Table 2 Loss-of-function of β-catenin signaling
Organ | Phenotype | Reference |
|---|---|---|
Mesoderm patterning | No mesoderm, no head structure | Haegel et al. [3] |
Huelsken et al. [4] | ||
Body axis | Absence and/or mislocation of anterior markers at embryonic day 5.5 | Huelsken et al. [4] |
Skin | Stem cells fail to differentiate into follicular keratinocytes, but adopt an epidermal fate | Heulsken et al. [35] |
Brain and craniofacial development | Brain malformation and failure of craniofacial development | Brault et al. [5] |