Table 1 Summary of the studies assessing P-cadherin expression in invasive breast cancer
Ref. | P-cadherin positive expression in breast cancer (n [%]) | Tumour size | Axillary lymph node metastasis | Histological grade | ER | PgR | HER2 | MIB1 | EGFR | Basal CKs | p53 | Patient overall survival | Independent prognostic factor | IHC P-cadherin mAb |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
[36] | 1/25 (4%) | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | NCC-CAD-299 (Takeichi gift) |
[35] | 9/45 (20%) | NS | NS | + (P < 0.01) | - (P < 0.01) | - (P < 0.05) | ND | ND | ND | NS | ND | ND | ND | NCC-CAD-299 (Takeichi gift) |
[47] | 95/183 (52%) | NS | NS | + (P = 0.0006) | - (P < 0.0001) | - (P < 0.0001) | ND | ND | ND | ND | ND | + (P = 0.0001) | Yes | Clone 56 (Transduction) |
[53] | 36/51 (71%) | ND | NS | ND | ND | ND | ND | ND | ND | ND | ND | - (P = 0.05) | Yes | N-19 pAb (Santa Cruz) |
[48] | 74/210 (35%) | + (P = 0.0568) | + (P = 0.0327) | + (P = 0.0001) | - (P = 0.0001) | - (P = 0.0001) | ND | ND | ND | ND | ND | + (P = 0.004) | No | Clone 56 (Transduction) |
[51] | 40/100 (40%) | NS | NS | + (P < 0.005) | - (P < 0.001) | - (P < 0.025) | ND | ND | + (P < 0.001) | ND | ND | ND | ND | Clone 56 (Transduction) |
[57] | 80/261 (31%) | + (P = 0.05) | NS | + (P < 0.0001) | - (P < 0.001) | ND | + (P = 0.04) | ND | ND | + (P < 0.001) | + (P < 0.0001) | + (P < 0.0001) | No | Clone 56 (Transduction) |
[44] | 46/147 (31%) | NS | NS | + (P = 0.0021) | - (P < 0.0001) | ND ND | + (P = 0.0036) | + (P = 0.0002) | ND ND | ND ND | + (P = 0.0064) | + (P = 0.0237) | ND | Clone 56 (Transduction) |