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  1. The PAM50-based (Prosigna) risk of recurrence (ROR) score and intrinsic subtypes are prognostic for women with high-risk breast cancer. We investigate the predictive ability of Prosigna regarding the effective...

    Authors: Maj-Britt Jensen, Anne-Vibeke Lænkholm, Torsten O. Nielsen, Jens Ole Eriksen, Pernille Wehn, Tressa Hood, Namratha Ram, Wesley Buckingham, Sean Ferree and Bent Ejlertsen
    Citation: Breast Cancer Research 2018 20:79
  2. The authors are retracting this article [1] after an investigation by the Ethics Committee of the Fourth Military Medical University (Xi’an, Shaanxi, China) of the following concerns that had been raised with ...

    Authors: Jun-Tang Li, Li-Feng Wang, Ya-Li Zhao, Tao Yang, Wei Li, Jing Zhao, Feng Yu, Lei Wang, Yan-Ling Meng, Ning-Ning Liu, Xiao-Shan Zhu, Chun-Fang Gao, Lin-Tao Jia and An-Gang Yang
    Citation: Breast Cancer Research 2018 20:77

    The original article was published in Breast Cancer Research 2014 16:454

  3. Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major cha...

    Authors: Aparna Shinde, Tomasz Wilmanski, Hao Chen, Dorothy Teegarden and Michael K. Wendt
    Citation: Breast Cancer Research 2018 20:76
  4. The 2013 update of the American Society of Clinical Oncology-College of American Pathologists (ASCO-CAP) human epidermal growth factor receptor 2 (HER2) testing guidelines recommend using an alternative chromo...

    Authors: Neelam V. Desai, Vanda Torous, Joel Parker, James T. Auman, Gary B. Rosson, Cassandra Cruz, Charles M. Perou, Stuart J. Schnitt and Nadine Tung
    Citation: Breast Cancer Research 2018 20:75
  5. Estrogen promotes breast cancer development and progression mainly through estrogen receptor (ER). However, blockage of estrogen production or action prevents development of and suppresses progression of ER-ne...

    Authors: Chuying Wang, Feng Bai, Li-han Zhang, Alexandria Scott, Enxiao Li and Xin-Hai Pei
    Citation: Breast Cancer Research 2018 20:74
  6. The ETS transcription factor ETV4 is involved in the main steps of organogenesis and is also a significant mediator of tumorigenesis and metastasis, such as in breast cancer. Indeed, ETV4 is overexpressed in b...

    Authors: Mandy Dumortier, Franck Ladam, Isabelle Damour, Sophie Vacher, Ivan Bièche, Nathalie Marchand, Yvan de Launoit, David Tulasne and Anne Chotteau-Lelièvre
    Citation: Breast Cancer Research 2018 20:73
  7. In primary breast cancer metastases frequently arise from a state of dormancy that may persist for extended periods of time. We investigated the efficacy of plasma micro-RNA (miR)-21, miR-23b, miR-190, miR-200...

    Authors: Chara Papadaki, Michalis Stratigos, Georgios Markakis, Maria Spiliotaki, Georgios Mastrostamatis, Christoforos Nikolaou, Dimitrios Mavroudis and Sofia Agelaki
    Citation: Breast Cancer Research 2018 20:72

    The Correction to this article has been published in Breast Cancer Research 2022 24:53

  8. Elevated PD-L1 expression on tumor cells, a context associated with an adaptive immune response, has been linked to the total burden of copy number variants (CNVs) in aneuploid tumors, to microsatellite instab...

    Authors: Michael T. Barrett, Elizabeth Lenkiewicz, Smriti Malasi, Anamika Basu, Jennifer Holmes Yearley, Lakshmanan Annamalai, Ann E. McCullough, Heidi E. Kosiorek, Pooja Narang, Melissa A. Wilson Sayres, Meixuan Chen, Karen S. Anderson and Barbara A. Pockaj
    Citation: Breast Cancer Research 2018 20:71
  9. Vitamin D has anticarcinogenic and immune-related properties and may protect against some diseases, including breast cancer. Vitamin D affects gene transcription and may influence DNA methylation.

    Authors: Katie M. O’Brien, Dale P. Sandler, Zongli Xu, H. Karimi Kinyamu, Jack A. Taylor and Clarice R. Weinberg
    Citation: Breast Cancer Research 2018 20:70
  10. In over 20% of breast conserving operations, postoperative pathological assessment of the excised tissue reveals positive margins, requiring additional surgery. Current techniques for intra-operative assessmen...

    Authors: Dustin W. Shipp, Emad A. Rakha, Alexey A. Koloydenko, R. Douglas Macmillan, Ian O. Ellis and Ioan Notingher
    Citation: Breast Cancer Research 2018 20:69

    The Editorial to this article has been published in Breast Cancer Research 2018 20:85

  11. After the publication of this work [1], an error was noticed in Fig. 2b, Fig. 3a and Fig. 5b. The Skp1 loading control was accidentally duplicated. We apologize for this error, which did not affect any of the ...

    Authors: Ma’anit Shapira, Eli Kakiashvili, Tzur Rosenberg and Dan D. Hershko
    Citation: Breast Cancer Research 2018 20:68

    The original article was published in Breast Cancer Research 2006 8:R46

  12. Circulating tumor cells (CTCs) are the major players in the metastatic process. A potential mechanism of cell migration and invasion is the formation of microtentacles in tumor cells. These structures are supp...

    Authors: G. Kallergi, D. Aggouraki, N. Zacharopoulou, C. Stournaras, V. Georgoulias and S. S. Martin
    Citation: Breast Cancer Research 2018 20:67
  13. Syndecan-1 (Sdc1), a cell surface heparan sulfate proteoglycan normally expressed primarily by epithelia and plasma cells, is aberrantly induced in stromal fibroblasts of breast carcinomas. Stromal fibroblast-...

    Authors: Colleen Chute, Xinhai Yang, Kristy Meyer, Ning Yang, Keelin O’Neil, Ildiko Kasza, Kevin Eliceiri, Caroline Alexander and Andreas Friedl
    Citation: Breast Cancer Research 2018 20:66
  14. The microenvironment and stress factors like glucocorticoids have a strong influence on breast cancer progression but their role in the first stages of breast cancer and, particularly, in myoepithelial cell re...

    Authors: Arantzazu Zubeldia-Plazaola, Leire Recalde-Percaz, Núria Moragas, Mireia Alcaraz, Xieng Chen, Mario Mancino, Patricia Fernández-Nogueira, Miquel Prats de Puig, Flavia Guzman, Aleix Noguera-Castells, Anna López-Plana, Estel Enreig, Neus Carbó, Vanessa Almendro, Pedro Gascón, Paloma Bragado…
    Citation: Breast Cancer Research 2018 20:65
  15. Adjuvant radiotherapy is the standard of care after breast-conserving surgery for primary breast cancer, despite a majority of patients being over- or under-treated. In contrast to adjuvant endocrine therapy a...

    Authors: Martin Sjöström, Johan Staaf, Patrik Edén, Fredrik Wärnberg, Jonas Bergh, Per Malmström, Mårten Fernö, Emma Niméus and Irma Fredriksson
    Citation: Breast Cancer Research 2018 20:64
  16. After the publication of this work [1] an error in Fig. 1c was brought to our attention: the Western blots for PRDX6 and β-actin were similar to those shown in lanes 5-6 of Fig. 4g. To verify these findings, w...

    Authors: Xin-Zhong Chang, Da-Qiang Li, Yi-Feng Hou, Jiong Wu, Jin-Song Lu, Gen-Hong Di, Wei Jin, Zhou-Luo Ou, Zhen-Zhou Shen and Zhi-Ming Shao
    Citation: Breast Cancer Research 2018 20:63

    The original article was published in Breast Cancer Research 2007 9:R76

  17. Tumor-infiltrating lymphocytes (TILs) evaluated in primary breast cancer (BC) convey prognostic information. Limited data in the metastatic setting are available.

    Authors: Maria Vittoria Dieci, Vassilena Tsvetkova, Enrico Orvieto, Federico Piacentini, Guido Ficarra, Gaia Griguolo, Federica Miglietta, Tommaso Giarratano, Claudia Omarini, Serena Bonaguro, Rocco Cappellesso, Camillo Aliberti, Grazia Vernaci, Carlo Alberto Giorgi, Giovanni Faggioni, Giulia Tasca…
    Citation: Breast Cancer Research 2018 20:62
  18. After the publication of this work [1] errors were noticed in the total protein loading controls for Figs. 1C, 2B, 3B and 4B.

    Authors: Kheng Tian Lim, Niamh Cosgrave, Arnold David Hill and Leonie S. Young
    Citation: Breast Cancer Research 2018 20:61

    The original article was published in Breast Cancer Research 2006 8:R33

  19. Endocrine resistance in estrogen receptor-positive (ER+) breast cancer is a major clinical problem and is associated with accelerated cancer cell growth, increased motility and acquisition of mesenchymal chara...

    Authors: Carla L. Alves, Daniel Elias, Maria B. Lyng, Martin Bak and Henrik J. Ditzel
    Citation: Breast Cancer Research 2018 20:60
  20. As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophag...

    Authors: Sara Donzelli, Elisa Milano, Magdalena Pruszko, Andrea Sacconi, Silvia Masciarelli, Ilaria Iosue, Elisa Melucci, Enzo Gallo, Irene Terrenato, Marcella Mottolese, Maciej Zylicz, Alicja Zylicz, Francesco Fazi, Giovanni Blandino and Giulia Fontemaggi
    Citation: Breast Cancer Research 2018 20:59
  21. Numerous studies have analyzed associations between apparent diffusion coefficient (ADC) and histopathological features such as Ki-67 proliferation index in breast cancer (BC), with mixed results. The purpose ...

    Authors: Alexey Surov, Paola Clauser, Yun-Woo Chang, Lihua Li, Laura Martincich, Savannah C. Partridge, Jin You Kim, Hans Jonas Meyer and Andreas Wienke
    Citation: Breast Cancer Research 2018 20:58
  22. After the publication of this work [1] an error was noticed in Fig. 3a and Fig. 5a.

    Authors: Joan S. Lewis-Wambi, Helen R. Kim, Chris Wambi, Roshani Patel, Jennifer R. Pyle, Andres J. Klein-Szanto and V. Craig Jordan
    Citation: Breast Cancer Research 2018 20:57

    The original article was published in Breast Cancer Research 2008 10:R104

  23. Breast cancer pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) varies with tumor subtype. The purpose of this study was to identify an early treatment window for predicting pCR based on tum...

    Authors: Quing Zhu, Susan Tannenbaum, Scott H. Kurtzman, Patricia DeFusco, Andrew Ricci Jr, Hamed Vavadi, Feifei Zhou, Chen Xu, Alex Merkulov, Poornima Hegde, Mark Kane, Liqun Wang and Kert Sabbath
    Citation: Breast Cancer Research 2018 20:56
  24. Altered lipid metabolism is an emerging hallmark of aggressive breast cancers. The N-myc downstream regulated gene (NDRG1) gene plays a critical role in peripheral nervous system myelination, as inactivating m...

    Authors: Christopher J. Sevinsky, Faiza Khan, Leila Kokabee, Anza Darehshouri, Krishna Rao Maddipati and Douglas S. Conklin
    Citation: Breast Cancer Research 2018 20:55
  25. Metastatic triple-negative breast cancer (TNBC) is a heterogeneous and incurable disease. Numerous studies have been conducted to seek molecular targets to treat TNBC effectively, but chemotherapy is still the...

    Authors: Kideok Jin, Niranjan B. Pandey and Aleksander S. Popel
    Citation: Breast Cancer Research 2018 20:54
  26. Systemic and chronic inflammatory conditions in patients with breast cancer have been associated with reduced patient survival and increased breast cancer aggressiveness. This paper characterizes the role of a...

    Authors: Ken Tawara, Celeste Bolin, Jordan Koncinsky, Sujatha Kadaba, Hunter Covert, Caleb Sutherland, Laura Bond, Joseph Kronz, Joel R. Garbow and Cheryl L. Jorcyk
    Citation: Breast Cancer Research 2018 20:53
  27. Resected HER2 breast cancer patients treated with adjuvant trastuzumab and chemotherapy have superior survival compared to patients treated with chemotherapy alone. We previously showed that trastuzumab and ch...

    Authors: Nadine Norton, Nicholas Fox, Christie-Ann McCarl, Kathleen S. Tenner, Karla Ballman, Courtney L. Erskine, Brian M. Necela, Donald Northfelt, Winston W. Tan, Carmen Calfa, Mark Pegram, Gerardo Colon-Otero, Edith A. Perez, Raphael Clynes and Keith L. Knutson
    Citation: Breast Cancer Research 2018 20:52
  28. The purpose of this work was to investigate noninvasive early detection of treatment response of breast cancer patients to neoadjuvant chemotherapy (NAC) using chemical exchange saturation transfer (CEST) meas...

    Authors: Erwin Krikken, Vitaliy Khlebnikov, Moritz Zaiss, Rajni A. Jibodh, Paul J. van Diest, Peter R. Luijten, Dennis W. J. Klomp, Hanneke W. M. van Laarhoven and Jannie P. Wijnen
    Citation: Breast Cancer Research 2018 20:51
  29. Obesity and type II diabetes are linked to increased breast cancer risk in postmenopausal women. Patients treated with the antidiabetic drug metformin for diabetes or metabolic syndrome have reduced breast can...

    Authors: Erin D. Giles, Sonali Jindal, Elizabeth A. Wellberg, Troy Schedin, Steven M. Anderson, Ann D. Thor, Dean P. Edwards, Paul S. MacLean and Pepper Schedin
    Citation: Breast Cancer Research 2018 20:50
  30. The percentage of mammographic dense tissue (PD) defined by pixel value threshold is a well-established risk factor for breast cancer. Recently there has been some evidence to suggest that an increased thresho...

    Authors: Chao Wang, Adam R. Brentnall, Jack Cuzick, Elaine F. Harkness, D. Gareth Evans and Susan Astley
    Citation: Breast Cancer Research 2018 20:49
  31. Circulating tumor cells (CTCs) carry independent prognostic information in patients with metastatic breast cancer (MBC) on different lines of therapy. Moreover, CTC clusters are suggested to add prognostic inf...

    Authors: Anna-Maria Larsson, Sara Jansson, Pär-Ola Bendahl, Charlotte Levin Tykjaer Jörgensen, Niklas Loman, Cecilia Graffman, Lotta Lundgren, Kristina Aaltonen and Lisa Rydén
    Citation: Breast Cancer Research 2018 20:48
  32. Endocrine therapies are the mainstay of treatment for oestrogen receptor (ER)-positive (ER+) breast cancer (BC). However, resistance remains problematic largely due to enhanced cross-talk between ER and growth fa...

    Authors: Ricardo Ribas, Sunil Pancholi, Aradhana Rani, Eugene Schuster, Stephanie K. Guest, Joanna Nikitorowicz-Buniak, Nikiana Simigdala, Allan Thornhill, Francesca Avogadri-Connors, Richard E. Cutler Jr, Alshad S. Lalani, Mitch Dowsett, Stephen R. Johnston and Lesley-Ann Martin
    Citation: Breast Cancer Research 2018 20:44
  33. After the publication of this article [1] we noticed that in Fig. 1, the gel images (1A and 1B lower panel) were incorrect.

    Authors: Anastasios D. Papanastasiou, Chaido Sirinian and Haralabos P. Kalofonos
    Citation: Breast Cancer Research 2018 20:47

    The original article was published in Breast Cancer Research 2012 14:R112

  34. Background parenchymal uptake (BPU), which refers to the level of Tc-99m sestamibi uptake within normal fibroglandular tissue on molecular breast imaging (MBI), has been identified as a breast cancer risk fact...

    Authors: Carrie B. Hruska, Jennifer R. Geske, Tiffinee N. Swanson, Alyssa N. Mammel, David S. Lake, Armando Manduca, Amy Lynn Conners, Dana H. Whaley, Christopher G. Scott, Rickey E. Carter, Deborah J. Rhodes, Michael K. O’Connor and Celine M. Vachon
    Citation: Breast Cancer Research 2018 20:46
  35. MicroRNAs (miRNAs) regulate gene expression and influence cancer. Primary transcripts of miRNAs (pri-miRNAs) are poorly annotated and little is known about the role of germline variation in miRNA genes and bre...

    Authors: Jeannette T. Bensen, Mariaelisa Graff, Kristin L. Young, Praveen Sethupathy, Joel Parker, Chad V. Pecot, Kevin Currin, Stephen A. Haddad, Edward A. Ruiz-Narváez, Christopher A. Haiman, Chi-Chen Hong, Lara E. Sucheston-Campbell, Qianqian Zhu, Song Liu, Song Yao, Elisa V. Bandera…
    Citation: Breast Cancer Research 2018 20:45
  36. Proteolytic impairment of the Fc effector functions of therapeutic monoclonal antibodies (mAbs) can compromise their antitumor efficacy in the tumor microenvironment and may represent an unappreciated mechanis...

    Authors: Hao-Ching Hsiao, Xuejun Fan, Robert E. Jordan, Ningyan Zhang and Zhiqiang An
    Citation: Breast Cancer Research 2018 20:43
  37. Psychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transc...

    Authors: A. N. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. G. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia and Y. Li
    Citation: Breast Cancer Research 2018 20:42
  38. The RhoA activating protein Net1 contributes to breast cancer cell proliferation, motility, and invasion in vitro, yet little is known about its roles in mammary gland tumorigenesis and metastasis.

    Authors: Yan Zuo, Arzu Ulu, Jeffrey T. Chang and Jeffrey A. Frost
    Citation: Breast Cancer Research 2018 20:41
  39. Detection of circulating ESR1 mutations is associated with acquired resistance to aromatase inhibitor (AI) in metastatic breast cancer. Until now, the presence of circulating ESR1 mutations at the end of adjuvant...

    Authors: Violette Allouchery, Ludivine Beaussire, Anne Perdrix, David Sefrioui, Laetitia Augusto, Cécile Guillemet, Nasrin Sarafan-Vasseur, Frédéric Di Fiore and Florian Clatot
    Citation: Breast Cancer Research 2018 20:40
  40. Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and treatment. After a diagnosis of ADH on biopsy a proportio...

    Authors: Tanjina Kader, Prue Hill, Emad A. Rakha, Ian G. Campbell and Kylie L. Gorringe
    Citation: Breast Cancer Research 2018 20:39
  41. Cognitive decline is among the most feared treatment-related outcomes of older adults with cancer. The majority of older patients with breast cancer self-report cognitive problems during and after chemotherapy...

    Authors: Bihong T. Chen, Sean K. Sethi, Taihao Jin, Sunita K. Patel, Ningrong Ye, Can-Lan Sun, Russell C. Rockne, E. Mark Haacke, James C. Root, Andrew J. Saykin, Tim A. Ahles, Andrei I. Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan…
    Citation: Breast Cancer Research 2018 20:38
  42. Rapidly evolving understanding of cancer biology has presented novel opportunities to translate that understanding into clinically relevant therapy. Palbociclib, a novel, first-in-class cyclin-dependent kinase...

    Authors: J. K. Kish, M. A. Ward, D. Garofalo, H. V. Ahmed, L. McRoy, J. Laney, G. Zanotti, J. Braverman, H. Yu and B. A. Feinberg
    Citation: Breast Cancer Research 2018 20:37
  43. Texture patterns have been shown to improve breast cancer risk segregation in addition to area-based mammographic density. The additional value of texture pattern scores on top of volumetric mammographic densi...

    Authors: Johanna O. P. Wanders, Carla H. van Gils, Nico Karssemeijer, Katharina Holland, Michiel Kallenberg, Petra H. M. Peeters, Mads Nielsen and Martin Lillholm
    Citation: Breast Cancer Research 2018 20:36
  44. The majority of estrogen receptor-positive (ERα+) breast cancers respond to endocrine therapies. However, resistance to endocrine therapies is common in 30% of cases, which may be due to altered ERα signaling and...

    Authors: Maria B. Padua, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Mayuri S. Prasad, Yangyang Hao, Xi Rao, Sheng Liu, Jun Wan, Yunlong Liu, Kyle McElyea, Max Jacobsen, George Sandusky, Sandra Althouse, Susan Perkins and Harikrishna Nakshatri
    Citation: Breast Cancer Research 2018 20:35
  45. The main purpose was to investigate the correlation between magnetic resonance imaging (MRI)-based response patterns halfway through neoadjuvant chemotherapy and immunotherapy (NAC) and pathological tumor resp...

    Authors: Briete Goorts, Kelly M. A. Dreuning, Janneke B. Houwers, Loes F. S. Kooreman, Evert-Jan G. Boerma, Ritse M. Mann, Marc B. I. Lobbes and Marjolein L. Smidt
    Citation: Breast Cancer Research 2018 20:34
  46. Younger age at onset of breast development, which has been declining in recent decades, is associated with increased breast cancer risk independent of age at menarche. Given the need to study the drivers of th...

    Authors: Lauren C. Houghton, Julia A. Knight, Mary Jane De Souza, Mandy Goldberg, Melissa L. White, Karen O’Toole, Wendy K. Chung, Angela R. Bradbury, Mary B. Daly, Irene L. Andrulis, Esther M. John, Saundra S. Buys and Mary Beth Terry
    Citation: Breast Cancer Research 2018 20:33
  47. Long noncoding RNAs (LncRNAs) represent a class of widespread and diverse endogenous RNAs that can posttranscriptionally regulate gene expression through the interaction with RNA-binding proteins and micro RNA...

    Authors: Yanchun Zhou, Xiuhua Meng, Shaoying Chen, Wei Li, Delin Li, Robert Singer and Wei Gu
    Citation: Breast Cancer Research 2018 20:32
  48. Breast cancer prognosis is strongly associated with tumor size at diagnosis. We aimed to identify factors associated with diagnosis of large (> 2 cm) compared to small tumors, and to examine implications for l...

    Authors: Fredrik Strand, Keith Humphreys, Johanna Holm, Mikael Eriksson, Sven Törnberg, Per Hall, Edward Azavedo and Kamila Czene
    Citation: Breast Cancer Research 2018 20:31
  49. Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC).

    Authors: Daniele Campa, Myrto Barrdahl, Aurelia Santoro, Gianluca Severi, Laura Baglietto, Hanane Omichessan, Rosario Tumino, H. B(as). Bueno-de-Mesquita, Petra H. Peeters, Elisabete Weiderpass, Maria-Dolores Chirlaque, Miguel Rodríguez-Barranco, Antonio Agudo, Marc Gunter, Laure Dossus, Vittorio Krogh…
    Citation: Breast Cancer Research 2018 20:29
  50. The ataxia telangiectasia mutated (ATM) gene is a moderate-risk breast cancer susceptibility gene; germline loss-of-function variants are found in up to 3% of hereditary breast and ovarian cancer (HBOC) families ...

    Authors: Anne-Laure Renault, Noura Mebirouk, Laetitia Fuhrmann, Guillaume Bataillon, Eve Cavaciuti, Dorothée Le Gal, Elodie Girard, Tatiana Popova, Philippe La Rosa, Juana Beauvallet, Séverine Eon-Marchais, Marie-Gabrielle Dondon, Catherine Dubois d’Enghien, Anthony Laugé, Walid Chemlali, Virginie Raynal…
    Citation: Breast Cancer Research 2018 20:28

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