Fig. 8
From: AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis
Elevated AMD1 predicts poor clinical outcome. (A) Kaplan-Meier survival analysis for OS, RFS, and DMFS of patients in NKI295 and GSE25066 datasets according to AMD1 expression status. The p value was determined using the log-rank test. (B) Kaplan-Meier survival analysis for OS, RFS, and DMFS of patients in an aggregate breast cancer dataset according to AMD1 expression status. The p value was determined using the log-rank test. (C) Analysis of the upper quartile survival for OS, RFS, and DMFS of patients in an aggregate breast cancer dataset. (D) A proposed model to illustrate mechanisms and functions of AMD1 overexpression and AMD1-mediated spermidine-eIF5A hypusination-TCF4 axis, promoting breast cancer aggressiveness (please see discussion)