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- Open Access
Breast screening with magnetic resonance imaging in high-risk women
© McLean et al.; licensee BioMed Central Ltd. 2012
- Published: 9 November 2012
- Magnetic Resonance Imaging
- Recall Rate
- Breast Screening
- Interval Cancer
- Screening Service
Women were identified from the Regional Genetic Centre database, following assessment by a consultant geneticist as high risk according to the NICE guidelines . Screening comprised annual MRI ± mammography, depending on their age, following the standards set by the NHSBSP . All investigations were double-read by NHSBSP-compliant radiologists.
A total of 142 women underwent 311 screening episodes between January 2008 and June 2012. There were 28 recalls (9%) for second-look ultrasound in 24 women. Thirteen lesions had a core biopsy, from which six (1.9%) malignancies were identified of varying histological type, size and grade. Seven lesions were benign. No ultrasound abnormality was found in the remaining 15 lesions. No interval cancers have developed.
In our unit, high-risk MRI screening is effective and efficient, with a cancer detection rate of 0.2 per 1,000 women screened and no false negative screens to date, with an acceptable recall rate for second-look ultrasound (within the standard set under the NHSBSP guidelines). This has been possible due to the close liaison between the departments of Genetics and Breast Screening.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.