Background
The PLU-1/JARID1B gene, which is upregulated in breast cancers, encodes for a 1,544-amino-acid multidomain protein that is exclusively localised to the nucleus. The protein contains several conserved domains, including the ARID DNA binding domain, both N and C jumonji domains, three PHD domains and putative nuclear localisation signals, indicating that it could regulate the transcription of specific genes either through direct binding or through other transcription factors [1, 2].
In this study, we aim to identify the target genes regulated by PLU-1/JARID1B and the possible mechanism of PLU-1/JARID1B-mediated transcriptional regulation.