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Table 10 BRCA promoter methylation percentages in normal breast from BRCA1/2 germline mutation carriers and nonmutation carriers

From: BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers

Probe BRCA1/2-N, median % (range) Non-BRCA-related-N, median % (range) Test statistica p Value
BRCA1.1 2 (0–3) 3 (0–5) 15.500 0.325
BRCA1.2 17 (13–26) 13 (13–17) 8.500 0.057
BRCA1.3 9 (6–16) 7 (5–8) 8.000 0.050
BRCA2.1 19 (15–26) 16 (14–19) 8.500 0.060
BRCA2.2 8 (6–16) 6 (5–12) 12.000 0.158
BRCA2.3 13 (10–28) 9 (8–14) 6.500 0.031*
BRCA2.4 8 (6–9) 5 (5–6) 2.000 0.005*
  1. Abbreviations: BRCA1/2-N, Normal breast tissue from BRCA1 and BRCA2 germline mutation carriers; Non-BRCA-related-N, Normal breast tissue from patients not known to have a BRCA1 or BRCA2 germline mutation
  2. aMann-Whitney U test for BRCA1/2-N together against non-BRCA-related-N
  3. *Statistically significant (two-sided p value <0.05)