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Volume 8 Supplement 1

Symposium Mammographicum 2006

  • Oral Presentation
  • Open Access

Audit of wide bore needle biopsies graded B3: does the final pathology justify the increasing rate of benign biopsy?

  • 1,
  • 1 and
  • 1
Breast Cancer Research20068 (Suppl 1) :P9

  • Published:


  • Invasive Ductal Carcinoma
  • Excision Biopsy
  • Atypical Ductal Hyperplasia
  • Breast Screen
  • Atypical Lobular Hyperplasia

A recent national audit of the West of London Breast Screening Service showed an increased rate of benign biopsy. This may be related to the increasing rate of wide bore needle (WBN) biopsies graded as B3 (indeterminate). Common B3 pathologies include atypical ductal hyperplasia (ADH), columnar cell change with hyperplasia or atypia (CCC) and intraduct papilloma (IP). Previous studies have shown an association of these lesions with malignancy [1, 2]. Our practise is to recommend excision biopsy of these B3 lesions.

We retrospectively audited surgical excision biopsies of B3 lesions between April 2004 and April 2005, recording mammogram findings, patient demographics, WBN and surgical excision pathological diagnoses.

Twenty-five women age 50–70 (mean age 58) had excision biopsy of their B3 lesions; 64% were microcalcifications, 28% masses and the remainder distortions.

The 14G core biopsy pathology included 38% ADH, 16% atypical lobular hyperplasia, 16% CCC and 12% IP.

The surgical excision pathology available in 14 of these women showed ductal carcinoma in situ in seven and invasive ductal carcinoma in situ in three, justifying our practise. We discuss how the surgical pathology correlates with that of the WBN.

Authors’ Affiliations

Charing Cross Hospital, London, UK


  1. Liberman L, Cohen MA, et al: Am J Roentgenol. 1995, 164: 1111-1113.View ArticleGoogle Scholar
  2. Simpson PT, Gale T, et al: Am J Surg Pathol. 2005, 29: 734-746. 10.1097/01.pas.0000157295.93914.3b.View ArticlePubMedGoogle Scholar


© BioMed Central 2006