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Clinical breast cancer and estrogen

Endocrine therapy, targeting estrogen production or the estrogen receptor, is a crucial component in the treatment of breast cancer. This has been recognized for over a century. Ovarian ablation is the oldest form of endocrine therapy, first used in 1896. This presentation will review: the history of endocrine therapy in the treatment of breast cancer; endocrine strategies in premenopausal and postmenopausal women; data on the use of endocrine therapy in early breast cancer; new directions in the endocrine therapy of metastatic breast cancer; and clinical implications of HER2-neu status and endocrine therapy.

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Chew, H. Clinical breast cancer and estrogen. Breast Cancer Res 5 (Suppl 1), 18 (2003).

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