Selective omission of sentinel lymph node biopsy in mastectomy for ductal carcinoma in situ: identifying eligible candidates

Table 2 Baseline characteristics according to DCIS upgraded to invasive disease

Variables	DCIS (n = 221)		Upgrade to invasive disease (n = 164)
Variables	N	(%)	N	(%)	p-value
Age (y)					0.234
≤ 50	132	59.7	88	53.7
> 50	89	40.3	76	46.3
Palpable mass or bloody nipple discharge					< 0.001
No	147	66.5	70	42.7
Yes	74	33.5	94	57.3
Clinical tumor size, median (range), cm	4 (0.5–10.4)		5.05 (1.0–12.9)		< 0.001
Suspicious axillary lymph node on radiologic evaluation					0.001
No	184	83.3	112	68.3
Yes	37	16.7	52	31.7
Suspicious microcalcification on radiologic evaluation					0.295
No	73	33	46	28
Yes	148	67	118	72
Nuclear grade^*,†					0.040
Low	34	18.6	19	13.6
Intermediate	110	60.1	74	52.9
High	39	21.3	47	33.6
Comedo necrosis^*,†					0.152
No	70	39.8	41	31.8
Yes	106	60.2	88	68.2
Hormone receptor^§					0.003
Negative	44	19.9	55	33.5
Positive	174	78.7	108	65.9
HER2^§					0.092
Negative	153	69.2	101	61.6
Positive	65	29.4	62	37.8
Ki-67 (%) ^§					< 0.001
< 14%	174	78.7	100	61.0
≥ 14%	44	19.9	62	37.8

ISSN: 1465-542X