Table 3 BRCA promoter methylation percentages in BRCA1/2-related and sporadic breast carcinomas by methylation-specific multiplex ligation-dependent probe amplification

BRCA1.1

3 (0–11)

3 (0–91)

3 (0–80)

0.140

BRCA1.2

21 (11–34)

17 (11–100)

15 (9–85)

0.00006*

BRCA1.3

11 (5–18)

9 (5–100)

7 (3–71)

0.00003*

BRCA2.1

24 (14–56)

21 (8–100)

15 (8–43)

9.85°10⁻¹³*

BRCA2.2

11 (5–27)

10 (5–100)

5 (3–15)

1.00°10⁻¹³*

BRCA2.3

17 (9–33)

14 (8–100)

9 (5–18)

1.00°10⁻¹³*

BRCA2.4

9 (0–18)

8 (0–100)

5 (2–12)

1.95°10⁻¹²*