Volume 7 Supplement 2

The Third International Symposium on the Molecular Biology of Breast Cancer

Meeting abstracts

Affymetrix, Agilent Technologies, Applied Biosystems, AstraZeneca, Novartis Oncology, Pfizer, Roche Diagnostics (Main Sponsors).

The Third International Symposium on the Molecular Biology of Breast Cancer.

Molde, Norway22-26 June 2005

Page 3 of 4

Microcell-mediated transfer of chromosome 6 into the breast cancer cell line MDA-MB-231: a specific set of genes is involved in the reversion of the tumorigenic phenotype

Authors: J Strissel, S Seitz, W Arnold, J Weimer, A Jacobsen, N Arnold and S Scherneck

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.14

Content type: Poster Presentation Published on: 17 June 2005
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Epigenetic silencing of tropomyosin alters transforming growth factor beta control of cell invasion and metastasis

Authors: A Bakin, A Varga, Q Zheng and A Safina

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.15

Content type: Poster Presentation Published on: 17 June 2005
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Hypermethylation of cyclin D₂ and DAP kinase is associated with the lobular subtype of breast cancer

Authors: U Lehmann, P Ahrens, LU Wingen, B Schlegelberger, F Länger and H Kreipe

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.16

Content type: Poster Presentation Published on: 17 June 2005
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Methylation profiling of carcinogenesis-associated genes in sporadic breast cancer

Authors: M Nemtsova, V Zemlyakova, E Kusnetsova, V Strelnikov, L Lyubchenko and D Zaletayev

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.17

Content type: Poster Presentation Published on: 17 June 2005
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Expression profiling of Wnt pathway genes in breast cancer

Authors: K Benhaj, B Gur, B Bozkurt, I Yulug, C Akcali and M Ozturk

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.18

Content type: Poster Presentation Published on: 17 June 2005
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Real-time PCR-based expression profiling of BRCA1-induced genes in primary breast tumors

Authors: B Gur, B Bozkurt, O Konu, S Seckin and IG Yulug

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.19

Content type: Poster Presentation Published on: 17 June 2005
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Development of a rapid screening approach for candidate gene sets in cancer

Authors: R Wittig, R Salowsky, S Blaich, S Lyer, JS Maa, O Müller, J Mollenhauer and A Poustka

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.20

Content type: Poster Presentation Published on: 17 June 2005
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Application of microarray analyses to identify genes involved in radiation-induced fibrosis

Authors: OK Rødningen, J Alsner, T Hastie, J Overgaard and A-L Børresen-Dale

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.21

Content type: Poster Presentation Published on: 17 June 2005
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Gene expression studies in radiation-sensitive cell lines

Authors: J Aarøe, R Gatti, A-L Børresen-Dale and O Rødningen

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.22

Content type: Poster Presentation Published on: 17 June 2005
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Breast tumors induced by high-dose radiation display similar genetic profiles

Authors: A Broeks, SR de Kemp, W Bakker, LM Braaf, FE van Leeuwen, M Stovall, MK Schmidt, NS Russell, LFA Wessels and LJ van 't Veer

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.23

Content type: Poster Presentation Published on: 17 June 2005
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Molecular characterization of breast cell lines: a tool for breast cancer studies

Authors: E Charafe-Jauffret, C Ginestier, F Monville, J Adélaïde, P Finetti, F Bertucci, L Xerri, J Jacquemier and D Birnbaum

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.24

Content type: Poster Presentation Published on: 17 June 2005
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Cell differentiation and dominant signaling pathway signatures in the molecular classification of human breast cancer cell lines

Authors: CA Wilson, J Dering, G Bernardo, HM Rong, C Ginther, R Ferdman, AM Cook, R Finn and DJ Slamon

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.25

Content type: Poster Presentation Published on: 17 June 2005
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Reproducibility of molecular portraits in early stage breast cancer

Authors: DSA Nuyten, HY Chang, PO Brown and MJ Van de Vijver

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.26

Content type: Poster Presentation Published on: 17 June 2005
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Subclassification and molecular characterization of early stage breast carcinomas using Applied Biosystems Human Genome Survey Microarrays

Authors: Y Wang, T Sørlie, C Xiao, L-A Macalik, H Johnsen, G Schroth, A-L Børresen-Dale and R Samaha

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.27

Content type: Poster Presentation Published on: 17 June 2005
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Lymph node metastases display gene expression profiles of their primary breast carcinomas

Authors: B Weigelt, LFA Wessels, AJ Bosma, AM Glas, DSA Nuyten, YD He, H Dai, JL Peterse and LJ van 't Veer

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.28

Content type: Poster Presentation Published on: 17 June 2005
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Genome-wide expression profiling of microdissected human breast tumor cells: tumor classification predictive of metastases and clinical outcome

Authors: U Vinatzer, B Dampier, M Pacher, K Kaserer, C Haslinger, N Schweifer and M Schreiber

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.29

Content type: Poster Presentation Published on: 17 June 2005
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Gene expression signature of hereditary breast cancer

Authors: V Dudaladava, M Jarzab, J Pamula, W Pekala, T Huzarski, J Lubinski, E Grzybowska and K Lisowska

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.30

Content type: Poster Presentation Published on: 17 June 2005
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Comparison of the expression profile in breast cancer and ovarian cancer

Authors: M Jarzab, V Dudaladava and K Simek

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.31

Content type: Poster Presentation Published on: 17 June 2005
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Comparative expressed sequence hybridisation revealed distinct chromosomal regions of differential gene expression in breast cancer subtypes

Authors: I Vanden Bempt, V Vanhentenrijk, M Drijkoningen and C De Wolf-Peeters

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.32

Content type: Poster Presentation Published on: 17 June 2005
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Gene expression profiling in breast cancer challenges the existence of intermediate histological grade

Authors: C Sotiriou, P Wirapati, S Loi, A Harris, J Bergh, J Smeds, V Praz, P Farmer, B Haibe-Kains, F Lallemand, M Buyse, M Piccart and M Delorenzi

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.33

Content type: Poster Presentation Published on: 17 June 2005
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Promoter composition predicts gene classes in microarray expression analyses of breast cancer

Authors: SH Nordgard, T Sørlie, SJ Chanock, A-L Børresen-Dale, K Gardner and VN Kristensen

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.34

Content type: Poster Presentation Published on: 17 June 2005
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Identification of differentially expressed genes in canine mammary tumor cell lines using a newly developed canine-specific cDNA microarray

Authors: NAS Rao, R van den Ham, M van Wolferen and JA Mol

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.35

Content type: Poster Presentation Published on: 17 June 2005
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Discovering genetic profiles by array-CGH in familial breast tumors

Authors: PM Nederlof, E van Beers, S Joosse, FBL Hogervorst, LFA Wessels, P Devilee, C Cornelisse, R Oldenburg, S Verhoef and LJ van 't Veer

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.36

Content type: Poster Presentation Published on: 17 June 2005
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Chromosomal imbalances mapped by array-based comparative genomic hybridization in an integrated approach to combat breast cancer in Denmark

Authors: J Li, X Zhang, TD Jensen, K Wang, S Kølvraa and L Bolund

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.37

Content type: Poster Presentation Published on: 17 June 2005
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Outcome signature genes in breast cancer: is there a unique set?

Authors: I Kela, L Ein-Dor, G Getz, D Givol and E Domany

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.38

Content type: Poster Presentation Published on: 17 June 2005
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Mapping the location of recurring amplicons in array-CGH data

Authors: OC Lingjærde, K Liestøl, L Baumbusch, HL Størvold and AL Børresen-Dale

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.39

Content type: Poster Presentation Published on: 17 June 2005
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Comparative genomic hybridization using oligonucleotide arrays and total genomic DNA

Authors: MT Barrett, N Sampas, A Ben-Dor, A Scheffer, P Anderson, P Tsang, C Gooden, R Walker, B Curry, R Kincaid, D Lipson, M Bittner, Z Yakhini, PS Meltzer, L Bruhn and S Laderman

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.40

Content type: Poster Presentation Published on: 17 June 2005
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DNA copy number changes in breast cancer samples using array-CGH profiling

Authors: R Argonza-Barrett, W Dorlijn and J Bailey

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.41

Content type: Poster Presentation Published on: 17 June 2005
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Quality control of DNA with on-chip electrophoresis for oligonucleotide-array comparative genomic hybridization

Authors: C Buhlmann, O Mueller, R Salowsky and S Lightfoot

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.42

Content type: Poster Presentation Published on: 17 June 2005
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Predicting survival from gene expression data by generalized partial least squares regression

Authors: HL Størvold and OC Lingjærde

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.43

Content type: Poster Presentation Published on: 17 June 2005
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Gene expression profiles and the TP53 mutation status are powerful prognostic markers of breast cancer

Authors: A Langerød, H Zhao, Ø Borgan, JM Nesland, T Hernandez-Boussard, IK Bukholm, R Kåresen, AL Børresen-Dale and SS Jeffrey

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.44

Content type: Poster Presentation Published on: 17 June 2005
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TP53 mutations among molecular subtypes of HER2-positive tumors

Authors: Å Helland, M Nicolau, Y Ji, A Langerød, DE Sommervoll, A Bergamaschi, JR Pollack, A-L Børresen-Dale and SS Jeffrey

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.45

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Mutant p53 exerts its gain of function through activation of the NF-κB pathway

Authors: A Damalas, L Weis, SH Nordgard, VN Kristensen, K Gardner, G Cheng, C Gelinas, M Levrero, S Strano, AL Børresen-Dale, V Rotter, M Oren and G Blandino

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.46

Content type: Poster Presentation Published on: 17 June 2005
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Expression of wild-type and mutated TP53in breast carcinomas

Authors: LO Baumbusch, S Myhre, A Langerød, A Bergamaschi, H Johnsen, S Geisler, PE Lønning and A-L Børresen-Dale

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.47

Content type: Poster Presentation Published on: 17 June 2005
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Independent prognostic value of somatic TP53gene mutations in 1794 breast cancer patients

Authors: M Olivier, A Langerød, P Carrieri, J Bergh, S Klaar, J Eyfjord, C Theillet, C Rodriguez, R Lidereau, I Bièche, J Varley, Y Bignon, N Uhrhammer, R Winqvist, A Jukkola-Vuorinen, D Niederacher…

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.48

Content type: Poster Presentation Published on: 17 June 2005
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Prognostic value genotypes and LOH at TP53 codon 72 and TP53mutations in primary breast cancer

Authors: M Kyndi, J Alsner, LL Hansen, FB Sørensen and J Overgaard

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.49

Content type: Poster Presentation Published on: 17 June 2005
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Evaluation of the arrayed primer extension resequencing assay for TP53mutation detection

Authors: EU Due, H Johnsen, CA Wilson, CJ Fæster, P Vu, A Bergamaschi, P Kringen and AL Børresen-Dale

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.50

Content type: Poster Presentation Published on: 17 June 2005
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Cancer gene mutation discovery and detection using array-based resequencing

Authors: T Tengs, JC Lee, JG Paez, X Zhao, T LaFramboise, G Giannoukos and RK Thomas

Citation: Breast Cancer Research 2005 7(Suppl 2):P4.51

Content type: Poster Presentation Published on: 17 June 2005
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Detection of circulating cancer cells in peripheral blood as a prognostic factor in early breast cancer

Authors: A Fabisiewicz, P Kober, M Koptyra, E Brewczynska, R Sienkiewicz-Kozlowska, T Pienkowski and JA Siedlecki

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.01

Content type: Poster Presentation Published on: 17 June 2005
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Detection of minimal disease in breast cancer

Authors: AJ Bosma, H Helgason, L Braaf, S Rodenhuis and LJ van 't Veer

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.02

Content type: Poster Presentation Published on: 17 June 2005
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Postoperative serum proteomic profiles and identification of biomarkers with prognosis value in high-risk early breast cancer patients

Authors: A Gonçalves, B Esterni, F Bertucci, R Sauvan, M Cubizolles, S Granjeaud, C Chabannon, G Houvenaegel, J Jacquemier, X-Y Meng, ET Fung, D Birnbaum, D Maraninchi, P Viens and JP Borg

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.03

Content type: Poster Presentation Published on: 17 June 2005
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Monitoring of minimal residual cancer in bone marrow in high-risk breast cancer patients treated with high-dose chemotherapy

Authors: V Drageset, JM Nesland, B Erikstein, E Skovlund, H Sommer, G Anker, E Wist, S Lundgren, J Bergh and G Kvalheim

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.04

Content type: Poster Presentation Published on: 17 June 2005
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Hypoxia promotes invasion and metastasis of breast cancer cells by increasing lysyl oxidase expression

Authors: JT Erler, SS Jeffrey and AJ Giaccia

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.05

Content type: Poster Presentation Published on: 17 June 2005
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Breast tumors induce the recruitment of AC133⁺KDR⁺ endothelial precursor cells mobilized by plasma vascular endothelial growth factor

Authors: M Botelho, I Amendoeira, J Diamond, S Dias and F Schmitt

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.06

Content type: Poster Presentation Published on: 17 June 2005
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The extracellular matrix composition and responsiveness to breast carcinoma therapy

Authors: SM Pupa, WS Argraves, S Cotrupi, S Giuffré, F Castiglioni, S Ménard and E Tagliabue

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.07

Content type: Poster Presentation Published on: 17 June 2005
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Characterization of extracellular matrix composition in breast carcinoma

Authors: A Bergamaschi, E Tagliabue, T Sørlie, J Nesland, R Orlandi, S Ménard and A-L Børresen-Dale

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.08

Content type: Poster Presentation Published on: 17 June 2005
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Brn-3b transcription factor in breast tumourigenesis: regulation of genes associated with growth and migration of cancer cells

Authors: SA Lee and VS Budhram-Mahadeo

Citation: Breast Cancer Research 2005 7(Suppl 2):P5.09

Content type: Poster Presentation Published on: 17 June 2005
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Identification of drug targets for the treatment of Basal-like tumors

Authors: KA Hoadley and CM Perou

Citation: Breast Cancer Research 2005 7(Suppl 2):P6.01

Content type: Poster Presentation Published on: 17 June 2005
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Determining the factors affecting breast cancer infectivity by oncolytic adenovirus

Authors: C Mysinger, C Soria, J Yeh, C O'Shea, L Timmerman and F McCormick

Citation: Breast Cancer Research 2005 7(Suppl 2):P6.02

Content type: Poster Presentation Published on: 17 June 2005
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Magnetic resonance spectroscopy of breast cancer tissue used for tumor classification and lymph node prediction

Authors: B Sitter, TF Bathen, LR Jensen, D Axelson, J Halgunset, HE Fjosne, S Lundgren and IS Gribbestad

Citation: Breast Cancer Research 2005 7(Suppl 2):P7.01

Content type: Poster Presentation Published on: 17 June 2005
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The Third International Symposium on the Molecular Biology of Breast Cancer

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