Objective
There is evidence to support the view that inflammatory processes are important in the development of local progression and metastases in patients with breast cancer. The sphingosine kinase-1/sphingosine-1-phosphate (SK1/S1P) pathway, which is a known mediator of inflammation, is critically implicated in breast cancer progression and chemotherapy resistance and is linked with poor prognosis. In this study we have investigated the implication of the SK1/S1P pathway in the interaction between tumour-associated macrophages and breast cancer cells.