Clevenger CV: Roles and regulation of stat family transcription factors in human breast cancer. Am J Pathol. 2004, 165: 1449-1460.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yu H, Jove R: The STATs of cancer – new molecular targets come of age. Nat Rev Cancer. 2004, 4: 97-105.
Article
CAS
PubMed
Google Scholar
Darnell JE: STATs and gene regulation. Science. 1997, 277: 1630-1635. 10.1126/science.277.5332.1630.
Article
CAS
PubMed
Google Scholar
Bromberg J: Stat proteins and oncogenesis. J Clin Invest. 2002, 109: 1139-1142. 10.1172/JCI200215617.
Article
CAS
PubMed
PubMed Central
Google Scholar
Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE, Albanese C, et al: Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res. 2006, 66: 2544-2552. 10.1158/0008-5472.CAN-05-2203.
Article
CAS
PubMed
Google Scholar
Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, et al: Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res. 2006, 12: 11-19. 10.1158/1078-0432.CCR-04-1752.
Article
CAS
PubMed
Google Scholar
Diaz N, Minton S, Cox C, Bowman T, Gritsko T, Garcia R, Eweis I, Wloch M, Livingston S, Seijo E, et al: Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res. 2006, 12: 20-28. 10.1158/1078-0432.CCR-04-1749.
Article
CAS
PubMed
Google Scholar
Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC: Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 2005, 7: 575-589. 10.1016/j.ccr.2005.05.007.
Article
CAS
PubMed
Google Scholar
Vultur A, Cao J, Arulanandam R, Turkson J, Jove R, Greer P, Craig A, Elliott B, Raptis L: Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. Oncogene. 2004, 23: 2600-2616. 10.1038/sj.onc.1207378.
Article
CAS
PubMed
Google Scholar
Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R: Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol Cancer Ther. 2004, 3: 261-269.
CAS
PubMed
Google Scholar
Dolled-Filhart M, Camp RL, Kowalski DP, Smith BL, Rimm DL: Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis. Clin Cancer Res. 2003, 9: 594-600.
CAS
PubMed
Google Scholar
Li L, Shaw PE: Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines. J Biol Chem. 2002, 277: 17397-17405. 10.1074/jbc.M109962200.
Article
CAS
PubMed
Google Scholar
Garcia R, Bowman TL, Niu G, Yu H, Minton S, Muro-Cacho CA, Cox CE, Falcone R, Fairclough R, Parsons S, et al: Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene. 2001, 20: 2499-2513. 10.1038/sj.onc.1204349.
Article
CAS
PubMed
Google Scholar
Garcia R, Yu CL, Hudnall A, Catlett R, Nelson KL, Smithgall T, Fujita DJ, Ethier SP, Jove R: Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ. 1997, 8: 1267-1276.
CAS
PubMed
Google Scholar
Watson CJ, Miller WR: Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br J Cancer. 1995, 71: 840-844.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dechow TN, Pedranzini L, Leitch A, Leslie K, Gerald WL, Linkov I, Bromberg JF: Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc Natl Acad Sci USA. 2004, 101: 10602-10607. 10.1073/pnas.0404100101.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cotarla I, Ren S, Zhang Y, Gehan E, Singh B, Furth PA: Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int J Cancer. 2004, 108: 665-671. 10.1002/ijc.11619.
Article
CAS
PubMed
Google Scholar
Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, Zervos AS, Carter B, Turkson J, Jove R: Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther. 2006, 5: 621-629. 10.1158/1535-7163.MCT-05-0268.
Article
CAS
PubMed
Google Scholar
Selander KS, Li L, Watson L, Merrell M, Dahmen H, Heinrich PC, Muller-Newen G, Harris KW: Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy. Cancer Res. 2004, 64: 6924-6933. 10.1158/0008-5472.CAN-03-2516.
Article
CAS
PubMed
Google Scholar
Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA: Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res. 2005, 65: 5054-5062. 10.1158/0008-5472.CAN-04-4281.
Article
CAS
PubMed
Google Scholar
Ling X, Arlinghaus RB: Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res. 2005, 65: 2532-2536. 10.1158/0008-5472.CAN-04-2425.
Article
CAS
PubMed
Google Scholar
Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG: Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell. 2006, 126: 489-502. 10.1016/j.cell.2006.05.047.
Article
CAS
PubMed
Google Scholar
Berclaz G, Altermatt HJ, Rohrbach V, Siragusa A, Dreher E, Smith PD: EGFR dependent expression of STAT3 (but not STAT1) in breast cancer. Int J Oncol. 2001, 19: 1155-1160.
CAS
PubMed
Google Scholar
Amorino GP, Hamilton VM, Valerie K, Dent P, Lammering G, Schmidt-Ullrich RK: Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells. Mol Biol Cell. 2002, 13: 2233-2244. 10.1091/mbc.01-12-0572.
Article
CAS
PubMed
PubMed Central
Google Scholar
Grant SL, Hammacher A, Douglas AM, Goss GA, Mansfield RK, Heath JK, Begley CG: An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells. Oncogene. 2002, 21: 460-474. 10.1038/sj.onc.1205100.
Article
CAS
PubMed
Google Scholar
Knupfer H, Preiss R: Significance of interleukin-6 (IL-6) in breast cancer (review). Breast Cancer Res Treat. 2007, 102: 129-135. 10.1007/s10549-006-9328-3.
Article
PubMed
Google Scholar
Kishimoto T: Interleukin-6: from basic science to medicine – 40 years in immunology. Annu Rev Immunol. 2005, 23: 1-21. 10.1146/annurev.immunol.23.021704.115806.
Article
CAS
PubMed
Google Scholar
Debnath J, Muthuswamy SK, Brugge JS: Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003, 30: 256-268. 10.1016/S1046-2023(03)00032-X.
Article
CAS
PubMed
Google Scholar
Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL, Massague J: Genes that mediate breast cancer metastasis to lung. Nature. 2005, 436: 518-524. 10.1038/nature03799.
Article
CAS
PubMed
PubMed Central
Google Scholar
Doane AS, Danso M, Lal P, Donaton M, Zhang L, Hudis C, Gerald WL: An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene. 2006, 25: 3994-4008. 10.1038/sj.onc.1209415.
Article
CAS
PubMed
Google Scholar
Rincon M, Broadwater G, Harris L, Crocker A, Weaver D, Dressler L, Berry D, Sutton L, Michaelson R, Messino M, et al: Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: results of cancer and leukemia group B trial 159806. Breast Cancer Res Treat. 2006, 100: 301-308. 10.1007/s10549-006-9251-7.
Article
CAS
PubMed
Google Scholar
Sartor CI, Dziubinski ML, Yu CL, Jove R, Ethier SP: Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res. 1997, 57: 978-987.
CAS
PubMed
Google Scholar
Ferrajoli A, Faderl S, Ravandi F, Estrov Z: The JAK-STAT pathway: a therapeutic target in hematological malignancies. Curr Cancer Drug Targets. 2006, 6: 671-679. 10.2174/156800906779010227.
Article
CAS
PubMed
Google Scholar
Levitzki A, Mishani E: Tyrphostins and other tyrosine kinase inhibitors. Annu Rev Biochem. 2006, 75: 93-109. 10.1146/annurev.biochem.75.103004.142657.
Article
CAS
PubMed
Google Scholar
Thompson JE: JAK protein kinase inhibitors. Drug News Perspect. 2005, 18: 305-310. 10.1358/dnp.2005.18.5.904198.
Article
CAS
PubMed
Google Scholar
Pedranzini L, Dechow T, Berishaj M, Comenzo R, Zhou P, Azare J, Bornmann W, Bromberg J: Pyridone 6, a pan-janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res. 2006, 66: 9714-9721. 10.1158/0008-5472.CAN-05-4280.
Article
CAS
PubMed
Google Scholar
Thompson JE, Cubbon RM, Cummings RT, Wicker LS, Frankshun R, Cunningham BR, Cameron PM, Meinke PT, Liverton N, Weng Y, et al: Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002, 12: 1219-1223. 10.1016/S0960-894X(02)00106-3.
Article
CAS
PubMed
Google Scholar
Nam S, Kim D, Cheng JQ, Zhang S, Lee JH, Buettner R, Mirosevich J, Lee FY, Jove R: Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res. 2005, 65: 9185-9189. 10.1158/0008-5472.CAN-05-1731.
Article
CAS
PubMed
Google Scholar
Song L, Morris M, Bagui T, Lee FY, Jove R, Haura EB: Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006, 66: 5542-5548. 10.1158/0008-5472.CAN-05-4620.
Article
CAS
PubMed
Google Scholar
Moasser MM, Basso A, Averbuch SD, Rosen N: The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001, 61: 7184-7188.
CAS
PubMed
Google Scholar
Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M, Ponomarev V, Gerald WL, Blasberg R, Massague J: Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest. 2005, 115: 44-55. 10.1172/JCI200522320.
Article
CAS
PubMed
PubMed Central
Google Scholar
Levy DE, Inghirami G: STAT3: a multifaceted oncogene. Proc Natl Acad Sci USA. 2006, 103: 10151-10152. 10.1073/pnas.0604042103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xi S, Gooding WE, Grandis JR: In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene. 2005, 24: 970-979. 10.1038/sj.onc.1208316.
Article
CAS
PubMed
Google Scholar
Turkson J: STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets. 2004, 8: 409-422. 10.1517/14728222.8.5.409.
Article
CAS
PubMed
Google Scholar
Turkson J, Zhang S, Mora LB, Burns A, Sebti S, Jove R: A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. J Biol Chem. 2005, 280: 32979-32988. 10.1074/jbc.M502694200.
Article
CAS
PubMed
Google Scholar
Alexander WS, Hilton DJ: The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol. 2004, 22: 503-529. 10.1146/annurev.immunol.22.091003.090312.
Article
CAS
PubMed
Google Scholar
Evans MK, Yu CR, Lohani A, Mahdi RM, Liu X, Trzeciak AR, Egwuagu CE: Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. Oncogene. 2007, 26: 1941-1948. 10.1038/sj.onc.1209993.
Article
CAS
PubMed
Google Scholar