Volume 14 Supplement 1

British Society of Breast Radiology Annual Scientific Meeting 2012

Open Access

Predicting risk of malignancy in subgroups of B3 breast lesions

  • ND Forester1,
  • M Brotherton1 and
  • A-M Wason1
Breast Cancer Research201214(Suppl 1):P57

https://doi.org/10.1186/bcr3312

Published: 9 November 2012

Introduction

Heterogeneity and varying malignancy risk makes B3 lesion management difficult. Can histological features predict malignancy risk?

Methods

A retrospective review of B3 lesions (April 2005 to March 2010) following 14G biopsy, followed to final pathology. Key phrases from pathology identified; atypia, radial scar/complex sclerosing lesion (RS/CSL), atypical intraductal proliferation (AIDP), atypical ductal/lobular hypertrophy (ADH/ALH), flat epithelial atypia (FEA), lobular in situ neoplasia (LISN), and so forth. Age-adjusted logistic regression to assess risk of malignancy (Stata11).

Results

A total of 205 B3 lesions were identified; 112 lesions with subsequent excision biopsy were analysed. Patients had mean age of 56 years (95% CI = 55 to 57 years). Thirty out of 112 lesions were upgraded to B5 diagnosis. Nine out of 112 had final diagnosis of LCIS. Multivariate analysis of odds ratios for malignancy, after age adjusting, is shown in Table 1.

Table 1

Pathology

Number

Odds ratio

Pvalue

95% CI

Atypia

53

7.48

< 0.001*

2.62 to 21.39

AIDP

10

4.87

0.034*

1.13 to 21.01

ADH

11

2.50

0.167

0.68 to 9.24

ALH

6

1.28

0.793

0.21 to 7.93

FEA

8

5.90

0.025*

1.25 to 27.67

CCC

31

5.10

0.001*

1.89 to 13.76

Papillary

14

0.57

0.44

0.14 to 2.38

LISN

30

0.55

0.28

0.18 to 1.64

RS/CSL

13

0.92

0.91

0.23 to 3.74

Epithelial proliferation

20

2.07

0.172

0.73 to 5.88

Mucocele-like

6

1.91

0.48

0.32 to 11.41

Fibroepithelial

10

No malignant diagnoses

Haemangioma

1

No malignant diagnoses

Spindle cell

2

No malignant diagnoses

*Significant P value.

Conclusion

Atypia on core biopsy significantly predicts malignancy, with 7.48 times the odds of malignancy compared with lesions without atypia (P < 0.001; 95% CI = 2.62 to 21.39). Similarly, lesions containing AIDP, FEA and columnar cell change (CCC) have significantly increased odds for malignancy. LISN did not confer an increased risk of malignancy. Stratifying lesions in this way can direct future management.

Authors’ Affiliations

(1)
Department of Breast Radiology

Copyright

© Forester et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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