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Immediate versus delayed repair of partial mastectomy defects in breast conservation
Breast Cancer Research volume 11, Article number: S8 (2009)
The authors previously compared the local tissue rearrangement, breast reduction, and latissimus dorsi flap reconstruction techniques for repairing partial mastectomy defects and showed the benefits of breast reduction.
In the present study, the authors focused solely on factors influencing outcome in 41 patients who underwent repair of a partial mastectomy defect using breast reduction.
Tumor location had a significant effect on the design of the parenchymal pedicle (P = 0.05). Most repairs were performed with an inferior pedicle. Fifty percent of the lower outer and central quadrant tumors required an amputative design with a free nipple graft. The complication rates for immediate and delayed repair were 24% and 50%, respectively. The superior pedicle was associated with the highest complication rates. Tumors in the upper outer quadrant of the breast were associated with the highest complication rate (35%). Ninety percent of patients with planned repairs had a viable nipple–areola complex (P = 0.05) and did not require a free nipple graft. More favorable cosmetic outcomes were achieved using an inferior pedicle; less favorable cosmetic outcomes were achieved for tumors in the upper inner quadrant of the breast. Larger defects did not result in less favorable cosmetic outcomes than smaller defects. Only 7% of patients had a positive tumor margin. Five percent of patients developed local breast cancer recurrence after a mean follow-up of 36 months.
The authors provide practical guidelines for repairing a partial mastectomy defect using breast reduction that should minimize the occurrence of complications and optimize the cosmetic outcome .
Kronowitz SJ, Hunt KK, Kuerer HM, et al: Practical guidelines for repair of partial mastectomy defects using the breast reduction technique in patients undergoing breast conservation therapy. Plast Reconstr Surg. 2007, 120: 1755-1768. 10.1097/01.prs.0000287130.77835.f6.
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Kronowitz, S., Hunt, K., Kuerer, H. et al. Immediate versus delayed repair of partial mastectomy defects in breast conservation. Breast Cancer Res 11 (Suppl 1), S8 (2009). https://doi.org/10.1186/bcr2269