncheng Dai, Jiaping Chen, Zhibin Hu, Xiaoxiang Guan and Hongbing Shen
    Citation: Breast Cancer Research 2014 16:422
    Content type: Research article Published on:

  31. Many Luminal breast cancers are heterogeneous, containing substantial numbers of estrogen (ER) and progesterone (PR) receptor-negative cells among the ER+ PR+ ones. One such subpopulation we call “Luminobasal”...

    Authors: Aaron J Knox, Allison L Scaling, Mauricio P Pinto, Brian S Bliesner, James M Haughian, Hany A Abdel-Hafiz and Kathryn B Horwitz
    Citation: Breast Cancer Research 2014 16:418
    Content type: Research article Published on:

  32. The management of metastatic breast cancer needs improvement. As clinical evaluation is not very accurate in determining the progression of disease, the analysis of circulating tumor DNA (ctDNA) has evolved to...

    Authors: Maryam Heidary, Martina Auer, Peter Ulz, Ellen Heitzer, Edgar Petru, Christin Gasch, Sabine Riethdorf, Oliver Mauermann, Ingrid Lafer, Gunda Pristauz, Sigurd Lax, Klaus Pantel, Jochen B Geigl and Michael R Speicher
    Citation: Breast Cancer Research 2014 16:421
    Content type: Research article Published on:

  33. Triple negative breast cancer (TNBC) is a heterogeneous collection of biologically diverse cancers, which contributes to variable clinical outcomes. Previously, we identified a TNBC subtype that has a luminal ...

    Authors: Brian D Lehmann, Joshua A Bauer, Johanna M Schafer, Christopher S Pendleton, Luojia Tang, Kimberly C Johnson, Xi Chen, Justin M Balko, Henry Gómez, Carlos L Arteaga, Gordon B Mills, Melinda E Sanders and Jennifer A Pietenpol
    Citation: Breast Cancer Research 2014 16:406
    Content type: Research article Published on:

  34. Matrix detachment triggers anoikis, a form of apoptosis, in most normal epithelial cells, while acquisition of anoikis resistance is a prime requisite for solid tumor growth. Of note, recent studies have revea...

    Authors: Sravanth K Hindupur, Sai A Balaji, Meera Saxena, Shubham Pandey, Gopalkrishnashetty Sreenivasmurthy Sravan, Namrata Heda, M Vijaya Kumar, Geetashree Mukherjee, Devaveena Dey and Annapoorni Rangarajan
    Citation: Breast Cancer Research 2014 16:420
    Content type: Research article Published on:

  35. Remodeling of cellular metabolism appears to be a consequence and possibly a cause of oncogenic transformation in human cancers. Specific aspects of altered tumor metabolism may be amenable to therapeutic inte...

    Authors: Xiaohu Tang, Chao-Chieh Lin, Ivan Spasojevic, Edwin S Iversen, Jen-Tsan Chi and Jeffrey R Marks
    Citation: Breast Cancer Research 2014 16:415
    Content type: Research article Published on:

  36. The estrogen receptor and human epidermal growth factor receptor (HER) signaling pathways are the dominant drivers of cell proliferation and survival in the majority of human breast cancers. Not surprisingly, ...

    Authors: Tejal A Patel, Bhuvanesh Dave, Angel A Rodriguez, Jenny C Chang, Edith A Perez and Gerardo Colon-Otero
    Citation: Breast Cancer Research 2014 16:419
    Content type: Review Published on:

    The Erratum to this article has been published in Breast Cancer Research 2014 16:468

  37. Telomere length (TL) is a biomarker of accumulated cellular damage and human aging. Evidence in healthy populations suggests that TL is impacted by a host of psychosocial and lifestyle factors, including physi...

    Authors: Sheila N Garland, Brad Johnson, Christina Palmer, Rebecca M Speck, Michelle Donelson, Sharon X Xie, Angela DeMichele and Jun J Mao
    Citation: Breast Cancer Research 2014 16:413
    Content type: Research article Published on:

  38. DNA methylation and histone modifications are important epigenetic modifications associated with gene (dys)regulation. The epigenetic modifications are balanced by epigenetic enzymes, so-called writers and era...

    Authors: Fahimeh Falahi, Michel van Kruchten, Nadine Martinet, Geke Hospers and Marianne G Rots
    Citation: Breast Cancer Research 2014 16:412
    Content type: Review Published on:

  39. In breast cancer, distinct expression profiles of microRNAs (miRNAs) have been associated with molecular subgroups and clinicopathological characteristics, implicating a diagnostic and prognostic role of miRNA...

    Authors: Raisa Krutilina, Wenlin Sun, Aarti Sethuraman, Martin Brown, Tiffany N Seagroves, Lawrence M Pfeffer, Tatyana Ignatova and Meiyun Fan
    Citation: Breast Cancer Research 2014 16:R78
    Content type: Research article Published on:

  40. Expression of indoleamine 2,3-dioxygenase (IDO) in primary breast cancer increases tumor growth and metastasis. However, the clinical significance of stromal IDO and the regulation of stromal IDO are unclear.

    Authors: Jing-Yi Chen, Chien-Feng Li, Cheng-Chin Kuo, Kelvin K Tsai, Ming-Feng Hou and Wen-Chun Hung
    Citation: Breast Cancer Research 2014 16:410
    Content type: Research article Published on:

  41. Despite improvements in adjuvant therapy, late systemic recurrences remain a lethal consequence of both early- and late-stage breast cancer. A delayed recurrence is thought to arise from a state of tumor dorma...

    Authors: Qing Cheng, Jeffrey T Chang, William R Gwin, Jun Zhu, Stefan Ambs, Joseph Geradts and H Kim Lyerly
    Citation: Breast Cancer Research 2014 16:407
    Content type: Research article Published on:

  42. Lineage tracing using inducible genetic labeling has emerged to be a powerful method for interrogating the developmental fate of cells in intact tissues. A common induction mechanism is the use of tamoxifen-de...

    Authors: Mona Shehata, Renée van Amerongen, Amber L Zeeman, Rajshekhar R Giraddi and John Stingl
    Citation: Breast Cancer Research 2014 16:411
    Content type: Research article Published on:

  44. We investigated Nestin expression in triple-negative breast cancer and examined how the modulation of Nestin expression affects cell cycle progression, survival, invasion and regulatory signaling in breast can...

    Authors: Zuowei Zhao, Ping Lu, Hao Zhang, Huanming Xu, Ningning Gao, Man Li and Caigang Liu
    Citation: Breast Cancer Research 2014 16:408
    Content type: Research article Published on:

  45. Phosphatidylinositol 3-kinase (PI3K) pathway deregulation (that is PIK3CA mutations and/or phosphatase and tensin homolog (PTEN) loss) has been shown to enhance breast cancer cell survival and confer resistanc...

    Authors: Binghe Xu, Zhongzhen Guan, Zhenzhou Shen, Zhongshen Tong, Zefei Jiang, Junlan Yang, Michelle DeSilvio, Mark Russo, Meggan Leigh and Catherine Ellis
    Citation: Breast Cancer Research 2014 16:405
    Content type: Research article Published on:

  46. UEV1A encodes a ubiquitin-conjugating enzyme variant (Ubc13), which is required for Ubc13-catalyzed Lys63-linked polyubiquitination of target proteins and nuclear factor κB (NF-кB) activation. Previous reports...

    Authors: Zhaojia Wu, Siqi Shen, Zhiling Zhang, Weiwei Zhang and Wei Xiao
    Citation: Breast Cancer Research 2014 16:R75
    Content type: Research article Published on:

    The Erratum to this article has been published in Breast Cancer Research 2017 19:41

  47. Peroxiredoxin-1 (PRDX1) is a multifunctional protein, acting as a hydrogen peroxide (H2O2) scavenger, molecular chaperone and immune modulator. Although differential PRDX1 expression has been described in many tu...

    Authors: Patrick C O’Leary, Marta Terrile, Malgorzata Bajor, Pawel Gaj, Bryan T Hennessy, Gordon B Mills, Agnieszka Zagozdzon, Darran P O’Connor, Donal J Brennan, Kate Connor, Jane Li, Ana Maria Gonzalez-Angulo, Han-Dong Sun, Jian-Xin Pu, Fredrik Pontén, Mathias Uhlén…
    Citation: Breast Cancer Research 2014 16:R79
    Content type: Research article Published on:

  48. Relationships of parity with breast cancer risk are complex. Parity is associated with decreased risk of postmenopausal hormone receptor–positive breast tumors, but may increase risk for basal-like breast canc...

    Authors: Melissa Rotunno, Xuezheng Sun, Jonine Figueroa, Mark E Sherman, Montserrat Garcia-Closas, Paul Meltzer, Tyisha Williams, Sallie Smith Schneider, D Joseph Jerry, Xiaohong R Yang and Melissa A Troester
    Citation: Breast Cancer Research 2014 16:R74
    Content type: Research article Published on:

  49. Molecular markers that predict responses to particular therapies are invaluable for optimization of patient treatment. The TRYPHAENA study showed that pertuzumab and trastuzumab with chemotherapy was an effica...

    Authors: Andreas Schneeweiss, Stephen Chia, Roberto Hegg, Christoph Tausch, Rahul Deb, Jayantha Ratnayake, Virginia McNally, Graham Ross, Astrid Kiermaier and Javier Cortés
    Citation: Breast Cancer Research 2014 16:R73
    Content type: Research article Published on:
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