Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celià-Terrassa T, Mercatali L, Khan Z, Goodarzi H, Hua Y, Wei Y, Hu G, Garcia BA, Ragoussis J, Amadori D, Harris AL, Kang Y: Direct targeting of Sec23a by miR-200 s influences cancer cell secretome and promotes metastatic colonization. Nat Med. 2011, 17: 1101-1108. 10.1038/nm.2401.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wendt MK, Taylor MA, Schiemann BJ, Schiemann WP: Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer. Mol Biol Cell. 2011, 22: 2423-2435. 10.1091/mbc.E11-04-0306.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED, Thompson EW: Epithelial–mesenchymal and mesenchymal–epithelial transitions in carcinoma progression. J Cell Physiol. 2007, 213: 374-383. 10.1002/jcp.21223.
Article
CAS
PubMed
Google Scholar
Pinto CA, Widodo E, Waltham M, Thompson EW: Breast cancer stem cells and epithelial mesenchymal plasticity: implications for chemoresistance. Cancer Lett. 2013, 341: 56-62. 10.1016/j.canlet.2013.06.003.
Article
CAS
PubMed
Google Scholar
Wendt MK, Smith JA, Schiemann WP: Transforming growth factor-β-induced epithelial–mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. Oncogene. 2010, 29: 6485-6498. 10.1038/onc.2010.377.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tischkowitz M, Brunet JS, Bégin LR, Huntsman DG, Cheang MC, Akslen LA, Nielsen TO, Foulkes WD: Use of immunohistochemical markers can refine prognosis in triple negative breast cancer. BMC Cancer. 2007, 7: 134-10.1186/1471-2407-7-134.
Article
PubMed
PubMed Central
Google Scholar
Dickler MN, Cobleigh MA, Miller KD, Klein PM, Winer EP: Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer. Breast Cancer Res Treat. 2009, 115: 115-121. 10.1007/s10549-008-0055-9.
Article
CAS
PubMed
Google Scholar
Dickler MN, Rugo HS, Eberle CA, Brogi E, Caravelli JF, Panageas KS, Boyd J, Yeh B, Lake DE, Dang CT, Gilewski TA, Bromberg JF, Seidman AD, D’Andrea GM, Moasser MM, Melisko M, Park JW, Dancey J, Norton L, Hudis CA: A phase II trial of erlotinib in combination with bevacizumab in patients with metastatic breast cancer. Clin Cancer Res. 2008, 14: 7878-7883. 10.1158/1078-0432.CCR-08-0141.
Article
CAS
PubMed
PubMed Central
Google Scholar
Smith IE, Walsh G, Skene A, Llombart A, Mayordomo JI, Detre S, Salter J, Clark E, Magill P, Dowsett M: A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer. J Clin Oncol. 2007, 25: 3816-3822. 10.1200/JCO.2006.09.6578.
Article
CAS
PubMed
Google Scholar
Madden SF, Clarke C, Aherne ST, Gaule P, O’Donovan N, Clynes M, Crown J, Gallagher WM: BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome. Breast Cancer Res. 2013, 15: R52-10.1186/bcr3444.
Article
PubMed
PubMed Central
Google Scholar
Johnson DE, Lu J, Chen H, Werner S, Williams LT: The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol Cell Biol. 1991, 11: 4627-4634.
Article
CAS
PubMed
PubMed Central
Google Scholar
Werner S, Duan DSR, de Vries C, Peters KG, Johnson DE, Williams LT: Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities. Mol Cell Biol. 1992, 12: 82-88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang F, Kan M, Yan G, Xu J, McKeehan WL: Alternately spliced NH2-terminal immunoglobulin-like loop I in the ectodomain of the fibroblast growth factor (FGF) receptor 1 lowers affinity for both heparin and FGF-1. J Biol Chem. 1995, 270: 10231-10235. 10.1074/jbc.270.17.10231.
Article
CAS
PubMed
Google Scholar
Kalinina J, Dutta K, Ilghari D, Beenken A, Goetz R, Eliseenkova AV, Cowburn D, Mohammadi M: The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition. Structure. 2012, 20: 77-88. 10.1016/j.str.2011.10.022.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luqmani YA, Mortimer C, Yiangou C, Johnston CL, Bansal GS, Sinnett D, Law M, Coombes RC: Expression of 2 variant forms of fibroblast growth factor receptor 1 in human breast. Int J Cancer. 1995, 64: 274-279. 10.1002/ijc.2910640411.
Article
CAS
PubMed
Google Scholar
Bruno IG, Jin W, Cote GJ: Correction of aberrant FGFR1 alternative RNA splicing through targeting of intronic regulatory elements. Hum Mol Genet. 2004, 13: 2409-2420. 10.1093/hmg/ddh272.
Article
CAS
PubMed
Google Scholar
Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M: TGF-β regulates isoform switching of FGF receptors and epithelial–mesenchymal transition. EMBO J. 2011, 30: 783-795. 10.1038/emboj.2010.351.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dawson PJ, Wolman SR, Tait L, Heppner GH, Miller FR: MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am J Pathol. 1996, 148: 313-319.
CAS
PubMed
PubMed Central
Google Scholar
Rak JW, McEachern D, Miller FR: Sequential alteration of peanut agglutinin binding-glycoprotein expression during progression of murine mammary neoplasia. Br J Cancer. 1992, 65: 641-648. 10.1038/bjc.1992.138.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pink JJ, Bilimoria MM, Assikis J, Jordan VC: Irreversible loss of the oestrogen receptor in T47D breast cancer cells following prolonged oestrogen deprivation. Br J Cancer. 1996, 74: 1227-1236. 10.1038/bjc.1996.521. A published erratum appears in Br J Cancer 1997, 75:1557
Article
CAS
PubMed
PubMed Central
Google Scholar
Wendt MK, Schiemann WP: Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-β signaling and metastasis. Breast Cancer Res. 2009, 11: R68-10.1186/bcr2360.
Article
PubMed
PubMed Central
Google Scholar
Hajra KM, Ji X, Fearon ER: Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements. Oncogene. 1999, 18: 7274-7279. 10.1038/sj.onc.1203336.
Article
CAS
PubMed
Google Scholar
Wendt MK, Smith JA, Schiemann WP: p130Cas is required for mammary tumor growth and transforming growth factor-β-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem. 2009, 284: 34145-34156. 10.1074/jbc.M109.023614.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wendt MK: Identification of stable markers of the EMT:MET process. Published in Gene Expression Omnibus (GEO) database 30 January 2014 [GEO:GSE54491]. [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE54491]
Wendt MK, Schiemann BJ, Parvani JG, Lee YH, Kang Y, Schiemann WP: TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer. Oncogene. 2013, 32: 2005-2015. 10.1038/onc.2012.230.
Article
CAS
PubMed
Google Scholar
Wendt MK, Molter J, Flask CA, Schiemann WP: In vivo dual substrate bioluminescent imaging. J Vis Exp. 2011, 56: 3245-
Google Scholar
Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, Mani SA: Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A. 2010, 107: 15449-15454. 10.1073/pnas.1004900107. A published erratum appears in Proc Natl Acad Sci U S A 2010, 107:19132
Article
CAS
PubMed
PubMed Central
Google Scholar
Plasari G, Calabrese A, Dusserre Y, Gronostajski RM, McNair A, Michalik L, Mermod N: Nuclear factor I-C links platelet-derived growth factor and transforming growth factor β1 signaling to skin wound healing progression. Mol Cell Biol. 2009, 29: 6006-6017. 10.1128/MCB.01921-08.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee KY, Jeong JW, Wang J, Ma L, Martin JF, Tsai SY, Lydon JP, DeMayo FJ: Bmp2 is critical for the murine uterine decidual response. Mol Cell Biol. 2007, 27: 5468-5478. 10.1128/MCB.00342-07.
Article
CAS
PubMed
PubMed Central
Google Scholar
Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J: Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res. 2011, 71: 245-254. 10.1158/0008-5472.CAN-10-2330.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hynes NE, Dey JH: Potential for targeting the fibroblast growth factor receptors in breast cancer. Cancer Res. 2010, 70: 5199-5202. 10.1158/0008-5472.CAN-10-0918. A published erratum appears in Cancer Res 2010, 70:7734
Article
CAS
PubMed
Google Scholar
Issa A, Gill JW, Heideman MR, Sahin O, Wiemann S, Dey JH, Hynes NE: Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. Breast Cancer Res. 2013, 15: R8-10.1186/bcr3379.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sharpe R, Pearson A, Herrera-Abreu MT, Johnson D, Mackay A, Welti JC, Natrajan R, Reynolds AR, Reis-Filho JS, Ashworth A, Turner NC: FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo. Clin Cancer Res. 2011, 17: 5275-5286. 10.1158/1078-0432.CCR-10-2727.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dey JH, Bianchi F, Voshol J, Bonenfant D, Oakeley EJ, Hynes NE: Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. Cancer Res. 2010, 70: 4151-4162. 10.1158/0008-5472.CAN-09-4479.
Article
CAS
PubMed
Google Scholar
Shibue T, Weinberg RA: Integrin β1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A. 2009, 106: 10290-10295. 10.1073/pnas.0904227106. Published errata appear in Proc Natl Acad Sci U S A 2009, 106:14734 and Proc Natl Acad Sci U S A 2014, 111:563
Article
CAS
PubMed
PubMed Central
Google Scholar
Barkan D, El Touny LH, Michalowski AM, Smith JA, Chu I, Davis AS, Webster JD, Hoover S, Simpson RM, Gauldie J, Green JE: Metastatic growth from dormant cells induced by a col-I–enriched fibrotic environment. Cancer Res. 2010, 70: 5706-5716. 10.1158/0008-5472.CAN-09-2356.
Article
CAS
PubMed
PubMed Central
Google Scholar
Barkan D, Kleinman H, Simmons JL, Asmussen H, Kamaraju AK, Hoenorhoff MJ, Liu ZY, Costes SV, Cho EH, Lockett S, Khanna C, Chambers AF, Green JE: Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res. 2008, 68: 6241-6250. 10.1158/0008-5472.CAN-07-6849.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zou L, Cao S, Kang N, Huebert RC, Shah VH: Fibronectin induces endothelial cell migration through β1-integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766. J Biol Chem. 2012, 287: 7190-7202. 10.1074/jbc.M111.304972.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mori S, Wu CY, Yamaji S, Saegusa J, Shi B, Ma Z, Kuwabara Y, Lam KS, Isseroff RR, Takada YK, Takada Y: Direct binding of integrin αvβ3 to FGF1 plays a role in FGF1 signaling. J Biol Chem. 2008, 283: 18066-18075. 10.1074/jbc.M801213200.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liang G, Chen G, Wei X, Zhao Y, Li X: Small molecule inhibition of fibroblast growth factor receptors in cancer. Cytokine Growth Factor Rev. 2013, 24: 467-475. 10.1016/j.cytogfr.2013.05.002.
Article
CAS
PubMed
Google Scholar
Wendt MK, Allington TM, Schiemann WP: Mechanisms of the epithelial–mesenchymal transition by TGF-β. Future Oncol. 2009, 5: 1145-1168. 10.2217/fon.09.90.
Article
CAS
PubMed
PubMed Central
Google Scholar