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Table 3 BRCA promoter methylation percentages in BRCA1/2-related and sporadic breast carcinomas by methylation-specific multiplex ligation-dependent probe amplification

From: BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers

Probe BRCA1C-C, median % (range) BRCA2-C, median % (range) Sporadic-C, median % (range) Test statistica p Value
BRCA1.1 3 (0–11) 3 (0–91) 3 (0–80) 2494.500 0.140
BRCA1.2 21 (11–34) 17 (11–100) 15 (9–85) 1795.500 0.00006*
BRCA1.3 11 (5–18) 9 (5–100) 7 (3–71) 1760.600 0.00003*
BRCA2.1 24 (14–56) 21 (8–100) 15 (8–43) 947.500 9.85°10−13*
BRCA2.2 11 (5–27) 10 (5–100) 5 (3–15) 596.000 1.00°10−13*
BRCA2.3 17 (9–33) 14 (8–100) 9 (5–18) 536.500 1.00°10−13*
BRCA2.4 9 (0–18) 8 (0–100) 5 (2–12) 984.500 1.95°10−12*
  1. Abbreviations: BRCA1-C Breast carcinomas from BRCA1 germline mutation carriers, BRCA2-C Breast carcinomas from BRCA2 germline mutation carriers, Sporadic-C Sporadic breast carcinoma
  2. aMann-Whitney U test for BRCA1-C and BRCA2-C together against Sporadic-C
  3. *Statistically significant (two-sided p value <0.05)