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PB.22: Does the Nottingham predictor of bidimensional product of calcium accurately predict the success of wide local excision for ductal carcinoma in situ surgery in our centre?
Breast Cancer Research volume 15, Article number: P22 (2013)
A 2007 Nottingham paper suggests that a mammographic bidimensional product (BDP) of <800 mm2 calcification in high-grade ductal carcinoma in situ (DCIS) and <400 mm2 in low/intermediate DCIS is a powerful predictor of successful excision. We wanted to see whether their results were reproducible at our centre.
Eighty-four consecutive cases of DCIS over 18 months were reviewed and examined to determine the BDP of calcium (extent of mammographic calcification was measured in two orthogonal planes on the oblique view). Was reoperation required? Does the pathology report show clear margins? We excluded 15 patients that had a mastectomy (18%).
See Table 1.
We did not obtain similar results to the Nottingham paper. The success rate of WLE for low-grade DCIS was not (significantly) affected by BDP. Had BDP led to a recommendation not to perform WLE, the majority (75%) of women in this low-risk group, most at risk of overtreatment, would have had a mastectomy when conservative surgery would have succeeded. While we have not the large numbers of the Nottingham paper, we feel that in our centre at least, BDP of calcification seems not to be a practically useful predictor of excision success in nonhigh-grade DCIS.
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Gray, R., Porter, G. & Steel, J. PB.22: Does the Nottingham predictor of bidimensional product of calcium accurately predict the success of wide local excision for ductal carcinoma in situ surgery in our centre?. Breast Cancer Res 15, P22 (2013). https://doi.org/10.1186/bcr3522
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