Correlation of ethnicity with breast density as assessed by Quantra™
© Tzias et al. 2011
Published: 4 November 2011
It is widely accepted that there is an association between mammographic density and breast cancer risk . Various studies have examined relationships between ethnicity and breast density patterns using the Wolfe classification system , with a view to investigating potential breast cancer risk. Quantra™ is a volumetric assessment tool, which allows reproducible objective measurement of mammographic breast density, eliminating inter-observer variability. Our study sought to investigate the correlation between ethnicity and breast density using Quantra™ measurements.
The Quantra™ value was recorded from the mammograms of symptomatic breast patients at St George's Hospital, London over a 6-month period. We compared three distinct ethnic groups; Black (African and Afro-Caribbean), Asian (Indian subcontinent) and White (Caucasian). Mean Quantra™ values were calculated for each group and the Kruskal-Wallis test was applied.
A total of 428 patients were included in the study. Mean breast density values for the three ethnic groups were as follows: Black, 24.31%; Asian, 21.94%; White, 24.74%. P = 0.0046 (Kruskal-Wallis).
There is a statistically significant difference between the objectively measured breast densities of these three ethnic groups. This is of relevance to the assessment of breast cancer risk.
- Boyd NF, Guo H, Martin LJ, Sun L, Stone J, Fishell E, Jong RA, Hislop G, Chiarelli A, Minkin S, Yaffe MJ: Mammographic density and the risk and detection of breast cancer. N Engl J Med. 2007, 356: 227-236. 10.1056/NEJMoa062790.View ArticlePubMedGoogle Scholar
- Turnbull AE, Kapera L, Cohen ME: Mammographic parenchymal patterns in Asian and Caucasian women attending for screening. Clin Radiol. 1993, 48: 38-40. 10.1016/S0009-9260(05)80105-9.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.