Guedj M, Marisa L, de Reynies A, Orsetti B, Schiappa R, Bibeau F, MacGrogan G, Lerebours F, Finetti P, Longy M, Bertheau P, Bertrand F, Bonnet F, Martin AL, Feugeas JP, Bieche I, Lehmann-Che J, Lidereau R, Birnbaum D, Bertucci F, de The H, Theillet C: A refined molecular taxonomy of breast cancer. Oncogene. 2012, 31: 1196-1206. 10.1038/onc.2011.301.
Article
CAS
PubMed
Google Scholar
Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 2011, 121: 2750-2767. 10.1172/JCI45014.
Article
CAS
PubMed
PubMed Central
Google Scholar
Collins LC, Cole KS, Marotti JD, Hu R, Schnitt SJ, Tamimi RM: Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health Study. Mod Pathol. 2011, 24: 924-931. 10.1038/modpathol.2011.54.
Article
PubMed
PubMed Central
Google Scholar
Park S, Koo J, Park HS, Kim JH, Choi SY, Lee JH, Park BW, Lee KS: Expression of androgen receptors in primary breast cancer. Ann Oncol. 2010, 21: 488-492. 10.1093/annonc/mdp510.
Article
CAS
PubMed
Google Scholar
Hu R, Dawood S, Holmes MD, Collins LC, Schnitt SJ, Cole K, Marotti JD, Hankinson SE, Colditz GA, Tamimi RM: Androgen receptor expression and breast cancer survival in postmenopausal women. Clin Cancer Res. 2011, 17: 1867-1874. 10.1158/1078-0432.CCR-10-2021.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bergh J, Jonsson PE, Lidbrink EK, Trudeau M, Eiermann W, Brattstrom D, Lindemann JP, Wiklund F, Henriksson R: FACT: an open-label randomized phase III study of fulvestrant and anastrozole in combination compared with anastrozole alone as first-line therapy for patients with receptor-positive postmenopausal breast cancer. J Clin Oncol. 2012, 30: 1919-1925. 10.1200/JCO.2011.38.1095.
Article
CAS
PubMed
Google Scholar
Mouridsen H, Gershanovich M, Sun Y, Perez-Carrion R, Boni C, Monnier A, Apffelstaedt J, Smith R, Sleeboom HP, Jaenicke F, Pluzanska A, Dank M, Becquart D, Bapsy PP, Salminen E, Snyder R, Chaudri-Ross H, Lang R, Wyld P, Bhatnagar A: Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group. J Clin Oncol. 2003, 21: 2101-2109. 10.1200/JCO.2003.04.194.
Article
CAS
PubMed
Google Scholar
Harvell DM, Richer JK, Singh M, Spoelstra N, Finlayson C, Borges VF, Elias AD, Horwitz KB: Estrogen regulated gene expression in response to neoadjuvant endocrine therapy of breast cancers: tamoxifen agonist effects dominate in the presence of an aromatase inhibitor. Breast Cancer Res Treat. 2008, 112: 489-501. 10.1007/s10549-008-9923-6.
Article
CAS
PubMed
Google Scholar
Harvell DM, Spoelstra NS, Singh M, McManaman JL, Finlayson C, Phang T, Trapp S, Hunter L, Dye WW, Borges VF, Elias A, Horwitz KB, Richer JK: Molecular signatures of neoadjuvant endocrine therapy for breast cancer: characteristics of response or intrinsic resistance. Breast Cancer Res Treat. 2008, 112: 475-488. 10.1007/s10549-008-9897-4.
Article
CAS
PubMed
Google Scholar
De Amicis F, Thirugnansampanthan J, Cui Y, Selever J, Beyer A, Parra I, Weigel NL, Herynk MH, Tsimelzon A, Lewis MT, Chamness GC, Hilsenbeck SG, Ando S, Fuqua SA: Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells. Breast Cancer Res Treat. 2010, 121: 1-11. 10.1007/s10549-009-0436-8.
Article
PubMed
Google Scholar
Spinola PG, Marchetti B, Merand Y, Belanger A, Labrie F: Effects of the aromatase inhibitor 4-hydroxyandrostenedione and the antiandrogen flutamide on growth and steroid levels in DMBA-induced rat mammary tumors. Breast Cancer Res Treat. 1988, 12: 287-296. 10.1007/BF01811241.
Article
CAS
PubMed
Google Scholar
Dimitrakakis C, Bondy C: Androgens and the breast. Breast Cancer Res. 2009, 11: 212-10.1186/bcr2413.
Article
PubMed
PubMed Central
Google Scholar
Gallicchio L, Macdonald R, Wood B, Rushovich E, Helzlsouer KJ: Androgens and musculoskeletal symptoms among breast cancer patients on aromatase inhibitor therapy. Breast Cancer Res Treat. 2011, 130: 569-577. 10.1007/s10549-011-1611-2.
Article
CAS
PubMed
Google Scholar
Morris KT, Toth-Fejel S, Schmidt J, Fletcher WS, Pommier RF: High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: a renewed role for adrenalectomy. Surgery. 2001, 130: 947-953. 10.1067/msy.2001.118378.
Article
CAS
PubMed
Google Scholar
Niemeier LA, Dabbs DJ, Beriwal S, Striebel JM, Bhargava R: Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod Pathol. 2010, 23: 205-212. 10.1038/modpathol.2009.159.
Article
CAS
PubMed
Google Scholar
Tsutsumi Y: Apocrine Carcinoma as Triple-negative Breast Cancer: Novel Definition of Apocrine-type Carcinoma as Estrogen/Progesterone Receptor-negative and Androgen Receptor-positive Invasive Ductal Carcinoma. Jpn J Clin Oncol. 2012, 42: 375-386. 10.1093/jjco/hys034.
Article
PubMed
Google Scholar
Doane AS, Danso M, Lal P, Donaton M, Zhang L, Hudis C, Gerald WL: An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene. 2006, 25: 3994-4008. 10.1038/sj.onc.1209415.
Article
CAS
PubMed
Google Scholar
Farmer P, Bonnefoi H, Becette V, Tubiana-Hulin M, Fumoleau P, Larsimont D, Macgrogan G, Bergh J, Cameron D, Goldstein D, Duss S, Nicoulaz AL, Brisken C, Fiche M, Delorenzi M, Iggo R: Identification of molecular apocrine breast tumours by microarray analysis. Oncogene. 2005, 24: 4660-4671. 10.1038/sj.onc.1208561.
Article
CAS
PubMed
Google Scholar
Robinson JL, Macarthur S, Ross-Innes CS, Tilley WD, Neal DE, Mills IG, Carroll JS: Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. Embo J. 2011, 30: 3019-3027. 10.1038/emboj.2011.216.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS, Brown M: Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell. 2011, 20: 119-131. 10.1016/j.ccr.2011.05.026.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gucalp A, Tolaney S, Isakoff SJ, Ingle JN, Liu MC, Carey LA, Blackwell K, Rugo H, Nabell L, Forero A, Stearns V, Doane AS, Danso M, Moynahan ME, Momen LF, Gonzalez JM, Akhtar A, Giri DD, Patil S, Feigin KN, Hudis CA, Traina TA: Phase II trial of bicalutamide in patients with androgen receptor-positive, estrogen receptor-negative metastatic Breast Cancer. Clin Cancer Res. 2013, 19: 5505-5512. 10.1158/1078-0432.CCR-12-3327.
Article
CAS
PubMed
PubMed Central
Google Scholar
Masiello D, Cheng S, Bubley GJ, Lu ML, Balk SP: Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. J Biol Chem. 2002, 277: 26321-26326. 10.1074/jbc.M203310200.
Article
CAS
PubMed
Google Scholar
Small EJ, Carroll PR: Prostate-specific antigen decline after casodex withdrawal: evidence for an antiandrogen withdrawal syndrome. Urology. 1994, 43: 408-410. 10.1016/0090-4295(94)90092-2.
Article
CAS
PubMed
Google Scholar
Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, de Wit R, Mulders P, Chi KN, Shore ND, Armstrong AJ, Flaig TW, Flechon A, Mainwaring P, Fleming M, Hainsworth JD, Hirmand M, Selby B, Seely L, de Bono JS: Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012, 367: 1187-1197. 10.1056/NEJMoa1207506.
Article
CAS
PubMed
Google Scholar
Jambal P, Badtke MM, Harrell JC, Borges VF, Post MD, Sollender GE, Spillman MA, Horwitz KB, Jacobsen BM: Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features. Breast Cancer Res Treat. 2013, 137: 431-448. 10.1007/s10549-012-2377-x.
Article
CAS
PubMed
Google Scholar
Magklara A, Brown TJ, Diamandis EP: Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3. Int J Cancer. 2002, 100: 507-514. 10.1002/ijc.10520.
Article
CAS
PubMed
Google Scholar
Chamberlain NL, Driver ED, Miesfeld RL: The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res. 1994, 22: 3181-3186. 10.1093/nar/22.15.3181.
Article
CAS
PubMed
PubMed Central
Google Scholar
Birrell SN, Bentel JM, Hickey TE, Ricciardelli C, Weger MA, Horsfall DJ, Tilley WD: Androgens induce divergent proliferative responses in human breast cancer cell lines. J Steroid Biochem Mol Biol. 1995, 52: 459-467. 10.1016/0960-0760(95)00005-K.
Article
CAS
PubMed
Google Scholar
Hall RE, Birrell SN, Tilley WD, Sutherland RL: MDA-MB-453, an androgen-responsive human breast carcinoma cell line with high level androgen receptor expression. Eur J Cancer. 1994, 30A: 484-490.
Article
CAS
PubMed
Google Scholar
Beyer C, McDonald P, Vidal N: Failure of 5-alpha-dihydrotestosterone to elicit estrous behavior in the ovariectomized rabbit. Endocrinology. 1970, 86: 939-941. 10.1210/endo-86-4-939.
Article
CAS
PubMed
Google Scholar
McDonald P, Beyer C, Newton F, Brien B, Baker R, Tan HS, Sampson C, Kitching P, Greenhill R, Pritchard D: Failure of 5alpha-dihydrotestosterone to initiate sexual behaviour in the castrated male rat. Nature. 1970, 227: 964-965. 10.1038/227964a0.
Article
CAS
PubMed
Google Scholar
Ryan KJ: Biological aromatization of steroids. J Biol Chem. 1959, 234: 268-272.
CAS
PubMed
Google Scholar
Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL: Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009, 324: 787-790. 10.1126/science.1168175.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 2011, 121:
Google Scholar
Moore NL, Buchanan G, Harris JM, Selth LA, Bianco-Miotto T, Hanson AR, Birrell SN, Butler LM, Hickey TE, Tilley WD: An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity. Endocr Relat Cancer. 2012, 19: 599-613. 10.1530/ERC-12-0065.
Article
CAS
PubMed
Google Scholar
Wilson VS, Bobseine K, Lambright CR, Gray LE: A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists. Toxicol Sci. 2002, 66: 69-81. 10.1093/toxsci/66.1.69.
Article
CAS
PubMed
Google Scholar
Kuenen-Boumeester V, Van der Kwast TH, Claassen CC, Look MP, Liem GS, Klijn JG, Henzen-Logmans SC: The clinical significance of androgen receptors in breast cancer and their relation to histological and cell biological parameters. Eur J Cancer. 1996, 32A: 1560-1565.
Article
CAS
PubMed
Google Scholar
Soreide JA, Lea OA, Varhaug JE, Skarstein A, Kvinnsland S: Androgen receptors in operable breast cancer: relation to other steroid hormone receptors, correlations to prognostic factors and predictive value for effect of adjuvant tamoxifen treatment. Eur J Surg Oncol. 1992, 18: 112-118.
CAS
PubMed
Google Scholar
Garay JP, Park BH: Androgen receptor as a targeted therapy for breast cancer. Am J Cancer Res. 2012, 2: 434-445.
CAS
PubMed
PubMed Central
Google Scholar
Hickey TE, Robinson JL, Carroll JS, Tilley WD: Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?. Mol Endocrinol. 2012, 26: 1252-1267. 10.1210/me.2012-1107.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moe RE, Anderson BO: Androgens and androgen receptors: a clinically neglected sector in breast cancer biology. J Surg Oncol. 2007, 95: 437-439. 10.1002/jso.20722.
Article
PubMed
Google Scholar
Peters AA, Buchanan G, Ricciardelli C, Bianco-Miotto T, Centenera MM, Harris JM, Jindal S, Segara D, Jia L, Moore NL, Henshall SM, Birrell SN, Coetzee GA, Sutherland RL, Butler LM, Tilley WD: Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Res. 2009, 69: 6131-6140.
Article
CAS
PubMed
Google Scholar
Poulin R, Baker D, Labrie F: Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line. Breast Cancer Res Treat. 1988, 12: 213-225. 10.1007/BF01805942.
Article
CAS
PubMed
Google Scholar
Macedo LF, Guo Z, Tilghman SL, Sabnis GJ, Qiu Y, Brodie A: Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole. Cancer Res. 2006, 66: 7775-7782. 10.1158/0008-5472.CAN-05-3984.
Article
CAS
PubMed
Google Scholar
Cops EJ, Bianco-Miotto T, Moore NL, Clarke CL, Birrell SN, Butler LM, Tilley WD: Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors. J Steroid Biochem Mol Biol. 2008, 110: 236-243. 10.1016/j.jsbmb.2007.10.014.
Article
CAS
PubMed
Google Scholar
Garay JP, Karakas B, Abukhdeir AM, Cosgrove DP, Gustin JP, Higgins MJ, Konishi H, Konishi Y, Lauring J, Mohseni M, Wang GM, Jelovac D, Weeraratna A, Sherman Baust CA, Morin PJ, Toubaji A, Meeker A, De Marzo AM, Lewis G, Subhawong A, Argani P, Park BH: The growth response to androgen receptor signaling in ERalpha-negative human breast cells is dependent on p21 and mediated by MAPK activation. Breast Cancer Res. 2012, 14: R27-10.1186/bcr3112.
Article
CAS
PubMed
PubMed Central
Google Scholar
Simon WE, Albrecht M, Trams G, Dietel M, Holzel F: In vitro growth promotion of human mammary carcinoma cells by steroid hormones, tamoxifen, and prolactin. J Natl Cancer Inst. 1984, 73: 313-321.
CAS
PubMed
Google Scholar
Recchione C, Venturelli E, Manzari A, Cavalleri A, Martinetti A, Secreto G: Testosterone, dihydrotestosterone and oestradiol levels in postmenopausal breast cancer tissues. J Steroid Biochem Mol Biol. 1995, 52: 541-546. 10.1016/0960-0760(95)00017-T.
Article
CAS
PubMed
Google Scholar
Swerdloff RS, Wang C: Dihydrotestosterone: a rationale for its use as a non-aromatizable androgen replacement therapeutic agent. Baillieres Clin Endocrinol Metab. 1998, 12: 501-506. 10.1016/S0950-351X(98)80267-X.
Article
CAS
PubMed
Google Scholar
Hall JM, Korach KS: Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol Endocrinol. 2003, 17: 792-803. 10.1210/me.2002-0438.
Article
CAS
PubMed
Google Scholar
Sauve K, Lepage J, Sanchez M, Heveker N, Tremblay A: Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway. Cancer Res. 2009, 69: 5793-5800. 10.1158/0008-5472.CAN-08-4924.
Article
CAS
PubMed
Google Scholar
Kasina S, Macoska JA: The CXCL12/CXCR4 axis promotes ligand-independent activation of the androgen receptor. Mol Cell Endocrinol. 2012, 351: 249-263. 10.1016/j.mce.2011.12.015.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kang Z, Janne OA, Palvimo JJ: Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor. Mol Endocrinol. 2004, 18: 2633-2648. 10.1210/me.2004-0245.
Article
CAS
PubMed
Google Scholar
Panet-Raymond V, Gottlieb B, Beitel LK, Pinsky L, Trifiro MA: Interactions between androgen and estrogen receptors and the effects on their transactivational properties. Mol Cell Endocrinol. 2000, 167: 139-150. 10.1016/S0303-7207(00)00279-3.
Article
CAS
PubMed
Google Scholar
Migliaccio A, Di Domenico M, Castoria G, Nanayakkara M, Lombardi M, de Falco A, Bilancio A, Varricchio L, Ciociola A, Auricchio F: Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action. Cancer Res. 2005, 65: 10585-10593. 10.1158/0008-5472.CAN-05-0912.
Article
CAS
PubMed
Google Scholar
Joseph JD, Lu N, Qian J, Sensintaffar J, Shao G, Brigham D, Moon M, Maneval EC, Chen I, Darimont B, Hager JH: A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509. Cancer Discov. 2013, 3: 1020-1029. 10.1158/2159-8290.CD-13-0226.
Article
CAS
PubMed
Google Scholar
Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, Yuan J, Kovats SG, Kim S, Cooke VG, Monahan JE, Stegmeier F, Roberts TM, Sellers WR, Zhou W, Zhu P: An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide). Cancer Discov. 2013, 3: 1030-1043. 10.1158/2159-8290.CD-13-0142.
Article
CAS
PubMed
Google Scholar