Menschutkin M: Ueber die Einwirkung des Chloracetyls auf phosphorige Säure. Ann Chem Pharm. 1865, 133: 317-320.
Article
Google Scholar
Fleisch H, Russell RGG, Bisaz S, Casey P, Mühlbauer R: The influence of pyrophsophate analogues (diphosphonates) on the precipitation and dissolution of calcium phosphate in vitro and in vivo. Calcif Tissue Res. 1968, 2(suppl): 10-10a.
Article
Google Scholar
Fleisch H, Russell RGG, Straumann F: Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis. Nature(London). 1966, 212: 901-903.
Article
CAS
Google Scholar
Francis MD, Russell RGG, Fleisch H: Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo. Science. 1969, 165: 1264-1266.
Article
CAS
PubMed
Google Scholar
Fleisch H, Russell RGG, Francis MD: Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo. Science. 1969, 165: 1262-1264.
Article
CAS
PubMed
Google Scholar
Jung A, Bisaz S, Fleisch H: The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals. Calcif Tissue Res. 1973, 11: 269-280.
Article
CAS
PubMed
Google Scholar
Schenk R, Merz WA, Mühlbauer R, Russell RGG, Fleisch H: Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl2MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats. Calcif Tissue Res. 1973, 11: 196-214.
Article
CAS
PubMed
Google Scholar
Gasser AB, Morgan DB, Fleisch HA, Richelle LJ: The influence of two diphosphonates on calcium metabolism in the rat. Clin Sci. 1972, 43: 31-45.
Article
CAS
PubMed
Google Scholar
Jung A, Mermillod B, Barras C, Baud M, Courvoisier B: Inhibition by two diphosphonates of bone lysis in tumor conditioned media. Cancer Res. 1981, 41: 3233-3237.
CAS
PubMed
Google Scholar
Martodam RR, Thornton KS, Sica DA, d'Souza F, Flora L, Mundy GR: The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hyper-calcemia of malignancy in the rat Leydig cell tumor. Calcif Tissue Int. 1983, 35: 512-519.
Article
CAS
PubMed
Google Scholar
Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, Mundy GR, Yoneda T: Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res. 1995, 55: 3551-3557.
CAS
PubMed
Google Scholar
Mundy GR, Yoneda T: Facilitation and suppression of bone metastasis. Clin Orthop Relat Res. 1995, 312: 34-44.
Google Scholar
van der Pluijm G, Vloedraven H, van Beek E, van der Wee-Pals L, Löwik C, Papapoulos S: Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro. J Clin Invest. 1996, 98: 698-705.
Article
CAS
PubMed
PubMed Central
Google Scholar
Boissier S, Magnetto S, Frappart L, Cuzin B, Ebetino FH, Delmas PD, Clezardin P: Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices. Cancer Res. 1997, 57: 3890-3894.
CAS
PubMed
Google Scholar
Shipman CM, Croucher PI, Russell RGG, Hlfrich MH, Rogers MJ: The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Res. 1998, 58: 5294-5297.
CAS
PubMed
Google Scholar
Masarachia P, Weinreb M, Balena R, Rodan GA: Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones. Bone. 1996, 19: 281-290. 10.1016/8756-3282(96)00182-2.
Article
CAS
PubMed
Google Scholar
Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF: Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res. 1995, 10: 1478-1487.
Article
CAS
PubMed
Google Scholar
Luckman SP, Coxon FP, Ebetino FH, Russell RGG, Rogers MG: Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages. J Bone Miner Res. 1998, 13: 1668-1678.
Article
CAS
PubMed
Google Scholar
Luckman SP, Hughes DE, Coxon FP, Russell RGG, Rogers MG: Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of gtp-binding proteins, including ras. J Bone Miner Res. 1998, 13: 581-589.
Article
CAS
PubMed
Google Scholar
van Beek E, Pieterman E, Cohen L, Löwik C, Papapoulos S: Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates. Biochem Biophys Res Commun. 1999, 264: 108-111. 10.1006/bbrc.1999.1499.
Article
CAS
PubMed
Google Scholar
Bergstrom JD, Bostedor RG, Masarachia PJ, Rewszka AA, Rodan GA: Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000, 373: 231-241. 10.1006/abbi.1999.1502.
Article
CAS
PubMed
Google Scholar
Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DF, Masarachia PJ, Wesolowski G, Russell RGG, Rodan GA, Reszka AA: Alendronate mechanism of action: gernylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci. 1999, 96: 133-138. 10.1073/pnas.96.1.133.
Article
CAS
PubMed
PubMed Central
Google Scholar
van Beek E, Löwik C, van der Pluijm G, Papapoulos S: The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: a clue to the mechanism of action of nitrogen-containing bisphosphonates. J Bone Miner Res. 1999, 14: 722-729.
Article
CAS
PubMed
Google Scholar
Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ: Structure-activity relationships for inhibition of farnesy diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exper Ther. 2001, 296: 235-242.
CAS
Google Scholar
Reszka AA, Halasy-Nagy J, Rodan GA: Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. Mol Pharmacol. 2001, 59: 193-202.
CAS
PubMed
Google Scholar
Rogers MJ, Brown RG, Hodkin V, Russell RGG, Watts DJ: Bis-phosphonates are incorporated into adenine nucleotides by human aminoacyl-trna synthetase enzymes. Biochem Biophys Res Commun. 1996, 224: 863-869. 10.1006/bbrc.1996.1113.
Article
CAS
PubMed
Google Scholar
Frith JC, Mönkkönen J, Blackburn GM, Russell RGG, Rogers MJ: Clodronate and liposome-encapsulated clodronate are metabolised to a toxic ATP analog, adenosine 5' (β,γ-dichloromethylene)triphosphate, by mammalian cells in vitro. J Bone Miner Res. 1997, 12: 1358-1367.
Article
CAS
PubMed
Google Scholar
Fleisch H: Bisphosphonates in Bone Disease. From the Laboratory to the Patient. New York: Academic Press;. 2000
Google Scholar
Fleisch H: Bisphosphonates: mechanisms of action. Endocr Rev. 1998, 19: 80-100. 10.1210/er.19.1.80.
Article
CAS
PubMed
Google Scholar
Russell RGG, Croucher PI, Rogers MJ: Bisphosphonates: pharmacology, mechanisms of action and clinical uses. Osteoporos Int. 1999, 2(suppl): s66-s80.
Article
Google Scholar