Figure 4
From: Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
Association of ERBB2 status with TXNRD1 and TXNIP expression. (a) Positive ERBB2 status is associated with significantly higher levels of thioredoxin reductase 1 (TXNDR1) expression. A significant association was obtained in all three individual cohorts and in the combined cohort including 788 patients with node-negative breast cancer. (b) In contrast to TXNDR1, a trend towards lower thioredoxin interacting protein (TXNIP) expression was obtained in ERBB2-status-positive carcinomas. This trend, however, amounted to statistical significance only in the combined cohort.