Page 61 of 108
There is increasing recognition of the role of the microenvironment in the control of both normal and tumour cell behaviour. In the breast, myoepithelial cells and fibroblasts can influence tumour cell behavio...
Through the use of surrogate markers of efficacy, neoadjuvant studies may facilitate the implementation of new treatments into clinical practice. However, disease-free survival is the current standard outcome ...
The original article was published in Breast Cancer Research 2008 10:R85
Phosphoinositide 3-kinase (PI3K)-activated signalling has a critical role in the evolution of aggressive tumourigenesis and is therefore a prime target for anticancer therapy. Previously we have shown that the...
Metastasis is a complex process involving loss of adhesion, migration, invasion and proliferation of cancer cells. Cell adhesion molecules play a pivotal role in this phenomenon by regulating cell–cell and cel...
Eph receptor tyrosine kinase signaling regulates cancer initiation and metastatic progression through multiple mechanisms. Studies of tumor-cell-autonomous effects of Eph receptors demonstrate their dual roles...
Breast carcinomas associated with pregnancy display a high frequency of inflammatory types, multifocal lesions and lymph node metastasis. Because pregnancy results in transfer to mothers of foetal stem cells t...
PolycombGroup (PcG) proteins maintain gene repression through histone modifications and have been implicated in stem cell regulation and cancer. EZH2 is part of Polycomb Repressive Complex 2 (PRC2) and trimeth...
Common variants that alter breast cancer risk are being discovered. Here, we determine how these variants influence breast cancer prognosis, risk and tumour characteristics.
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
Although phase I to III trials represent the standard for introducing new drugs to clinical therapy, there has been increasing demand for translational research in oncology over the past decade. Thus, for most...
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
This article is part of a Supplement: Volume 10 Supplement 4
Hormonal factors are implicated in tumor progression and it is possible that factors influencing breast cancer induction could affect prognosis. Our study investigated the effects of menstrual risk factors on ...
At physiologic concentration in serum, the bile acid sodium deoxycholate (DC) induces survival and migration of breast cancer cells. Here we provide evidence of a novel mechanism by which DC reduces apoptosis ...
Despite intensive study of the mechanisms of chemotherapeutic drug resistance in human breast cancer, few reports have systematically investigated the mechanisms that underlie resistance to the chemotherapy-se...
The ability to measure biochemical and molecular processes underlies progress in breast cancer biology and treatment. These assays have traditionally been performed by analysis of cell culture or tissue sample...
This article is part of a Supplement: Volume 10 Supplement 1
Metastasis is an enormously complex process that remains to be a major problem in the management of cancer. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of ...
This article is part of a Supplement: Volume 10 Supplement 1
Over the past 8 years there has been a wealth of breast cancer gene expression studies. The majority of these studies have focused upon characterising a tumour at presentation, before treatment, rather than lo...
Estrogen deprivation using aromatase inhibitors is one of the standard treatments for postmenopausal women with estrogen receptor (ER)-positive breast cancer. However, one of the consequences of prolonged estr...
The Correction to this article has been published in Breast Cancer Research 2018 20:57
Anti-oestrogens have been the mainstay of therapy in patients with oestrogen-receptor (ER) positive breast cancer and have provided significant improvements in survival. However, their benefits are limited by ...
Laboratory and epidemiologic studies have suggested a modifying effect of cardiac glycosides (for example, digoxin and digitoxin) on cancer risk. We explored the association between digoxin treatment and invas...
Basal-like carcinomas (BLCs) and human epidermal growth factor receptor 2 overexpressing (HER2+) carcinomas are the subgroups of breast cancers that have the most aggressive clinical behaviour. In contrast to ...
Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasion. The Plasminogen Activation (PA) system, including urokinase plasminogen activator (uPA), its...
Our understanding of the events that occur in cancer progression has been enhanced by the use of cell lines in vitro. Changes in gene expression, induction of signalling, and cell motility can all be investigated...
Many women newly diagnosed with breast cancer and with a strong family history of breast cancer are referred to a family cancer service for genetic counselling and for consideration of genetic testing for germ...
The fate of cells that disseminate from a primary breast tumour remains poorly understood. Studies of the kinetics of recurrence in breast cancer patients are raising important questions about the biology of t...
Basal-like breast cancers (BLBC) frequently overexpress the epidermal growth factor receptor (EGFR) and subsequently have high levels of signaling through the MAP kinase pathway, which is thought to contribute...
2022 Citation Impact
7.4 - 2-year Impact Factor
7.4 - 5-year Impact Factor
1.764 - SNIP (Source Normalized Impact per Paper)
2.408 - SJR (SCImago Journal Rank)
2023 Speed
20 days submission to first editorial decision for all manuscripts (Median)
129 days submission to accept (Median)
2023 Usage
2,432,781 downloads
1,561 Altmetric mentions