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Predicting risk of malignancy in subgroups of B3 breast lesions


Heterogeneity and varying malignancy risk makes B3 lesion management difficult. Can histological features predict malignancy risk?


A retrospective review of B3 lesions (April 2005 to March 2010) following 14G biopsy, followed to final pathology. Key phrases from pathology identified; atypia, radial scar/complex sclerosing lesion (RS/CSL), atypical intraductal proliferation (AIDP), atypical ductal/lobular hypertrophy (ADH/ALH), flat epithelial atypia (FEA), lobular in situ neoplasia (LISN), and so forth. Age-adjusted logistic regression to assess risk of malignancy (Stata11).


A total of 205 B3 lesions were identified; 112 lesions with subsequent excision biopsy were analysed. Patients had mean age of 56 years (95% CI = 55 to 57 years). Thirty out of 112 lesions were upgraded to B5 diagnosis. Nine out of 112 had final diagnosis of LCIS. Multivariate analysis of odds ratios for malignancy, after age adjusting, is shown in Table 1.

Table 1


Atypia on core biopsy significantly predicts malignancy, with 7.48 times the odds of malignancy compared with lesions without atypia (P < 0.001; 95% CI = 2.62 to 21.39). Similarly, lesions containing AIDP, FEA and columnar cell change (CCC) have significantly increased odds for malignancy. LISN did not confer an increased risk of malignancy. Stratifying lesions in this way can direct future management.

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Forester, N., Brotherton, M. & Wason, AM. Predicting risk of malignancy in subgroups of B3 breast lesions. Breast Cancer Res 14 (Suppl 1), P57 (2012).

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