Table 10 BRCA promoter methylation percentages in normal breast from BRCA1/2 germline mutation carriers and nonmutation carriers
From: BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers
Probe | BRCA1/2-N, median % (range) | Non-BRCA-related-N, median % (range) | Test statistica | p Value |
|---|---|---|---|---|
BRCA1.1 | 2 (0–3) | 3 (0–5) | 15.500 | 0.325 |
BRCA1.2 | 17 (13–26) | 13 (13–17) | 8.500 | 0.057 |
BRCA1.3 | 9 (6–16) | 7 (5–8) | 8.000 | 0.050 |
BRCA2.1 | 19 (15–26) | 16 (14–19) | 8.500 | 0.060 |
BRCA2.2 | 8 (6–16) | 6 (5–12) | 12.000 | 0.158 |
BRCA2.3 | 13 (10–28) | 9 (8–14) | 6.500 | 0.031* |
BRCA2.4 | 8 (6–9) | 5 (5–6) | 2.000 | 0.005* |