Goepfert TM, McCarthy M, Kittrell FS, Stephens C, Ullrich RL, Brinkley BR, Medina D: Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells. FASEB J. 2000, 14: 2221-2229. 10.1096/fj.00-0165com.
Article
CAS
PubMed
Google Scholar
Women's Health Initiative: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002, 288: 321-333.
Article
Google Scholar
Ross RK, Paganini-Hill A, Wan PC, Pike MC: Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin. J Natl Cancer Inst. 2000, 92: 328-332. 10.1093/jnci/92.4.328.
Article
CAS
PubMed
Google Scholar
Klijn JG, Setyono-Han B, Foekens JA: Progesterone antagonists and progesterone receptor modulators in the treatment of breast cancer. Steroids. 2000, 65: 825-830. 10.1016/S0039-128X(00)00195-1.
Article
CAS
PubMed
Google Scholar
Lanari C, Molinolo AA, Pasqualini CD: Inhibitory effect of medroxyprogesterone acetate on foreign body tumorigenesis in mice. J Natl Cancer Inst. 1986, 77: 157-164.
CAS
PubMed
Google Scholar
Molinolo AA, Lanari C, Charreau EH, Sanjuan N, Pasqualini CD: Mouse mammary tumors induced by medroxyprogesterone acetate: immunohistochemistry and hormonal receptors. J Natl Cancer Inst. 1987, 79: 1341-1350.
CAS
PubMed
Google Scholar
Lanari C, Kordon E, Molinolo A, Pasqualini CD, Charreau EH: Mammary adenocarcinomas induced by medroxyprogesterone acetate: hormone dependence and EGF receptors of BALB/c in vivo sublines. Int J Cancer. 1989, 43: 845-850.
Article
CAS
PubMed
Google Scholar
Nagasawa H, Aoki M, Sakagami N, Ishida M: Medroxyprogesterone acetate enhances spontaneous mammary tumorigenesis and uterine adenomyosis in mice. Breast Cancer Res Treat. 1988, 12: 59-66.
Article
CAS
PubMed
Google Scholar
Kordon EC, Molinolo AA, Pasqualini CD, Charreau EH, Pazos P, Dran G, Lanari C: Progesterone induction of mammary carcinomas in BALB/c female mice. Correlation between progestin dependence and morphology. Breast Cancer Res Treat. 1993, 28: 29-39.
Article
CAS
PubMed
Google Scholar
Pazos P, Lanari C, Meiss R, Charreau EH, Pasqualini CD: Mammary carcinogenesis induced by I-methyl-I-nitrosourea (MNU) and medroxyprogesterone acetate (MPA) in BALB/c mice. Breast Cancer Res Treat. 1992, 20: 133-138.
Article
CAS
PubMed
Google Scholar
Aldaz CM, Liao QY, Paladugu A, Rehm S, Wang H: Allelotypic and cytogenetic characterization of chemically induced mouse mammary tumors: high frequency of chromosome 4 loss of heterozygosity at advanced stages of progression. Mol Carcinog. 1996, 17: 126-133. 10.1002/(SICI)1098-2744(199611)17:3<126::AID-MC4>3.0.CO;2-D.
Article
CAS
PubMed
Google Scholar
Lydon JP, Ge G, Kittrell FS, Medina D, O'Malley BW: Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function. Cancer Res. 1999, 59: 4276-4284.
CAS
PubMed
Google Scholar
Huggins C: Endocrine-induced regression of cancers. Science. 1967, 156: 1050-1054.
Article
CAS
PubMed
Google Scholar
Lange CA, Richer JK, Horwitz KB: Hypothesis: progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals. Mol Endocrinol. 1999, 13: 829-836. 10.1210/me.13.6.829.
Article
CAS
PubMed
Google Scholar
Lamb C, Simian M, Molinolo A, Pazos P, Lanari C: Regulation of cell growth of a progestin-dependent murine mammary carcinoma in vitro: progesterone receptor involvement in serum or growth factor-induced cell proliferation. J Steroid Biochem Mol Biol. 1999, 70: 133-142. 10.1016/S0960-0760(99)00108-9.
Article
CAS
PubMed
Google Scholar
Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf DM, Horwitz KB: Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J Biol Chem. 2002, 277: 5209-5218. 10.1074/jbc.M110090200.
Article
CAS
PubMed
Google Scholar
Shyamala G, Yang X, Cardiff RD, Dale E: Impact of progesterone receptor on cell-fate decisions during mammary gland development. Proc Natl Acad Sci USA. 2000, 97: 3044-3049. 10.1073/pnas.97.7.3044.
Article
CAS
PubMed
PubMed Central
Google Scholar
McKenna NJ, Lanz RB, O'Malley BW: Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev. 1999, 20: 321-344. 10.1210/er.20.3.321.
CAS
PubMed
Google Scholar
Giangrande PH, McDonnell DP: The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res. 1999, 54: 291-313.
CAS
PubMed
Google Scholar
Clemm DL, Sherman L, Boonyaratanakornkit V, Schrader WT, Weigel NL, Edwards DP: Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Mol Endocrinol. 2000, 14: 52-65. 10.1210/me.14.1.52.
Article
CAS
PubMed
Google Scholar
Edwards DP, Weigel NL, Nordeen SK, Beck CA: Modulators of cellular protein phosphorylation alter the trans-activation function of human progesterone receptor and the biological activity of progesterone antagonists. Breast Cancer Res Treat. 1993, 27: 41-56.
Article
CAS
PubMed
Google Scholar
Jacobsen BM, Richer JK, Schittone SA, Horwitz KB: New human breast cancer cells to study progesterone receptor (PR) isoform ratio effects and ligand-independent gene regulation. J Biol Chem. 2002, 277: 27793-27800. 10.1074/jbc.M202584200.
Article
CAS
PubMed
Google Scholar
Elizalde P, Labriola L, Salatino M, Movsichoff F, Proietti C, Pecci A, Coso O, Kornblihtt A, Charreau E: Heregulin regulates the progesterone receptor (Pr) transcriptional activity by a mechanism that requires a functional erbB-2 and mitogen-activated protein kinases (MAPK) activation. In Proceedings of the AACR, New Orleans. Buenos Aires: Instituto de Biología y Medicina Experimental, and Facultad de Ciencias Exactas y Naturales, UBA; March. 2001, 24-28.
Google Scholar
Migliaccio A, Piccolo D, Castoria G, Di Domenico M, Bilancio A, Lombardi M, Gong W, Beato M, Auricchio F: Activation of the Src/p21ras/Erk pathway by progesterone receptor via crosstalk with estrogen receptor. EMBO J. 1998, 17: 2008-2018. 10.1093/emboj/17.7.2008.
Article
CAS
PubMed
PubMed Central
Google Scholar
Maller JL: The elusive progesterone receptor in Xenopus oocytes. Proc Natl Acad Sci USA. 2001, 98: 8-10. 10.1073/pnas.98.1.8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bardon S, Vignon F, Montcourrier P, Rochefort H: Steroid receptor-mediated cytotoxicity of an antiestrogen and an antiprogestin in breast cancer cells. Cancer Research. 1987, 47: 1441-1448.
CAS
PubMed
Google Scholar
Vanzulli S, Efeyan A, Benavides F, Helguero L, Peters G, Shen J, Conti CJ, Lanari C, Molinolo A: p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas. Carcinogenesis. 2002, 23: 749-757. 10.1093/carcin/23.5.749.
Article
CAS
PubMed
Google Scholar
Nishino Y, Schneider MR, Michna H: Enhancement of the anti-tumor efficacy of the antiprogestin, onapristone, by combination with the antiestrogen, ICI 164384. J Cancer Res Clin Oncol. 1994, 120: 298-302.
Article
CAS
PubMed
Google Scholar